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Protein

Cytokine SCM-1 beta

Gene

XCL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic activity for lymphocytes but not for monocytes or neutrophils.By similarity

GO - Molecular functioni

  • chemokine activity Source: ProtInc

GO - Biological processi

  • blood circulation Source: ProtInc
  • cell chemotaxis Source: GOC
  • immune response Source: InterPro
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine SCM-1 beta
Alternative name(s):
C motif chemokine 2
XC chemokine ligand 2
Gene namesi
Name:XCL2
Synonyms:SCYC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10646. XCL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35576.

Polymorphism and mutation databases

BioMutaiXCL2.
DMDMi11387207.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 11493Cytokine SCM-1 betaPRO_0000005251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 69Sequence Analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9UBD3.
PRIDEiQ9UBD3.

PTM databases

PhosphoSiteiQ9UBD3.

Expressioni

Gene expression databases

BgeeiQ9UBD3.
CleanExiHS_XCL2.
GenevisibleiQ9UBD3. HS.

Organism-specific databases

HPAiHPA057725.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-9P604113EBI-10319095,EBI-10172052
NOTCH2NLQ7Z3S93EBI-10319095,EBI-945833

Protein-protein interaction databases

BioGridi112713. 2 interactions.
IntActiQ9UBD3. 2 interactions.
STRINGi9606.ENSP00000356793.

Structurei

3D structure databases

ProteinModelPortaliQ9UBD3.
SMRiQ9UBD3. Positions 22-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the intercrine gamma family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47852.
GeneTreeiENSGT00390000005120.
HOGENOMiHOG000036685.
HOVERGENiHBG102118.
InParanoidiQ9UBD3.
KOiK05507.
OMAiCANPEAN.
OrthoDBiEOG7RBZBM.
PhylomeDBiQ9UBD3.
TreeFamiTF334888.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
IPR008105. Chemokine_XCL1.
[Graphical view]
PANTHERiPTHR12015:SF3. PTHR12015:SF3. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR01731. LYMPHOTACTIN.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLILALLG ICSLTAYIVE GVGSEVSHRR TCVSLTTQRL PVSRIKTYTI
60 70 80 90 100
TEGSLRAVIF ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT
110
GTQQSTNTAV TLTG
Length:114
Mass (Da):12,567
Last modified:May 1, 2000 - v1
Checksum:iE7F3C283F02D6D9D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281H → D.
Corresponds to variant rs4301615 [ dbSNP | Ensembl ].
VAR_048713
Natural varianti29 – 291R → K.
Corresponds to variant rs4501820 [ dbSNP | Ensembl ].
VAR_059212

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63789 Genomic DNA. Translation: BAA09858.1.
AL031736 Genomic DNA. Translation: CAB46689.1.
BC069360 mRNA. Translation: AAH69360.1.
BC070308 mRNA. Translation: AAH70308.1.
CCDSiCCDS1273.1.
RefSeqiNP_003166.1. NM_003175.3.
UniGeneiHs.458346.

Genome annotation databases

EnsembliENST00000367819; ENSP00000356793; ENSG00000143185.
GeneIDi6846.
KEGGihsa:6846.
UCSCiuc001gfn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

XCL2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63789 Genomic DNA. Translation: BAA09858.1.
AL031736 Genomic DNA. Translation: CAB46689.1.
BC069360 mRNA. Translation: AAH69360.1.
BC070308 mRNA. Translation: AAH70308.1.
CCDSiCCDS1273.1.
RefSeqiNP_003166.1. NM_003175.3.
UniGeneiHs.458346.

3D structure databases

ProteinModelPortaliQ9UBD3.
SMRiQ9UBD3. Positions 22-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112713. 2 interactions.
IntActiQ9UBD3. 2 interactions.
STRINGi9606.ENSP00000356793.

PTM databases

PhosphoSiteiQ9UBD3.

Polymorphism and mutation databases

BioMutaiXCL2.
DMDMi11387207.

Proteomic databases

PaxDbiQ9UBD3.
PRIDEiQ9UBD3.

Protocols and materials databases

DNASUi6846.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367819; ENSP00000356793; ENSG00000143185.
GeneIDi6846.
KEGGihsa:6846.
UCSCiuc001gfn.4. human.

Organism-specific databases

CTDi6846.
GeneCardsiGC01M168510.
HGNCiHGNC:10646. XCL2.
HPAiHPA057725.
MIMi604828. gene.
neXtProtiNX_Q9UBD3.
PharmGKBiPA35576.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47852.
GeneTreeiENSGT00390000005120.
HOGENOMiHOG000036685.
HOVERGENiHBG102118.
InParanoidiQ9UBD3.
KOiK05507.
OMAiCANPEAN.
OrthoDBiEOG7RBZBM.
PhylomeDBiQ9UBD3.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GenomeRNAii6846.
NextBioi26727.
PROiQ9UBD3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBD3.
CleanExiHS_XCL2.
GenevisibleiQ9UBD3. HS.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
IPR008105. Chemokine_XCL1.
[Graphical view]
PANTHERiPTHR12015:SF3. PTHR12015:SF3. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR01731. LYMPHOTACTIN.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin."
    Yoshida T., Imai T., Takagi S., Nishimura M., Ishikawa I., Yaoi T., Yoshie O.
    FEBS Lett. 395:82-88(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  4. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.

Entry informationi

Entry nameiXCL2_HUMAN
AccessioniPrimary (citable) accession number: Q9UBD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.