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Q9UBC0 (HNF6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hepatocyte nuclear factor 6

Short name=HNF-6
Alternative name(s):
One cut domain family member 1
One cut homeobox 1
Gene names
Name:ONECUT1
Synonyms:HNF6, HNF6A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.

Subunit structure

Binds DNA as a monomer By similarity.

Subcellular location

Nucleus.

Tissue specificity

Highly expressed in liver; lower expression in testis and skin.

Sequence similarities

Belongs to the CUT homeobox family.

Contains 1 CUT DNA-binding domain.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell differentiation

Inferred from electronic annotation. Source: Ensembl

cell fate commitment

Inferred from electronic annotation. Source: Ensembl

cilium assembly

Inferred from electronic annotation. Source: Ensembl

endocrine pancreas development

Traceable author statement. Source: Reactome

endoderm development

Inferred from electronic annotation. Source: Ensembl

epithelial cell development

Inferred from electronic annotation. Source: Ensembl

glucose metabolic process

Inferred from electronic annotation. Source: Ensembl

liver development

Inferred from electronic annotation. Source: Ensembl

negative regulation of transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of cell-matrix adhesion

Inferred from electronic annotation. Source: Ensembl

regulation of transcription, DNA-templated

Non-traceable author statement Ref.5. Source: UniProtKB

spleen development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from sequence or structural similarity. Source: BHF-UCL

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Hepatocyte nuclear factor 6
PRO_0000202402

Regions

DNA binding283 – 36987CUT
DNA binding385 – 44460Homeobox
Compositional bias69 – 724Poly-His
Compositional bias124 – 13815Poly-His
Compositional bias455 – 4606Poly-Ser

Natural variations

Natural variant751P → A. Ref.5
Corresponds to variant rs74805019 [ dbSNP | Ensembl ].
VAR_010729

Experimental info

Sequence conflict2201A → T Ref.5
Sequence conflict2201A → T Ref.6
Sequence conflict2841S → N in AAB61705. Ref.6
Sequence conflict2881Q → H in AAB61705. Ref.6
Sequence conflict3181R → K in AAB61705. Ref.6
Sequence conflict3861K → Q in AAB61705. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q9UBC0 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: F47F78957A6ECFC2

FASTA46551,023
        10         20         30         40         50         60 
MNAQLTMEAI GELHGVSHEP VPAPADLLGG SPHARSSVAH RGSHLPPAHP RSMGMASLLD 

        70         80         90        100        110        120 
GGSGGGDYHH HHRAPEHSLA GPLHPTMTMA CETPPGMSMP TTYTTLTPLQ PLPPISTVSD 

       130        140        150        160        170        180 
KFPHHHHHHH HHHHPHHHQR LAGNVSGSFT LMRDERGLAS MNNLYTPYHK DVAGMGQSLS 

       190        200        210        220        230        240 
PLSSSGLGSI HNSQQGLPHY AHPGAAMPTD KMLTPNGFEA HHPAMLGRHG EQHLTPTSAG 

       250        260        270        280        290        300 
MVPINGLPPH HPHAHLNAQG HGQLLGTARE PNPSVTGAQV SNGSNSGQME EINTKEVAQR 

       310        320        330        340        350        360 
ITTELKRYSI PQAIFAQRVL CRSQGTLSDL LRNPKPWSKL KSGRETFRRM WKWLQEPEFQ 

       370        380        390        400        410        420 
RMSALRLAAC KRKEQEHGKD RGNTPKKPRL VFTDVQRRTL HAIFKENKRP SKELQITISQ 

       430        440        450        460 
QLGLELSTVS NFFMNARRRS LDKWQDEGSS NSGNSSSSSS TCTKA 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of the human hepatocyte nuclear factor 6 gene."
Furuta H., Horikawa Y., Wang Y.-Q., Bell G.I.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The sequence of human mRNA for the hepatocyte nuclear factor-6 alpha."
Furuta H., Wang Y.-Q., Bell G.I.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion."
Moeller A.M., Ek J., Durviaux S.M., Urhammer S.A., Clausen J.O., Eiberg H., Hansen T., Rousseau G.G., Lemaigre F.P., Pedersen O.
Diabetologia 42:1011-1016(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-368, VARIANT ALA-75.
[6]"Yeast one-hybrid cloning of the partial human cDNA for hepatocyte nuclear factor 6."
Samadani U., Costa R.H.
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 174-465.
+Additional computationally mapped references.

Web resources

Wikipedia

Hepatocyte nuclear factors entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF035581, AF035580 Genomic DNA. Translation: AAD02033.1.
U96173 mRNA. Translation: AAD00826.1.
CH471082 Genomic DNA. Translation: EAW77461.1.
BC140830 mRNA. Translation: AAI40831.1.
Y17739 Genomic DNA. Translation: CAB50769.1.
U77975 mRNA. Translation: AAB61705.1.
CCDSCCDS10150.1.
RefSeqNP_004489.1. NM_004498.2.
UniGeneHs.658573.

3D structure databases

ProteinModelPortalQ9UBC0.
SMRQ9UBC0. Positions 291-437.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109417. 6 interactions.
STRING9606.ENSP00000302630.

PTM databases

PhosphoSiteQ9UBC0.

Polymorphism databases

DMDM13627184.

Proteomic databases

PaxDbQ9UBC0.
PRIDEQ9UBC0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000305901; ENSP00000302630; ENSG00000169856.
GeneID3175.
KEGGhsa:3175.
UCSCuc002aci.2. human.

Organism-specific databases

CTD3175.
GeneCardsGC15M053049.
HGNCHGNC:8138. ONECUT1.
HPAHPA003457.
MIM604164. gene.
neXtProtNX_Q9UBC0.
PharmGKBPA31924.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG307335.
HOGENOMHOG000232114.
HOVERGENHBG005981.
InParanoidQ9UBC0.
KOK08026.
OMAQMEEVNT.
OrthoDBEOG7BW0K4.
PhylomeDBQ9UBC0.
TreeFamTF318206.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
SignaLinkQ9UBC0.

Gene expression databases

ArrayExpressQ9UBC0.
BgeeQ9UBC0.
CleanExHS_ONECUT1.
GenevestigatorQ9UBC0.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR003350. Hmoeo_CUT.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSONECUT1. human.
GenomeRNAi3175.
NextBio12598.
PROQ9UBC0.
SOURCESearch...

Entry information

Entry nameHNF6_HUMAN
AccessionPrimary (citable) accession number: Q9UBC0
Secondary accession number(s): B2RTV4, Q99744, Q9UMR6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM