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Protein

Tuftelin-interacting protein 11

Gene

TFIP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.1 Publication

GO - Molecular functioni

GO - Biological processi

  • biomineral tissue development Source: UniProtKB-KW
  • mRNA splicing, via spliceosome Source: UniProtKB
  • negative regulation of DNA ligase activity Source: BHF-UCL
  • negative regulation of double-strand break repair via nonhomologous end joining Source: BHF-UCL
  • negative regulation of protein binding Source: BHF-UCL
  • negative regulation of protein complex assembly Source: BHF-UCL
  • protection from non-homologous end joining at telomere Source: BHF-UCL
  • regulation of transcription, DNA-templated Source: InterPro
  • RNA processing Source: UniProtKB
  • spliceosomal complex disassembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Biomineralization, mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100109-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Tuftelin-interacting protein 11
Alternative name(s):
Septin and tuftelin-interacting protein 1
Short name:
STIP-1
Gene namesi
Name:TFIP11
Synonyms:STIP
ORF Names:HSPC006
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:17165. TFIP11.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles.By similarity

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-SubCell
  • nuclear chromosome, telomeric region Source: BHF-UCL
  • nuclear speck Source: LIFEdb
  • nucleolus Source: BHF-UCL
  • proteinaceous extracellular matrix Source: Ensembl
  • spliceosomal complex Source: UniProtKB
  • U2-type post-mRNA release spliceosomal complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi24144.
OpenTargetsiENSG00000100109.
PharmGKBiPA38441.

Polymorphism and mutation databases

BioMutaiTFIP11.
DMDMi22096235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725011 – 837Tuftelin-interacting protein 11Add BLAST837

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei59PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBB9.
MaxQBiQ9UBB9.
PaxDbiQ9UBB9.
PeptideAtlasiQ9UBB9.
PRIDEiQ9UBB9.

PTM databases

iPTMnetiQ9UBB9.
PhosphoSitePlusiQ9UBB9.

Expressioni

Gene expression databases

BgeeiENSG00000100109.
CleanExiHS_TFIP11.
ExpressionAtlasiQ9UBB9. baseline and differential.
GenevisibleiQ9UBB9. HS.

