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Protein

Phosphatidylinositol 4-kinase beta

Gene

PI4KB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).By similarity3 Publications

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.1 Publication

Enzyme regulationi

Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ (By similarity).By similarity

GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB
  • 1-phosphatidylinositol 4-kinase activity Source: Reactome
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • phosphatidylinositol biosynthetic process Source: Reactome
  • phosphatidylinositol-mediated signaling Source: InterPro
  • receptor-mediated endocytosis Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS07046-MONOMER.
ZFISH:HS07046-MONOMER.
BRENDAi2.7.1.67. 2681.
ReactomeiR-HSA-1660514. Synthesis of PIPs at the Golgi membrane.
SIGNORiQ9UBF8.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-kinase beta (EC:2.7.1.67)
Short name:
PI4K-beta
Short name:
PI4Kbeta
Short name:
PtdIns 4-kinase beta
Alternative name(s):
NPIK
PI4K92
Gene namesi
Name:PI4KB
Synonyms:PIK4CB
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8984. PI4KB.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • cytosol Source: Reactome
  • endosome Source: ProtInc
  • Golgi membrane Source: Reactome
  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • rough endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi40 – 42LSV → AAA: Small decrease in C10ORF76-binding. No effect on ACBD3-, nor RAB11B-binding. 1 Publication3
Mutagenesisi43 – 45IDP → AAA: Drastically decreased ACBD3-binding. No effect on C10ORF76-, nor RAB11B-binding. 1 Publication3
Mutagenesisi46 – 47EV → AA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication2
Mutagenesisi49 – 50QK → AA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication2
Mutagenesisi52C → A: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication1
Mutagenesisi53 – 54QE → AA: Drastically decreased C10ORF76- and RAB11B-binding. 6-fold increase in ACBD3-binding. 1 Publication2
Mutagenesisi55 – 56VL → AA: Drastically decreased ACBD3-binding. No effect on C10ORF76-, nor RAB11B-binding. 1 Publication2
Mutagenesisi57 – 59EKV → AAA: No effect on ACBD3-, C10ORF76-, nor RAB11B-binding. 1 Publication3

Organism-specific databases

DisGeNETi5298.
OpenTargetsiENSG00000143393.
PharmGKBiPA162399420.

Chemistry databases

ChEMBLiCHEMBL3268.
GuidetoPHARMACOLOGYi2149.

Polymorphism and mutation databases

BioMutaiPI4KB.
DMDMi38372507.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000888292 – 816Phosphatidylinositol 4-kinase betaAdd BLAST815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Modified residuei258PhosphoserineCombined sources1 Publication1
Modified residuei263Phosphothreonine1 Publication1
Modified residuei266PhosphoserineCombined sources1 Publication1
Modified residuei275PhosphoserineBy similarity1
Modified residuei277PhosphoserineCombined sources1 Publication1
Modified residuei284PhosphoserineBy similarity1
Modified residuei294Phosphoserine2 Publications1
Modified residuei428PhosphoserineCombined sources1
Modified residuei438Phosphothreonine1 Publication1
Modified residuei511PhosphoserineCombined sources1 Publication1
Modified residuei517PhosphothreonineCombined sources1
Modified residuei519Phosphothreonine1 Publication1
Isoform 21 Publication (identifier: Q9UBF8-2)
Modified residuei294PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UBF8.
MaxQBiQ9UBF8.
PaxDbiQ9UBF8.
PeptideAtlasiQ9UBF8.
PRIDEiQ9UBF8.

PTM databases

iPTMnetiQ9UBF8.
PhosphoSitePlusiQ9UBF8.

Miscellaneous databases

PMAP-CutDBQ9UBF8.

Expressioni

Tissue specificityi

Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver.3 Publications

Gene expression databases

BgeeiENSG00000143393.
CleanExiHS_PI4KB.
ExpressionAtlasiQ9UBF8. baseline and differential.
GenevisibleiQ9UBF8. HS.

Organism-specific databases

HPAiCAB022071.
HPA006280.
HPA006281.

Interactioni

Subunit structurei

Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (PubMed:17555535). Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity). Interacts with ACBD3. Interacts with YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (PubMed:23572552).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ACBD3Q9H3P74EBI-1053214,EBI-1791792
NSP034952EBI-1053214,EBI-2548993From a different organism.

GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111316. 13 interactors.
DIPiDIP-42267N.
IntActiQ9UBF8. 10 interactors.
MINTiMINT-1681077.
STRINGi9606.ENSP00000271657.

Chemistry databases

BindingDBiQ9UBF8.

Structurei

Secondary structure

1816
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi45 – 63Combined sources19
Helixi129 – 134Combined sources6
Helixi141 – 150Combined sources10
Helixi154 – 163Combined sources10
Helixi164 – 166Combined sources3
Helixi169 – 173Combined sources5
Helixi176 – 185Combined sources10
Helixi188 – 204Combined sources17
Helixi206 – 218Combined sources13
Helixi234 – 242Combined sources9
Helixi308 – 323Combined sources16
Helixi324 – 326Combined sources3
Helixi330 – 341Combined sources12
Turni342 – 344Combined sources3
Helixi345 – 347Combined sources3
Beta strandi349 – 351Combined sources3
Beta strandi357 – 359Combined sources3
Beta strandi361 – 365Combined sources5
Helixi368 – 370Combined sources3
Beta strandi372 – 374Combined sources3
Beta strandi376 – 380Combined sources5
Beta strandi382 – 390Combined sources9
Turni394 – 396Combined sources3
Beta strandi397 – 405Combined sources9
Turni409 – 411Combined sources3
Beta strandi512 – 514Combined sources3
Helixi522 – 527Combined sources6
Helixi537 – 546Combined sources10
Turni549 – 552Combined sources4
Beta strandi556 – 564Combined sources9
Helixi570 – 588Combined sources19
Beta strandi593 – 595Combined sources3
Beta strandi600 – 602Combined sources3
Beta strandi604 – 606Combined sources3
Beta strandi608 – 610Combined sources3
Beta strandi614 – 618Combined sources5
Helixi619 – 625Combined sources7
Helixi630 – 637Combined sources8
Helixi644 – 667Combined sources24
Beta strandi670 – 672Combined sources3
Turni674 – 676Combined sources3
Beta strandi677 – 680Combined sources4
Beta strandi685 – 687Combined sources3
Helixi698 – 702Combined sources5
Helixi712 – 717Combined sources6
Helixi724 – 741Combined sources18
Helixi744 – 755Combined sources12
Helixi761 – 763Combined sources3
Helixi768 – 774Combined sources7
Helixi782 – 796Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N73NMR-B1-68[»]
4D0LX-ray2.94A/C/E121-799[»]
4D0MX-ray6.00A/C/G/I/M/O/Q/S/W/Y/c/g121-799[»]
4WAEX-ray3.32A128-799[»]
4WAGX-ray3.41A128-799[»]
5C46X-ray2.65E121-799[»]
5C4GX-ray3.20E121-799[»]
5EUQX-ray3.20E121-248[»]
E523-799[»]
ProteinModelPortaliQ9UBF8.
SMRiQ9UBF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 242PIK helicalPROSITE-ProRule annotationAdd BLAST214
Domaini558 – 765PI3K/PI4KPROSITE-ProRule annotationCuratedAdd BLAST208

Sequence similaritiesi

Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
Contains 1 PIK helical domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0903. Eukaryota.
ENOG410XPH3. LUCA.
GeneTreeiENSGT00550000074892.
HOVERGENiHBG053597.
InParanoidiQ9UBF8.
KOiK19801.
PhylomeDBiQ9UBF8.
TreeFamiTF102042.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9UBF8-1) [UniParc]FASTAAdd to basket
Also known as: NPIK-B1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDTVVEPAP LKPTSEPTSG PPGNNGGSLL SVITEGVGEL SVIDPEVAQK
60 70 80 90 100
ACQEVLEKVK LLHGGVAVSS RGTPLELVNG DGVDSEIRCL DDPPAQIREE
110 120 130 140 150
EDEMGAAVAS GTAKGARRRR QNNSAKQSWL LRLFESKLFD ISMAISYLYN
160 170 180 190 200
SKEPGVQAYI GNRLFCFRNE DVDFYLPQLL NMYIHMDEDV GDAIKPYIVH
210 220 230 240 250
RCRQSINFSL QCALLLGAYS SDMHISTQRH SRGTKLRKLI LSDELKPAHR
260 270 280 290 300
KRELPSLSPA PDTGLSPSKR THQRSKSDAT ASISLSSNLK RTASNPKVEN
310 320 330 340 350
EDEELSSSTE SIDNSFSSPV RLAPEREFIK SLMAIGKRLA TLPTKEQKTQ
360 370 380 390 400
RLISELSLLN HKLPARVWLP TAGFDHHVVR VPHTQAVVLN SKDKAPYLIY
410 420 430 440 450
VEVLECENFD TTSVPARIPE NRIRSTRSVE NLPECGITHE QRAGSFSTVP
460 470 480 490 500
NYDNDDEAWS VDDIGELQVE LPEVHTNSCD NISQFSVDSI TSQESKEPVF
510 520 530 540 550
IAAGDIRRRL SEQLAHTPTA FKRDPEDPSA VALKEPWQEK VRRIREGSPY
560 570 580 590 600
GHLPNWRLLS VIVKCGDDLR QELLAFQVLK QLQSIWEQER VPLWIKPYKI
610 620 630 640 650
LVISADSGMI EPVVNAVSIH QVKKQSQLSL LDYFLQEHGS YTTEAFLSAQ
660 670 680 690 700
RNFVQSCAGY CLVCYLLQVK DRHNGNILLD AEGHIIHIDF GFILSSSPRN
710 720 730 740 750
LGFETSAFKL TTEFVDVMGG LDGDMFNYYK MLMLQGLIAA RKHMDKVVQI
760 770 780 790 800
VEIMQQGSQL PCFHGSSTIR NLKERFHMSM TEEQLQLLVE QMVDGSMRSI
810
TTKLYDGFQY LTNGIM
Length:816
Mass (Da):91,379
Last modified:May 1, 2000 - v1
Checksum:iCAD8791729BB4308
GO
Isoform 21 Publication (identifier: Q9UBF8-2) [UniParc]FASTAAdd to basket
Also known as: NPIK-C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     304-318: Missing.

Show »
Length:801
Mass (Da):89,807
Checksum:i22E1ABA37AA9A2BD
GO
Isoform 3 (identifier: Q9UBF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.

Show »
Length:484
Mass (Da):54,976
Checksum:i395A9DF64FC58A8C
GO

Sequence cautioni

The sequence BAA21661 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH70326 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAW53450 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216L → V in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti339L → V in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti340A → V in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti370P → S in AAC51156 (PubMed:9020160).Curated1
Sequence conflicti446F → S in BAG57793 (PubMed:14702039).Curated1
Sequence conflicti754M → L in BAG57793 (PubMed:14702039).Curated1
Sequence conflicti796S → G in BAG57793 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0371331 – 332Missing in isoform 3. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_050627304 – 318Missing in isoform 2. 3 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011121 mRNA. Translation: CAA09495.1.
AJ011122 mRNA. No translation available.
AJ011123 mRNA. Translation: CAA09496.1.
AB005910 mRNA. Translation: BAA21661.1. Different initiation.
U81802 mRNA. Translation: AAC51156.1.
AK294606 mRNA. Translation: BAG57793.1.
AL391069 Genomic DNA. Translation: CAH70324.1.
AL391069 Genomic DNA. Translation: CAH70325.1.
AL391069 Genomic DNA. Translation: CAH70326.1. Sequence problems.
CH471121 Genomic DNA. Translation: EAW53449.1.
CH471121 Genomic DNA. Translation: EAW53450.1. Sequence problems.
BC000029 mRNA. Translation: AAH00029.1.
BC040300 mRNA. Translation: AAH40300.1.
CCDSiCCDS55637.1. [Q9UBF8-3]
CCDS55638.1. [Q9UBF8-2]
CCDS81376.1. [Q9UBF8-1]
PIRiJC5706.
RefSeqiNP_001185702.1. NM_001198773.2. [Q9UBF8-2]
NP_001185703.1. NM_001198774.1. [Q9UBF8-2]
NP_001185704.1. NM_001198775.2. [Q9UBF8-3]
NP_001317650.1. NM_001330721.1.
NP_002642.1. NM_002651.3.
XP_016856979.1. XM_017001490.1. [Q9UBF8-1]
XP_016856980.1. XM_017001491.1. [Q9UBF8-1]
XP_016856981.1. XM_017001492.1. [Q9UBF8-2]
UniGeneiHs.632465.

