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Protein

Origin recognition complex subunit 3

Gene

ORC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.1 Publication

GO - Molecular functioni

  • DNA replication origin binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135336-MONOMER.
ReactomeiR-HSA-113507. E2F-enabled inhibition of pre-replication complex formation.
R-HSA-176187. Activation of ATR in response to replication stress.
R-HSA-68616. Assembly of the ORC complex at the origin of replication.
R-HSA-68689. CDC6 association with the ORC:origin complex.
R-HSA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-HSA-68867. Assembly of the pre-replicative complex.
R-HSA-68949. Orc1 removal from chromatin.
R-HSA-68962. Activation of the pre-replicative complex.
R-HSA-69298. Association of licensing factors with the pre-replicative complex.
R-HSA-69300. Removal of licensing factors from origins.

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 3
Alternative name(s):
Origin recognition complex subunit Latheo
Gene namesi
Name:ORC3
Synonyms:LATHEO, ORC3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:8489. ORC3.

Subcellular locationi

GO - Cellular componenti

  • DNA replication preinitiation complex Source: GO_Central
  • nuclear chromosome, telomeric region Source: BHF-UCL
  • nuclear origin of replication recognition complex Source: UniProtKB
  • nuclear pre-replicative complex Source: GO_Central
  • nucleoplasm Source: HPA
  • origin recognition complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23595.
OpenTargetsiENSG00000135336.
PharmGKBiPA32810.

Polymorphism and mutation databases

BioMutaiORC3.
DMDMi8928268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001270831 – 711Origin recognition complex subunit 3Add BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBD5.
MaxQBiQ9UBD5.
PaxDbiQ9UBD5.
PeptideAtlasiQ9UBD5.
PRIDEiQ9UBD5.

PTM databases

iPTMnetiQ9UBD5.
PhosphoSitePlusiQ9UBD5.

Expressioni

Gene expression databases

BgeeiENSG00000135336.
ExpressionAtlasiQ9UBD5. baseline and differential.
GenevisibleiQ9UBD5. HS.

Organism-specific databases

HPAiHPA039553.
HPA053748.

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ORC1Q1341512EBI-374916,EBI-374847
ORC4O4392912EBI-374916,EBI-374889
ORC5O4391315EBI-374916,EBI-374928
ORC6Q9Y5N64EBI-374916,EBI-374840

Protein-protein interaction databases

BioGridi117130. 43 interactors.
DIPiDIP-31735N.
IntActiQ9UBD5. 36 interactors.
MINTiMINT-1201384.
STRINGi9606.ENSP00000257789.

Structurei

3D structure databases

ProteinModelPortaliQ9UBD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC3 family.Curated

Phylogenomic databases

eggNOGiKOG2538. Eukaryota.
ENOG410XT1W. LUCA.
GeneTreeiENSGT00390000011376.
HOVERGENiHBG007599.
InParanoidiQ9UBD5.
KOiK02605.
OMAiHLECGRM.
OrthoDBiEOG091G0AI5.
PhylomeDBiQ9UBD5.
TreeFamiTF101093.

Family and domain databases

InterProiIPR020795. ORC3.
[Graphical view]
PANTHERiPTHR12748. PTHR12748. 1 hit.
PfamiPF07034. ORC3_N. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSSMSKGC FVFKPNSKKR KISLPIEDYF NKGKNEPEDS KLRFETYQLI
60 70 80 90 100
WQQMKSENER LQEELNKNLF DNLIEFLQKS HSGFQKNSRD LGGQIKLREI
110 120 130 140 150
PTAALVLGVN VTDHDLTFGS LTEALQNNVT PYVVSLQAKD CPDMKHFLQK
160 170 180 190 200
LISQLMDCCV DIKSKEEESV HVTQRKTHYS MDSLSSWYMT VTQKTDPKML
210 220 230 240 250
SKKRTTSSQW QSPPVVVILK DMESFATKVL QDFIIISSQH LHEFPLILIF
260 270 280 290 300
GIATSPIIIH RLLPHAVSSL LCIELFQSLS CKEHLTTVLD KLLLTTQFPF
310 320 330 340 350
KINEKVLQVL TNIFLYHDFS VQNFIKGLQL SLLEHFYSQP LSVLCCNLPE
360 370 380 390 400
AKRRINFLSN NQCENIRRLP SFRRYVEKQA SEKQVALLTN ERYLKEETQL
410 420 430 440 450
LLENLHVYHM NYFLVLRCLH KFTSSLPKYP LGRQIRELYC TCLEKNIWDS
460 470 480 490 500
EEYASVLQLL RMLAKDELMT ILEKCFKVFK SYCENHLGST AKRIEEFLAQ
510 520 530 540 550
FQSLDETKEE EDASGSQPKG LQKTDLYHLQ KSLLEMKELR RSKKQTKFEV
560 570 580 590 600
LRENVVNFID CLVREYLLPP ETQPLHEVVY FSAAHALREH LNAAPRIALH
610 620 630 640 650
TALNNPYYYL KNEALKSEEG CIPNIAPDIC IAYKLHLECS RLINLVDWSE
660 670 680 690 700
AFATVVTAAE KMDANSATSE EMNEIIHARF IRAVSELELL GFIKPTKQKT
710
DHVARLTWGG C
Length:711
Mass (Da):82,254
Last modified:May 1, 2000 - v1
Checksum:iE713569A11B39B1C
GO
Isoform 2 (identifier: Q9UBD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-505: D → DA

Note: No experimental confirmation available.
Show »
Length:712
Mass (Da):82,325
Checksum:i2F7953FCB84DD63F
GO
Isoform 3 (identifier: Q9UBD5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Note: No experimental confirmation available.
Show »
Length:568
Mass (Da):65,929
Checksum:i6FEEBF7290C82A97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56S → F in BAD96515 (Ref. 5) Curated1
Sequence conflicti86K → R in CAB45715 (PubMed:11230166).Curated1
Sequence conflicti137Q → R in CAB45715 (PubMed:11230166).Curated1
Sequence conflicti471I → M in BAD96515 (Ref. 5) Curated1
Sequence conflicti531K → R in CAB45715 (PubMed:11230166).Curated1
Sequence conflicti539L → F in AAD40220 (PubMed:10402192).Curated1
Sequence conflicti539L → F in AAA96313 (Ref. 10) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01451694Q → K.1 PublicationCorresponds to variant rs2307365dbSNPEnsembl.1
Natural variantiVAR_014517126Q → R.1 PublicationCorresponds to variant rs2307371dbSNPEnsembl.1
Natural variantiVAR_014518217V → I.1 PublicationCorresponds to variant rs2307389dbSNPEnsembl.1
Natural variantiVAR_014519247I → V.1 PublicationCorresponds to variant rs2307374dbSNPEnsembl.1
Natural variantiVAR_014520287T → M.Corresponds to variant rs2307381dbSNPEnsembl.1
Natural variantiVAR_014521389T → P.Corresponds to variant rs2307372dbSNPEnsembl.1
Natural variantiVAR_014522588R → C.Corresponds to variant rs2307370dbSNPEnsembl.1
Natural variantiVAR_020656626A → T.1 PublicationCorresponds to variant rs28381545dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0448931 – 143Missing in isoform 3. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_017129505D → DA in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135044 mRNA. Translation: AAD30282.1.
AF125507 mRNA. Translation: AAD18057.1.
AF093535 mRNA. Translation: AAD40220.1.
AL080116 mRNA. Translation: CAB45715.1.
AK222795 mRNA. Translation: BAD96515.1.
AK303195 mRNA. Translation: BAG64287.1.
AK315911 mRNA. Translation: BAH14282.1.
AY623113 Genomic DNA. Translation: AAT38109.1.
AL451126, AL133211 Genomic DNA. Translation: CAI10900.1.
AL133211, AL451126 Genomic DNA. Translation: CAI21539.1.
AL451126, AL133211 Genomic DNA. Translation: CAM13063.1.
AL133211, AL451126 Genomic DNA. Translation: CAM28255.1.
BC035494 mRNA. Translation: AAH35494.1.
BC047689 mRNA. Translation: AAH47689.1. Different termination.
U50950 mRNA. Translation: AAA96313.1.
CCDSiCCDS43486.1. [Q9UBD5-1]
CCDS5012.1. [Q9UBD5-2]
CCDS56440.1. [Q9UBD5-3]
PIRiT12452.
RefSeqiNP_001184188.1. NM_001197259.1. [Q9UBD5-3]
NP_036513.2. NM_012381.3. [Q9UBD5-1]
NP_862820.1. NM_181837.2. [Q9UBD5-2]
UniGeneiHs.410228.