Organism-specific databases

HPAiHPA027085.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-1105213,EBI-743598
ADCK3Q8NI607EBI-1105213,EBI-745535
AIMP2Q131555EBI-1105213,EBI-745226
ALS2CR11Q53TS83EBI-1105213,EBI-739879
ARMCX1Q9P2913EBI-1105213,EBI-2843626
ATP5OP480473EBI-1105213,EBI-355815
BMFQ96LC95EBI-1105213,EBI-3919268
C1orf109Q9NX045EBI-1105213,EBI-8643161
C6orf165Q8IYR03EBI-1105213,EBI-749051
CARD9Q9H2573EBI-1105213,EBI-751319
CCDC116Q8IYX33EBI-1105213,EBI-744311
CCDC121Q6ZUS55EBI-1105213,EBI-2836982
CCDC146Q8IYE0-23EBI-1105213,EBI-10247802
CCDC151A5D8V75EBI-1105213,EBI-8466445
CCDC151A5D8V7-23EBI-1105213,EBI-10173824
CCDC42Q96M953EBI-1105213,EBI-747041
CCDC68Q9H2F95EBI-1105213,EBI-2813327
CCHCR1Q8TD31-37EBI-1105213,EBI-10175300
CCND3P302813EBI-1105213,EBI-375013
CCNG1P519593EBI-1105213,EBI-3905829
CCNL1Q9UK583EBI-1105213,EBI-2836773
CENPUQ71F233EBI-1105213,EBI-2515234
CEP57Q86XR83EBI-1105213,EBI-308614
CEP57L1Q8IYX83EBI-1105213,EBI-1104570
COX5BP106063EBI-1105213,EBI-1053725
EIF3AQ24JU43EBI-1105213,EBI-10239221
FAM13CQ8NE313EBI-1105213,EBI-751248
FAM156AQ8NDB63EBI-1105213,EBI-749727
FAM161AQ3B8207EBI-1105213,EBI-719941
FAM50BQ9Y2473EBI-1105213,EBI-742802
GCC1Q96CN93EBI-1105213,EBI-746252
GCFC2P163834EBI-1105213,EBI-954074
GEMP550405EBI-1105213,EBI-744104
GNG4B1APZ03EBI-1105213,EBI-10175453
GOLGA1Q928053EBI-1105213,EBI-6164177
GPS2Q132275EBI-1105213,EBI-713355
HAUS1Q96CS23EBI-1105213,EBI-2514791
HMG20BQ9P0W23EBI-1105213,EBI-713401
HOOK1Q9UJC35EBI-1105213,EBI-746704
IKBIPQ70UQ03EBI-1105213,EBI-2557212
IMP3Q9NV313EBI-1105213,EBI-747481
KANSL1I3L4J33EBI-1105213,EBI-10178305
KRT20P359006EBI-1105213,EBI-742094
KRT6AP025384EBI-1105213,EBI-702198
KRT6BP042595EBI-1105213,EBI-740907
KRT6CP486683EBI-1105213,EBI-2564105
KRT8P057873EBI-1105213,EBI-297852
LATS1Q6PJG33EBI-1105213,EBI-10253976
LCA5Q86VQ03EBI-1105213,EBI-6658186
LCA5LO954473EBI-1105213,EBI-8473670
LENG1Q96BZ83EBI-1105213,EBI-726510
LIN37Q96GY33EBI-1105213,EBI-748884
LMO1P258005EBI-1105213,EBI-8639312
LMO4P619685EBI-1105213,EBI-2798728
LOC729862Q0VAF85EBI-1105213,EBI-10226726
LOC729862Q0VAF93EBI-1105213,EBI-10226748
METTL17Q9H7H04EBI-1105213,EBI-749353
MTFR2Q6P4443EBI-1105213,EBI-10252703
NDC80O147775EBI-1105213,EBI-715849
NFU1Q9UMS05EBI-1105213,EBI-725252
OIP5O434825EBI-1105213,EBI-536879
PBX4Q9BYU15EBI-1105213,EBI-10302990
PDE4DIPQ8TBR03EBI-1105213,EBI-10240575
POLLQ9UGP5-23EBI-1105213,EBI-10320765
POLR1CO151604EBI-1105213,EBI-1055079
PPP1R18Q6NYC83EBI-1105213,EBI-2557469
PRPF31F1T0A53EBI-1105213,EBI-10177194
PRPF31Q8WWY34EBI-1105213,EBI-1567797
RCOR3Q9P2K33EBI-1105213,EBI-743428
RHNO1Q9BSD35EBI-1105213,EBI-9658624
RRP7AQ9Y3A43EBI-1105213,EBI-7223720
S100PP258153EBI-1105213,EBI-743700
SAP30BPQ9UHR53EBI-1105213,EBI-751683
SCNM1Q9BWG64EBI-1105213,EBI-748391
SFR1Q86XK33EBI-1105213,EBI-1104535
SH2D4AQ9H7885EBI-1105213,EBI-747035
SH2D4AQ9H788-23EBI-1105213,EBI-10308083
SH3GLB1Q9Y3715EBI-1105213,EBI-2623095
SMARCE1Q969G35EBI-1105213,EBI-455078
SNRPBP14678-25EBI-1105213,EBI-372475
SNW1Q135735EBI-1105213,EBI-632715
SNX20Q7Z6143EBI-1105213,EBI-744896
SSX2IPQ9Y2D83EBI-1105213,EBI-2212028
STRNO438153EBI-1105213,EBI-1046642
TCAF1Q9Y4C23EBI-1105213,EBI-750484
TFPTA0A024R4Q54EBI-1105213,EBI-11527449
TFPTG5E9B53EBI-1105213,EBI-10178002
THAP7Q9BT495EBI-1105213,EBI-741350
THAP8Q8NA923EBI-1105213,EBI-717429
TNNT1P138053EBI-1105213,EBI-726527
TRAF3IP3Q9Y2283EBI-1105213,EBI-765817
TSHZ3A1L0U73EBI-1105213,EBI-10171826
TSPYL4Q9UJ043EBI-1105213,EBI-308511
TXLNAP402225EBI-1105213,EBI-359793
VPS37CA5D8V63EBI-1105213,EBI-2559305
ZC2HC1CQ53FD03EBI-1105213,EBI-740767
ZFYVE26Q96H433EBI-1105213,EBI-10286915
ZGPATQ8N5A53EBI-1105213,EBI-3439227
ZGPATQ8N5A5-25EBI-1105213,EBI-10183064
ZMAT2Q96NC03EBI-1105213,EBI-2682299
ZNF417Q8TAU34EBI-1105213,EBI-740727
ZSCAN12O433093EBI-1105213,EBI-1210440

