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Protein

Ammonium transporter Rh type C

Gene

RHCG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.4 Publications

GO - Molecular functioni

GO - Biological processi

  • amine transport Source: UniProtKB
  • ammonium transport Source: UniProtKB
  • cellular ion homeostasis Source: UniProtKB
  • epithelial cell differentiation Source: UniProtKB
  • homeostatic process Source: UniProtKB
  • organic cation transport Source: GO_Central
  • regulation of pH Source: Ensembl
  • transepithelial ammonium transport Source: UniProtKB

Keywordsi

Biological processAmmonia transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-444411. Rhesus glycoproteins mediate ammonium transport.

Protein family/group databases

TCDBi1.A.11.4.1. the ammonium transporter channel (amt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Ammonium transporter Rh type C
Alternative name(s):
Rh glycoprotein kidney
Rhesus blood group family type C glycoprotein
Short name:
Rh family type C glycoprotein
Short name:
Rh type C glycoprotein
Tumor-related protein DRC2
Gene namesi
Name:RHCG
Synonyms:C15orf6, CDRC2, PDRC2, RHGK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140519.12.
HGNCiHGNC:18140. RHCG.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicIEP:9
Transmembranei10 – 30HelicalIEP:Add BLAST21
Topological domaini31 – 60ExtracellularIEP:Add BLAST30
Transmembranei61 – 81HelicalIEP:Add BLAST21
Topological domaini82 – 85CytoplasmicIEP:4
Transmembranei86 – 106HelicalIEP:Add BLAST21
Topological domaini107 – 123ExtracellularIEP:Add BLAST17
Transmembranei124 – 144HelicalIEP:Add BLAST21
Topological domaini145 – 148CytoplasmicIEP:4
Transmembranei149 – 169HelicalIEP:Add BLAST21
Topological domaini170 – 177ExtracellularIEP:8
Transmembranei178 – 200HelicalIEP:Add BLAST23
Topological domaini201 – 218CytoplasmicIEP:Add BLAST18
Transmembranei219 – 239HelicalIEP:Add BLAST21
Topological domaini240 – 250ExtracellularIEP:Add BLAST11
Transmembranei251 – 271HelicalIEP:Add BLAST21
Topological domaini272 – 281CytoplasmicIEP:10
Transmembranei282 – 302HelicalIEP:Add BLAST21
Topological domaini303ExtracellularIEP:1
Transmembranei304 – 324HelicalIEP:Add BLAST21
Topological domaini325 – 345CytoplasmicIEP:Add BLAST21
Transmembranei346 – 366HelicalIEP:Add BLAST21
Topological domaini367 – 394ExtracellularIEP:Add BLAST28
Transmembranei395 – 415HelicalIEP:Add BLAST21
Topological domaini416 – 479CytoplasmicIEP:Add BLAST64

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi74F → L: Reduction of ammonia transport. 1 Publication1
Mutagenesisi137V → I: Reduction of ammonia transport. 1 Publication1
Mutagenesisi177D → N: Loss of function. 1 Publication1
Mutagenesisi235F → V: Reduction of ammonia transport. 1 Publication1

Organism-specific databases

DisGeNETi51458.
OpenTargetsiENSG00000140519.
PharmGKBiPA134876043.

Chemistry databases

DrugBankiDB09326. Ammonia N-13.

Polymorphism and mutation databases

BioMutaiRHCG.
DMDMi74734928.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002835771 – 479Ammonium transporter Rh type CAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UBD6.
PeptideAtlasiQ9UBD6.
PRIDEiQ9UBD6.

PTM databases

iPTMnetiQ9UBD6.
PhosphoSitePlusiQ9UBD6.

Expressioni

Tissue specificityi

Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney.3 Publications

Developmental stagei

Specifically expressed in fetal kidney.1 Publication

Gene expression databases

BgeeiENSG00000140519.
CleanExiHS_RHCG.
ExpressionAtlasiQ9UBD6. baseline and differential.
GenevisibleiQ9UBD6. HS.

Organism-specific databases

HPAiHPA041874.
HPA043317.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-15853497,EBI-15853497

GO - Molecular functioni

  • ankyrin binding Source: UniProtKB
  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi119552. 1 interactor.
DIPiDIP-59334N.
STRINGi9606.ENSP00000268122.