Genome annotation databases

EnsembliENST00000368872; ENSP00000357866; ENSG00000143393. [Q9UBF8-2]
ENST00000368873; ENSP00000357867; ENSG00000143393. [Q9UBF8-1]
ENST00000368874; ENSP00000357868; ENSG00000143393. [Q9UBF8-2]
ENST00000529142; ENSP00000433149; ENSG00000143393. [Q9UBF8-3]
GeneIDi5298.
KEGGihsa:5298.
UCSCiuc001ext.4. human. [Q9UBF8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011121 mRNA. Translation: CAA09495.1.
AJ011122 mRNA. No translation available.
AJ011123 mRNA. Translation: CAA09496.1.
AB005910 mRNA. Translation: BAA21661.1. Different initiation.
U81802 mRNA. Translation: AAC51156.1.
AK294606 mRNA. Translation: BAG57793.1.
AL391069 Genomic DNA. Translation: CAH70324.1.
AL391069 Genomic DNA. Translation: CAH70325.1.
AL391069 Genomic DNA. Translation: CAH70326.1. Sequence problems.
CH471121 Genomic DNA. Translation: EAW53449.1.
CH471121 Genomic DNA. Translation: EAW53450.1. Sequence problems.
BC000029 mRNA. Translation: AAH00029.1.
BC040300 mRNA. Translation: AAH40300.1.
CCDSiCCDS55637.1. [Q9UBF8-3]
CCDS55638.1. [Q9UBF8-2]
CCDS81376.1. [Q9UBF8-1]
PIRiJC5706.
RefSeqiNP_001185702.1. NM_001198773.2. [Q9UBF8-2]
NP_001185703.1. NM_001198774.1. [Q9UBF8-2]
NP_001185704.1. NM_001198775.2. [Q9UBF8-3]
NP_001317650.1. NM_001330721.1.
NP_002642.1. NM_002651.3.
XP_016856979.1. XM_017001490.1. [Q9UBF8-1]
XP_016856980.1. XM_017001491.1. [Q9UBF8-1]
XP_016856981.1. XM_017001492.1. [Q9UBF8-2]
UniGeneiHs.632465.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N73NMR-B1-68[»]
4D0LX-ray2.94A/C/E121-799[»]
4D0MX-ray6.00A/C/G/I/M/O/Q/S/W/Y/c/g121-799[»]
4WAEX-ray3.32A128-799[»]
4WAGX-ray3.41A128-799[»]
5C46X-ray2.65E121-799[»]
5C4GX-ray3.20E121-799[»]
5EUQX-ray3.20E121-248[»]
E523-799[»]
ProteinModelPortaliQ9UBF8.
SMRiQ9UBF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111316. 13 interactors.
DIPiDIP-42267N.
IntActiQ9UBF8. 10 interactors.
MINTiMINT-1681077.
STRINGi9606.ENSP00000271657.

Chemistry databases

BindingDBiQ9UBF8.
ChEMBLiCHEMBL3268.
GuidetoPHARMACOLOGYi2149.

PTM databases

iPTMnetiQ9UBF8.
PhosphoSitePlusiQ9UBF8.

Polymorphism and mutation databases

BioMutaiPI4KB.
DMDMi38372507.

Proteomic databases

EPDiQ9UBF8.
MaxQBiQ9UBF8.
PaxDbiQ9UBF8.
PeptideAtlasiQ9UBF8.
PRIDEiQ9UBF8.

Protocols and materials databases

DNASUi5298.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368872; ENSP00000357866; ENSG00000143393. [Q9UBF8-2]
ENST00000368873; ENSP00000357867; ENSG00000143393. [Q9UBF8-1]
ENST00000368874; ENSP00000357868; ENSG00000143393. [Q9UBF8-2]
ENST00000529142; ENSP00000433149; ENSG00000143393. [Q9UBF8-3]
GeneIDi5298.
KEGGihsa:5298.
UCSCiuc001ext.4. human. [Q9UBF8-1]

Organism-specific databases

CTDi5298.
DisGeNETi5298.
GeneCardsiPI4KB.
H-InvDBHIX0001056.
HGNCiHGNC:8984. PI4KB.
HPAiCAB022071.
HPA006280.
HPA006281.
MIMi602758. gene.
neXtProtiNX_Q9UBF8.
OpenTargetsiENSG00000143393.
PharmGKBiPA162399420.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0903. Eukaryota.
ENOG410XPH3. LUCA.
GeneTreeiENSGT00550000074892.
HOVERGENiHBG053597.
InParanoidiQ9UBF8.
KOiK19801.
PhylomeDBiQ9UBF8.
TreeFamiTF102042.

Enzyme and pathway databases

BioCyciMetaCyc:HS07046-MONOMER.
ZFISH:HS07046-MONOMER.
BRENDAi2.7.1.67. 2681.
ReactomeiR-HSA-1660514. Synthesis of PIPs at the Golgi membrane.
SIGNORiQ9UBF8.

Miscellaneous databases

ChiTaRSiPI4KB. human.
GeneWikiiPI4KB.
GenomeRNAii5298.
PMAP-CutDBQ9UBF8.
PROiQ9UBF8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143393.
CleanExiHS_PI4KB.
ExpressionAtlasiQ9UBF8. baseline and differential.
GenevisibleiQ9UBF8. HS.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPI4KB_HUMAN
AccessioniPrimary (citable) accession number: Q9UBF8
Secondary accession number(s): B4DGI2
, O15096, P78405, Q5VWB9, Q5VWC0, Q5VWC1, Q9BWR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.