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Q9UBC9 (SPRR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Small proline-rich protein 3
Alternative name(s):
22 kDa pancornulin
Cornifin beta
Esophagin
Gene names
Name:SPRR3
Synonyms:SPRC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cross-linked envelope protein of keratinocytes.

Subcellular location

Cytoplasm.

Induction

During squamous differentiation of epidermal keratinocytes.

Sequence similarities

Belongs to the cornifin (SPRR) family.

Mass spectrometry

Molecular mass is 17239 Da from positions 2 - 169. Determined by ESI. Variants Del 98-Cys--Pro-105 and Val-149. Ref.5

Molecular mass is 18065 Da from positions 2 - 169. Determined by ESI. Ref.5

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 169168Small proline-rich protein 3
PRO_0000150003

Regions

Repeat43 – 5081
Repeat51 – 5882
Repeat59 – 6683
Repeat67 – 7484
Repeat75 – 8285
Repeat83 – 9086
Repeat91 – 9887
Repeat99 – 10688
Repeat107 – 11489
Repeat115 – 122810
Repeat123 – 130811
Repeat131 – 138812
Repeat139 – 146813
Repeat147 – 154814
Region43 – 15411214 X 8 AA approximate tandem repeats

Amino acid modifications

Modified residue21N-acetylserine Ref.5

Natural variations

Natural variant98 – 1058Missing.
VAR_065255
Natural variant1491L → V. Ref.5 Ref.6 Ref.11
Corresponds to variant rs1055935 [ dbSNP | Ensembl ].
VAR_023377
Natural variant1561T → M.
Corresponds to variant rs2075740 [ dbSNP | Ensembl ].
VAR_053048

Experimental info

Sequence conflict191Q → H in AAM74559. Ref.3
Sequence conflict61 – 688Missing no nucleotide entry Ref.2
Sequence conflict61 – 688Missing in CAB65098. Ref.4
Sequence conflict61 – 688Missing in AAH17802. Ref.9

Sequences

Sequence LengthMass (Da)Tools
Q9UBC9 [UniParc].

Last modified February 11, 2002. Version 2.
Checksum: B8E522AF798F1ECB

FASTA16918,154
        10         20         30         40         50         60 
MSSYQQKQTF TPPPQLQQQQ VKQPSQPPPQ EIFVPTTKEP CHSKVPQPGN TKIPEPGCTK 

        70         80         90        100        110        120 
VPEPGCTKVP EPGCTKVPEP GCTKVPEPGC TKVPEPGCTK VPEPGYTKVP EPGSIKVPDQ 

       130        140        150        160 
GFIKFPEPGA IKVPEQGYTK VPVPGYTKLP EPCPSTVTPG PAQQKTKQK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins."
Gibbs S., Fijneman R., Wiegant J., Geurts van Kessel A., van de Putte P., Backendorf C.
Genomics 16:630-637(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Peripheral blood.
[2]"Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts."
Robinson P.A., Marley J.J., High A.S., Hume W.J.
Arch. Oral Biol. 39:251-259(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors."
Abraham J.M., Wang S., Suzuki H., Jiang H.Y., Rosenblum-Vos L.S., Yin J., Meltzer S.J.
Cell Growth Differ. 7:855-860(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library."
Marenholz I., Zirra M., Fischer D.F., Backendorf C., Ziegler A., Mischke D.
Genome Res. 11:341-355(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Characterization of two isoforms of human SPRR3 from saliva of preterm human newborn and autoptic fetal oral mucosa, parotid and submandibular gland samples."
Manconi B., Cabras T., Pisano E., Nemolato S., Inzitari R., Iavarone F., Fanali C., Sanna M.T., Tirone C., Vento G., Romagnoli C., Faa G., Castagnola M., Messana I.
Biochem. Biophys. Res. Commun. 398:477-481(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], MASS SPECTROMETRY, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, VARIANTS DEL 98-CYS--PRO-104 AND VAL-149.
Tissue: Oral mucosa, Parotid gland, Saliva and Submandibular gland.
[6]NIEHS SNPs program
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-149.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tongue.
[8]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Retina.
[9]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-149.
Tissue: Skeletal muscle.
[12]"The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation."
Greco M.A., Lorand L., Lane W.S., Baden H.P., Parameswaran K.N.P., Kvedar J.C.
J. Invest. Dermatol. 104:204-210(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 8-40 AND 140-165.
Tissue: Keratinocyte.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF077374 Genomic DNA. Translation: AAD11938.1.
AY118269 mRNA. Translation: AAM74559.1.
AJ243667 mRNA. Translation: CAB65098.1.
DQ017955 Genomic DNA. Translation: AAY26394.1.
AK311823 mRNA. Translation: BAG34765.1.
EF553525 mRNA. Translation: ABQ66270.1.
AL356867 Genomic DNA. Translation: CAI19803.1.
CH471121 Genomic DNA. Translation: EAW53353.1.
CH471121 Genomic DNA. Translation: EAW53354.1.
BC017802 mRNA. Translation: AAH17802.1.
RefSeqNP_001091058.1. NM_001097589.1.
NP_005407.1. NM_005416.2.
UniGeneHs.139322.

3D structure databases

ProteinModelPortalQ9UBC9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000295367.

PTM databases

PhosphoSiteQ9UBC9.

Proteomic databases

PaxDbQ9UBC9.
PeptideAtlasQ9UBC9.
PRIDEQ9UBC9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295367; ENSP00000295367; ENSG00000163209.
ENST00000331860; ENSP00000330391; ENSG00000163209.
GeneID6707.
KEGGhsa:6707.
UCSCuc001fax.4. human.

Organism-specific databases

CTD6707.
GeneCardsGC01P152974.
H-InvDBHIX0001078.
HGNCHGNC:11268. SPRR3.
HPAHPA044467.
MIM182271. gene.
neXtProtNX_Q9UBC9.
PharmGKBPA36097.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39062.
HOVERGENHBG079213.
InParanoidQ9UBC9.
OMAPGHTKVP.
PhylomeDBQ9UBC9.
TreeFamTF338205.

Gene expression databases

ArrayExpressQ9UBC9.
BgeeQ9UBC9.
CleanExHS_SPRR3.
GenevestigatorQ9UBC9.

Family and domain databases

InterProIPR003302. Cornifin.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERPTHR23263. PTHR23263. 1 hit.
PfamPF02389. Cornifin. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSPRR3.
GenomeRNAi6707.
NextBio26152.
PROQ9UBC9.
SOURCESearch...

Entry information

Entry nameSPRR3_HUMAN
AccessionPrimary (citable) accession number: Q9UBC9
Secondary accession number(s): A5YKK8 expand/collapse secondary AC list , B2R4G8, D3DV32, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UDG3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM