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Q9UBC0

- HNF6_HUMAN

UniProt

Q9UBC0 - HNF6_HUMAN

Protein

Hepatocyte nuclear factor 6

Gene

ONECUT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi283 – 36987CUTPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi385 – 44460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
    2. sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. B cell differentiation Source: Ensembl
    2. cell fate commitment Source: Ensembl
    3. cilium assembly Source: Ensembl
    4. endocrine pancreas development Source: Reactome
    5. endoderm development Source: Ensembl
    6. epithelial cell development Source: Ensembl
    7. glucose metabolic process Source: Ensembl
    8. liver development Source: Ensembl
    9. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    10. positive regulation of cell migration Source: Ensembl
    11. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    12. regulation of cell-matrix adhesion Source: Ensembl
    13. regulation of transcription, DNA-templated Source: UniProtKB
    14. spleen development Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_13673. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
    REACT_13778. Regulation of gene expression in early pancreatic precursor cells.
    SignaLinkiQ9UBC0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatocyte nuclear factor 6
    Short name:
    HNF-6
    Alternative name(s):
    One cut domain family member 1
    One cut homeobox 1
    Gene namesi
    Name:ONECUT1
    Synonyms:HNF6, HNF6A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:8138. ONECUT1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31924.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Hepatocyte nuclear factor 6PRO_0000202402Add
    BLAST

    Proteomic databases

    PaxDbiQ9UBC0.
    PRIDEiQ9UBC0.

    PTM databases

    PhosphoSiteiQ9UBC0.

    Expressioni

    Tissue specificityi

    Highly expressed in liver; lower expression in testis and skin.

    Gene expression databases

    ArrayExpressiQ9UBC0.
    BgeeiQ9UBC0.
    CleanExiHS_ONECUT1.
    GenevestigatoriQ9UBC0.

    Organism-specific databases

    HPAiHPA003457.

    Interactioni

    Subunit structurei

    Binds DNA as a monomer.By similarity

    Protein-protein interaction databases

    BioGridi109417. 6 interactions.
    STRINGi9606.ENSP00000302630.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBC0.
    SMRiQ9UBC0. Positions 291-437.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi69 – 724Poly-His
    Compositional biasi124 – 13815Poly-HisAdd
    BLAST
    Compositional biasi455 – 4606Poly-Ser

    Sequence similaritiesi

    Belongs to the CUT homeobox family.Curated
    Contains 1 CUT DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG307335.
    HOGENOMiHOG000232114.
    HOVERGENiHBG005981.
    InParanoidiQ9UBC0.
    KOiK08026.
    OMAiQMEEVNT.
    OrthoDBiEOG7BW0K4.
    PhylomeDBiQ9UBC0.
    TreeFamiTF318206.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR003350. Hmoeo_CUT.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view]
    PfamiPF02376. CUT. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS51042. CUT. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UBC0-1 [UniParc]FASTAAdd to Basket

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    MNAQLTMEAI GELHGVSHEP VPAPADLLGG SPHARSSVAH RGSHLPPAHP    50
    RSMGMASLLD GGSGGGDYHH HHRAPEHSLA GPLHPTMTMA CETPPGMSMP 100
    TTYTTLTPLQ PLPPISTVSD KFPHHHHHHH HHHHPHHHQR LAGNVSGSFT 150
    LMRDERGLAS MNNLYTPYHK DVAGMGQSLS PLSSSGLGSI HNSQQGLPHY 200
    AHPGAAMPTD KMLTPNGFEA HHPAMLGRHG EQHLTPTSAG MVPINGLPPH 250
    HPHAHLNAQG HGQLLGTARE PNPSVTGAQV SNGSNSGQME EINTKEVAQR 300
    ITTELKRYSI PQAIFAQRVL CRSQGTLSDL LRNPKPWSKL KSGRETFRRM 350
    WKWLQEPEFQ RMSALRLAAC KRKEQEHGKD RGNTPKKPRL VFTDVQRRTL 400
    HAIFKENKRP SKELQITISQ QLGLELSTVS NFFMNARRRS LDKWQDEGSS 450
    NSGNSSSSSS TCTKA 465
    Length:465
    Mass (Da):51,023
    Last modified:May 1, 2000 - v1
    Checksum:iF47F78957A6ECFC2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti220 – 2201A → T(PubMed:10491763)Curated
    Sequence conflicti220 – 2201A → T1 PublicationCurated
    Sequence conflicti284 – 2841S → N in AAB61705. 1 PublicationCurated
    Sequence conflicti288 – 2881Q → H in AAB61705. 1 PublicationCurated
    Sequence conflicti318 – 3181R → K in AAB61705. 1 PublicationCurated
    Sequence conflicti386 – 3861K → Q in AAB61705. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti75 – 751P → A.1 Publication
    Corresponds to variant rs74805019 [ dbSNP | Ensembl ].
    VAR_010729

