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Q9UBD5

- ORC3_HUMAN

UniProt

Q9UBD5 - ORC3_HUMAN

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Protein
Origin recognition complex subunit 3
Gene
ORC3, LATHEO, ORC3L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.1 Publication

GO - Molecular functioni

  1. DNA replication origin binding Source: ProtInc
  2. protein binding Source: IntAct

GO - Biological processi

  1. DNA replication Source: Reactome
  2. G1/S transition of mitotic cell cycle Source: Reactome
  3. mitotic cell cycle Source: Reactome
  4. neural precursor cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_1095. Activation of the pre-replicative complex.
REACT_1156. Orc1 removal from chromatin.
REACT_1181. Association of licensing factors with the pre-replicative complex.
REACT_1321. E2F-enabled inhibition of pre-replication complex formation.
REACT_1707. CDC6 association with the ORC:origin complex.
REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
REACT_207. Removal of licensing factors from origins.
REACT_2243. Assembly of the pre-replicative complex.
REACT_567. Assembly of the ORC complex at the origin of replication.
REACT_6769. Activation of ATR in response to replication stress.

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 3
Alternative name(s):
Origin recognition complex subunit Latheo
Gene namesi
Name:ORC3
Synonyms:LATHEO, ORC3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:8489. ORC3.

Subcellular locationi

GO - Cellular componenti

  1. nuclear origin of replication recognition complex Source: UniProtKB
  2. nucleoplasm Source: Reactome
  3. origin recognition complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32810.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711Origin recognition complex subunit 3
PRO_0000127083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Phosphoserine1 Publication
Modified residuei516 – 5161Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UBD5.
PaxDbiQ9UBD5.
PRIDEiQ9UBD5.

PTM databases

PhosphoSiteiQ9UBD5.

Expressioni

Gene expression databases

ArrayExpressiQ9UBD5.
BgeeiQ9UBD5.
GenevestigatoriQ9UBD5.

Organism-specific databases

HPAiHPA053748.

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ORC1Q1341512EBI-374916,EBI-374847
ORC4O4392912EBI-374916,EBI-374889
ORC5O4391315EBI-374916,EBI-374928
ORC6Q9Y5N64EBI-374916,EBI-374840

Protein-protein interaction databases

BioGridi117130. 21 interactions.
DIPiDIP-31735N.
IntActiQ9UBD5. 20 interactions.
MINTiMINT-1201384.

Structurei

3D structure databases

ProteinModelPortaliQ9UBD5.

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC3 family.

Phylogenomic databases

eggNOGiNOG296366.
HOVERGENiHBG007599.
KOiK02605.
OMAiCFVFKPN.
OrthoDBiEOG78PV8B.
PhylomeDBiQ9UBD5.
TreeFamiTF101093.

Family and domain databases

InterProiIPR020795. ORC3.
[Graphical view]
PANTHERiPTHR12748. PTHR12748. 1 hit.
PfamiPF07034. ORC3_N. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UBD5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATSSMSKGC FVFKPNSKKR KISLPIEDYF NKGKNEPEDS KLRFETYQLI    50
WQQMKSENER LQEELNKNLF DNLIEFLQKS HSGFQKNSRD LGGQIKLREI 100
PTAALVLGVN VTDHDLTFGS LTEALQNNVT PYVVSLQAKD CPDMKHFLQK 150
LISQLMDCCV DIKSKEEESV HVTQRKTHYS MDSLSSWYMT VTQKTDPKML 200
SKKRTTSSQW QSPPVVVILK DMESFATKVL QDFIIISSQH LHEFPLILIF 250
GIATSPIIIH RLLPHAVSSL LCIELFQSLS CKEHLTTVLD KLLLTTQFPF 300
KINEKVLQVL TNIFLYHDFS VQNFIKGLQL SLLEHFYSQP LSVLCCNLPE 350
AKRRINFLSN NQCENIRRLP SFRRYVEKQA SEKQVALLTN ERYLKEETQL 400
LLENLHVYHM NYFLVLRCLH KFTSSLPKYP LGRQIRELYC TCLEKNIWDS 450
EEYASVLQLL RMLAKDELMT ILEKCFKVFK SYCENHLGST AKRIEEFLAQ 500
FQSLDETKEE EDASGSQPKG LQKTDLYHLQ KSLLEMKELR RSKKQTKFEV 550
LRENVVNFID CLVREYLLPP ETQPLHEVVY FSAAHALREH LNAAPRIALH 600
TALNNPYYYL KNEALKSEEG CIPNIAPDIC IAYKLHLECS RLINLVDWSE 650
AFATVVTAAE KMDANSATSE EMNEIIHARF IRAVSELELL GFIKPTKQKT 700
DHVARLTWGG C 711
Length:711
Mass (Da):82,254
Last modified:May 1, 2000 - v1
Checksum:iE713569A11B39B1C
GO
Isoform 2 (identifier: Q9UBD5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-505: D → DA

Note: No experimental confirmation available.

