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Protein

Coatomer subunit gamma-2

Gene

COPG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: Reactome
  • intracellular protein transport Source: InterPro
  • intra-Golgi vesicle-mediated transport Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-33868-MONOMER.
ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit gamma-2
Alternative name(s):
Gamma-2-coat protein
Short name:
Gamma-2-COP
Gene namesi
Name:COPG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:2237. COPG2.

Subcellular locationi

GO - Cellular componenti

  • COPI vesicle coat Source: UniProtKB
  • cytosol Source: Reactome
  • endoplasmic reticulum membrane Source: Reactome
  • Golgi membrane Source: Reactome
  • transport vesicle Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26958.
OpenTargetsiENSG00000158623.
PharmGKBiPA26753.

Polymorphism and mutation databases

BioMutaiCOPG2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938621 – 871Coatomer subunit gamma-2Add BLAST871

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei594PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBF2.
MaxQBiQ9UBF2.
PaxDbiQ9UBF2.
PeptideAtlasiQ9UBF2.
PRIDEiQ9UBF2.

PTM databases

iPTMnetiQ9UBF2.
PhosphoSitePlusiQ9UBF2.

Expressioni

Gene expression databases

BgeeiENSG00000266779.
CleanExiHS_COPG2.
ExpressionAtlasiQ9UBF2. baseline and differential.
GenevisibleiQ9UBF2. HS.

Interactioni

Subunit structurei

Oligomeric complex. Binds to CDC42. Interacts with JAGN1.1 Publication

Protein-protein interaction databases

BioGridi117926. 34 interactors.
IntActiQ9UBF2. 12 interactors.
MINTiMINT-4990643.
STRINGi9606.ENSP00000393912.

Structurei

3D structure databases

ProteinModelPortaliQ9UBF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 101HEAT 1Add BLAST38
Repeati283 – 320HEAT 2Add BLAST38
Repeati321 – 355HEAT 3Add BLAST35
Repeati356 – 392HEAT 4Add BLAST37
Repeati395 – 430HEAT 5Add BLAST36
Repeati467 – 504HEAT 6Add BLAST38

Sequence similaritiesi

Belongs to the COPG family.Curated
Contains 6 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1078. Eukaryota.
COG5240. LUCA.
GeneTreeiENSGT00390000016313.
HOVERGENiHBG004368.
InParanoidiQ9UBF2.
KOiK17267.
OMAiFFEHQLV.
OrthoDBiEOG091G0HWQ.
PhylomeDBiQ9UBF2.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1480. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR032154. Coatomer_g_Cpla.
IPR017106. Coatomer_gsu.
IPR013040. Coatomer_gsu_app_Ig-like-sub.
[Graphical view]
PANTHERiPTHR10261. PTHR10261. 1 hit.
PfamiPF01602. Adaptin_N. 1 hit.
PF16381. Coatomer_g_Cpla. 1 hit.
PF08752. COP-gamma_platf. 1 hit.
[Graphical view]
PIRSFiPIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIKKFDKKDE ESGSGSNPFQ HLEKSAVLQE ARIFNETPIN PRRCLHILTK
60 70 80 90 100
ILYLLNQGEH FGTTEATEAF FAMTRLFQSN DQTLRRMCYL TIKEMATISE
110 120 130 140 150
DVIIVTSSLT KDMTGKEDVY RGPAIRALCR ITDGTMLQAI ERYMKQAIVD
160 170 180 190 200
KVSSVSSSAL VSSLHMMKIS YDVVKRWINE AQEAASSDNI MVQYHALGVL
210 220 230 240 250
YHLRKNDRLA VSKMLNKFTK SGLKSQFAYC MLIRIASRLL KETEDGHESP
260 270 280 290 300
LFDFIESCLR NKHEMVIYEA ASAIIHLPNC TARELAPAVS VLQLFCSSPK
310 320 330 340 350
PALRYAAVRT LNKVAMKHPS AVTACNLDLE NLITDSNRSI ATLAITTLLK
360 370 380 390 400
TGSESSVDRL MKQISSFVSE ISDEFKVVVV QAISALCQKY PRKHSVMMTF
410 420 430 440 450
LSNMLRDDGG FEYKRAIVDC IISIVEENPE SKEAGLAHLC EFIEDCEHTV
460 470 480 490 500
LATKILHLLG KEGPRTPVPS KYIRFIFNRV VLENEAVRAA AVSALAKFGA
510 520 530 540 550
QNESLLPSIL VLLQRCMMDT DDEVRDRATF YLNVLQQRQM ALNATYIFNG
560 570 580 590 600
LTVSVPGMEK ALHQYTLEPS EKPFDMKSIP LAMAPVFEQK AEITLVATKP
610 620 630 640 650
EKLAPSRQDI FQEQLAAIPE FLNIGPLFKS SEPVQLTEAE TEYFVRCIKH
660 670 680 690 700
MFTNHIVFQF DCTNTLNDQL LEKVTVQMEP SDSYEVLSCI PAPSLPYNQP
710 720 730 740 750
GICYTLVRLP DDDPTAVAGS FSCTMKFTVR DCDPNTGVPD EDGYDDEYVL
760 770 780 790 800
EDLEVTVSDH IQKVLKPNFA AAWEEVGDTF EKEETFALSS TKTLEEAVNN
810 820 830 840 850
IITFLGMQPC ERSDKVPENK NSHSLYLAGI FRGGYDLLVR SRLALADGVT
860 870
MQVTVRSKER TPVDVILASV G
Length:871
Mass (Da):97,622
Last modified:May 1, 2000 - v1
Checksum:iD361A0E74069CBEB
GO
Isoform 2 (identifier: Q9UBF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     717-726: VAGSFSCTMK → GTNPQKGGDT
     727-871: Missing.

Note: No experimental confirmation available.
Show »
Length:726
Mass (Da):81,483
Checksum:i808D4BC052AE37D6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060181547I → L.Corresponds to variant rs10128dbSNPEnsembl.1
Natural variantiVAR_060182626P → L.Corresponds to variant rs17333054dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055534717 – 726VAGSFSCTMK → GTNPQKGGDT in isoform 2. 1 Publication10
Alternative sequenceiVSP_055535727 – 871Missing in isoform 2. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207598 mRNA. Translation: AAF19433.1.
AF157833 mRNA. Translation: AAF14271.1.
AB047847 mRNA. Translation: BAB17658.1.
AK291409 mRNA. Translation: BAF84098.1.
AC090520 Genomic DNA. No translation available.
AC009274 Genomic DNA. No translation available.
AC007938 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24085.1.
CH471070 Genomic DNA. Translation: EAW83769.1.
BC017443 mRNA. Translation: AAH17443.2.
BC110796 mRNA. Translation: AAI10797.1.
CCDSiCCDS75662.1. [Q9UBF2-1]
CCDS78275.1. [Q9UBF2-2]
RefSeqiNP_001276962.1. NM_001290033.1. [Q9UBF2-2]
NP_036265.3. NM_012133.5. [Q9UBF2-1]
UniGeneiHs.6421.

Genome annotation databases

EnsembliENST00000330992; ENSP00000331218; ENSG00000158623. [Q9UBF2-2]
ENST00000425248; ENSP00000402346; ENSG00000158623. [Q9UBF2-1]
GeneIDi26958.
KEGGihsa:26958.
UCSCiuc033ahl.2. human. [Q9UBF2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207598 mRNA. Translation: AAF19433.1.
AF157833 mRNA. Translation: AAF14271.1.
AB047847 mRNA. Translation: BAB17658.1.
AK291409 mRNA. Translation: BAF84098.1.
AC090520 Genomic DNA. No translation available.
AC009274 Genomic DNA. No translation available.
AC007938 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24085.1.
CH471070 Genomic DNA. Translation: EAW83769.1.
BC017443 mRNA. Translation: AAH17443.2.
BC110796 mRNA. Translation: AAI10797.1.
CCDSiCCDS75662.1. [Q9UBF2-1]
CCDS78275.1. [Q9UBF2-2]
RefSeqiNP_001276962.1. NM_001290033.1. [Q9UBF2-2]
NP_036265.3. NM_012133.5. [Q9UBF2-1]
UniGeneiHs.6421.

3D structure databases

ProteinModelPortaliQ9UBF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117926. 34 interactors.
IntActiQ9UBF2. 12 interactors.
MINTiMINT-4990643.
STRINGi9606.ENSP00000393912.

PTM databases

iPTMnetiQ9UBF2.
PhosphoSitePlusiQ9UBF2.

Polymorphism and mutation databases

BioMutaiCOPG2.

Proteomic databases

EPDiQ9UBF2.
MaxQBiQ9UBF2.
PaxDbiQ9UBF2.
PeptideAtlasiQ9UBF2.
PRIDEiQ9UBF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330992; ENSP00000331218; ENSG00000158623. [Q9UBF2-2]
ENST00000425248; ENSP00000402346; ENSG00000158623. [Q9UBF2-1]
GeneIDi26958.
KEGGihsa:26958.
UCSCiuc033ahl.2. human. [Q9UBF2-1]

Organism-specific databases

CTDi26958.
DisGeNETi26958.
GeneCardsiCOPG2.
H-InvDBHIX0201202.
HGNCiHGNC:2237. COPG2.
MIMi604355. gene.
neXtProtiNX_Q9UBF2.
OpenTargetsiENSG00000158623.
PharmGKBiPA26753.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1078. Eukaryota.
COG5240. LUCA.
GeneTreeiENSGT00390000016313.
HOVERGENiHBG004368.
InParanoidiQ9UBF2.
KOiK17267.
OMAiFFEHQLV.
OrthoDBiEOG091G0HWQ.
PhylomeDBiQ9UBF2.

Enzyme and pathway databases

BioCyciZFISH:G66-33868-MONOMER.
ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

ChiTaRSiCOPG2. human.
GeneWikiiCOPG2.
GenomeRNAii26958.
PROiQ9UBF2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000266779.
CleanExiHS_COPG2.
ExpressionAtlasiQ9UBF2. baseline and differential.
GenevisibleiQ9UBF2. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1480. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR032154. Coatomer_g_Cpla.
IPR017106. Coatomer_gsu.
IPR013040. Coatomer_gsu_app_Ig-like-sub.
[Graphical view]
PANTHERiPTHR10261. PTHR10261. 1 hit.
PfamiPF01602. Adaptin_N. 1 hit.
PF16381. Coatomer_g_Cpla. 1 hit.
PF08752. COP-gamma_platf. 1 hit.
[Graphical view]
PIRSFiPIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOPG2_HUMAN
AccessioniPrimary (citable) accession number: Q9UBF2
Secondary accession number(s): A6NH74
, Q2NLA0, Q54AC3, Q8WVW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.