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Q9UBC7 (GALP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galanin-like peptide
Gene names
Name:GALP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion. Isoform 2 exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2 By similarity.

Subcellular location

Secreted.

Tissue specificity

Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells. Ref.4

Sequence similarities

Belongs to the galanin family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UBC7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UBC7-2)

Also known as: Alarin; del/E3;

The sequence of this isoform differs from the canonical sequence as follows:
     30-115: GRGGWTLNSA...KIPKEEDVLK → SSTFPKWVTKTERGRQPLR
Note: Cleavage of the signal peptide generates a peptide of 25 amino acids, termed alarin because of the N-terminal alanine and the C-terminal serine. Involved in ganglionic differentiation in neuroblastic tumor tissues. Vasoactive peptide.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Chain25 – 8460Galanin-like peptide
PRO_0000010463
Propeptide87 – 11630 By similarity
PRO_0000010464

Natural variations

Alternative sequence30 – 11586GRGGW…EDVLK → SSTFPKWVTKTERGRQPLR in isoform 2.
VSP_030460
Natural variant721I → M.
Corresponds to variant rs3745833 [ dbSNP | Ensembl ].
VAR_020426

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: EDFDE8EAE6217B51

FASTA11612,545
        10         20         30         40         50         60 
MAPPSVPLVL LLVLLLSLAE TPASAPAHRG RGGWTLNSAG YLLGPVLHLP QMGDQDGKRE 

        70         80         90        100        110 
TALEILDLWK AIDGLPYSHP PQPSKRNVME TFAKPEIGDL GMLSMKIPKE EDVLKS 

« Hide

Isoform 2 (Alarin) (del/E3) [UniParc].

Checksum: 967E210BA7BAF4E8
Show »

FASTA495,321

References

[1]"Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus."
Ohtaki T., Kumano S., Ishibashi Y., Ogi K., Matsui H., Harada M., Kitada C., Kurokawa T., Onda H., Fujino M.
J. Biol. Chem. 274:37041-37045(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Differential splicing leads to the novel peptide alarin another member of the galanin-like peptide family."
Kofler B., Moritz K., Fenninger K.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene."
Santic R., Fenninger K., Graf K., Schneider R., Hauser-Kronberger C., Schilling F.H., Kogner P., Ratschek M., Jones N., Sperl W., Kofler B.
J. Mol. Neurosci. 29:145-152(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING.
Tissue: Neuroblastoma.
[4]"Alarin is a vasoactive peptide."
Santic R., Schmidhuber S.M., Lang R., Rauch I., Voglas E., Eberhard N., Bauer J.W., Brain S.D., Kofler B.
Proc. Natl. Acad. Sci. U.S.A. 104:10217-10222(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY (ISOFORM 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF188492 mRNA. Translation: AAF19724.1.
AF188493 mRNA. Translation: AAF19725.1.
AY329637 mRNA. Translation: AAQ99038.1.
CCDSCCDS12940.1. [Q9UBC7-1]
CCDS46202.1. [Q9UBC7-2]
RefSeqNP_001139018.1. NM_001145546.1. [Q9UBC7-2]
NP_149097.1. NM_033106.3. [Q9UBC7-1]
UniGeneHs.283915.

3D structure databases

ProteinModelPortalQ9UBC7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000349884.

Polymorphism databases

DMDM20138432.

Proteomic databases

MaxQBQ9UBC7.
PaxDbQ9UBC7.
PRIDEQ9UBC7.

Protocols and materials databases

DNASU85569.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357330; ENSP00000349884; ENSG00000197487. [Q9UBC7-1]
ENST00000440823; ENSP00000411521; ENSG00000197487. [Q9UBC7-2]
ENST00000590002; ENSP00000464698; ENSG00000197487. [Q9UBC7-2]
GeneID85569.
KEGGhsa:85569.
UCSCuc002qmo.1. human. [Q9UBC7-1]
uc010eti.2. human. [Q9UBC7-2]

Organism-specific databases

CTD85569.
GeneCardsGC19P056688.
HGNCHGNC:24840. GALP.
HPAHPA053938.
MIM611178. gene.
neXtProtNX_Q9UBC7.
PharmGKBPA162389277.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG83747.
HOGENOMHOG000112691.
HOVERGENHBG018628.
InParanoidQ9UBC7.
OMARETRHGS.
OrthoDBEOG738070.
PhylomeDBQ9UBC7.
TreeFamTF339481.

Gene expression databases

BgeeQ9UBC7.
CleanExHS_GALP.
GenevestigatorQ9UBC7.

Family and domain databases

InterProIPR008174. Galanin.
[Graphical view]
PfamPF01296. Galanin. 1 hit.
[Graphical view]
PROSITEPS00861. GALANIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi85569.
NextBio76180.
PROQ9UBC7.
SOURCESearch...

Entry information

Entry nameGALP_HUMAN
AccessionPrimary (citable) accession number: Q9UBC7
Secondary accession number(s): A1KXL3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM