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Protein

Hepatocyte nuclear factor 6

Gene

ONECUT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi283 – 36987CUTPROSITE-ProRule annotationAdd
BLAST
DNA bindingi385 – 44460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_13673. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
REACT_13778. Regulation of gene expression in early pancreatic precursor cells.
SignaLinkiQ9UBC0.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 6
Short name:
HNF-6
Alternative name(s):
One cut domain family member 1
One cut homeobox 1
Gene namesi
Name:ONECUT1
Synonyms:HNF6, HNF6A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:8138. ONECUT1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31924.

Polymorphism and mutation databases

DMDMi13627184.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Hepatocyte nuclear factor 6PRO_0000202402Add
BLAST

Proteomic databases

PaxDbiQ9UBC0.
PRIDEiQ9UBC0.

PTM databases

PhosphoSiteiQ9UBC0.

Expressioni

Tissue specificityi

Highly expressed in liver; lower expression in testis and skin.

Gene expression databases

BgeeiQ9UBC0.
CleanExiHS_ONECUT1.
ExpressionAtlasiQ9UBC0. baseline.
GenevisibleiQ9UBC0. HS.

Organism-specific databases

HPAiHPA003457.

Interactioni

Subunit structurei

Binds DNA as a monomer.By similarity

Protein-protein interaction databases

BioGridi109417. 6 interactions.
STRINGi9606.ENSP00000302630.

Structurei

3D structure databases

ProteinModelPortaliQ9UBC0.
SMRiQ9UBC0. Positions 291-437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi69 – 724Poly-His
Compositional biasi124 – 13815Poly-HisAdd
BLAST
Compositional biasi455 – 4606Poly-Ser

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 1 CUT DNA-binding domain.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG307335.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiQ9UBC0.
KOiK08026.
OMAiCEAPPGM.
OrthoDBiEOG7BW0K4.
PhylomeDBiQ9UBC0.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UBC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAQLTMEAI GELHGVSHEP VPAPADLLGG SPHARSSVAH RGSHLPPAHP
60 70 80 90 100
RSMGMASLLD GGSGGGDYHH HHRAPEHSLA GPLHPTMTMA CETPPGMSMP
110 120 130 140 150
TTYTTLTPLQ PLPPISTVSD KFPHHHHHHH HHHHPHHHQR LAGNVSGSFT
160 170 180 190 200
LMRDERGLAS MNNLYTPYHK DVAGMGQSLS PLSSSGLGSI HNSQQGLPHY
210 220 230 240 250
AHPGAAMPTD KMLTPNGFEA HHPAMLGRHG EQHLTPTSAG MVPINGLPPH
260 270 280 290 300
HPHAHLNAQG HGQLLGTARE PNPSVTGAQV SNGSNSGQME EINTKEVAQR
310 320 330 340 350
ITTELKRYSI PQAIFAQRVL CRSQGTLSDL LRNPKPWSKL KSGRETFRRM
360 370 380 390 400
WKWLQEPEFQ RMSALRLAAC KRKEQEHGKD RGNTPKKPRL VFTDVQRRTL
410 420 430 440 450
HAIFKENKRP SKELQITISQ QLGLELSTVS NFFMNARRRS LDKWQDEGSS
460
NSGNSSSSSS TCTKA
Length:465
Mass (Da):51,023
Last modified:May 1, 2000 - v1
Checksum:iF47F78957A6ECFC2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201A → T (PubMed:10491763).Curated
Sequence conflicti220 – 2201A → T (Ref. 6) Curated
Sequence conflicti284 – 2841S → N in AAB61705 (Ref. 6) Curated
Sequence conflicti288 – 2881Q → H in AAB61705 (Ref. 6) Curated
Sequence conflicti318 – 3181R → K in AAB61705 (Ref. 6) Curated
Sequence conflicti386 – 3861K → Q in AAB61705 (Ref. 6) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751P → A.1 Publication
Corresponds to variant rs74805019 [ dbSNP | Ensembl ].
VAR_010729

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035581, AF035580 Genomic DNA. Translation: AAD02033.1.
U96173 mRNA. Translation: AAD00826.1.
CH471082 Genomic DNA. Translation: EAW77461.1.
BC140830 mRNA. Translation: AAI40831.1.
Y17739 Genomic DNA. Translation: CAB50769.1.
U77975 mRNA. Translation: AAB61705.1.
CCDSiCCDS10150.1.
RefSeqiNP_004489.1. NM_004498.2.
UniGeneiHs.658573.

Genome annotation databases

EnsembliENST00000305901; ENSP00000302630; ENSG00000169856.
GeneIDi3175.
KEGGihsa:3175.
UCSCiuc002aci.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Hepatocyte nuclear factors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035581, AF035580 Genomic DNA. Translation: AAD02033.1.
U96173 mRNA. Translation: AAD00826.1.
CH471082 Genomic DNA. Translation: EAW77461.1.
BC140830 mRNA. Translation: AAI40831.1.
Y17739 Genomic DNA. Translation: CAB50769.1.
U77975 mRNA. Translation: AAB61705.1.
CCDSiCCDS10150.1.
RefSeqiNP_004489.1. NM_004498.2.
UniGeneiHs.658573.

3D structure databases

ProteinModelPortaliQ9UBC0.
SMRiQ9UBC0. Positions 291-437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109417. 6 interactions.
STRINGi9606.ENSP00000302630.

PTM databases

PhosphoSiteiQ9UBC0.

Polymorphism and mutation databases

DMDMi13627184.

Proteomic databases

PaxDbiQ9UBC0.
PRIDEiQ9UBC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305901; ENSP00000302630; ENSG00000169856.
GeneIDi3175.
KEGGihsa:3175.
UCSCiuc002aci.2. human.

Organism-specific databases

CTDi3175.
GeneCardsiGC15M053049.
HGNCiHGNC:8138. ONECUT1.
HPAiHPA003457.
MIMi604164. gene.
neXtProtiNX_Q9UBC0.
PharmGKBiPA31924.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG307335.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiQ9UBC0.
KOiK08026.
OMAiCEAPPGM.
OrthoDBiEOG7BW0K4.
PhylomeDBiQ9UBC0.
TreeFamiTF318206.

Enzyme and pathway databases

ReactomeiREACT_13673. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
REACT_13778. Regulation of gene expression in early pancreatic precursor cells.
SignaLinkiQ9UBC0.

Miscellaneous databases

ChiTaRSiONECUT1. human.
GenomeRNAii3175.
NextBioi12598.
PROiQ9UBC0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBC0.
CleanExiHS_ONECUT1.
ExpressionAtlasiQ9UBC0. baseline.
GenevisibleiQ9UBC0. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the human hepatocyte nuclear factor 6 gene."
    Furuta H., Horikawa Y., Wang Y.-Q., Bell G.I.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The sequence of human mRNA for the hepatocyte nuclear factor-6 alpha."
    Furuta H., Wang Y.-Q., Bell G.I.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion."
    Moeller A.M., Ek J., Durviaux S.M., Urhammer S.A., Clausen J.O., Eiberg H., Hansen T., Rousseau G.G., Lemaigre F.P., Pedersen O.
    Diabetologia 42:1011-1016(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-368, VARIANT ALA-75.
  6. "Yeast one-hybrid cloning of the partial human cDNA for hepatocyte nuclear factor 6."
    Samadani U., Costa R.H.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 174-465.

Entry informationi

Entry nameiHNF6_HUMAN
AccessioniPrimary (citable) accession number: Q9UBC0
Secondary accession number(s): B2RTV4, Q99744, Q9UMR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.