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Q9UBC7

- GALP_HUMAN

UniProt

Q9UBC7 - GALP_HUMAN

Protein

Galanin-like peptide

Gene

GALP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Isoform 1: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
    Isoform 2: Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (PubMed:23537644).1 Publication

    GO - Biological processi

    1. behavioral response to starvation Source: Ensembl
    2. neuropeptide signaling pathway Source: UniProtKB-KW
    3. regulation of appetite Source: Ensembl
    4. response to insulin Source: Ensembl

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Hormone, Neuropeptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galanin-like peptide
    Gene namesi
    Name:GALP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:24840. GALP.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162389277.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 8460Galanin-like peptidePRO_0000010463Add
    BLAST
    Propeptidei87 – 11630By similarityPRO_0000010464Add
    BLAST

    Keywords - PTMi

    Cleavage on pair of basic residues

    Proteomic databases

    MaxQBiQ9UBC7.
    PaxDbiQ9UBC7.
    PRIDEiQ9UBC7.

    Expressioni

    Tissue specificityi

    Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells.

    Gene expression databases

    BgeeiQ9UBC7.
    CleanExiHS_GALP.
    GenevestigatoriQ9UBC7.

    Organism-specific databases

    HPAiHPA053938.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000349884.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBC7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the galanin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG83747.
    HOGENOMiHOG000112691.
    HOVERGENiHBG018628.
    InParanoidiQ9UBC7.
    OMAiRETRHGS.
    OrthoDBiEOG738070.
    PhylomeDBiQ9UBC7.
    TreeFamiTF339481.

    Family and domain databases

    InterProiIPR008174. Galanin.
    [Graphical view]
    PfamiPF01296. Galanin. 1 hit.
    [Graphical view]
    PROSITEiPS00861. GALANIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UBC7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPPSVPLVL LLVLLLSLAE TPASAPAHRG RGGWTLNSAG YLLGPVLHLP    50
    QMGDQDGKRE TALEILDLWK AIDGLPYSHP PQPSKRNVME TFAKPEIGDL 100
    GMLSMKIPKE EDVLKS 116
    Length:116
    Mass (Da):12,545
    Last modified:May 1, 2000 - v1
    Checksum:iEDFDE8EAE6217B51
    GO
    Isoform 2 (identifier: Q9UBC7-2) [UniParc]FASTAAdd to Basket

    Also known as: Alarin, del/E3

    The sequence of this isoform differs from the canonical sequence as follows:
         30-115: GRGGWTLNSA...KIPKEEDVLK → SSTFPKWVTKTERGRQPLR

    Note: Cleavage of the signal peptide generates a peptide of 25 amino acids, termed alarin because of the N-terminal alanine and the C-terminal serine. Involved in ganglionic differentiation in neuroblastic tumor tissues. Vasoactive peptide.

    Show »
    Length:49
    Mass (Da):5,321
    Checksum:i967E210BA7BAF4E8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti72 – 721I → M.
    Corresponds to variant rs3745833 [ dbSNP | Ensembl ].
    VAR_020426

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei30 – 11586GRGGW…EDVLK → SSTFPKWVTKTERGRQPLR in isoform 2. 1 PublicationVSP_030460Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF188492 mRNA. Translation: AAF19724.1.
    AF188493 mRNA. Translation: AAF19725.1.
    AY329637 mRNA. Translation: AAQ99038.1.
    CCDSiCCDS12940.1. [Q9UBC7-1]
    CCDS46202.1. [Q9UBC7-2]
    RefSeqiNP_001139018.1. NM_001145546.1. [Q9UBC7-2]
    NP_149097.1. NM_033106.3. [Q9UBC7-1]
    UniGeneiHs.283915.

    Genome annotation databases

    EnsembliENST00000357330; ENSP00000349884; ENSG00000197487. [Q9UBC7-1]
    ENST00000440823; ENSP00000411521; ENSG00000197487. [Q9UBC7-2]
    ENST00000590002; ENSP00000464698; ENSG00000197487. [Q9UBC7-2]
    GeneIDi85569.
    KEGGihsa:85569.
    UCSCiuc002qmo.1. human. [Q9UBC7-1]
    uc010eti.2. human. [Q9UBC7-2]

    Polymorphism databases

    DMDMi20138432.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF188492 mRNA. Translation: AAF19724.1 .
    AF188493 mRNA. Translation: AAF19725.1 .
    AY329637 mRNA. Translation: AAQ99038.1 .
    CCDSi CCDS12940.1. [Q9UBC7-1 ]
    CCDS46202.1. [Q9UBC7-2 ]
    RefSeqi NP_001139018.1. NM_001145546.1. [Q9UBC7-2 ]
    NP_149097.1. NM_033106.3. [Q9UBC7-1 ]
    UniGenei Hs.283915.

    3D structure databases

    ProteinModelPortali Q9UBC7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000349884.

    Polymorphism databases

    DMDMi 20138432.

    Proteomic databases

    MaxQBi Q9UBC7.
    PaxDbi Q9UBC7.
    PRIDEi Q9UBC7.

    Protocols and materials databases

    DNASUi 85569.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357330 ; ENSP00000349884 ; ENSG00000197487 . [Q9UBC7-1 ]
    ENST00000440823 ; ENSP00000411521 ; ENSG00000197487 . [Q9UBC7-2 ]
    ENST00000590002 ; ENSP00000464698 ; ENSG00000197487 . [Q9UBC7-2 ]
    GeneIDi 85569.
    KEGGi hsa:85569.
    UCSCi uc002qmo.1. human. [Q9UBC7-1 ]
    uc010eti.2. human. [Q9UBC7-2 ]

    Organism-specific databases

    CTDi 85569.
    GeneCardsi GC19P056688.
    HGNCi HGNC:24840. GALP.
    HPAi HPA053938.
    MIMi 611178. gene.
    neXtProti NX_Q9UBC7.
    PharmGKBi PA162389277.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83747.
    HOGENOMi HOG000112691.
    HOVERGENi HBG018628.
    InParanoidi Q9UBC7.
    OMAi RETRHGS.
    OrthoDBi EOG738070.
    PhylomeDBi Q9UBC7.
    TreeFami TF339481.

    Miscellaneous databases

    GenomeRNAii 85569.
    NextBioi 76180.
    PROi Q9UBC7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UBC7.
    CleanExi HS_GALP.
    Genevestigatori Q9UBC7.

    Family and domain databases

    InterProi IPR008174. Galanin.
    [Graphical view ]
    Pfami PF01296. Galanin. 1 hit.
    [Graphical view ]
    PROSITEi PS00861. GALANIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus."
      Ohtaki T., Kumano S., Ishibashi Y., Ogi K., Matsui H., Harada M., Kitada C., Kurokawa T., Onda H., Fujino M.
      J. Biol. Chem. 274:37041-37045(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Differential splicing leads to the novel peptide alarin another member of the galanin-like peptide family."
      Kofler B., Moritz K., Fenninger K.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene."
      Santic R., Fenninger K., Graf K., Schneider R., Hauser-Kronberger C., Schilling F.H., Kogner P., Ratschek M., Jones N., Sperl W., Kofler B.
      J. Mol. Neurosci. 29:145-152(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
      Tissue: Neuroblastoma.
    4. Cited for: TISSUE SPECIFICITY (ISOFORM 2).
    5. "Alarin but not its alternative-splicing form, GALP (Galanin-like peptide) has antimicrobial activity."
      Wada A., Wong P.F., Hojo H., Hasegawa M., Ichinose A., Llanes R., Kubo Y., Senba M., Ichinose Y.
      Biochem. Biophys. Res. Commun. 434:223-227(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION (ISOFORM 2).

    Entry informationi

    Entry nameiGALP_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBC7
    Secondary accession number(s): A1KXL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3