Q9UBD3 (XCL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytokine SCM-1 beta

Alternative name(s):
C motif chemokine 2
XC chemokine ligand 2

Gene names

Name:	XCL2
Synonyms:	SCYC2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Chemotactic activity for lymphocytes but not for monocytes or neutrophils By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the intercrine gamma family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	blood circulation Traceable author statement PubMed 7875320. Source: ProtInc chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro signal transduction Traceable author statement PubMed 7875320. Source: ProtInc
Cellular_component	extracellular region Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	chemokine activity Traceable author statement PubMed 7875320. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.4
	Chain	22 – 114	93	Cytokine SCM-1 beta		PRO_0000005251
Amino acid modifications
	Disulfide bond	32 ↔ 69		Potential
Natural variations
	Natural variant	28	1	H → D. Corresponds to variant rs4301615 [ dbSNP | Ensembl ].		VAR_048713
	Natural variant	29	1	R → K. Corresponds to variant rs4501820 [ dbSNP | Ensembl ].		VAR_059212

Sequences

	Sequence		Length	Mass (Da)
	Q9UBD3 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: E7F3C283F02D6D9D	FASTA	114	12,567
	10 20 30 40 50 60 MRLLILALLG ICSLTAYIVE GVGSEVSHRR TCVSLTTQRL PVSRIKTYTI TEGSLRAVIF 70 80 90 100 110 ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT GTQQSTNTAV TLTG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of two highly related genes encoding SCM-1/human lymphotactin." Yoshida T., Imai T., Takagi S., Nishimura M., Ishikawa I., Yaoi T., Yoshie O. FEBS Lett. 395:82-88(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
[4]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-36.
+	Additional computationally mapped references.

Web resources

Wikipedia

XCL2 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	D63789 Genomic DNA. Translation: BAA09858.1. AL031736 Genomic DNA. Translation: CAB46689.1. BC069360 mRNA. Translation: AAH69360.1. BC070308 mRNA. Translation: AAH70308.1.
IPI	IPI00002528.
RefSeq	NP_003166.1. NM_003175.3.
UniGene	Hs.458346.
3D structure databases
ProteinModelPortal	Q9UBD3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000356793.
PTM databases
PhosphoSite	Q9UBD3.
Polymorphism databases
DMDM	11387207.
Proteomic databases
PaxDb	Q9UBD3.
Protocols and materials databases
DNASU	6846.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367819; ENSP00000356793; ENSG00000143185.
GeneID	6846.
KEGG	hsa:6846.
UCSC	uc001gfn.4. human.
Organism-specific databases
CTD	6846.
GeneCards	GC01M168510.
HGNC	HGNC:10646. XCL2.
MIM	604828. gene.
neXtProt	NX_Q9UBD3.
PharmGKB	PA35576.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47852.
HOGENOM	HOG000036685.
HOVERGEN	HBG102118.
InParanoid	Q9UBD3.
KO	K05507.
OMA	CANPEAN.
OrthoDB	EOG4XSKRH.
PhylomeDB	Q9UBD3.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q9UBD3.
CleanEx	HS_XCL2.
Genevestigator	Q9UBD3.
GermOnline	ENSG00000143185. Homo sapiens.
Family and domain databases
InterPro	IPR001811. Chemokine_IL8-like_dom. IPR008105. Chemokine_XCL1. [Graphical view]
Pfam	PF00048. IL8. 1 hit. [Graphical view]
PRINTS	PR01731. LYMPHOTACTIN.
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	6846.
NextBio	26727.
SOURCE	Search...

Entry information

Entry name

XCL2_HUMAN

Accession

Primary (citable) accession number: Q9UBD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.