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Protein

Small proline-rich protein 3

Gene

SPRR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cross-linked envelope protein of keratinocytes.

GO - Molecular functioni

  • structural molecule activity Source: UniProtKB

GO - Biological processi

  • epidermis development Source: UniProtKB
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: InterPro
  • wound healing Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 3
Alternative name(s):
22 kDa pancornulin
Cornifin beta
Esophagin
Gene namesi
Name:SPRR3
Synonyms:SPRC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11268. SPRR3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36097.

Polymorphism and mutation databases

BioMutaiSPRR3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 169168Small proline-rich protein 3PRO_0000150003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9UBC9.
PaxDbiQ9UBC9.
PeptideAtlasiQ9UBC9.
PRIDEiQ9UBC9.

PTM databases

PhosphoSiteiQ9UBC9.

Expressioni

Inductioni

During squamous differentiation of epidermal keratinocytes.

Gene expression databases

BgeeiQ9UBC9.
CleanExiHS_SPRR3.
ExpressionAtlasiQ9UBC9. baseline and differential.
GenevisibleiQ9UBC9. HS.

Interactioni

Protein-protein interaction databases

BioGridi112585. 6 interactions.
STRINGi9606.ENSP00000295367.

Structurei

3D structure databases

ProteinModelPortaliQ9UBC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 5081
Repeati51 – 5882
Repeati59 – 6683
Repeati67 – 7484
Repeati75 – 8285
Repeati83 – 9086
Repeati91 – 9887
Repeati99 – 10688
Repeati107 – 11489
Repeati115 – 122810
Repeati123 – 130811
Repeati131 – 138812
Repeati139 – 146813
Repeati147 – 154814

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 15411214 X 8 AA approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG39062.
GeneTreeiENSGT00730000111065.
HOVERGENiHBG079213.
InParanoidiQ9UBC9.
OMAiPGHTKVP.
PhylomeDBiQ9UBC9.
TreeFamiTF338205.

Family and domain databases

InterProiIPR003302. Cornifin.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF02389. Cornifin. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYQQKQTF TPPPQLQQQQ VKQPSQPPPQ EIFVPTTKEP CHSKVPQPGN
60 70 80 90 100
TKIPEPGCTK VPEPGCTKVP EPGCTKVPEP GCTKVPEPGC TKVPEPGCTK
110 120 130 140 150
VPEPGYTKVP EPGSIKVPDQ GFIKFPEPGA IKVPEQGYTK VPVPGYTKLP
160
EPCPSTVTPG PAQQKTKQK
Length:169
Mass (Da):18,154
Last modified:February 11, 2002 - v2
Checksum:iB8E522AF798F1ECB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191Q → H in AAM74559 (PubMed:8809402).Curated
Sequence conflicti61 – 688Missing no nucleotide entry (PubMed:8018055).Curated
Sequence conflicti61 – 688Missing in CAB65098 (PubMed:11230159).Curated
Sequence conflicti61 – 688Missing in AAH17802 (PubMed:16710414).Curated

Mass spectrometryi

Molecular mass is 17239 Da from positions 2 - 169. Determined by ESI. Variants Del 98-Cys--Pro-105 and Val-149.1 Publication
Molecular mass is 18065 Da from positions 2 - 169. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti98 – 1058Missing .
VAR_065255
Natural varianti149 – 1491L → V.3 Publications
Corresponds to variant rs1055935 [ dbSNP | Ensembl ].
VAR_023377
Natural varianti156 – 1561T → M.
Corresponds to variant rs2075740 [ dbSNP | Ensembl ].
VAR_053048

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077374 Genomic DNA. Translation: AAD11938.1.
AY118269 mRNA. Translation: AAM74559.1.
AJ243667 mRNA. Translation: CAB65098.1.
DQ017955 Genomic DNA. Translation: AAY26394.1.
AK311823 mRNA. Translation: BAG34765.1.
EF553525 mRNA. Translation: ABQ66270.1.
AL356867 Genomic DNA. Translation: CAI19803.1.
CH471121 Genomic DNA. Translation: EAW53353.1.
CH471121 Genomic DNA. Translation: EAW53354.1.
BC017802 mRNA. Translation: AAH17802.1.
CCDSiCCDS1033.1.
RefSeqiNP_001091058.1. NM_001097589.1.
NP_005407.1. NM_005416.2.
UniGeneiHs.139322.

