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Q9UBD3

- XCL2_HUMAN

UniProt

Q9UBD3 - XCL2_HUMAN

Protein

Cytokine SCM-1 beta

Gene

XCL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic activity for lymphocytes but not for monocytes or neutrophils.By similarity

    GO - Molecular functioni

    1. chemokine activity Source: ProtInc

    GO - Biological processi

    1. blood circulation Source: ProtInc
    2. cell chemotaxis Source: GOC
    3. immune response Source: InterPro
    4. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytokine SCM-1 beta
    Alternative name(s):
    C motif chemokine 2
    XC chemokine ligand 2
    Gene namesi
    Name:XCL2
    Synonyms:SCYC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10646. XCL2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35576.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 11493Cytokine SCM-1 betaPRO_0000005251Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 69Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ9UBD3.
    PRIDEiQ9UBD3.

    PTM databases

    PhosphoSiteiQ9UBD3.

    Expressioni

    Gene expression databases

    BgeeiQ9UBD3.
    CleanExiHS_XCL2.
    GenevestigatoriQ9UBD3.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000356793.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBD3.
    SMRiQ9UBD3. Positions 22-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the intercrine gamma family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47852.
    HOGENOMiHOG000036685.
    HOVERGENiHBG102118.
    InParanoidiQ9UBD3.
    KOiK05507.
    OMAiATQACIF.
    OrthoDBiEOG7RBZBM.
    PhylomeDBiQ9UBD3.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR001811. Chemokine_IL8-like_dom.
    IPR008105. Chemokine_XCL1.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR01731. LYMPHOTACTIN.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UBD3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLLILALLG ICSLTAYIVE GVGSEVSHRR TCVSLTTQRL PVSRIKTYTI    50
    TEGSLRAVIF ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT 100
    GTQQSTNTAV TLTG 114
    Length:114
    Mass (Da):12,567
    Last modified:May 1, 2000 - v1
    Checksum:iE7F3C283F02D6D9D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281H → D.
    Corresponds to variant rs4301615 [ dbSNP | Ensembl ].
    VAR_048713
    Natural varianti29 – 291R → K.
    Corresponds to variant rs4501820 [ dbSNP | Ensembl ].
    VAR_059212

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63789 Genomic DNA. Translation: BAA09858.1.
    AL031736 Genomic DNA. Translation: CAB46689.1.
    BC069360 mRNA. Translation: AAH69360.1.
    BC070308 mRNA. Translation: AAH70308.1.
    CCDSiCCDS1273.1.
    RefSeqiNP_003166.1. NM_003175.3.
    UniGeneiHs.458346.

    Genome annotation databases

    EnsembliENST00000367819; ENSP00000356793; ENSG00000143185.
    GeneIDi6846.
    KEGGihsa:6846.
    UCSCiuc001gfn.4. human.

    Polymorphism databases

    DMDMi11387207.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    XCL2 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63789 Genomic DNA. Translation: BAA09858.1 .
    AL031736 Genomic DNA. Translation: CAB46689.1 .
    BC069360 mRNA. Translation: AAH69360.1 .
    BC070308 mRNA. Translation: AAH70308.1 .
    CCDSi CCDS1273.1.
    RefSeqi NP_003166.1. NM_003175.3.
    UniGenei Hs.458346.

    3D structure databases

    ProteinModelPortali Q9UBD3.
    SMRi Q9UBD3. Positions 22-114.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000356793.

    PTM databases

    PhosphoSitei Q9UBD3.

    Polymorphism databases

    DMDMi 11387207.

    Proteomic databases

    PaxDbi Q9UBD3.
    PRIDEi Q9UBD3.

    Protocols and materials databases

    DNASUi 6846.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367819 ; ENSP00000356793 ; ENSG00000143185 .
    GeneIDi 6846.
    KEGGi hsa:6846.
    UCSCi uc001gfn.4. human.

    Organism-specific databases

    CTDi 6846.
    GeneCardsi GC01M168510.
    HGNCi HGNC:10646. XCL2.
    MIMi 604828. gene.
    neXtProti NX_Q9UBD3.
    PharmGKBi PA35576.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47852.
    HOGENOMi HOG000036685.
    HOVERGENi HBG102118.
    InParanoidi Q9UBD3.
    KOi K05507.
    OMAi ATQACIF.
    OrthoDBi EOG7RBZBM.
    PhylomeDBi Q9UBD3.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GenomeRNAii 6846.
    NextBioi 26727.
    PROi Q9UBD3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UBD3.
    CleanExi HS_XCL2.
    Genevestigatori Q9UBD3.

    Family and domain databases

    InterProi IPR001811. Chemokine_IL8-like_dom.
    IPR008105. Chemokine_XCL1.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR01731. LYMPHOTACTIN.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin."
      Yoshida T., Imai T., Takagi S., Nishimura M., Ishikawa I., Yaoi T., Yoshie O.
      FEBS Lett. 395:82-88(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    4. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-36.

    Entry informationi

    Entry nameiXCL2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3