Structurei

Secondary structure

1479
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 29ND:20
Helixi55 – 71ND:17
Helixi73 – 77ND:5
Helixi78 – 80ND:3
Helixi85 – 109ND:25
Turni114 – 116ND:3
Beta strandi117 – 119ND:3
Helixi122 – 142ND:21
Helixi148 – 170ND:23
Turni181 – 184ND:4
Helixi185 – 198ND:14
Helixi204 – 207ND:4
Turni208 – 210ND:3
Helixi215 – 235ND:21
Turni236 – 239ND:4
Helixi243 – 270ND:28
Helixi279 – 284ND:6
Helixi285 – 287ND:3
Helixi288 – 292ND:5
Turni293 – 299ND:7
Helixi303 – 332ND:30
Helixi340 – 343ND:4
Helixi345 – 360ND:16
Helixi385 – 416ND:32
Helixi432 – 434ND:3
Turni440 – 442ND:3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HD6X-ray2.10A2-479[»]
ProteinModelPortaliQ9UBD6.
SMRiQ9UBD6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UBD6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
HOVERGENiHBG004374.
InParanoidiQ9UBD6.
KOiK06580.
OMAiDLENEFY.
OrthoDBiEOG091G06KX.
PhylomeDBiQ9UBD6.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiView protein in InterPro
IPR029020. Ammonium/urea_transptr.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
PfamiView protein in Pfam
PF00909. Ammonium_transp. 1 hit.
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UBD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWNTNLRWR LPLTCLLLQV IMVILFGVFV RYDFEADAHW WSERTHKNLS
60 70 80 90 100
DMENEFYYRY PSFQDVHVMV FVGFGFLMTF LQRYGFSAVG FNFLLAAFGI
110 120 130 140 150
QWALLMQGWF HFLQDRYIVV GVENLINADF CVASVCVAFG AVLGKVSPIQ
160 170 180 190 200
LLIMTFFQVT LFAVNEFILL NLLKVKDAGG SMTIHTFGAY FGLTVTRILY
210 220 230 240 250
RRNLEQSKER QNSVYQSDLF AMIGTLFLWM YWPSFNSAIS YHGDSQHRAA
260 270 280 290 300
INTYCSLAAC VLTSVAISSA LHKKGKLDMV HIQNATLAGG VAVGTAAEMM
310 320 330 340 350
LMPYGALIIG FVCGIISTLG FVYLTPFLES RLHIQDTCGI NNLHGIPGII
360 370 380 390 400
GGIVGAVTAA SASLEVYGKE GLVHSFDFQG FNGDWTARTQ GKFQIYGLLV
410 420 430 440 450
TLAMALMGGI IVGLILRLPF WGQPSDENCF EDAVYWEMPE GNSTVYIPED
460 470
PTFKPSGPSV PSVPMVSPLP MASSVPLVP
Length:479
Mass (Da):53,179
Last modified:May 1, 2000 - v1
Checksum:iE5D8024D720D4589
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242H → R in AAP81044 (Ref. 6) IKR:1
Sequence conflicti442N → D in AAP81044 (Ref. 6) IKR:1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031496202R → C. Corresponds to variant dbSNP:rs17807723Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193809 mRNA. Translation: AAF19372.1.
AF219986
, AF219981, AF219982, AF219983, AF219984, AF219985 Genomic DNA. Translation: AAG02171.1.
AF081497 mRNA. Translation: AAD55748.1.
AF284446 Genomic DNA. Translation: AAG02414.1.
AY257182 mRNA. Translation: AAP81044.1.
AK290899 mRNA. Translation: BAF83588.1.
AK313238 mRNA. Translation: BAG36049.1.
AC013391 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02051.1.
BC030965 mRNA. Translation: AAH30965.1.
CCDSiCCDS10351.1.
RefSeqiNP_001307970.1. NM_001321041.1.
NP_057405.1. NM_016321.2.
UniGeneiHs.459284.

Genome annotation databases

EnsembliENST00000268122; ENSP00000268122; ENSG00000140519.
GeneIDi51458.
KEGGihsa:51458.
UCSCiuc002bnz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRHCG_HUMAN
AccessioniPrimary (citable) accession number: Q9UBD6
Secondary accession number(s): A8K4D4, Q6X3Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families