Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UBD5

- ORC3_HUMAN

UniProt

Q9UBD5 - ORC3_HUMAN

Protein

Origin recognition complex subunit 3

Gene

ORC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.1 Publication

    GO - Molecular functioni

    1. DNA replication origin binding Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. DNA replication Source: Reactome
    2. G1/S transition of mitotic cell cycle Source: Reactome
    3. mitotic cell cycle Source: Reactome
    4. neural precursor cell proliferation Source: Ensembl

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_1095. Activation of the pre-replicative complex.
    REACT_1156. Orc1 removal from chromatin.
    REACT_1181. Association of licensing factors with the pre-replicative complex.
    REACT_1321. E2F-enabled inhibition of pre-replication complex formation.
    REACT_1707. CDC6 association with the ORC:origin complex.
    REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
    REACT_207. Removal of licensing factors from origins.
    REACT_2243. Assembly of the pre-replicative complex.
    REACT_567. Assembly of the ORC complex at the origin of replication.
    REACT_6769. Activation of ATR in response to replication stress.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Origin recognition complex subunit 3
    Alternative name(s):
    Origin recognition complex subunit Latheo
    Gene namesi
    Name:ORC3
    Synonyms:LATHEO, ORC3L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:8489. ORC3.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear origin of replication recognition complex Source: UniProtKB
    2. nucleoplasm Source: Reactome
    3. origin recognition complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32810.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 711711Origin recognition complex subunit 3PRO_0000127083Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231Phosphoserine1 Publication
    Modified residuei516 – 5161Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UBD5.
    PaxDbiQ9UBD5.
    PRIDEiQ9UBD5.

    PTM databases

    PhosphoSiteiQ9UBD5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UBD5.
    BgeeiQ9UBD5.
    GenevestigatoriQ9UBD5.

    Organism-specific databases

    HPAiHPA053748.

    Interactioni

    Subunit structurei

    Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ORC1Q1341512EBI-374916,EBI-374847
    ORC4O4392912EBI-374916,EBI-374889
    ORC5O4391315EBI-374916,EBI-374928
    ORC6Q9Y5N64EBI-374916,EBI-374840

    Protein-protein interaction databases

    BioGridi117130. 21 interactions.
    DIPiDIP-31735N.
    IntActiQ9UBD5. 20 interactions.
    MINTiMINT-1201384.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBD5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ORC3 family.Curated

    Phylogenomic databases

    eggNOGiNOG296366.
    HOVERGENiHBG007599.
    KOiK02605.
    OMAiCFVFKPN.
    OrthoDBiEOG78PV8B.
    PhylomeDBiQ9UBD5.
    TreeFamiTF101093.

    Family and domain databases

    InterProiIPR020795. ORC3.
    [Graphical view]
    PANTHERiPTHR12748. PTHR12748. 1 hit.
    PfamiPF07034. ORC3_N. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UBD5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATSSMSKGC FVFKPNSKKR KISLPIEDYF NKGKNEPEDS KLRFETYQLI    50
    WQQMKSENER LQEELNKNLF DNLIEFLQKS HSGFQKNSRD LGGQIKLREI 100
    PTAALVLGVN VTDHDLTFGS LTEALQNNVT PYVVSLQAKD CPDMKHFLQK 150
    LISQLMDCCV DIKSKEEESV HVTQRKTHYS MDSLSSWYMT VTQKTDPKML 200
    SKKRTTSSQW QSPPVVVILK DMESFATKVL QDFIIISSQH LHEFPLILIF 250
    GIATSPIIIH RLLPHAVSSL LCIELFQSLS CKEHLTTVLD KLLLTTQFPF 300
    KINEKVLQVL TNIFLYHDFS VQNFIKGLQL SLLEHFYSQP LSVLCCNLPE 350
    AKRRINFLSN NQCENIRRLP SFRRYVEKQA SEKQVALLTN ERYLKEETQL 400
    LLENLHVYHM NYFLVLRCLH KFTSSLPKYP LGRQIRELYC TCLEKNIWDS 450
    EEYASVLQLL RMLAKDELMT ILEKCFKVFK SYCENHLGST AKRIEEFLAQ 500
    FQSLDETKEE EDASGSQPKG LQKTDLYHLQ KSLLEMKELR RSKKQTKFEV 550
    LRENVVNFID CLVREYLLPP ETQPLHEVVY FSAAHALREH LNAAPRIALH 600
    TALNNPYYYL KNEALKSEEG CIPNIAPDIC IAYKLHLECS RLINLVDWSE 650
    AFATVVTAAE KMDANSATSE EMNEIIHARF IRAVSELELL GFIKPTKQKT 700
    DHVARLTWGG C 711
    Length:711
    Mass (Da):82,254
    Last modified:May 1, 2000 - v1
    Checksum:iE713569A11B39B1C
    GO
    Isoform 2 (identifier: Q9UBD5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         505-505: D → DA

    Note: No experimental confirmation available.