Genome annotation databases

EnsembliENST00000257789; ENSP00000257789; ENSG00000135336. [Q9UBD5-2]
ENST00000392844; ENSP00000376586; ENSG00000135336. [Q9UBD5-1]
ENST00000546266; ENSP00000444695; ENSG00000135336. [Q9UBD5-3]
GeneIDi23595.
KEGGihsa:23595.
UCSCiuc003pmg.4. human. [Q9UBD5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135044 mRNA. Translation: AAD30282.1.
AF125507 mRNA. Translation: AAD18057.1.
AF093535 mRNA. Translation: AAD40220.1.
AL080116 mRNA. Translation: CAB45715.1.
AK222795 mRNA. Translation: BAD96515.1.
AK303195 mRNA. Translation: BAG64287.1.
AK315911 mRNA. Translation: BAH14282.1.
AY623113 Genomic DNA. Translation: AAT38109.1.
AL451126, AL133211 Genomic DNA. Translation: CAI10900.1.
AL133211, AL451126 Genomic DNA. Translation: CAI21539.1.
AL451126, AL133211 Genomic DNA. Translation: CAM13063.1.
AL133211, AL451126 Genomic DNA. Translation: CAM28255.1.
BC035494 mRNA. Translation: AAH35494.1.
BC047689 mRNA. Translation: AAH47689.1. Different termination.
U50950 mRNA. Translation: AAA96313.1.
CCDSiCCDS43486.1. [Q9UBD5-1]
CCDS5012.1. [Q9UBD5-2]
CCDS56440.1. [Q9UBD5-3]
PIRiT12452.
RefSeqiNP_001184188.1. NM_001197259.1. [Q9UBD5-3]
NP_036513.2. NM_012381.3. [Q9UBD5-1]
NP_862820.1. NM_181837.2. [Q9UBD5-2]
UniGeneiHs.410228.

3D structure databases

ProteinModelPortaliQ9UBD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117130. 43 interactors.
DIPiDIP-31735N.
IntActiQ9UBD5. 36 interactors.
MINTiMINT-1201384.
STRINGi9606.ENSP00000257789.

PTM databases

iPTMnetiQ9UBD5.
PhosphoSitePlusiQ9UBD5.

Polymorphism and mutation databases

BioMutaiORC3.
DMDMi8928268.

Proteomic databases

EPDiQ9UBD5.
MaxQBiQ9UBD5.
PaxDbiQ9UBD5.
PeptideAtlasiQ9UBD5.
PRIDEiQ9UBD5.

Protocols and materials databases

DNASUi23595.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257789; ENSP00000257789; ENSG00000135336. [Q9UBD5-2]
ENST00000392844; ENSP00000376586; ENSG00000135336. [Q9UBD5-1]
ENST00000546266; ENSP00000444695; ENSG00000135336. [Q9UBD5-3]
GeneIDi23595.
KEGGihsa:23595.
UCSCiuc003pmg.4. human. [Q9UBD5-1]

Organism-specific databases

CTDi23595.
DisGeNETi23595.
GeneCardsiORC3.
HGNCiHGNC:8489. ORC3.
HPAiHPA039553.
HPA053748.
MIMi604972. gene.
neXtProtiNX_Q9UBD5.
OpenTargetsiENSG00000135336.
PharmGKBiPA32810.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2538. Eukaryota.
ENOG410XT1W. LUCA.
GeneTreeiENSGT00390000011376.
HOVERGENiHBG007599.
InParanoidiQ9UBD5.
KOiK02605.
OMAiHLECGRM.
OrthoDBiEOG091G0AI5.
PhylomeDBiQ9UBD5.
TreeFamiTF101093.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135336-MONOMER.
ReactomeiR-HSA-113507. E2F-enabled inhibition of pre-replication complex formation.
R-HSA-176187. Activation of ATR in response to replication stress.
R-HSA-68616. Assembly of the ORC complex at the origin of replication.
R-HSA-68689. CDC6 association with the ORC:origin complex.
R-HSA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-HSA-68867. Assembly of the pre-replicative complex.
R-HSA-68949. Orc1 removal from chromatin.
R-HSA-68962. Activation of the pre-replicative complex.
R-HSA-69298. Association of licensing factors with the pre-replicative complex.
R-HSA-69300. Removal of licensing factors from origins.

Miscellaneous databases

ChiTaRSiORC3. human.
GeneWikiiORC3.
ORC3L.
GenomeRNAii23595.
PROiQ9UBD5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135336.
ExpressionAtlasiQ9UBD5. baseline and differential.
GenevisibleiQ9UBD5. HS.

Family and domain databases

InterProiIPR020795. ORC3.
[Graphical view]
PANTHERiPTHR12748. PTHR12748. 1 hit.
PfamiPF07034. ORC3_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiORC3_HUMAN
AccessioniPrimary (citable) accession number: Q9UBD5
Secondary accession number(s): A2A2T5
, B4E025, Q13565, Q53GY6, Q5T159, Q6IUY7, Q86TN5, Q9UG44, Q9UNT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.