Genome annotation databases

EnsembliENST00000295367; ENSP00000295367; ENSG00000163209.
ENST00000331860; ENSP00000330391; ENSG00000163209.
GeneIDi6707.
KEGGihsa:6707.
UCSCiuc001fax.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077374 Genomic DNA. Translation: AAD11938.1.
AY118269 mRNA. Translation: AAM74559.1.
AJ243667 mRNA. Translation: CAB65098.1.
DQ017955 Genomic DNA. Translation: AAY26394.1.
AK311823 mRNA. Translation: BAG34765.1.
EF553525 mRNA. Translation: ABQ66270.1.
AL356867 Genomic DNA. Translation: CAI19803.1.
CH471121 Genomic DNA. Translation: EAW53353.1.
CH471121 Genomic DNA. Translation: EAW53354.1.
BC017802 mRNA. Translation: AAH17802.1.
CCDSiCCDS1033.1.
RefSeqiNP_001091058.1. NM_001097589.1.
NP_005407.1. NM_005416.2.
UniGeneiHs.139322.

3D structure databases

ProteinModelPortaliQ9UBC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112585. 6 interactions.
STRINGi9606.ENSP00000295367.

PTM databases

PhosphoSiteiQ9UBC9.

Polymorphism and mutation databases

BioMutaiSPRR3.

Proteomic databases

MaxQBiQ9UBC9.
PaxDbiQ9UBC9.
PeptideAtlasiQ9UBC9.
PRIDEiQ9UBC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295367; ENSP00000295367; ENSG00000163209.
ENST00000331860; ENSP00000330391; ENSG00000163209.
GeneIDi6707.
KEGGihsa:6707.
UCSCiuc001fax.4. human.

Organism-specific databases

CTDi6707.
GeneCardsiGC01P152974.
H-InvDBHIX0001078.
HGNCiHGNC:11268. SPRR3.
MIMi182271. gene.
neXtProtiNX_Q9UBC9.
PharmGKBiPA36097.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39062.
GeneTreeiENSGT00730000111065.
HOVERGENiHBG079213.
InParanoidiQ9UBC9.
OMAiPGHTKVP.
PhylomeDBiQ9UBC9.
TreeFamiTF338205.

Miscellaneous databases

ChiTaRSiSPRR3. human.
GeneWikiiSPRR3.
GenomeRNAii6707.
NextBioi26152.
PROiQ9UBC9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBC9.
CleanExiHS_SPRR3.
ExpressionAtlasiQ9UBC9. baseline and differential.
GenevisibleiQ9UBC9. HS.

Family and domain databases

InterProiIPR003302. Cornifin.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF02389. Cornifin. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins."
    Gibbs S., Fijneman R., Wiegant J., Geurts van Kessel A., van de Putte P., Backendorf C.
    Genomics 16:630-637(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Peripheral blood.
  2. "Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts."
    Robinson P.A., Marley J.J., High A.S., Hume W.J.
    Arch. Oral Biol. 39:251-259(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors."
    Abraham J.M., Wang S., Suzuki H., Jiang H.Y., Rosenblum-Vos L.S., Yin J., Meltzer S.J.
    Cell Growth Differ. 7:855-860(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library."
    Marenholz I., Zirra M., Fischer D.F., Backendorf C., Ziegler A., Mischke D.
    Genome Res. 11:341-355(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Characterization of two isoforms of human SPRR3 from saliva of preterm human newborn and autoptic fetal oral mucosa, parotid and submandibular gland samples."
    Manconi B., Cabras T., Pisano E., Nemolato S., Inzitari R., Iavarone F., Fanali C., Sanna M.T., Tirone C., Vento G., Romagnoli C., Faa G., Castagnola M., Messana I.
    Biochem. Biophys. Res. Commun. 398:477-481(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MASS SPECTROMETRY, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, VARIANTS DEL 98-CYS--PRO-104 AND VAL-149.
    Tissue: Oral mucosa, Parotid gland, Saliva and Submandibular gland.
  6. NIEHS SNPs program
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-149.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  9. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-149.
    Tissue: Skeletal muscle.
  12. "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation."
    Greco M.A., Lorand L., Lane W.S., Baden H.P., Parameswaran K.N.P., Kvedar J.C.
    J. Invest. Dermatol. 104:204-210(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 8-40 AND 140-165.
    Tissue: Keratinocyte.

Entry informationi

Entry nameiSPRR3_HUMAN
AccessioniPrimary (citable) accession number: Q9UBC9
Secondary accession number(s): A5YKK8
, B2R4G8, D3DV32, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UDG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: July 22, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.