    Show »
    Length:712
    Mass (Da):82,325
    Checksum:i2F7953FCB84DD63F
    GO
    Isoform 3 (identifier: Q9UBD5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-143: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:568
    Mass (Da):65,929
    Checksum:i6FEEBF7290C82A97
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561S → F in BAD96515. 1 PublicationCurated
    Sequence conflicti86 – 861K → R in CAB45715. (PubMed:11230166)Curated
    Sequence conflicti137 – 1371Q → R in CAB45715. (PubMed:11230166)Curated
    Sequence conflicti471 – 4711I → M in BAD96515. 1 PublicationCurated
    Sequence conflicti531 – 5311K → R in CAB45715. (PubMed:11230166)Curated
    Sequence conflicti539 – 5391L → F in AAD40220. (PubMed:10402192)Curated
    Sequence conflicti539 – 5391L → F in AAA96313. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti94 – 941Q → K.1 Publication
    Corresponds to variant rs2307365 [ dbSNP | Ensembl ].
    VAR_014516
    Natural varianti126 – 1261Q → R.1 Publication
    Corresponds to variant rs2307371 [ dbSNP | Ensembl ].
    VAR_014517
    Natural varianti217 – 2171V → I.1 Publication
    Corresponds to variant rs2307389 [ dbSNP | Ensembl ].
    VAR_014518
    Natural varianti247 – 2471I → V.1 Publication
    Corresponds to variant rs2307374 [ dbSNP | Ensembl ].
    VAR_014519
    Natural varianti287 – 2871T → M.
    Corresponds to variant rs2307381 [ dbSNP | Ensembl ].
    VAR_014520
    Natural varianti389 – 3891T → P.
    Corresponds to variant rs2307372 [ dbSNP | Ensembl ].
    VAR_014521
    Natural varianti588 – 5881R → C.
    Corresponds to variant rs2307370 [ dbSNP | Ensembl ].
    VAR_014522
    Natural varianti626 – 6261A → T.1 Publication
    Corresponds to variant rs28381545 [ dbSNP | Ensembl ].
    VAR_020656

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 143143Missing in isoform 3. 1 PublicationVSP_044893Add
    BLAST
    Alternative sequencei505 – 5051D → DA in isoform 2. 2 PublicationsVSP_017129

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135044 mRNA. Translation: AAD30282.1.
    AF125507 mRNA. Translation: AAD18057.1.
    AF093535 mRNA. Translation: AAD40220.1.
    AL080116 mRNA. Translation: CAB45715.1.
    AK222795 mRNA. Translation: BAD96515.1.
    AK303195 mRNA. Translation: BAG64287.1.
    AK315911 mRNA. Translation: BAH14282.1.
    AY623113 Genomic DNA. Translation: AAT38109.1.
    AL451126, AL133211 Genomic DNA. Translation: CAI10900.1.
    AL133211, AL451126 Genomic DNA. Translation: CAI21539.1.
    AL451126, AL133211 Genomic DNA. Translation: CAM13063.1.
    AL133211, AL451126 Genomic DNA. Translation: CAM28255.1.
    BC035494 mRNA. Translation: AAH35494.1.
    BC047689 mRNA. Translation: AAH47689.1. Different termination.
    U50950 mRNA. Translation: AAA96313.1.
    CCDSiCCDS43486.1. [Q9UBD5-1]
    CCDS5012.1. [Q9UBD5-2]
    CCDS56440.1. [Q9UBD5-3]
    PIRiT12452.
    RefSeqiNP_001184188.1. NM_001197259.1. [Q9UBD5-3]
    NP_036513.2. NM_012381.3. [Q9UBD5-1]
    NP_862820.1. NM_181837.2. [Q9UBD5-2]
    UniGeneiHs.410228.

    Genome annotation databases

    EnsembliENST00000257789; ENSP00000257789; ENSG00000135336. [Q9UBD5-2]
    ENST00000392844; ENSP00000376586; ENSG00000135336. [Q9UBD5-1]
    ENST00000546266; ENSP00000444695; ENSG00000135336. [Q9UBD5-3]
    GeneIDi23595.
    KEGGihsa:23595.
    UCSCiuc003pmg.3. human. [Q9UBD5-2]
    uc003pmh.3. human. [Q9UBD5-1]

    Polymorphism databases

    DMDMi8928268.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135044 mRNA. Translation: AAD30282.1 .
    AF125507 mRNA. Translation: AAD18057.1 .
    AF093535 mRNA. Translation: AAD40220.1 .
    AL080116 mRNA. Translation: CAB45715.1 .
    AK222795 mRNA. Translation: BAD96515.1 .
    AK303195 mRNA. Translation: BAG64287.1 .
    AK315911 mRNA. Translation: BAH14282.1 .
    AY623113 Genomic DNA. Translation: AAT38109.1 .
    AL451126 , AL133211 Genomic DNA. Translation: CAI10900.1 .
    AL133211 , AL451126 Genomic DNA. Translation: CAI21539.1 .
    AL451126 , AL133211 Genomic DNA. Translation: CAM13063.1 .
    AL133211 , AL451126 Genomic DNA. Translation: CAM28255.1 .
    BC035494 mRNA. Translation: AAH35494.1 .
    BC047689 mRNA. Translation: AAH47689.1 . Different termination.
    U50950 mRNA. Translation: AAA96313.1 .
    CCDSi CCDS43486.1. [Q9UBD5-1 ]
    CCDS5012.1. [Q9UBD5-2 ]
    CCDS56440.1. [Q9UBD5-3 ]
    PIRi T12452.
    RefSeqi NP_001184188.1. NM_001197259.1. [Q9UBD5-3 ]
    NP_036513.2. NM_012381.3. [Q9UBD5-1 ]
    NP_862820.1. NM_181837.2. [Q9UBD5-2 ]
    UniGenei Hs.410228.

    3D structure databases

    ProteinModelPortali Q9UBD5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117130. 21 interactions.
    DIPi DIP-31735N.
    IntActi Q9UBD5. 20 interactions.
    MINTi MINT-1201384.

    PTM databases

    PhosphoSitei Q9UBD5.

    Polymorphism databases

    DMDMi 8928268.

    Proteomic databases

    MaxQBi Q9UBD5.
    PaxDbi Q9UBD5.
    PRIDEi Q9UBD5.

    Protocols and materials databases

    DNASUi 23595.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257789 ; ENSP00000257789 ; ENSG00000135336 . [Q9UBD5-2 ]
    ENST00000392844 ; ENSP00000376586 ; ENSG00000135336 . [Q9UBD5-1 ]
    ENST00000546266 ; ENSP00000444695 ; ENSG00000135336 . [Q9UBD5-3 ]
    GeneIDi 23595.
    KEGGi hsa:23595.
    UCSCi uc003pmg.3. human. [Q9UBD5-2 ]
    uc003pmh.3. human. [Q9UBD5-1 ]

    Organism-specific databases

    CTDi 23595.
    GeneCardsi GC06P088299.
    HGNCi HGNC:8489. ORC3.
    HPAi HPA053748.
    MIMi 604972. gene.
    neXtProti NX_Q9UBD5.
    PharmGKBi PA32810.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG296366.
    HOVERGENi HBG007599.
    KOi K02605.
    OMAi CFVFKPN.
    OrthoDBi EOG78PV8B.
    PhylomeDBi Q9UBD5.
    TreeFami TF101093.

    Enzyme and pathway databases

    Reactomei REACT_1095. Activation of the pre-replicative complex.
    REACT_1156. Orc1 removal from chromatin.
    REACT_1181. Association of licensing factors with the pre-replicative complex.
    REACT_1321. E2F-enabled inhibition of pre-replication complex formation.
    REACT_1707. CDC6 association with the ORC:origin complex.
    REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
    REACT_207. Removal of licensing factors from origins.
    REACT_2243. Assembly of the pre-replicative complex.
    REACT_567. Assembly of the ORC complex at the origin of replication.
    REACT_6769. Activation of ATR in response to replication stress.

    Miscellaneous databases

    ChiTaRSi ORC3. human.
    GeneWikii ORC3.
    ORC3L.
    GenomeRNAii 23595.
    NextBioi 46252.
    PROi Q9UBD5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UBD5.
    Bgeei Q9UBD5.
    Genevestigatori Q9UBD5.

    Family and domain databases

    InterProi IPR020795. ORC3.
    [Graphical view ]
    PANTHERi PTHR12748. PTHR12748. 1 hit.
    Pfami PF07034. ORC3_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Tugal T., Zou-Yang X.H., Gavin K., Pappin D., Canas B., Kobayashi R., Hunt T., Stillman B.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "cDNA cloning of a homolog for Saccharomyces cerevisiae ORC3 from Homo sapiens."
      Dean F.B., O'Donnell M.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant."
      Pinto S., Quintana D.G., Smith P., Mihalek R.M., Hou Z.-H., Boynton S., Jones C.J., Handricks M., Velinzon K., Wohlschlegel J.A., Austin R.J., Lane W.S., Dutta A., Tully T.
      Neuron 23:45-54(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Liver.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Thymus.
    7. NIEHS SNPs program
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-94; ARG-126; ILE-217; VAL-247 AND THR-626.
    8. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-671 (ISOFORM 2).
      Tissue: Testis and Uterus.
    10. Mihalek R., Homanics G.E.
      Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 156-542 (ISOFORM 1).
      Tissue: Brain.
    11. "The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle."
      Ohta S., Tatsumi Y., Fujita M., Tsurimoto T., Obuse C.
      J. Biol. Chem. 278:41535-41540(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE ORC COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, ASSEMBLY OF THE ORC COMPLEX.
    12. "ATP-dependent assembly of the human origin recognition complex."
      Siddiqui K., Stillman B.
      J. Biol. Chem. 282:32370-32383(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: RECONSTITUTION OF THE ORC COMPLEX, DISASSEMBLY OF THE ORC COMPLEX.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-516, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing."
      Chan K.M., Zhang Z.
      J. Biol. Chem. 287:15024-15033(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BINDING TO HISTONE H3 AND H4 TRIMETHYLATION MARKS.

    Entry informationi

    Entry nameiORC3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBD5
    Secondary accession number(s): A2A2T5
    , B4E025, Q13565, Q53GY6, Q5T159, Q6IUY7, Q86TN5, Q9UG44, Q9UNT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3