Protein-protein interaction databases

BioGridi117294. 143 interactors.
IntActiQ9UBB9. 231 interactors.
MINTiMINT-3078852.
STRINGi9606.ENSP00000383892.

Structurei

3D structure databases

ProteinModelPortaliQ9UBB9.
SMRiQ9UBB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 195G-patchPROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 50Required for interaction with DHX151 PublicationAdd BLAST50
Regioni710 – 734Required for nuclear speckle localizationBy similarityAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi700 – 705Nuclear localization signalBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 19Poly-Asp5

Sequence similaritiesi

Belongs to the TFP11/STIP family.Curated
Contains 1 G-patch domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2184. Eukaryota.
ENOG410XP4Y. LUCA.
GeneTreeiENSGT00390000012739.
HOGENOMiHOG000230470.
HOVERGENiHBG055868.
InParanoidiQ9UBB9.
KOiK13103.
OMAiDECARVF.
OrthoDBiEOG091G04T2.
PhylomeDBiQ9UBB9.
TreeFamiTF314887.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR022783. GCFC_dom.
IPR024933. STIP.
IPR022159. STIP/TFIP11_N.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF07842. GCFC. 1 hit.
PF12457. TIP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF017706. TFIP11. 1 hit.
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLSHLYRDG EGRIDDDDDE RENFEITDWD LQNEFNPNRQ RHWQTKEEAT
60 70 80 90 100
YGVWAERDSD DERPSFGGKR ARDYSAPVNF ISAGLKKGAA EEAELEDSDD
110 120 130 140 150
EEKPVKQDDF PKDFGPRKLK TGGNFKPSQK GFAGGTKSFM DFGSWERHTK
160 170 180 190 200
GIGQKLLQKM GYVPGRGLGK NAQGIINPIE AKQRKGKGAV GAYGSERTTQ
210 220 230 240 250
SMQDFPVVDS EEEAEEEFQK ELSQWRKDPS GSKKKPKYSY KTVEELKAKG
260 270 280 290 300
RISKKLTAPQ KELSQVKVID MTGREQKVYY SYSQISHKHN VPDDGLPLQS
310 320 330 340 350
QQLPQSGKEA KAPGFALPEL EHNLQLLIDL TEQEIIQNDR QLQYERDMVV
360 370 380 390 400
NLFHELEKMT EVLDHEERVI SNLSKVLEMV EECERRMQPD CSNPLTLDEC
410 420 430 440 450
ARIFETLQDK YYEEYRMSDR VDLAVAIVYP LMKEYFKEWD PLKDCTYGTE
460 470 480 490 500
IISKWKSLLE NDQLLSHGGQ DLSADAFHRL IWEVWMPFVR NIVTQWQPRN
510 520 530 540 550
CDPMVDFLDS WVHIIPVWIL DNILDQLIFP KLQKEVENWN PLTDTVPIHS
560 570 580 590 600
WIHPWLPLMQ ARLEPLYSPI RSKLSSALQK WHPSDSSAKL ILQPWKDVFT
610 620 630 640 650
PGSWEAFMVK NIVPKLGMCL GELVINPHQQ HMDAFYWVID WEGMISVSSL
660 670 680 690 700
VGLLEKHFFP KWLQVLCSWL SNSPNYEEIT KWYLGWKSMF SDQVLAHPSV
710 720 730 740 750
KDKFNEALDI MNRAVSSNVG AYMQPGAREN IAYLTHTERR KDFQYEAMQE
760 770 780 790 800
RREAENMAQR GIGVAASSVP MNFKDLIETK AEEHNIVFMP VIGKRHEGKQ
810 820 830
LYTFGRIVIY IDRGVVFVQG EKTWVPTSLQ SLIDMAK
Length:837
Mass (Da):96,820
Last modified:May 1, 2000 - v1
Checksum:iF4C44F8411517289
GO
Isoform 2 (identifier: Q9UBB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-641: Missing.
     642-663: EGMISVSSLVGLLEKHFFPKWL → MATSEILPSFVATMDASNFSFW

