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Protein

Galanin-like peptide

Gene

GALP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Isoform 1: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
Isoform 2: Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (PubMed:23537644).1 Publication

GO - Molecular functioni

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • behavioral response to starvation Source: Ensembl
  • defense response to bacterium Source: UniProtKB-KW
  • defense response to Gram-negative bacterium Source: UniProtKB
  • modification of morphology or physiology of other organism Source: UniProtKB
  • neuropeptide signaling pathway Source: UniProtKB-KW
  • regulation of appetite Source: Ensembl
  • response to insulin Source: Ensembl

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Hormone, Neuropeptide

Enzyme and pathway databases

SIGNORiQ9UBC7

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin-like peptide
Gene namesi
Name:GALP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197487.8
HGNCiHGNC:24840 GALP
MIMi611178 gene
neXtProtiNX_Q9UBC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi85569
OpenTargetsiENSG00000197487
PharmGKBiPA162389277

Polymorphism and mutation databases

BioMutaiGALP
DMDMi20138432

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001046325 – 84Galanin-like peptideAdd BLAST60
PropeptideiPRO_000001046487 – 116By similarityAdd BLAST30

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

MaxQBiQ9UBC7
PaxDbiQ9UBC7
PeptideAtlasiQ9UBC7
PRIDEiQ9UBC7
ProteomicsDBi83942
83943 [Q9UBC7-2]

PTM databases

iPTMnetiQ9UBC7
PhosphoSitePlusiQ9UBC7

Expressioni

Tissue specificityi

Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells.

Gene expression databases

BgeeiENSG00000197487
CleanExiHS_GALP
GenevisibleiQ9UBC7 HS

Organism-specific databases

HPAiHPA053938

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9UBC7, 2 interactors
STRINGi9606.ENSP00000349884

Structurei

3D structure databases

ProteinModelPortaliQ9UBC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the galanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JE0F Eukaryota
ENOG4111D06 LUCA
GeneTreeiENSGT00390000016349
HOGENOMiHOG000112691
HOVERGENiHBG018628
InParanoidiQ9UBC7
OMAiWKAIDGL
OrthoDBiEOG091G1256
PhylomeDBiQ9UBC7
TreeFamiTF339481

Family and domain databases

InterProiView protein in InterPro
IPR008174 Galanin
PfamiView protein in Pfam
PF01296 Galanin, 1 hit
PROSITEiView protein in PROSITE
PS00861 GALANIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPSVPLVL LLVLLLSLAE TPASAPAHRG RGGWTLNSAG YLLGPVLHLP
60 70 80 90 100
QMGDQDGKRE TALEILDLWK AIDGLPYSHP PQPSKRNVME TFAKPEIGDL
110
GMLSMKIPKE EDVLKS
Length:116
Mass (Da):12,545
Last modified:May 1, 2000 - v1
Checksum:iEDFDE8EAE6217B51
GO
Isoform 2 (identifier: Q9UBC7-2) [UniParc]FASTAAdd to basket
Also known as: Alarin, del/E3

The sequence of this isoform differs from the canonical sequence as follows:
     30-115: GRGGWTLNSA...KIPKEEDVLK → SSTFPKWVTKTERGRQPLR

Note: Cleavage of the signal peptide generates a peptide of 25 amino acids, termed alarin because of the N-terminal alanine and the C-terminal serine. Involved in ganglionic differentiation in neuroblastic tumor tissues. Vasoactive peptide.
Show »
Length:49
Mass (Da):5,321
Checksum:i967E210BA7BAF4E8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02042672I → M. Corresponds to variant dbSNP:rs3745833Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03046030 – 115GRGGW…EDVLK → SSTFPKWVTKTERGRQPLR in isoform 2. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188492 mRNA Translation: AAF19724.1
AF188493 mRNA Translation: AAF19725.1
AY329637 mRNA Translation: AAQ99038.1
CCDSiCCDS12940.1 [Q9UBC7-1]
CCDS46202.1 [Q9UBC7-2]
RefSeqiNP_001139018.1, NM_001145546.1 [Q9UBC7-2]
NP_149097.1, NM_033106.3 [Q9UBC7-1]
UniGeneiHs.283915

Genome annotation databases

EnsembliENST00000357330; ENSP00000349884; ENSG00000197487 [Q9UBC7-1]
ENST00000440823; ENSP00000411521; ENSG00000197487 [Q9UBC7-2]
ENST00000590002; ENSP00000464698; ENSG00000197487 [Q9UBC7-2]
GeneIDi85569
KEGGihsa:85569
UCSCiuc002qmo.1 human [Q9UBC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGALP_HUMAN
AccessioniPrimary (citable) accession number: Q9UBC7
Secondary accession number(s): A1KXL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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