Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UBC7

- GALP_HUMAN

UniProt

Q9UBC7 - GALP_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Galanin-like peptide

Gene

GALP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Isoform 1: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
Isoform 2: Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (PubMed:23537644).1 Publication

GO - Biological processi

  1. behavioral response to starvation Source: Ensembl
  2. defense response to bacterium Source: UniProtKB-KW
  3. neuropeptide signaling pathway Source: UniProtKB-KW
  4. regulation of appetite Source: Ensembl
  5. response to insulin Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Hormone, Neuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin-like peptide
Gene namesi
Name:GALP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:24840. GALP.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389277.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 8460Galanin-like peptidePRO_0000010463Add
BLAST
Propeptidei87 – 11630By similarityPRO_0000010464Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

MaxQBiQ9UBC7.
PaxDbiQ9UBC7.
PRIDEiQ9UBC7.

Expressioni

Tissue specificityi

Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells.

Gene expression databases

BgeeiQ9UBC7.
CleanExiHS_GALP.
GenevestigatoriQ9UBC7.

Organism-specific databases

HPAiHPA053938.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349884.

Structurei

3D structure databases

ProteinModelPortaliQ9UBC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the galanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG83747.
GeneTreeiENSGT00390000016349.
HOGENOMiHOG000112691.
HOVERGENiHBG018628.
InParanoidiQ9UBC7.
OMAiRETRHGS.
OrthoDBiEOG738070.
PhylomeDBiQ9UBC7.
TreeFamiTF339481.

Family and domain databases

InterProiIPR008174. Galanin.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UBC7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPSVPLVL LLVLLLSLAE TPASAPAHRG RGGWTLNSAG YLLGPVLHLP
60 70 80 90 100
QMGDQDGKRE TALEILDLWK AIDGLPYSHP PQPSKRNVME TFAKPEIGDL
110
GMLSMKIPKE EDVLKS
Length:116
Mass (Da):12,545
Last modified:May 1, 2000 - v1
Checksum:iEDFDE8EAE6217B51
GO
Isoform 2 (identifier: Q9UBC7-2) [UniParc]FASTAAdd to Basket

Also known as: Alarin, del/E3

The sequence of this isoform differs from the canonical sequence as follows:
     30-115: GRGGWTLNSA...KIPKEEDVLK → SSTFPKWVTKTERGRQPLR

Note: Cleavage of the signal peptide generates a peptide of 25 amino acids, termed alarin because of the N-terminal alanine and the C-terminal serine. Involved in ganglionic differentiation in neuroblastic tumor tissues. Vasoactive peptide.

Show »
Length:49
Mass (Da):5,321
Checksum:i967E210BA7BAF4E8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721I → M.
Corresponds to variant rs3745833 [ dbSNP | Ensembl ].
VAR_020426

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei30 – 11586GRGGW…EDVLK → SSTFPKWVTKTERGRQPLR in isoform 2. 1 PublicationVSP_030460Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188492 mRNA. Translation: AAF19724.1.
AF188493 mRNA. Translation: AAF19725.1.
AY329637 mRNA. Translation: AAQ99038.1.
CCDSiCCDS12940.1. [Q9UBC7-1]
CCDS46202.1. [Q9UBC7-2]
RefSeqiNP_001139018.1. NM_001145546.1. [Q9UBC7-2]
NP_149097.1. NM_033106.3. [Q9UBC7-1]
UniGeneiHs.283915.

Genome annotation databases

EnsembliENST00000357330; ENSP00000349884; ENSG00000197487. [Q9UBC7-1]
ENST00000440823; ENSP00000411521; ENSG00000197487. [Q9UBC7-2]
ENST00000590002; ENSP00000464698; ENSG00000197487. [Q9UBC7-2]
GeneIDi85569.
KEGGihsa:85569.
UCSCiuc002qmo.1. human. [Q9UBC7-1]
uc010eti.2. human. [Q9UBC7-2]

Polymorphism databases

DMDMi20138432.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188492 mRNA. Translation: AAF19724.1 .
AF188493 mRNA. Translation: AAF19725.1 .
AY329637 mRNA. Translation: AAQ99038.1 .
CCDSi CCDS12940.1. [Q9UBC7-1 ]
CCDS46202.1. [Q9UBC7-2 ]
RefSeqi NP_001139018.1. NM_001145546.1. [Q9UBC7-2 ]
NP_149097.1. NM_033106.3. [Q9UBC7-1 ]
UniGenei Hs.283915.

3D structure databases

ProteinModelPortali Q9UBC7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000349884.

Polymorphism databases

DMDMi 20138432.

Proteomic databases

MaxQBi Q9UBC7.
PaxDbi Q9UBC7.
PRIDEi Q9UBC7.

Protocols and materials databases

DNASUi 85569.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357330 ; ENSP00000349884 ; ENSG00000197487 . [Q9UBC7-1 ]
ENST00000440823 ; ENSP00000411521 ; ENSG00000197487 . [Q9UBC7-2 ]
ENST00000590002 ; ENSP00000464698 ; ENSG00000197487 . [Q9UBC7-2 ]
GeneIDi 85569.
KEGGi hsa:85569.
UCSCi uc002qmo.1. human. [Q9UBC7-1 ]
uc010eti.2. human. [Q9UBC7-2 ]

Organism-specific databases

CTDi 85569.
GeneCardsi GC19P056688.
HGNCi HGNC:24840. GALP.
HPAi HPA053938.
MIMi 611178. gene.
neXtProti NX_Q9UBC7.
PharmGKBi PA162389277.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG83747.
GeneTreei ENSGT00390000016349.
HOGENOMi HOG000112691.
HOVERGENi HBG018628.
InParanoidi Q9UBC7.
OMAi RETRHGS.
OrthoDBi EOG738070.
PhylomeDBi Q9UBC7.
TreeFami TF339481.

Miscellaneous databases

GenomeRNAii 85569.
NextBioi 76180.
PROi Q9UBC7.
SOURCEi Search...

Gene expression databases

Bgeei Q9UBC7.
CleanExi HS_GALP.
Genevestigatori Q9UBC7.

Family and domain databases

InterProi IPR008174. Galanin.
[Graphical view ]
Pfami PF01296. Galanin. 1 hit.
[Graphical view ]
PROSITEi PS00861. GALANIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus."
    Ohtaki T., Kumano S., Ishibashi Y., Ogi K., Matsui H., Harada M., Kitada C., Kurokawa T., Onda H., Fujino M.
    J. Biol. Chem. 274:37041-37045(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Differential splicing leads to the novel peptide alarin another member of the galanin-like peptide family."
    Kofler B., Moritz K., Fenninger K.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene."
    Santic R., Fenninger K., Graf K., Schneider R., Hauser-Kronberger C., Schilling F.H., Kogner P., Ratschek M., Jones N., Sperl W., Kofler B.
    J. Mol. Neurosci. 29:145-152(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
    Tissue: Neuroblastoma.
  4. Cited for: TISSUE SPECIFICITY (ISOFORM 2).
  5. "Alarin but not its alternative-splicing form, GALP (Galanin-like peptide) has antimicrobial activity."
    Wada A., Wong P.F., Hojo H., Hasegawa M., Ichinose A., Llanes R., Kubo Y., Senba M., Ichinose Y.
    Biochem. Biophys. Res. Commun. 434:223-227(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORM 2).

Entry informationi

Entry nameiGALP_HUMAN
AccessioniPrimary (citable) accession number: Q9UBC7
Secondary accession number(s): A1KXL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3