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Q9UBF2

- COPG2_HUMAN

UniProt

Q9UBF2 - COPG2_HUMAN

Protein

Coatomer subunit gamma-2

Gene

COPG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. intra-Golgi vesicle-mediated transport Source: UniProtKB
    3. retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
    4. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coatomer subunit gamma-2
    Alternative name(s):
    Gamma-2-coat protein
    Short name:
    Gamma-2-COP
    Gene namesi
    Name:COPG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:2237. COPG2.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmic vesicleCOPI-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Tends to be more abundant in the trans-Golgi network compared to the cis-Golgi.By similarity

    GO - Cellular componenti

    1. COPI vesicle coat Source: UniProtKB
    2. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26753.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 871871Coatomer subunit gamma-2PRO_0000193862Add
    BLAST

    Proteomic databases

    MaxQBiQ9UBF2.
    PaxDbiQ9UBF2.
    PeptideAtlasiQ9UBF2.
    PRIDEiQ9UBF2.

    PTM databases

    PhosphoSiteiQ9UBF2.

    Expressioni

    Gene expression databases

    CleanExiHS_COPG2.
    GenevestigatoriQ9UBF2.

    Interactioni

    Subunit structurei

    Oligomeric complex. Binds to CDC42.

    Protein-protein interaction databases

    BioGridi117926. 20 interactions.
    IntActiQ9UBF2. 9 interactions.
    MINTiMINT-4990643.
    STRINGi9606.ENSP00000393912.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBF2.
    SMRiQ9UBF2. Positions 20-311, 606-870.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati64 – 10138HEAT 1Add
    BLAST
    Repeati283 – 32038HEAT 2Add
    BLAST
    Repeati321 – 35535HEAT 3Add
    BLAST
    Repeati356 – 39237HEAT 4Add
    BLAST
    Repeati395 – 43036HEAT 5Add
    BLAST
    Repeati467 – 50438HEAT 6Add
    BLAST

    Sequence similaritiesi

    Belongs to the COPG family.Curated
    Contains 6 HEAT repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5240.
    HOVERGENiHBG004368.
    KOiK17267.
    OMAiIKHTFAN.
    PhylomeDBiQ9UBF2.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    2.60.40.1480. 1 hit.
    3.30.310.30. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    IPR017106. Coatomer_gsu.
    IPR013040. Coatomer_gsu_app_Ig-like-sub.
    [Graphical view]
    PANTHERiPTHR10261. PTHR10261. 1 hit.
    PfamiPF01602. Adaptin_N. 1 hit.
    PF08752. COP-gamma_platf. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037093. Coatomer_gamma_subunit. 1 hit.
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UBF2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIKKFDKKDE ESGSGSNPFQ HLEKSAVLQE ARIFNETPIN PRRCLHILTK    50
    ILYLLNQGEH FGTTEATEAF FAMTRLFQSN DQTLRRMCYL TIKEMATISE 100
    DVIIVTSSLT KDMTGKEDVY RGPAIRALCR ITDGTMLQAI ERYMKQAIVD 150
    KVSSVSSSAL VSSLHMMKIS YDVVKRWINE AQEAASSDNI MVQYHALGVL 200
    YHLRKNDRLA VSKMLNKFTK SGLKSQFAYC MLIRIASRLL KETEDGHESP 250
    LFDFIESCLR NKHEMVIYEA ASAIIHLPNC TARELAPAVS VLQLFCSSPK 300
    PALRYAAVRT LNKVAMKHPS AVTACNLDLE NLITDSNRSI ATLAITTLLK 350
    TGSESSVDRL MKQISSFVSE ISDEFKVVVV QAISALCQKY PRKHSVMMTF 400
    LSNMLRDDGG FEYKRAIVDC IISIVEENPE SKEAGLAHLC EFIEDCEHTV 450
    LATKILHLLG KEGPRTPVPS KYIRFIFNRV VLENEAVRAA AVSALAKFGA 500
    QNESLLPSIL VLLQRCMMDT DDEVRDRATF YLNVLQQRQM ALNATYIFNG 550
    LTVSVPGMEK ALHQYTLEPS EKPFDMKSIP LAMAPVFEQK AEITLVATKP 600
    EKLAPSRQDI FQEQLAAIPE FLNIGPLFKS SEPVQLTEAE TEYFVRCIKH 650
    MFTNHIVFQF DCTNTLNDQL LEKVTVQMEP SDSYEVLSCI PAPSLPYNQP 700
    GICYTLVRLP DDDPTAVAGS FSCTMKFTVR DCDPNTGVPD EDGYDDEYVL 750
    EDLEVTVSDH IQKVLKPNFA AAWEEVGDTF EKEETFALSS TKTLEEAVNN 800
    IITFLGMQPC ERSDKVPENK NSHSLYLAGI FRGGYDLLVR SRLALADGVT 850
    MQVTVRSKER TPVDVILASV G 871
    Length:871
    Mass (Da):97,622
    Last modified:May 1, 2000 - v1
    Checksum:iD361A0E74069CBEB
    GO
    Isoform 2 (identifier: Q9UBF2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         717-726: VAGSFSCTMK → GTNPQKGGDT
         727-871: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:726
    Mass (Da):81,483
    Checksum:i808D4BC052AE37D6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti547 – 5471I → L.
    Corresponds to variant rs10128 [ dbSNP | Ensembl ].
    VAR_060181
    Natural varianti626 – 6261P → L.
    Corresponds to variant rs17333054 [ dbSNP | Ensembl ].
    VAR_060182

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei717 – 72610VAGSFSCTMK → GTNPQKGGDT in isoform 2. 1 PublicationVSP_055534
    Alternative sequencei727 – 871145Missing in isoform 2. 1 PublicationVSP_055535Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF207598 mRNA. Translation: AAF19433.1.
    AF157833 mRNA. Translation: AAF14271.1.
    AB047847 mRNA. Translation: BAB17658.1.
    AK291409 mRNA. Translation: BAF84098.1.
    AC090520 Genomic DNA. No translation available.
    AC009274 Genomic DNA. No translation available.
    AC007938 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24085.1.
    CH471070 Genomic DNA. Translation: EAW83769.1.
    BC017443 mRNA. Translation: AAH17443.2.
    BC110796 mRNA. Translation: AAI10797.1.
    RefSeqiNP_036265.3. NM_012133.5.
    UniGeneiHs.6421.

    Genome annotation databases

    GeneIDi26958.
    KEGGihsa:26958.
    UCSCiuc003vqh.1. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF207598 mRNA. Translation: AAF19433.1 .
    AF157833 mRNA. Translation: AAF14271.1 .
    AB047847 mRNA. Translation: BAB17658.1 .
    AK291409 mRNA. Translation: BAF84098.1 .
    AC090520 Genomic DNA. No translation available.
    AC009274 Genomic DNA. No translation available.
    AC007938 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24085.1 .
    CH471070 Genomic DNA. Translation: EAW83769.1 .
    BC017443 mRNA. Translation: AAH17443.2 .
    BC110796 mRNA. Translation: AAI10797.1 .
    RefSeqi NP_036265.3. NM_012133.5.
    UniGenei Hs.6421.

    3D structure databases

    ProteinModelPortali Q9UBF2.
    SMRi Q9UBF2. Positions 20-311, 606-870.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117926. 20 interactions.
    IntActi Q9UBF2. 9 interactions.
    MINTi MINT-4990643.
    STRINGi 9606.ENSP00000393912.

    PTM databases

    PhosphoSitei Q9UBF2.

    Proteomic databases

    MaxQBi Q9UBF2.
    PaxDbi Q9UBF2.
    PeptideAtlasi Q9UBF2.
    PRIDEi Q9UBF2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 26958.
    KEGGi hsa:26958.
    UCSCi uc003vqh.1. human.

    Organism-specific databases

    CTDi 26958.
    GeneCardsi GC07M130146.
    H-InvDB HIX0201202.
    HGNCi HGNC:2237. COPG2.
    MIMi 604355. gene.
    neXtProti NX_Q9UBF2.
    PharmGKBi PA26753.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5240.
    HOVERGENi HBG004368.
    KOi K17267.
    OMAi IKHTFAN.
    PhylomeDBi Q9UBF2.

    Miscellaneous databases

    GeneWikii COPG2.
    GenomeRNAii 26958.
    NextBioi 49412.
    PROi Q9UBF2.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_COPG2.
    Genevestigatori Q9UBF2.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    2.60.40.1480. 1 hit.
    3.30.310.30. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    IPR017106. Coatomer_gsu.
    IPR013040. Coatomer_gsu_app_Ig-like-sub.
    [Graphical view ]
    PANTHERi PTHR10261. PTHR10261. 1 hit.
    Pfami PF01602. Adaptin_N. 1 hit.
    PF08752. COP-gamma_platf. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037093. Coatomer_gamma_subunit. 1 hit.
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Newly identified coatomer subunits reveal multiple copy complexes acting in the early secretory pathway."
      Whitney J.A., Godzich M., Kreis T.E.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome."
      Blagitko N., Schulz U., Schinzel A.A., Ropers H.-H., Kalscheuer V.M.
      Hum. Mol. Genet. 8:2387-2396(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Identification and characterization of novel isoforms of COP I subunits."
      Futatsumori M., Kasai K., Takatsu H., Shin H.-W., Nakayama K.
      J. Biochem. 128:793-801(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-871 (ISOFORM 1).
      Tissue: Brain and Eye.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOPG2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBF2
    Secondary accession number(s): A6NH74
    , Q2NLA0, Q54AC3, Q8WVW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3