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Q9UBF2

- COPG2_HUMAN

UniProt

Q9UBF2 - COPG2_HUMAN

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Protein
Coatomer subunit gamma-2
Gene
COPG2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. intra-Golgi vesicle-mediated transport Source: UniProtKB
  2. intracellular protein transport Source: InterPro
  3. retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit gamma-2
Alternative name(s):
Gamma-2-coat protein
Short name:
Gamma-2-COP
Gene namesi
Name:COPG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:2237. COPG2.

Subcellular locationi

Cytoplasmcytosol By similarity. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmic vesicleCOPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it By similarity. Tends to be more abundant in the trans-Golgi network compared to the cis-Golgi By similarity.

GO - Cellular componenti

  1. COPI vesicle coat Source: UniProtKB
  2. cytosol Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 871871Coatomer subunit gamma-2
PRO_0000193862Add
BLAST

Proteomic databases

MaxQBiQ9UBF2.
PaxDbiQ9UBF2.
PeptideAtlasiQ9UBF2.
PRIDEiQ9UBF2.

PTM databases

PhosphoSiteiQ9UBF2.

Expressioni

Gene expression databases

CleanExiHS_COPG2.
GenevestigatoriQ9UBF2.

Interactioni

Subunit structurei

Oligomeric complex. Binds to CDC42.

Protein-protein interaction databases

BioGridi117926. 20 interactions.
IntActiQ9UBF2. 8 interactions.
MINTiMINT-4990643.
STRINGi9606.ENSP00000393912.

Structurei

3D structure databases

ProteinModelPortaliQ9UBF2.
SMRiQ9UBF2. Positions 20-311, 606-870.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 10138HEAT 1
Add
BLAST
Repeati283 – 32038HEAT 2
Add
BLAST
Repeati321 – 35535HEAT 3
Add
BLAST
Repeati356 – 39237HEAT 4
Add
BLAST
Repeati395 – 43036HEAT 5
Add
BLAST
Repeati467 – 50438HEAT 6
Add
BLAST

Sequence similaritiesi

Belongs to the COPG family.
Contains 6 HEAT repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5240.
HOVERGENiHBG004368.
KOiK17267.
OMAiIKHTFAN.
PhylomeDBiQ9UBF2.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1480. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR017106. Coatomer_gsu.
IPR013040. Coatomer_gsu_app_Ig-like-sub.
[Graphical view]
PANTHERiPTHR10261. PTHR10261. 1 hit.
PfamiPF01602. Adaptin_N. 1 hit.
PF08752. COP-gamma_platf. 1 hit.
[Graphical view]
PIRSFiPIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UBF2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MIKKFDKKDE ESGSGSNPFQ HLEKSAVLQE ARIFNETPIN PRRCLHILTK    50
ILYLLNQGEH FGTTEATEAF FAMTRLFQSN DQTLRRMCYL TIKEMATISE 100
DVIIVTSSLT KDMTGKEDVY RGPAIRALCR ITDGTMLQAI ERYMKQAIVD 150
KVSSVSSSAL VSSLHMMKIS YDVVKRWINE AQEAASSDNI MVQYHALGVL 200
YHLRKNDRLA VSKMLNKFTK SGLKSQFAYC MLIRIASRLL KETEDGHESP 250
LFDFIESCLR NKHEMVIYEA ASAIIHLPNC TARELAPAVS VLQLFCSSPK 300
PALRYAAVRT LNKVAMKHPS AVTACNLDLE NLITDSNRSI ATLAITTLLK 350
TGSESSVDRL MKQISSFVSE ISDEFKVVVV QAISALCQKY PRKHSVMMTF 400
LSNMLRDDGG FEYKRAIVDC IISIVEENPE SKEAGLAHLC EFIEDCEHTV 450
LATKILHLLG KEGPRTPVPS KYIRFIFNRV VLENEAVRAA AVSALAKFGA 500
QNESLLPSIL VLLQRCMMDT DDEVRDRATF YLNVLQQRQM ALNATYIFNG 550
LTVSVPGMEK ALHQYTLEPS EKPFDMKSIP LAMAPVFEQK AEITLVATKP 600
EKLAPSRQDI FQEQLAAIPE FLNIGPLFKS SEPVQLTEAE TEYFVRCIKH 650
MFTNHIVFQF DCTNTLNDQL LEKVTVQMEP SDSYEVLSCI PAPSLPYNQP 700
GICYTLVRLP DDDPTAVAGS FSCTMKFTVR DCDPNTGVPD EDGYDDEYVL 750
EDLEVTVSDH IQKVLKPNFA AAWEEVGDTF EKEETFALSS TKTLEEAVNN 800
IITFLGMQPC ERSDKVPENK NSHSLYLAGI FRGGYDLLVR SRLALADGVT 850
MQVTVRSKER TPVDVILASV G 871
Length:871
Mass (Da):97,622
Last modified:May 1, 2000 - v1
Checksum:iD361A0E74069CBEB
GO
Isoform 2 (identifier: Q9UBF2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     717-726: VAGSFSCTMK → GTNPQKGGDT
     727-871: Missing.

Note: No experimental confirmation available.

Show »
Length:726
Mass (Da):81,483
Checksum:i808D4BC052AE37D6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti547 – 5471I → L.
Corresponds to variant rs10128 [ dbSNP | Ensembl ].
VAR_060181
Natural varianti626 – 6261P → L.
Corresponds to variant rs17333054 [ dbSNP | Ensembl ].
VAR_060182

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei717 – 72610VAGSFSCTMK → GTNPQKGGDT in isoform 2.
VSP_055534
Alternative sequencei727 – 871145Missing in isoform 2.
VSP_055535Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF207598 mRNA. Translation: AAF19433.1.
AF157833 mRNA. Translation: AAF14271.1.
AB047847 mRNA. Translation: BAB17658.1.
AK291409 mRNA. Translation: BAF84098.1.
AC090520 Genomic DNA. No translation available.
AC009274 Genomic DNA. No translation available.
AC007938 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24085.1.
CH471070 Genomic DNA. Translation: EAW83769.1.
BC017443 mRNA. Translation: AAH17443.2.
BC110796 mRNA. Translation: AAI10797.1.
RefSeqiNP_036265.3. NM_012133.5.
UniGeneiHs.6421.

Genome annotation databases

EnsembliENST00000582694; ENSP00000462407; ENSG00000266779.
GeneIDi26958.
KEGGihsa:26958.
UCSCiuc003vqh.1. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF207598 mRNA. Translation: AAF19433.1 .
AF157833 mRNA. Translation: AAF14271.1 .
AB047847 mRNA. Translation: BAB17658.1 .
AK291409 mRNA. Translation: BAF84098.1 .
AC090520 Genomic DNA. No translation available.
AC009274 Genomic DNA. No translation available.
AC007938 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24085.1 .
CH471070 Genomic DNA. Translation: EAW83769.1 .
BC017443 mRNA. Translation: AAH17443.2 .
BC110796 mRNA. Translation: AAI10797.1 .
RefSeqi NP_036265.3. NM_012133.5.
UniGenei Hs.6421.

3D structure databases

ProteinModelPortali Q9UBF2.
SMRi Q9UBF2. Positions 20-311, 606-870.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117926. 20 interactions.
IntActi Q9UBF2. 8 interactions.
MINTi MINT-4990643.
STRINGi 9606.ENSP00000393912.

PTM databases

PhosphoSitei Q9UBF2.

Proteomic databases

MaxQBi Q9UBF2.
PaxDbi Q9UBF2.
PeptideAtlasi Q9UBF2.
PRIDEi Q9UBF2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000582694 ; ENSP00000462407 ; ENSG00000266779 .
GeneIDi 26958.
KEGGi hsa:26958.
UCSCi uc003vqh.1. human.

Organism-specific databases

CTDi 26958.
GeneCardsi GC07M130146.
H-InvDB HIX0201202.
HGNCi HGNC:2237. COPG2.
MIMi 604355. gene.
neXtProti NX_Q9UBF2.
PharmGKBi PA26753.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5240.
HOVERGENi HBG004368.
KOi K17267.
OMAi IKHTFAN.
PhylomeDBi Q9UBF2.

Miscellaneous databases

GeneWikii COPG2.
GenomeRNAii 26958.
NextBioi 49412.
PROi Q9UBF2.
SOURCEi Search...

Gene expression databases

CleanExi HS_COPG2.
Genevestigatori Q9UBF2.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
2.60.40.1480. 1 hit.
3.30.310.30. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR017106. Coatomer_gsu.
IPR013040. Coatomer_gsu_app_Ig-like-sub.
[Graphical view ]
PANTHERi PTHR10261. PTHR10261. 1 hit.
Pfami PF01602. Adaptin_N. 1 hit.
PF08752. COP-gamma_platf. 1 hit.
[Graphical view ]
PIRSFi PIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Newly identified coatomer subunits reveal multiple copy complexes acting in the early secretory pathway."
    Whitney J.A., Godzich M., Kreis T.E.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome."
    Blagitko N., Schulz U., Schinzel A.A., Ropers H.-H., Kalscheuer V.M.
    Hum. Mol. Genet. 8:2387-2396(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Identification and characterization of novel isoforms of COP I subunits."
    Futatsumori M., Kasai K., Takatsu H., Shin H.-W., Nakayama K.
    J. Biochem. 128:793-801(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-871 (ISOFORM 1).
    Tissue: Brain and Eye.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOPG2_HUMAN
AccessioniPrimary (citable) accession number: Q9UBF2
Secondary accession number(s): A6NH74
, Q2NLA0, Q54AC3, Q8WVW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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