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Q9UBD3

- XCL2_HUMAN

UniProt

Q9UBD3 - XCL2_HUMAN

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Protein

Cytokine SCM-1 beta

Gene

XCL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Chemotactic activity for lymphocytes but not for monocytes or neutrophils.By similarity

GO - Molecular functioni

  1. chemokine activity Source: ProtInc

GO - Biological processi

  1. blood circulation Source: ProtInc
  2. cell chemotaxis Source: GOC
  3. immune response Source: InterPro
  4. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine SCM-1 beta
Alternative name(s):
C motif chemokine 2
XC chemokine ligand 2
Gene namesi
Name:XCL2
Synonyms:SCYC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10646. XCL2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 11493Cytokine SCM-1 betaPRO_0000005251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 69Sequence Analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9UBD3.
PRIDEiQ9UBD3.

PTM databases

PhosphoSiteiQ9UBD3.

Expressioni

Gene expression databases

BgeeiQ9UBD3.
CleanExiHS_XCL2.
GenevestigatoriQ9UBD3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356793.

Structurei

3D structure databases

ProteinModelPortaliQ9UBD3.
SMRiQ9UBD3. Positions 22-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the intercrine gamma family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47852.
GeneTreeiENSGT00390000005120.
HOGENOMiHOG000036685.
HOVERGENiHBG102118.
InParanoidiQ9UBD3.
KOiK05507.
OMAiATQACIF.
OrthoDBiEOG7RBZBM.
PhylomeDBiQ9UBD3.
TreeFamiTF334888.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
IPR008105. Chemokine_XCL1.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR01731. LYMPHOTACTIN.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBD3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLLILALLG ICSLTAYIVE GVGSEVSHRR TCVSLTTQRL PVSRIKTYTI
60 70 80 90 100
TEGSLRAVIF ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT
110
GTQQSTNTAV TLTG
Length:114
Mass (Da):12,567
Last modified:May 1, 2000 - v1
Checksum:iE7F3C283F02D6D9D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281H → D.
Corresponds to variant rs4301615 [ dbSNP | Ensembl ].
VAR_048713
Natural varianti29 – 291R → K.
Corresponds to variant rs4501820 [ dbSNP | Ensembl ].
VAR_059212

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63789 Genomic DNA. Translation: BAA09858.1.
AL031736 Genomic DNA. Translation: CAB46689.1.
BC069360 mRNA. Translation: AAH69360.1.
BC070308 mRNA. Translation: AAH70308.1.
CCDSiCCDS1273.1.
RefSeqiNP_003166.1. NM_003175.3.
UniGeneiHs.458346.

Genome annotation databases

EnsembliENST00000367819; ENSP00000356793; ENSG00000143185.
GeneIDi6846.
KEGGihsa:6846.
UCSCiuc001gfn.4. human.

Polymorphism databases

DMDMi11387207.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

XCL2 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63789 Genomic DNA. Translation: BAA09858.1 .
AL031736 Genomic DNA. Translation: CAB46689.1 .
BC069360 mRNA. Translation: AAH69360.1 .
BC070308 mRNA. Translation: AAH70308.1 .
CCDSi CCDS1273.1.
RefSeqi NP_003166.1. NM_003175.3.
UniGenei Hs.458346.

3D structure databases

ProteinModelPortali Q9UBD3.
SMRi Q9UBD3. Positions 22-114.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000356793.

PTM databases

PhosphoSitei Q9UBD3.

Polymorphism databases

DMDMi 11387207.

Proteomic databases

PaxDbi Q9UBD3.
PRIDEi Q9UBD3.

Protocols and materials databases

DNASUi 6846.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367819 ; ENSP00000356793 ; ENSG00000143185 .
GeneIDi 6846.
KEGGi hsa:6846.
UCSCi uc001gfn.4. human.

Organism-specific databases

CTDi 6846.
GeneCardsi GC01M168510.
HGNCi HGNC:10646. XCL2.
MIMi 604828. gene.
neXtProti NX_Q9UBD3.
PharmGKBi PA35576.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47852.
GeneTreei ENSGT00390000005120.
HOGENOMi HOG000036685.
HOVERGENi HBG102118.
InParanoidi Q9UBD3.
KOi K05507.
OMAi ATQACIF.
OrthoDBi EOG7RBZBM.
PhylomeDBi Q9UBD3.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GenomeRNAii 6846.
NextBioi 26727.
PROi Q9UBD3.
SOURCEi Search...

Gene expression databases

Bgeei Q9UBD3.
CleanExi HS_XCL2.
Genevestigatori Q9UBD3.

Family and domain databases

InterProi IPR001811. Chemokine_IL8-like_dom.
IPR008105. Chemokine_XCL1.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
PRINTSi PR01731. LYMPHOTACTIN.
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin."
    Yoshida T., Imai T., Takagi S., Nishimura M., Ishikawa I., Yaoi T., Yoshie O.
    FEBS Lett. 395:82-88(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  4. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.

Entry informationi

Entry nameiXCL2_HUMAN
AccessioniPrimary (citable) accession number: Q9UBD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3