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035581, AF035580 Genomic DNA. Translation: AAD02033.1.
    U96173 mRNA. Translation: AAD00826.1.
    CH471082 Genomic DNA. Translation: EAW77461.1.
    BC140830 mRNA. Translation: AAI40831.1.
    Y17739 Genomic DNA. Translation: CAB50769.1.
    U77975 mRNA. Translation: AAB61705.1.
    CCDSiCCDS10150.1.
    RefSeqiNP_004489.1. NM_004498.2.
    UniGeneiHs.658573.

    Genome annotation databases

    EnsembliENST00000305901; ENSP00000302630; ENSG00000169856.
    GeneIDi3175.
    KEGGihsa:3175.
    UCSCiuc002aci.2. human.

    Polymorphism databases

    DMDMi13627184.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Hepatocyte nuclear factors entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035581 , AF035580 Genomic DNA. Translation: AAD02033.1 .
    U96173 mRNA. Translation: AAD00826.1 .
    CH471082 Genomic DNA. Translation: EAW77461.1 .
    BC140830 mRNA. Translation: AAI40831.1 .
    Y17739 Genomic DNA. Translation: CAB50769.1 .
    U77975 mRNA. Translation: AAB61705.1 .
    CCDSi CCDS10150.1.
    RefSeqi NP_004489.1. NM_004498.2.
    UniGenei Hs.658573.

    3D structure databases

    ProteinModelPortali Q9UBC0.
    SMRi Q9UBC0. Positions 291-437.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109417. 6 interactions.
    STRINGi 9606.ENSP00000302630.

    PTM databases

    PhosphoSitei Q9UBC0.

    Polymorphism databases

    DMDMi 13627184.

    Proteomic databases

    PaxDbi Q9UBC0.
    PRIDEi Q9UBC0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305901 ; ENSP00000302630 ; ENSG00000169856 .
    GeneIDi 3175.
    KEGGi hsa:3175.
    UCSCi uc002aci.2. human.

    Organism-specific databases

    CTDi 3175.
    GeneCardsi GC15M053049.
    HGNCi HGNC:8138. ONECUT1.
    HPAi HPA003457.
    MIMi 604164. gene.
    neXtProti NX_Q9UBC0.
    PharmGKBi PA31924.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307335.
    HOGENOMi HOG000232114.
    HOVERGENi HBG005981.
    InParanoidi Q9UBC0.
    KOi K08026.
    OMAi QMEEVNT.
    OrthoDBi EOG7BW0K4.
    PhylomeDBi Q9UBC0.
    TreeFami TF318206.

    Enzyme and pathway databases

    Reactomei REACT_13673. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
    REACT_13778. Regulation of gene expression in early pancreatic precursor cells.
    SignaLinki Q9UBC0.

    Miscellaneous databases

    ChiTaRSi ONECUT1. human.
    GenomeRNAii 3175.
    NextBioi 12598.
    PROi Q9UBC0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UBC0.
    Bgeei Q9UBC0.
    CleanExi HS_ONECUT1.
    Genevestigatori Q9UBC0.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR003350. Hmoeo_CUT.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view ]
    Pfami PF02376. CUT. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS51042. CUT. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the human hepatocyte nuclear factor 6 gene."
      Furuta H., Horikawa Y., Wang Y.-Q., Bell G.I.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The sequence of human mRNA for the hepatocyte nuclear factor-6 alpha."
      Furuta H., Wang Y.-Q., Bell G.I.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion."
      Moeller A.M., Ek J., Durviaux S.M., Urhammer S.A., Clausen J.O., Eiberg H., Hansen T., Rousseau G.G., Lemaigre F.P., Pedersen O.
      Diabetologia 42:1011-1016(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-368, VARIANT ALA-75.
    6. "Yeast one-hybrid cloning of the partial human cDNA for hepatocyte nuclear factor 6."
      Samadani U., Costa R.H.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 174-465.

    Entry informationi

    Entry nameiHNF6_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBC0
    Secondary accession number(s): B2RTV4, Q99744, Q9UMR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3