Show »
Length:712
Mass (Da):82,325
Checksum:i2F7953FCB84DD63F
GO
Isoform 3 (identifier: Q9UBD5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Note: No experimental confirmation available.

Show »
Length:568
Mass (Da):65,929
Checksum:i6FEEBF7290C82A97
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941Q → K.1 Publication
Corresponds to variant rs2307365 [ dbSNP | Ensembl ].
VAR_014516
Natural varianti126 – 1261Q → R.1 Publication
Corresponds to variant rs2307371 [ dbSNP | Ensembl ].
VAR_014517
Natural varianti217 – 2171V → I.1 Publication
Corresponds to variant rs2307389 [ dbSNP | Ensembl ].
VAR_014518
Natural varianti247 – 2471I → V.1 Publication
Corresponds to variant rs2307374 [ dbSNP | Ensembl ].
VAR_014519
Natural varianti287 – 2871T → M.
Corresponds to variant rs2307381 [ dbSNP | Ensembl ].
VAR_014520
Natural varianti389 – 3891T → P.
Corresponds to variant rs2307372 [ dbSNP | Ensembl ].
VAR_014521
Natural varianti588 – 5881R → C.
Corresponds to variant rs2307370 [ dbSNP | Ensembl ].
VAR_014522
Natural varianti626 – 6261A → T.1 Publication
Corresponds to variant rs28381545 [ dbSNP | Ensembl ].
VAR_020656

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 143143Missing in isoform 3.
VSP_044893Add
BLAST
Alternative sequencei505 – 5051D → DA in isoform 2.
VSP_017129

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561S → F in BAD96515. 1 Publication
Sequence conflicti86 – 861K → R in CAB45715. 1 Publication
Sequence conflicti137 – 1371Q → R in CAB45715. 1 Publication
Sequence conflicti471 – 4711I → M in BAD96515. 1 Publication
Sequence conflicti531 – 5311K → R in CAB45715. 1 Publication
Sequence conflicti539 – 5391L → F in AAD40220. 1 Publication
Sequence conflicti539 – 5391L → F in AAA96313. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF135044 mRNA. Translation: AAD30282.1.
AF125507 mRNA. Translation: AAD18057.1.
AF093535 mRNA. Translation: AAD40220.1.
AL080116 mRNA. Translation: CAB45715.1.
AK222795 mRNA. Translation: BAD96515.1.
AK303195 mRNA. Translation: BAG64287.1.
AK315911 mRNA. Translation: BAH14282.1.
AY623113 Genomic DNA. Translation: AAT38109.1.
AL451126, AL133211 Genomic DNA. Translation: CAI10900.1.
AL133211, AL451126 Genomic DNA. Translation: CAI21539.1.
AL451126, AL133211 Genomic DNA. Translation: CAM13063.1.
AL133211, AL451126 Genomic DNA. Translation: CAM28255.1.
BC035494 mRNA. Translation: AAH35494.1.
BC047689 mRNA. Translation: AAH47689.1. Different termination.
U50950 mRNA. Translation: AAA96313.1.
CCDSiCCDS43486.1. [Q9UBD5-1]
CCDS5012.1. [Q9UBD5-2]
CCDS56440.1. [Q9UBD5-3]
PIRiT12452.
RefSeqiNP_001184188.1. NM_001197259.1. [Q9UBD5-3]
NP_036513.2. NM_012381.3. [Q9UBD5-1]
NP_862820.1. NM_181837.2. [Q9UBD5-2]
UniGeneiHs.410228.

Genome annotation databases

EnsembliENST00000257789; ENSP00000257789; ENSG00000135336. [Q9UBD5-2]
ENST00000392844; ENSP00000376586; ENSG00000135336. [Q9UBD5-1]
ENST00000546266; ENSP00000444695; ENSG00000135336. [Q9UBD5-3]
GeneIDi23595.
KEGGihsa:23595.
UCSCiuc003pmg.3. human. [Q9UBD5-2]
uc003pmh.3. human. [Q9UBD5-1]

Polymorphism databases

DMDMi8928268.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF135044 mRNA. Translation: AAD30282.1 .
AF125507 mRNA. Translation: AAD18057.1 .
AF093535 mRNA. Translation: AAD40220.1 .
AL080116 mRNA. Translation: CAB45715.1 .
AK222795 mRNA. Translation: BAD96515.1 .
AK303195 mRNA. Translation: BAG64287.1 .
AK315911 mRNA. Translation: BAH14282.1 .
AY623113 Genomic DNA. Translation: AAT38109.1 .
AL451126 , AL133211 Genomic DNA. Translation: CAI10900.1 .
AL133211 , AL451126 Genomic DNA. Translation: CAI21539.1 .
AL451126 , AL133211 Genomic DNA. Translation: CAM13063.1 .
AL133211 , AL451126 Genomic DNA. Translation: CAM28255.1 .
BC035494 mRNA. Translation: AAH35494.1 .
BC047689 mRNA. Translation: AAH47689.1 . Different termination.
U50950 mRNA. Translation: AAA96313.1 .
CCDSi CCDS43486.1. [Q9UBD5-1 ]
CCDS5012.1. [Q9UBD5-2 ]
CCDS56440.1. [Q9UBD5-3 ]
PIRi T12452.
RefSeqi NP_001184188.1. NM_001197259.1. [Q9UBD5-3 ]
NP_036513.2. NM_012381.3. [Q9UBD5-1 ]
NP_862820.1. NM_181837.2. [Q9UBD5-2 ]
UniGenei Hs.410228.

3D structure databases

ProteinModelPortali Q9UBD5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117130. 21 interactions.
DIPi DIP-31735N.
IntActi Q9UBD5. 20 interactions.
MINTi MINT-1201384.

PTM databases

PhosphoSitei Q9UBD5.

Polymorphism databases

DMDMi 8928268.

Proteomic databases

MaxQBi Q9UBD5.
PaxDbi Q9UBD5.
PRIDEi Q9UBD5.

Protocols and materials databases

DNASUi 23595.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257789 ; ENSP00000257789 ; ENSG00000135336 . [Q9UBD5-2 ]
ENST00000392844 ; ENSP00000376586 ; ENSG00000135336 . [Q9UBD5-1 ]
ENST00000546266 ; ENSP00000444695 ; ENSG00000135336 . [Q9UBD5-3 ]
GeneIDi 23595.
KEGGi hsa:23595.
UCSCi uc003pmg.3. human. [Q9UBD5-2 ]
uc003pmh.3. human. [Q9UBD5-1 ]

Organism-specific databases

CTDi 23595.
GeneCardsi GC06P088299.
HGNCi HGNC:8489. ORC3.
HPAi HPA053748.
MIMi 604972. gene.
neXtProti NX_Q9UBD5.
PharmGKBi PA32810.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG296366.
HOVERGENi HBG007599.
KOi K02605.
OMAi CFVFKPN.
OrthoDBi EOG78PV8B.
PhylomeDBi Q9UBD5.
TreeFami TF101093.

Enzyme and pathway databases

Reactomei REACT_1095. Activation of the pre-replicative complex.
REACT_1156. Orc1 removal from chromatin.
REACT_1181. Association of licensing factors with the pre-replicative complex.
REACT_1321. E2F-enabled inhibition of pre-replication complex formation.
REACT_1707. CDC6 association with the ORC:origin complex.
REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
REACT_207. Removal of licensing factors from origins.
REACT_2243. Assembly of the pre-replicative complex.
REACT_567. Assembly of the ORC complex at the origin of replication.
REACT_6769. Activation of ATR in response to replication stress.

Miscellaneous databases

ChiTaRSi ORC3. human.
GeneWikii ORC3.
ORC3L.
GenomeRNAii 23595.
NextBioi 46252.
PROi Q9UBD5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UBD5.
Bgeei Q9UBD5.
Genevestigatori Q9UBD5.

Family and domain databases

InterProi IPR020795. ORC3.
[Graphical view ]
PANTHERi PTHR12748. PTHR12748. 1 hit.
Pfami PF07034. ORC3_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Tugal T., Zou-Yang X.H., Gavin K., Pappin D., Canas B., Kobayashi R., Hunt T., Stillman B.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "cDNA cloning of a homolog for Saccharomyces cerevisiae ORC3 from Homo sapiens."
    Dean F.B., O'Donnell M.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant."
    Pinto S., Quintana D.G., Smith P., Mihalek R.M., Hou Z.-H., Boynton S., Jones C.J., Handricks M., Velinzon K., Wohlschlegel J.A., Austin R.J., Lane W.S., Dutta A., Tully T.
    Neuron 23:45-54(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Thymus.
  7. NIEHS SNPs program
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-94; ARG-126; ILE-217; VAL-247 AND THR-626.
  8. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-671 (ISOFORM 2).
    Tissue: Testis and Uterus.
  10. Mihalek R., Homanics G.E.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 156-542 (ISOFORM 1).
    Tissue: Brain.
  11. "The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle."
    Ohta S., Tatsumi Y., Fujita M., Tsurimoto T., Obuse C.
    J. Biol. Chem. 278:41535-41540(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE ORC COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, ASSEMBLY OF THE ORC COMPLEX.
  12. "ATP-dependent assembly of the human origin recognition complex."
    Siddiqui K., Stillman B.
    J. Biol. Chem. 282:32370-32383(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECONSTITUTION OF THE ORC COMPLEX, DISASSEMBLY OF THE ORC COMPLEX.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-516, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing."
    Chan K.M., Zhang Z.
    J. Biol. Chem. 287:15024-15033(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BINDING TO HISTONE H3 AND H4 TRIMETHYLATION MARKS.

Entry informationi

Entry nameiORC3_HUMAN
AccessioniPrimary (citable) accession number: Q9UBD5
Secondary accession number(s): A2A2T5
, B4E025, Q13565, Q53GY6, Q5T159, Q6IUY7, Q86TN5, Q9UG44, Q9UNT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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