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Q9UBC9

- SPRR3_HUMAN

UniProt

Q9UBC9 - SPRR3_HUMAN

Protein

Small proline-rich protein 3

Gene

SPRR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cross-linked envelope protein of keratinocytes.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. structural molecule activity Source: UniProtKB

    GO - Biological processi

    1. epidermis development Source: UniProtKB
    2. keratinization Source: UniProtKB-KW
    3. keratinocyte differentiation Source: UniProtKB
    4. peptide cross-linking Source: InterPro
    5. wound healing Source: UniProtKB

    Keywords - Biological processi

    Keratinization

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small proline-rich protein 3
    Alternative name(s):
    22 kDa pancornulin
    Cornifin beta
    Esophagin
    Gene namesi
    Name:SPRR3
    Synonyms:SPRC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11268. SPRR3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36097.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 169168Small proline-rich protein 3PRO_0000150003Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9UBC9.
    PaxDbiQ9UBC9.
    PeptideAtlasiQ9UBC9.
    PRIDEiQ9UBC9.

    PTM databases

    PhosphoSiteiQ9UBC9.

    Expressioni

    Inductioni

    During squamous differentiation of epidermal keratinocytes.

    Gene expression databases

    ArrayExpressiQ9UBC9.
    BgeeiQ9UBC9.
    CleanExiHS_SPRR3.
    GenevestigatoriQ9UBC9.

    Organism-specific databases

    HPAiHPA044467.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000295367.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBC9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati43 – 5081
    Repeati51 – 5882
    Repeati59 – 6683
    Repeati67 – 7484
    Repeati75 – 8285
    Repeati83 – 9086
    Repeati91 – 9887
    Repeati99 – 10688
    Repeati107 – 11489
    Repeati115 – 122810
    Repeati123 – 130811
    Repeati131 – 138812
    Repeati139 – 146813
    Repeati147 – 154814

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni43 – 15411214 X 8 AA approximate tandem repeatsAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cornifin (SPRR) family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG39062.
    HOVERGENiHBG079213.
    InParanoidiQ9UBC9.
    OMAiPGHTKVP.
    PhylomeDBiQ9UBC9.
    TreeFamiTF338205.

    Family and domain databases

    InterProiIPR003302. Cornifin.
    IPR026075. SPRR/LCE.
    [Graphical view]
    PANTHERiPTHR23263. PTHR23263. 1 hit.
    PfamiPF02389. Cornifin. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UBC9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYQQKQTF TPPPQLQQQQ VKQPSQPPPQ EIFVPTTKEP CHSKVPQPGN    50
    TKIPEPGCTK VPEPGCTKVP EPGCTKVPEP GCTKVPEPGC TKVPEPGCTK 100
    VPEPGYTKVP EPGSIKVPDQ GFIKFPEPGA IKVPEQGYTK VPVPGYTKLP 150
    EPCPSTVTPG PAQQKTKQK 169
    Length:169
    Mass (Da):18,154
    Last modified:February 11, 2002 - v2
    Checksum:iB8E522AF798F1ECB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191Q → H in AAM74559. (PubMed:8809402)Curated
    Sequence conflicti61 – 688Missing no nucleotide entry (PubMed:8018055)Curated
    Sequence conflicti61 – 688Missing in CAB65098. (PubMed:11230159)Curated
    Sequence conflicti61 – 688Missing in AAH17802. (PubMed:16710414)Curated

    Mass spectrometryi

    Molecular mass is 17239 Da from positions 2 - 169. Determined by ESI. Variants Del 98-Cys--Pro-105 and Val-149.1 Publication
    Molecular mass is 18065 Da from positions 2 - 169. Determined by ESI. 1 Publication

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti98 – 1058Missing.
    VAR_065255
    Natural varianti149 – 1491L → V.3 Publications
    Corresponds to variant rs1055935 [ dbSNP | Ensembl ].
    VAR_023377
    Natural varianti156 – 1561T → M.
    Corresponds to variant rs2075740 [ dbSNP | Ensembl ].
    VAR_053048

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077374 Genomic DNA. Translation: AAD11938.1.
    AY118269 mRNA. Translation: AAM74559.1.
    AJ243667 mRNA. Translation: CAB65098.1.
    DQ017955 Genomic DNA. Translation: AAY26394.1.
    AK311823 mRNA. Translation: BAG34765.1.
    EF553525 mRNA. Translation: ABQ66270.1.
    AL356867 Genomic DNA. Translation: CAI19803.1.
    CH471121 Genomic DNA. Translation: EAW53353.1.
    CH471121 Genomic DNA. Translation: EAW53354.1.
    BC017802 mRNA. Translation: AAH17802.1.
    CCDSiCCDS1033.1.
    RefSeqiNP_001091058.1. NM_001097589.1.
    NP_005407.1. NM_005416.2.
    UniGeneiHs.139322.

