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Protein

Heat shock transcription factor, X-linked

Gene

HSFX1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi98 – 282185By similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock transcription factor, X-linked
Gene namesi
Name:HSFX1
Synonyms:LW-1
AND
Name:HSFX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:29603. HSFX1.
HGNC:32701. HSFX2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145008220.

Polymorphism and mutation databases

BioMutaiHSFX1.
DMDMi74761890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Heat shock transcription factor, X-linkedPRO_0000339188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki215 – 215Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9UBD0.
PRIDEiQ9UBD0.

PTM databases

iPTMnetiQ9UBD0.
PhosphoSiteiQ9UBD0.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Gene expression databases

BgeeiQ9UBD0.
CleanExiHS_HSFX1.
GenevisibleiQ9UBD0. HS.

Organism-specific databases

HPAiHPA051700.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542533EBI-947253,EBI-930964

Protein-protein interaction databases

BioGridi325062. 8 interactions.
576546. 1 interaction.
IntActiQ9UBD0. 6 interactions.
MINTiMINT-2873219.
STRINGi9606.ENSP00000431063.

Structurei

3D structure databases

ProteinModelPortaliQ9UBD0.
SMRiQ9UBD0. Positions 99-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HSF family.Curated

Phylogenomic databases

eggNOGiKOG0627. Eukaryota.
COG5169. LUCA.
GeneTreeiENSGT00510000047153.
HOGENOMiHOG000112958.
InParanoidiQ9UBD0.
OMAiPFPQKLW.
OrthoDBiEOG7992QF.
PhylomeDBiQ9UBD0.
TreeFamiTF330401.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR027730. HSFX.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 1 hit.
PTHR10015:SF163. PTHR10015:SF163. 1 hit.
PfamiPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UBD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDKRSLSMA RCEERNSRGQ DHGLERVPFP PQLQSETYLH PADPSPAWDD
60 70 80 90 100
PGSTGSPNLR LLTEEIAFQP LAEEASFRRP HPDGDVPPQG EDNLLSLPFP
110 120 130 140 150
QKLWRLVSSN QFSSIWWDDS GACRVINQKL FEKEILKRDV AHKVFATTSI
160 170 180 190 200
KSFFRQLNLY GFRKRRQCTF RTFTRIFSAK RLVSILNKLE FYCHPYFQRD
210 220 230 240 250
SPHLLVRMKR RVGVKSAPRH QEEDKPEAAG SCLAPADTEQ QDHTSPNEND
260 270 280 290 300
QVTPQHREPA GPNTQIRSGS APPATPVMVP DSAVASDNSP VTQPAGEWSE
310 320 330 340 350
GSQAHVTPVA AVPGPAALPF LYVPGSPTQM NSYGPVVALP TASRSTLAMD
360 370 380 390 400
TTGLPAPGML PFCHLWVPVT LVAAGAAQPA ASMVMFPHLP ALHHHCPHSH
410 420
RTSQYMPASD GPQAYPDYAD QST
Length:423
Mass (Da):46,742
Last modified:May 1, 2000 - v1
Checksum:iEB27C8CD82C1C806
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139980 mRNA. Translation: AAD45879.1.
AF139982, AF139981 Genomic DNA. Translation: AAD45880.1.
CH471169 Genomic DNA. Translation: EAW99371.1.
BC021706 mRNA. Translation: AAH21706.1.
CCDSiCCDS44011.1.
CCDS48179.1.
RefSeqiNP_001157887.1. NM_001164415.2.
NP_057237.1. NM_016153.2.
UniGeneiHs.656936.
Hs.709146.

Genome annotation databases

EnsembliENST00000370416; ENSP00000359444; ENSG00000171116.
ENST00000598963; ENSP00000469223; ENSG00000268738.
GeneIDi100130086.
100506164.
KEGGihsa:100130086.
hsa:100506164.
UCSCiuc022cgk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139980 mRNA. Translation: AAD45879.1.
AF139982, AF139981 Genomic DNA. Translation: AAD45880.1.
CH471169 Genomic DNA. Translation: EAW99371.1.
BC021706 mRNA. Translation: AAH21706.1.
CCDSiCCDS44011.1.
CCDS48179.1.
RefSeqiNP_001157887.1. NM_001164415.2.
NP_057237.1. NM_016153.2.
UniGeneiHs.656936.
Hs.709146.

3D structure databases

ProteinModelPortaliQ9UBD0.
SMRiQ9UBD0. Positions 99-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi325062. 8 interactions.
576546. 1 interaction.
IntActiQ9UBD0. 6 interactions.
MINTiMINT-2873219.
STRINGi9606.ENSP00000431063.

PTM databases

iPTMnetiQ9UBD0.
PhosphoSiteiQ9UBD0.

Polymorphism and mutation databases

BioMutaiHSFX1.
DMDMi74761890.

Proteomic databases

PaxDbiQ9UBD0.
PRIDEiQ9UBD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370416; ENSP00000359444; ENSG00000171116.
ENST00000598963; ENSP00000469223; ENSG00000268738.
GeneIDi100130086.
100506164.
KEGGihsa:100130086.
hsa:100506164.
UCSCiuc022cgk.2. human.

Organism-specific databases

CTDi100130086.
100506164.
GeneCardsiHSFX1.
HSFX2.
HGNCiHGNC:29603. HSFX1.
HGNC:32701. HSFX2.
HPAiHPA051700.
neXtProtiNX_Q9UBD0.
PharmGKBiPA145008220.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0627. Eukaryota.
COG5169. LUCA.
GeneTreeiENSGT00510000047153.
HOGENOMiHOG000112958.
InParanoidiQ9UBD0.
OMAiPFPQKLW.
OrthoDBiEOG7992QF.
PhylomeDBiQ9UBD0.
TreeFamiTF330401.

Miscellaneous databases

NextBioi20789221.
PROiQ9UBD0.

Gene expression databases

BgeeiQ9UBD0.
CleanExiHS_HSFX1.
GenevisibleiQ9UBD0. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR027730. HSFX.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 1 hit.
PTHR10015:SF163. PTHR10015:SF163. 1 hit.
PfamiPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a testis-specific gene LW-1 in cancers."
    Wang L., Thibodeau S.N.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility."
    Shinka T., Sato Y., Chen G., Naroda T., Kinoshita K., Unemi Y., Tsuji K., Toida K., Iwamoto T., Nakahori Y.
    Biol. Reprod. 71:297-306(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  5. "In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."
    Blomster H.A., Imanishi S.Y., Siimes J., Kastu J., Morrice N.A., Eriksson J.E., Sistonen L.
    J. Biol. Chem. 285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION AT LYS-215.
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiHSFX1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 1, 2000
Last modified: March 16, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.