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Q9UBC0

- HNF6_HUMAN

UniProt

Q9UBC0 - HNF6_HUMAN

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Protein

Hepatocyte nuclear factor 6

Gene

ONECUT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi283 – 36987CUTPROSITE-ProRule annotationAdd
BLAST
DNA bindingi385 – 44460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL

GO - Biological processi

  1. B cell differentiation Source: Ensembl
  2. cell fate commitment Source: Ensembl
  3. cilium assembly Source: Ensembl
  4. endocrine pancreas development Source: Reactome
  5. endoderm development Source: Ensembl
  6. epithelial cell development Source: Ensembl
  7. glucose metabolic process Source: Ensembl
  8. liver development Source: Ensembl
  9. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  10. positive regulation of cell migration Source: Ensembl
  11. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  12. regulation of cell-matrix adhesion Source: Ensembl
  13. regulation of transcription, DNA-templated Source: UniProtKB
  14. spleen development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_13673. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
REACT_13778. Regulation of gene expression in early pancreatic precursor cells.
SignaLinkiQ9UBC0.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 6
Short name:
HNF-6
Alternative name(s):
One cut domain family member 1
One cut homeobox 1
Gene namesi
Name:ONECUT1
Synonyms:HNF6, HNF6A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:8138. ONECUT1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31924.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Hepatocyte nuclear factor 6PRO_0000202402Add
BLAST

Proteomic databases

PaxDbiQ9UBC0.
PRIDEiQ9UBC0.

PTM databases

PhosphoSiteiQ9UBC0.

Expressioni

Tissue specificityi

Highly expressed in liver; lower expression in testis and skin.

Gene expression databases

BgeeiQ9UBC0.
CleanExiHS_ONECUT1.
ExpressionAtlasiQ9UBC0. baseline.
GenevestigatoriQ9UBC0.

Organism-specific databases

HPAiHPA003457.

Interactioni

Subunit structurei

Binds DNA as a monomer.By similarity

Protein-protein interaction databases

BioGridi109417. 6 interactions.
STRINGi9606.ENSP00000302630.

Structurei

3D structure databases

ProteinModelPortaliQ9UBC0.
SMRiQ9UBC0. Positions 291-437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi69 – 724Poly-His
Compositional biasi124 – 13815Poly-HisAdd
BLAST
Compositional biasi455 – 4606Poly-Ser

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 1 CUT DNA-binding domain.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG307335.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiQ9UBC0.
KOiK08026.
OMAiQMEEVNT.
OrthoDBiEOG7BW0K4.
PhylomeDBiQ9UBC0.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UBC0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAQLTMEAI GELHGVSHEP VPAPADLLGG SPHARSSVAH RGSHLPPAHP
60 70 80 90 100
RSMGMASLLD GGSGGGDYHH HHRAPEHSLA GPLHPTMTMA CETPPGMSMP
110 120 130 140 150
TTYTTLTPLQ PLPPISTVSD KFPHHHHHHH HHHHPHHHQR LAGNVSGSFT
160 170 180 190 200
LMRDERGLAS MNNLYTPYHK DVAGMGQSLS PLSSSGLGSI HNSQQGLPHY
210 220 230 240 250
AHPGAAMPTD KMLTPNGFEA HHPAMLGRHG EQHLTPTSAG MVPINGLPPH
260 270 280 290 300
HPHAHLNAQG HGQLLGTARE PNPSVTGAQV SNGSNSGQME EINTKEVAQR
310 320 330 340 350
ITTELKRYSI PQAIFAQRVL CRSQGTLSDL LRNPKPWSKL KSGRETFRRM
360 370 380 390 400
WKWLQEPEFQ RMSALRLAAC KRKEQEHGKD RGNTPKKPRL VFTDVQRRTL
410 420 430 440 450
HAIFKENKRP SKELQITISQ QLGLELSTVS NFFMNARRRS LDKWQDEGSS
460
NSGNSSSSSS TCTKA
Length:465
Mass (Da):51,023
Last modified:May 1, 2000 - v1
Checksum:iF47F78957A6ECFC2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201A → T(PubMed:10491763)Curated
Sequence conflicti220 – 2201A → T1 PublicationCurated
Sequence conflicti284 – 2841S → N in AAB61705. 1 PublicationCurated
Sequence conflicti288 – 2881Q → H in AAB61705. 1 PublicationCurated
Sequence conflicti318 – 3181R → K in AAB61705. 1 PublicationCurated
Sequence conflicti386 – 3861K → Q in AAB61705. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751P → A.1 Publication
Corresponds to variant rs74805019 [ dbSNP | Ensembl ].
VAR_010729

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035581, AF035580 Genomic DNA. Translation: AAD02033.1.
U96173 mRNA. Translation: AAD00826.1.
CH471082 Genomic DNA. Translation: EAW77461.1.
BC140830 mRNA. Translation: AAI40831.1.
Y17739 Genomic DNA. Translation: CAB50769.1.
U77975 mRNA. Translation: AAB61705.1.
CCDSiCCDS10150.1.
RefSeqiNP_004489.1. NM_004498.2.
UniGeneiHs.658573.

Genome annotation databases

EnsembliENST00000305901; ENSP00000302630; ENSG00000169856.
GeneIDi3175.
KEGGihsa:3175.
UCSCiuc002aci.2. human.

Polymorphism databases

DMDMi13627184.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Hepatocyte nuclear factors entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035581 , AF035580 Genomic DNA. Translation: AAD02033.1 .
U96173 mRNA. Translation: AAD00826.1 .
CH471082 Genomic DNA. Translation: EAW77461.1 .
BC140830 mRNA. Translation: AAI40831.1 .
Y17739 Genomic DNA. Translation: CAB50769.1 .
U77975 mRNA. Translation: AAB61705.1 .
CCDSi CCDS10150.1.
RefSeqi NP_004489.1. NM_004498.2.
UniGenei Hs.658573.

3D structure databases

ProteinModelPortali Q9UBC0.
SMRi Q9UBC0. Positions 291-437.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109417. 6 interactions.
STRINGi 9606.ENSP00000302630.

PTM databases

PhosphoSitei Q9UBC0.

Polymorphism databases

DMDMi 13627184.

Proteomic databases

PaxDbi Q9UBC0.
PRIDEi Q9UBC0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305901 ; ENSP00000302630 ; ENSG00000169856 .
GeneIDi 3175.
KEGGi hsa:3175.
UCSCi uc002aci.2. human.

Organism-specific databases

CTDi 3175.
GeneCardsi GC15M053049.
HGNCi HGNC:8138. ONECUT1.
HPAi HPA003457.
MIMi 604164. gene.
neXtProti NX_Q9UBC0.
PharmGKBi PA31924.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307335.
GeneTreei ENSGT00530000063019.
HOGENOMi HOG000232114.
HOVERGENi HBG005981.
InParanoidi Q9UBC0.
KOi K08026.
OMAi QMEEVNT.
OrthoDBi EOG7BW0K4.
PhylomeDBi Q9UBC0.
TreeFami TF318206.

Enzyme and pathway databases

Reactomei REACT_13673. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
REACT_13778. Regulation of gene expression in early pancreatic precursor cells.
SignaLinki Q9UBC0.

Miscellaneous databases

ChiTaRSi ONECUT1. human.
GenomeRNAii 3175.
NextBioi 12598.
PROi Q9UBC0.
SOURCEi Search...

Gene expression databases

Bgeei Q9UBC0.
CleanExi HS_ONECUT1.
ExpressionAtlasi Q9UBC0. baseline.
Genevestigatori Q9UBC0.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view ]
Pfami PF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the human hepatocyte nuclear factor 6 gene."
    Furuta H., Horikawa Y., Wang Y.-Q., Bell G.I.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The sequence of human mRNA for the hepatocyte nuclear factor-6 alpha."
    Furuta H., Wang Y.-Q., Bell G.I.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion."
    Moeller A.M., Ek J., Durviaux S.M., Urhammer S.A., Clausen J.O., Eiberg H., Hansen T., Rousseau G.G., Lemaigre F.P., Pedersen O.
    Diabetologia 42:1011-1016(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-368, VARIANT ALA-75.
  6. "Yeast one-hybrid cloning of the partial human cDNA for hepatocyte nuclear factor 6."
    Samadani U., Costa R.H.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 174-465.

Entry informationi

Entry nameiHNF6_HUMAN
AccessioniPrimary (citable) accession number: Q9UBC0
Secondary accession number(s): B2RTV4, Q99744, Q9UMR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3