    Genome annotation databases

    EnsembliENST00000295367; ENSP00000295367; ENSG00000163209.
    ENST00000331860; ENSP00000330391; ENSG00000163209.
    GeneIDi6707.
    KEGGihsa:6707.
    UCSCiuc001fax.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077374 Genomic DNA. Translation: AAD11938.1 .
    AY118269 mRNA. Translation: AAM74559.1 .
    AJ243667 mRNA. Translation: CAB65098.1 .
    DQ017955 Genomic DNA. Translation: AAY26394.1 .
    AK311823 mRNA. Translation: BAG34765.1 .
    EF553525 mRNA. Translation: ABQ66270.1 .
    AL356867 Genomic DNA. Translation: CAI19803.1 .
    CH471121 Genomic DNA. Translation: EAW53353.1 .
    CH471121 Genomic DNA. Translation: EAW53354.1 .
    BC017802 mRNA. Translation: AAH17802.1 .
    CCDSi CCDS1033.1.
    RefSeqi NP_001091058.1. NM_001097589.1.
    NP_005407.1. NM_005416.2.
    UniGenei Hs.139322.

    3D structure databases

    ProteinModelPortali Q9UBC9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000295367.

    PTM databases

    PhosphoSitei Q9UBC9.

    Proteomic databases

    MaxQBi Q9UBC9.
    PaxDbi Q9UBC9.
    PeptideAtlasi Q9UBC9.
    PRIDEi Q9UBC9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295367 ; ENSP00000295367 ; ENSG00000163209 .
    ENST00000331860 ; ENSP00000330391 ; ENSG00000163209 .
    GeneIDi 6707.
    KEGGi hsa:6707.
    UCSCi uc001fax.4. human.

    Organism-specific databases

    CTDi 6707.
    GeneCardsi GC01P152974.
    H-InvDB HIX0001078.
    HGNCi HGNC:11268. SPRR3.
    HPAi HPA044467.
    MIMi 182271. gene.
    neXtProti NX_Q9UBC9.
    PharmGKBi PA36097.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39062.
    HOVERGENi HBG079213.
    InParanoidi Q9UBC9.
    OMAi PGHTKVP.
    PhylomeDBi Q9UBC9.
    TreeFami TF338205.

    Miscellaneous databases

    GeneWikii SPRR3.
    GenomeRNAii 6707.
    NextBioi 26152.
    PROi Q9UBC9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UBC9.
    Bgeei Q9UBC9.
    CleanExi HS_SPRR3.
    Genevestigatori Q9UBC9.

    Family and domain databases

    InterProi IPR003302. Cornifin.
    IPR026075. SPRR/LCE.
    [Graphical view ]
    PANTHERi PTHR23263. PTHR23263. 1 hit.
    Pfami PF02389. Cornifin. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins."
      Gibbs S., Fijneman R., Wiegant J., Geurts van Kessel A., van de Putte P., Backendorf C.
      Genomics 16:630-637(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Peripheral blood.
    2. "Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts."
      Robinson P.A., Marley J.J., High A.S., Hume W.J.
      Arch. Oral Biol. 39:251-259(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors."
      Abraham J.M., Wang S., Suzuki H., Jiang H.Y., Rosenblum-Vos L.S., Yin J., Meltzer S.J.
      Cell Growth Differ. 7:855-860(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library."
      Marenholz I., Zirra M., Fischer D.F., Backendorf C., Ziegler A., Mischke D.
      Genome Res. 11:341-355(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Characterization of two isoforms of human SPRR3 from saliva of preterm human newborn and autoptic fetal oral mucosa, parotid and submandibular gland samples."
      Manconi B., Cabras T., Pisano E., Nemolato S., Inzitari R., Iavarone F., Fanali C., Sanna M.T., Tirone C., Vento G., Romagnoli C., Faa G., Castagnola M., Messana I.
      Biochem. Biophys. Res. Commun. 398:477-481(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], MASS SPECTROMETRY, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, VARIANTS DEL 98-CYS--PRO-104 AND VAL-149.
      Tissue: Oral mucosa, Parotid gland, Saliva and Submandibular gland.
    6. NIEHS SNPs program
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-149.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Retina.
    9. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-149.
      Tissue: Skeletal muscle.
    12. "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation."
      Greco M.A., Lorand L., Lane W.S., Baden H.P., Parameswaran K.N.P., Kvedar J.C.
      J. Invest. Dermatol. 104:204-210(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 8-40 AND 140-165.
      Tissue: Keratinocyte.

    Entry informationi

    Entry nameiSPRR3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBC9
    Secondary accession number(s): A5YKK8
    , B2R4G8, D3DV32, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UDG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: February 11, 2002
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3