Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ammonium transporter Rh type C

Gene

RHCG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.4 Publications

GO - Molecular functioni

  • ammonium transmembrane transporter activity Source: UniProtKB
  • ankyrin binding Source: UniProtKB

GO - Biological processi

  • amine transport Source: UniProtKB
  • ammonium transport Source: UniProtKB
  • cellular ion homeostasis Source: UniProtKB
  • epithelial cell differentiation Source: UniProtKB
  • homeostatic process Source: UniProtKB
  • nitrogen utilization Source: GO_Central
  • organic cation transport Source: GO_Central
  • regulation of pH Source: Ensembl
  • transepithelial ammonium transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ammonia transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140519-MONOMER.
ReactomeiR-HSA-444411. Rhesus glycoproteins mediate ammonium transport.

Protein family/group databases

TCDBi1.A.11.4.1. the ammonium transporter channel (amt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Ammonium transporter Rh type C
Alternative name(s):
Rh glycoprotein kidney
Rhesus blood group family type C glycoprotein
Short name:
Rh family type C glycoprotein
Short name:
Rh type C glycoprotein
Tumor-related protein DRC2
Gene namesi
Name:RHCG
Synonyms:C15orf6, CDRC2, PDRC2, RHGK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:18140. RHCG.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 60ExtracellularSequence analysisAdd BLAST30
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Topological domaini82 – 85CytoplasmicSequence analysis4
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 123ExtracellularSequence analysisAdd BLAST17
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 148CytoplasmicSequence analysis4
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 177ExtracellularSequence analysis8
Transmembranei178 – 200HelicalSequence analysisAdd BLAST23
Topological domaini201 – 218CytoplasmicSequence analysisAdd BLAST18
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 250ExtracellularSequence analysisAdd BLAST11
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 281CytoplasmicSequence analysis10
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303ExtracellularSequence analysis1
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 345CytoplasmicSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 394ExtracellularSequence analysisAdd BLAST28
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 479CytoplasmicSequence analysisAdd BLAST64

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • basolateral plasma membrane Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi74F → L: Reduction of ammonia transport. 1 Publication1
Mutagenesisi137V → I: Reduction of ammonia transport. 1 Publication1
Mutagenesisi177D → N: Loss of function. 1 Publication1
Mutagenesisi235F → V: Reduction of ammonia transport. 1 Publication1

Organism-specific databases

DisGeNETi51458.
OpenTargetsiENSG00000140519.
PharmGKBiPA134876043.

Polymorphism and mutation databases

BioMutaiRHCG.
DMDMi74734928.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002835771 – 479Ammonium transporter Rh type CAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UBD6.
PeptideAtlasiQ9UBD6.
PRIDEiQ9UBD6.

PTM databases

iPTMnetiQ9UBD6.
PhosphoSitePlusiQ9UBD6.

Expressioni

Tissue specificityi

Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney.3 Publications

Developmental stagei

Specifically expressed in fetal kidney.1 Publication

Gene expression databases

BgeeiENSG00000140519.
CleanExiHS_RHCG.
ExpressionAtlasiQ9UBD6. baseline and differential.
GenevisibleiQ9UBD6. HS.

Organism-specific databases

HPAiHPA041874.
HPA043317.

Interactioni

Subunit structurei

Homotrimer.1 Publication

GO - Molecular functioni

  • ankyrin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119552. 1 interactor.
DIPiDIP-59334N.
STRINGi9606.ENSP00000268122.

Structurei

Secondary structure

1479
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 29Combined sources20
Helixi55 – 71Combined sources17
Helixi73 – 77Combined sources5
Helixi78 – 80Combined sources3
Helixi85 – 109Combined sources25
Turni114 – 116Combined sources3
Beta strandi117 – 119Combined sources3
Helixi122 – 142Combined sources21
Helixi148 – 170Combined sources23
Turni181 – 184Combined sources4
Helixi185 – 198Combined sources14
Helixi204 – 207Combined sources4
Turni208 – 210Combined sources3
Helixi215 – 235Combined sources21
Turni236 – 239Combined sources4
Helixi243 – 270Combined sources28
Helixi279 – 284Combined sources6
Helixi285 – 287Combined sources3
Helixi288 – 292Combined sources5
Turni293 – 299Combined sources7
Helixi303 – 332Combined sources30
Helixi340 – 343Combined sources4
Helixi345 – 360Combined sources16
Helixi385 – 416Combined sources32
Helixi432 – 434Combined sources3
Turni440 – 442Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HD6X-ray2.10A2-479[»]
ProteinModelPortaliQ9UBD6.
SMRiQ9UBD6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UBD6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
HOVERGENiHBG004374.
InParanoidiQ9UBD6.
KOiK06580.
OMAiDMENEFY.
OrthoDBiEOG091G06KX.
PhylomeDBiQ9UBD6.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UBD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWNTNLRWR LPLTCLLLQV IMVILFGVFV RYDFEADAHW WSERTHKNLS
60 70 80 90 100
DMENEFYYRY PSFQDVHVMV FVGFGFLMTF LQRYGFSAVG FNFLLAAFGI
110 120 130 140 150
QWALLMQGWF HFLQDRYIVV GVENLINADF CVASVCVAFG AVLGKVSPIQ
160 170 180 190 200
LLIMTFFQVT LFAVNEFILL NLLKVKDAGG SMTIHTFGAY FGLTVTRILY
210 220 230 240 250
RRNLEQSKER QNSVYQSDLF AMIGTLFLWM YWPSFNSAIS YHGDSQHRAA
260 270 280 290 300
INTYCSLAAC VLTSVAISSA LHKKGKLDMV HIQNATLAGG VAVGTAAEMM
310 320 330 340 350
LMPYGALIIG FVCGIISTLG FVYLTPFLES RLHIQDTCGI NNLHGIPGII
360 370 380 390 400
GGIVGAVTAA SASLEVYGKE GLVHSFDFQG FNGDWTARTQ GKFQIYGLLV
410 420 430 440 450
TLAMALMGGI IVGLILRLPF WGQPSDENCF EDAVYWEMPE GNSTVYIPED
460 470
PTFKPSGPSV PSVPMVSPLP MASSVPLVP
Length:479
Mass (Da):53,179
Last modified:May 1, 2000 - v1
Checksum:iE5D8024D720D4589
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242H → R in AAP81044 (Ref. 6) Curated1
Sequence conflicti442N → D in AAP81044 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031496202R → C.Corresponds to variant rs17807723dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193809 mRNA. Translation: AAF19372.1.
AF219986
, AF219981, AF219982, AF219983, AF219984, AF219985 Genomic DNA. Translation: AAG02171.1.
AF081497 mRNA. Translation: AAD55748.1.
AF284446 Genomic DNA. Translation: AAG02414.1.
AY257182 mRNA. Translation: AAP81044.1.
AK290899 mRNA. Translation: BAF83588.1.
AK313238 mRNA. Translation: BAG36049.1.
AC013391 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02051.1.
BC030965 mRNA. Translation: AAH30965.1.
CCDSiCCDS10351.1.
RefSeqiNP_001307970.1. NM_001321041.1.
NP_057405.1. NM_016321.2.
UniGeneiHs.459284.

Genome annotation databases

EnsembliENST00000268122; ENSP00000268122; ENSG00000140519.
GeneIDi51458.
KEGGihsa:51458.
UCSCiuc002bnz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193809 mRNA. Translation: AAF19372.1.
AF219986
, AF219981, AF219982, AF219983, AF219984, AF219985 Genomic DNA. Translation: AAG02171.1.
AF081497 mRNA. Translation: AAD55748.1.
AF284446 Genomic DNA. Translation: AAG02414.1.
AY257182 mRNA. Translation: AAP81044.1.
AK290899 mRNA. Translation: BAF83588.1.
AK313238 mRNA. Translation: BAG36049.1.
AC013391 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02051.1.
BC030965 mRNA. Translation: AAH30965.1.
CCDSiCCDS10351.1.
RefSeqiNP_001307970.1. NM_001321041.1.
NP_057405.1. NM_016321.2.
UniGeneiHs.459284.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HD6X-ray2.10A2-479[»]
ProteinModelPortaliQ9UBD6.
SMRiQ9UBD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119552. 1 interactor.
DIPiDIP-59334N.
STRINGi9606.ENSP00000268122.

Protein family/group databases

TCDBi1.A.11.4.1. the ammonium transporter channel (amt) family.

PTM databases

iPTMnetiQ9UBD6.
PhosphoSitePlusiQ9UBD6.

Polymorphism and mutation databases

BioMutaiRHCG.
DMDMi74734928.

Proteomic databases

PaxDbiQ9UBD6.
PeptideAtlasiQ9UBD6.
PRIDEiQ9UBD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268122; ENSP00000268122; ENSG00000140519.
GeneIDi51458.
KEGGihsa:51458.
UCSCiuc002bnz.4. human.

Organism-specific databases

CTDi51458.
DisGeNETi51458.
GeneCardsiRHCG.
HGNCiHGNC:18140. RHCG.
HPAiHPA041874.
HPA043317.
MIMi605381. gene.
neXtProtiNX_Q9UBD6.
OpenTargetsiENSG00000140519.
PharmGKBiPA134876043.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
HOVERGENiHBG004374.
InParanoidiQ9UBD6.
KOiK06580.
OMAiDMENEFY.
OrthoDBiEOG091G06KX.
PhylomeDBiQ9UBD6.
TreeFamiTF314450.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140519-MONOMER.
ReactomeiR-HSA-444411. Rhesus glycoproteins mediate ammonium transport.

Miscellaneous databases

ChiTaRSiRHCG. human.
EvolutionaryTraceiQ9UBD6.
GeneWikiiRHCG.
GenomeRNAii51458.
PROiQ9UBD6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140519.
CleanExiHS_RHCG.
ExpressionAtlasiQ9UBD6. baseline and differential.
GenevisibleiQ9UBD6. HS.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHCG_HUMAN
AccessioniPrimary (citable) accession number: Q9UBD6
Secondary accession number(s): A8K4D4, Q6X3Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.