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Q9UBD3 (XCL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytokine SCM-1 beta
Alternative name(s):
C motif chemokine 2
XC chemokine ligand 2
Gene names
Name:XCL2
Synonyms:SCYC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chemotactic activity for lymphocytes but not for monocytes or neutrophils By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine gamma family.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processblood circulation

Traceable author statement PubMed 7875320. Source: ProtInc

cell chemotaxis

Traceable author statement PubMed 7875320. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

signal transduction

Traceable author statement PubMed 7875320. Source: ProtInc

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionchemokine activity

Traceable author statement PubMed 7875320. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.4
Chain22 – 11493Cytokine SCM-1 beta
PRO_0000005251

Amino acid modifications

Disulfide bond32 ↔ 69 Potential

Natural variations

Natural variant281H → D.
Corresponds to variant rs4301615 [ dbSNP | Ensembl ].
VAR_048713
Natural variant291R → K.
Corresponds to variant rs4501820 [ dbSNP | Ensembl ].
VAR_059212

Sequences

Sequence LengthMass (Da)Tools
Q9UBD3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: E7F3C283F02D6D9D

FASTA11412,567
        10         20         30         40         50         60 
MRLLILALLG ICSLTAYIVE GVGSEVSHRR TCVSLTTQRL PVSRIKTYTI TEGSLRAVIF 

        70         80         90        100        110 
ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT GTQQSTNTAV TLTG 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of two highly related genes encoding SCM-1/human lymphotactin."
Yoshida T., Imai T., Takagi S., Nishimura M., Ishikawa I., Yaoi T., Yoshie O.
FEBS Lett. 395:82-88(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood.
[4]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-36.
+Additional computationally mapped references.

Web resources

Wikipedia

XCL2 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D63789 Genomic DNA. Translation: BAA09858.1.
AL031736 Genomic DNA. Translation: CAB46689.1.
BC069360 mRNA. Translation: AAH69360.1.
BC070308 mRNA. Translation: AAH70308.1.
RefSeqNP_003166.1. NM_003175.3.
UniGeneHs.458346.

3D structure databases

ProteinModelPortalQ9UBD3.
SMRQ9UBD3. Positions 22-114.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000356793.

PTM databases

PhosphoSiteQ9UBD3.

Polymorphism databases

DMDM11387207.

Proteomic databases

PaxDbQ9UBD3.
PRIDEQ9UBD3.

Protocols and materials databases

DNASU6846.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367819; ENSP00000356793; ENSG00000143185.
GeneID6846.
KEGGhsa:6846.
UCSCuc001gfn.4. human.

Organism-specific databases

CTD6846.
GeneCardsGC01M168510.
HGNCHGNC:10646. XCL2.
MIM604828. gene.
neXtProtNX_Q9UBD3.
PharmGKBPA35576.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47852.
HOGENOMHOG000036685.
HOVERGENHBG102118.
InParanoidQ9UBD3.
KOK05507.
OMACANPEAN.
OrthoDBEOG7RBZBM.
PhylomeDBQ9UBD3.
TreeFamTF334888.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ9UBD3.
CleanExHS_XCL2.
GenevestigatorQ9UBD3.

Family and domain databases

InterProIPR001811. Chemokine_IL8-like_dom.
IPR008105. Chemokine_XCL1.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
PRINTSPR01731. LYMPHOTACTIN.
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi6846.
NextBio26727.
PROQ9UBD3.
SOURCESearch...

Entry information

Entry nameXCL2_HUMAN
AccessionPrimary (citable) accession number: Q9UBD3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM