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Protein

NF-kappa-B inhibitor-like protein 1

Gene

NFKBIL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.1 Publication

GO - Biological processi

  • cellular response to lipopolysaccharide Source: UniProtKB
  • cytoplasmic sequestering of transcription factor Source: ProtInc
  • I-kappaB kinase/NF-kappaB signaling Source: GO_Central
  • negative regulation of lipopolysaccharide-mediated signaling pathway Source: UniProtKB
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of toll-like receptor signaling pathway Source: UniProtKB
  • negative regulation of tumor necrosis factor production Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor-like protein 1
Alternative name(s):
Inhibitor of kappa B-like protein
Short name:
I-kappa-B-like protein
Short name:
IkappaBL
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Gene namesi
Name:NFKBIL1
Synonyms:IKBL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:7800. NFKBIL1.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus.

GO - Cellular componenti

  • cytosol Source: Ensembl
  • intermediate filament cytoskeleton Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Rheumatoid arthritis (RA)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionAn inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
See also OMIM:180300

Organism-specific databases

MalaCardsiNFKBIL1.
MIMi180300. phenotype.
PharmGKBiPA31604.

Polymorphism and mutation databases

BioMutaiNFKBIL1.
DMDMi44888077.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381NF-kappa-B inhibitor-like protein 1PRO_0000067009Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei150 – 1501PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBC1.
MaxQBiQ9UBC1.
PaxDbiQ9UBC1.
PRIDEiQ9UBC1.

PTM databases

iPTMnetiQ9UBC1.
PhosphoSiteiQ9UBC1.

Expressioni

Tissue specificityi

Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.

Gene expression databases

BgeeiQ9UBC1.
CleanExiHS_NFKBIL1.
ExpressionAtlasiQ9UBC1. baseline and differential.
GenevisibleiQ9UBC1. HS.

Organism-specific databases

HPAiHPA006298.

Interactioni

Subunit structurei

Interacts with CACTIN (via N-terminal domain); the interaction occurs in a proinflammatory-independent manner.1 Publication

Protein-protein interaction databases

BioGridi110862. 31 interactions.
IntActiQ9UBC1. 12 interactions.
STRINGi9606.ENSP00000365318.

Structurei

3D structure databases

ProteinModelPortaliQ9UBC1.
SMRiQ9UBC1. Positions 32-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 9330ANK 1Add
BLAST
Repeati97 – 13034ANK 2Add
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IZ7E. Eukaryota.
ENOG4111NZ2. LUCA.
HOGENOMiHOG000043101.
HOVERGENiHBG048799.
InParanoidiQ9UBC1.
KOiK09256.
OMAiHSWRQQE.
PhylomeDBiQ9UBC1.
TreeFamiTF333242.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNPSPQVPE EEASTSVCRP KSSMASTSRR QRRERRFRRY LSAGRLVRAQ
60 70 80 90 100
ALLQRHPGLD VDAGQPPPLH RACARHDAPA LCLLLRLGAD PAHQDRHGDT
110 120 130 140 150
ALHAAARQGP DAYTDFFLPL LSRCPSAMGI KNKDGETPGQ ILGWGPPWDS
160 170 180 190 200
AEEEEEDDAS KEREWRQKLQ GELEDEWQEV MGRFEGDASH ETQEPESFSA
210 220 230 240 250
WSDRLAREHA QKCQQQQREA EGSCRPPRAE GSSQSWRQQE EEQRLFRERA
260 270 280 290 300
RAKEEELRES RARRAQEALG DREPKPTRAG PREEHPRGAG RGSLWRFGDV
310 320 330 340 350
PWPCPGGGDP EAMAAALVAR GPPLEEQGAL RRYLRVQQVR WHPDRFLQRF
360 370 380
RSQIETWELG RVMGAVTALS QALNRHAEAL K
Length:381
Mass (Da):43,204
Last modified:May 1, 2000 - v1
Checksum:iF466991A92A93F4C
GO
Isoform 2 (identifier: Q9UBC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:358
Mass (Da):40,774
Checksum:iB2DF68E09AA28AA2
GO
Isoform 3 (identifier: Q9UBC1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-185: Missing.

Note: No experimental confirmation available.
Show »
Length:366
Mass (Da):41,368
Checksum:i872AAC6A001FACB9
GO

Sequence cautioni

The sequence BAG62473.1 differs from that shown. Reason: Erroneous termination at position 255. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481R → Q in BAG62473 (Ref. 7) Curated
Sequence conflicti238 – 2392QQ → HE in CAA54867 (PubMed:8081366).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti224 – 2241C → R Polymorphism found in the MHC 7.1 haplotype (HLA-A3,B7,DR15) population. 3 Publications
Corresponds to variant rs3130062 [ dbSNP | Ensembl ].
VAR_017798

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323Missing in isoform 2. 1 PublicationVSP_041075Add
BLAST
Alternative sequencei171 – 18515Missing in isoform 3. 1 PublicationVSP_046261Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77909 mRNA. Translation: CAA54867.1.
AB000876 Genomic DNA. No translation available.
AB000882 Genomic DNA. No translation available.
AF097419 mRNA. Translation: AAD38108.1.
AF097420 mRNA. Translation: AAD38109.1.
AF097421 mRNA. Translation: AAD38110.1.
AF097422 mRNA. Translation: AAD38111.1.
AF097423 mRNA. Translation: AAD38112.1.
AF097424 mRNA. Translation: AAD38113.1.
AF097425 mRNA. Translation: AAD38114.1.
AF097426 mRNA. Translation: AAD38115.1.
AF097427 mRNA. Translation: AAD38116.1.
AF097428 mRNA. Translation: AAD38117.1.
AF097429 mRNA. Translation: AAD38118.1.
Y14768 Genomic DNA. Translation: CAA75072.1.
AK300818 mRNA. Translation: BAG62473.1. Sequence problems.
BA000025 Genomic DNA. Translation: BAB63398.1.
AB088115 Genomic DNA. Translation: BAC54951.1.
AC004181 Genomic DNA. No translation available.
AL662847 Genomic DNA. No translation available.
AL662801 Genomic DNA. Translation: CAI18289.1.
BX001040, AL929587 Genomic DNA. Translation: CAI18643.2.
AL929587, BX001040 Genomic DNA. Translation: CAI18667.2.
BX248516 Genomic DNA. Translation: CAI41933.2.
CR753892 Genomic DNA. Translation: CAQ06929.1.
CR942185 Genomic DNA. Translation: CAQ07709.1.
BX927320 Genomic DNA. Translation: CAQ09991.1.
BX001040, AL929587 Genomic DNA. Translation: CAI18641.2.
AL929587, BX001040 Genomic DNA. Translation: CAI18666.2.
BX248516 Genomic DNA. Translation: CAI41931.2.
CR753892 Genomic DNA. Translation: CAQ06928.1.
CR942185 Genomic DNA. Translation: CAQ07708.1.
BX927320 Genomic DNA. Translation: CAQ09990.1.
CH471081 Genomic DNA. Translation: EAX03417.1.
CH471081 Genomic DNA. Translation: EAX03418.1.
BC143671 mRNA. Translation: AAI43672.1.
CCDSiCCDS4700.1. [Q9UBC1-1]
CCDS47399.1. [Q9UBC1-3]
CCDS47400.1. [Q9UBC1-2]
PIRiS60561.
RefSeqiNP_001138433.1. NM_001144961.1.
NP_001138434.1. NM_001144962.1.
NP_001138435.1. NM_001144963.1.
NP_004998.3. NM_005007.3.
UniGeneiHs.2764.

Genome annotation databases

EnsembliENST00000376148; ENSP00000365318; ENSG00000204498.
ENST00000383500; ENSP00000372992; ENSG00000206440. [Q9UBC1-3]
ENST00000400279; ENSP00000383137; ENSG00000206440. [Q9UBC1-2]
ENST00000400285; ENSP00000383142; ENSG00000206440. [Q9UBC1-1]
ENST00000414391; ENSP00000414084; ENSG00000234530. [Q9UBC1-3]
ENST00000419122; ENSP00000394486; ENSG00000234530. [Q9UBC1-1]
ENST00000419623; ENSP00000414206; ENSG00000236346. [Q9UBC1-3]
ENST00000421396; ENSP00000399871; ENSG00000235125. [Q9UBC1-3]
ENST00000424652; ENSP00000395544; ENSG00000236346. [Q9UBC1-1]
ENST00000428467; ENSP00000407809; ENSG00000236346. [Q9UBC1-2]
ENST00000430501; ENSP00000404901; ENSG00000236196. [Q9UBC1-3]
ENST00000430961; ENSP00000411174; ENSG00000235125. [Q9UBC1-2]
ENST00000432160; ENSP00000411611; ENSG00000227565. [Q9UBC1-1]
ENST00000434332; ENSP00000413952; ENSG00000234530. [Q9UBC1-2]
ENST00000442947; ENSP00000396656; ENSG00000235125. [Q9UBC1-1]
ENST00000451911; ENSP00000413643; ENSG00000227565. [Q9UBC1-3]
ENST00000453377; ENSP00000395977; ENSG00000227565. [Q9UBC1-2]
ENST00000455376; ENSP00000408426; ENSG00000236196. [Q9UBC1-1]
ENST00000456607; ENSP00000401830; ENSG00000236196. [Q9UBC1-2]
GeneIDi4795.
KEGGihsa:4795.
UCSCiuc003nub.4. human. [Q9UBC1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77909 mRNA. Translation: CAA54867.1.
AB000876 Genomic DNA. No translation available.
AB000882 Genomic DNA. No translation available.
AF097419 mRNA. Translation: AAD38108.1.
AF097420 mRNA. Translation: AAD38109.1.
AF097421 mRNA. Translation: AAD38110.1.
AF097422 mRNA. Translation: AAD38111.1.
AF097423 mRNA. Translation: AAD38112.1.
AF097424 mRNA. Translation: AAD38113.1.
AF097425 mRNA. Translation: AAD38114.1.
AF097426 mRNA. Translation: AAD38115.1.
AF097427 mRNA. Translation: AAD38116.1.
AF097428 mRNA. Translation: AAD38117.1.
AF097429 mRNA. Translation: AAD38118.1.
Y14768 Genomic DNA. Translation: CAA75072.1.
AK300818 mRNA. Translation: BAG62473.1. Sequence problems.
BA000025 Genomic DNA. Translation: BAB63398.1.
AB088115 Genomic DNA. Translation: BAC54951.1.
AC004181 Genomic DNA. No translation available.
AL662847 Genomic DNA. No translation available.
AL662801 Genomic DNA. Translation: CAI18289.1.
BX001040, AL929587 Genomic DNA. Translation: CAI18643.2.
AL929587, BX001040 Genomic DNA. Translation: CAI18667.2.
BX248516 Genomic DNA. Translation: CAI41933.2.
CR753892 Genomic DNA. Translation: CAQ06929.1.
CR942185 Genomic DNA. Translation: CAQ07709.1.
BX927320 Genomic DNA. Translation: CAQ09991.1.
BX001040, AL929587 Genomic DNA. Translation: CAI18641.2.
AL929587, BX001040 Genomic DNA. Translation: CAI18666.2.
BX248516 Genomic DNA. Translation: CAI41931.2.
CR753892 Genomic DNA. Translation: CAQ06928.1.
CR942185 Genomic DNA. Translation: CAQ07708.1.
BX927320 Genomic DNA. Translation: CAQ09990.1.
CH471081 Genomic DNA. Translation: EAX03417.1.
CH471081 Genomic DNA. Translation: EAX03418.1.
BC143671 mRNA. Translation: AAI43672.1.
CCDSiCCDS4700.1. [Q9UBC1-1]
CCDS47399.1. [Q9UBC1-3]
CCDS47400.1. [Q9UBC1-2]
PIRiS60561.
RefSeqiNP_001138433.1. NM_001144961.1.
NP_001138434.1. NM_001144962.1.
NP_001138435.1. NM_001144963.1.
NP_004998.3. NM_005007.3.
UniGeneiHs.2764.

3D structure databases

ProteinModelPortaliQ9UBC1.
SMRiQ9UBC1. Positions 32-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110862. 31 interactions.
IntActiQ9UBC1. 12 interactions.
STRINGi9606.ENSP00000365318.

PTM databases

iPTMnetiQ9UBC1.
PhosphoSiteiQ9UBC1.

Polymorphism and mutation databases

BioMutaiNFKBIL1.
DMDMi44888077.

Proteomic databases

EPDiQ9UBC1.
MaxQBiQ9UBC1.
PaxDbiQ9UBC1.
PRIDEiQ9UBC1.

Protocols and materials databases

DNASUi4795.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376148; ENSP00000365318; ENSG00000204498.
ENST00000383500; ENSP00000372992; ENSG00000206440. [Q9UBC1-3]
ENST00000400279; ENSP00000383137; ENSG00000206440. [Q9UBC1-2]
ENST00000400285; ENSP00000383142; ENSG00000206440. [Q9UBC1-1]
ENST00000414391; ENSP00000414084; ENSG00000234530. [Q9UBC1-3]
ENST00000419122; ENSP00000394486; ENSG00000234530. [Q9UBC1-1]
ENST00000419623; ENSP00000414206; ENSG00000236346. [Q9UBC1-3]
ENST00000421396; ENSP00000399871; ENSG00000235125. [Q9UBC1-3]
ENST00000424652; ENSP00000395544; ENSG00000236346. [Q9UBC1-1]
ENST00000428467; ENSP00000407809; ENSG00000236346. [Q9UBC1-2]
ENST00000430501; ENSP00000404901; ENSG00000236196. [Q9UBC1-3]
ENST00000430961; ENSP00000411174; ENSG00000235125. [Q9UBC1-2]
ENST00000432160; ENSP00000411611; ENSG00000227565. [Q9UBC1-1]
ENST00000434332; ENSP00000413952; ENSG00000234530. [Q9UBC1-2]
ENST00000442947; ENSP00000396656; ENSG00000235125. [Q9UBC1-1]
ENST00000451911; ENSP00000413643; ENSG00000227565. [Q9UBC1-3]
ENST00000453377; ENSP00000395977; ENSG00000227565. [Q9UBC1-2]
ENST00000455376; ENSP00000408426; ENSG00000236196. [Q9UBC1-1]
ENST00000456607; ENSP00000401830; ENSG00000236196. [Q9UBC1-2]
GeneIDi4795.
KEGGihsa:4795.
UCSCiuc003nub.4. human. [Q9UBC1-1]

Organism-specific databases

CTDi4795.
GeneCardsiNFKBIL1.
HGNCiHGNC:7800. NFKBIL1.
HPAiHPA006298.
MalaCardsiNFKBIL1.
MIMi180300. phenotype.
601022. gene.
neXtProtiNX_Q9UBC1.
PharmGKBiPA31604.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ7E. Eukaryota.
ENOG4111NZ2. LUCA.
HOGENOMiHOG000043101.
HOVERGENiHBG048799.
InParanoidiQ9UBC1.
KOiK09256.
OMAiHSWRQQE.
PhylomeDBiQ9UBC1.
TreeFamiTF333242.

Miscellaneous databases

GeneWikiiNFKBIL1.
GenomeRNAii4795.
PROiQ9UBC1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBC1.
CleanExiHS_NFKBIL1.
ExpressionAtlasiQ9UBC1. baseline and differential.
GenevisibleiQ9UBC1. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins."
    Albertella M.R., Campbell D.R.
    Hum. Mol. Genet. 3:793-799(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Premonocytic leukemia.
  2. "Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region."
    Shiina T., Tamiya G., Oka A., Yamagata T., Yamagata N., Kikkawa E., Goto K., Mizuki N., Watanabe K., Fukuzumi Y., Taguchi S., Sugawara C., Ono A., Chen L., Yamazaki M., Tashiro H., Ando A., Ikemura T., Kimura M., Inoko H.
    Genomics 47:372-382(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The central MHC gene IKBL carries a structural polymorphism that is associated with HLA-A3,B7,DR15."
    Allcock R.J.N., Christiansen F.T., Price P.
    Immunogenetics 49:660-665(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-224.
  4. "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."
    Neville M.J., Campbell R.D.
    J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions."
    Shiina T., Ota M., Katsuyama Y., Hashimoto N., Inoko H.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-224.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ARG-224.
    Tissue: Brain.
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-150, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways."
    Atzei P., Gargan S., Curran N., Moynagh P.N.
    J. Biol. Chem. 285:36804-36817(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CACTIN, SUBCELLULAR LOCATION.
  13. "Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis."
    Okamoto K., Makino S., Yoshikawa Y., Takaki A., Nagatsuka Y., Ota M., Tamiya G., Kimura A., Bahram S., Inoko H.
    Am. J. Hum. Genet. 72:303-312(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISEASE.

Entry informationi

Entry nameiIKBL1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBC1
Secondary accession number(s): A6NL91
, B4DUW1, Q14625, Q5HYU4, Q5RJ72, Q5ST96, Q5STV4, Q5STV5, Q9UBX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.