Note: No experimental confirmation available.
Show »
Length:196
Mass (Da):22,431
Checksum:i0E4DBC70BB97D704
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054069177N → S.Corresponds to variant rs6005062dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0039981 – 641Missing in isoform 2. 1 PublicationAdd BLAST641
Alternative sequenceiVSP_003999642 – 663EGMIS…FPKWL → MATSEILPSFVATMDASNFS FW in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070662 mRNA. Translation: AAD20968.1.
AL080147 mRNA. Translation: CAB45740.1.
AL050258 mRNA. Translation: CAB43360.1.
BT007274 mRNA. Translation: AAP35938.1.
CT841511 mRNA. Translation: CAJ86441.1.
Z95115, Z99714 Genomic DNA. Translation: CAI17979.1.
Z99714, Z95115 Genomic DNA. Translation: CAI17878.1.
CH471095 Genomic DNA. Translation: EAW59723.1.
BC011599 mRNA. Translation: AAH11599.1.
CCDSiCCDS13838.1. [Q9UBB9-1]
PIRiT12531.
RefSeqiNP_001008697.1. NM_001008697.1. [Q9UBB9-1]
NP_036275.1. NM_012143.2. [Q9UBB9-1]
XP_011528381.1. XM_011530079.1. [Q9UBB9-1]
XP_016884224.1. XM_017028735.1. [Q9UBB9-1]
UniGeneiHs.20225.

Genome annotation databases

EnsembliENST00000405938; ENSP00000384297; ENSG00000100109. [Q9UBB9-1]
ENST00000407148; ENSP00000385861; ENSG00000100109. [Q9UBB9-1]
ENST00000407431; ENSP00000383892; ENSG00000100109. [Q9UBB9-1]
ENST00000407690; ENSP00000384421; ENSG00000100109. [Q9UBB9-1]
ENST00000619735; ENSP00000480171; ENSG00000100109. [Q9UBB9-1]
GeneIDi24144.
KEGGihsa:24144.
UCSCiuc003acr.4. human. [Q9UBB9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070662 mRNA. Translation: AAD20968.1.
AL080147 mRNA. Translation: CAB45740.1.
AL050258 mRNA. Translation: CAB43360.1.
BT007274 mRNA. Translation: AAP35938.1.
CT841511 mRNA. Translation: CAJ86441.1.
Z95115, Z99714 Genomic DNA. Translation: CAI17979.1.
Z99714, Z95115 Genomic DNA. Translation: CAI17878.1.
CH471095 Genomic DNA. Translation: EAW59723.1.
BC011599 mRNA. Translation: AAH11599.1.
CCDSiCCDS13838.1. [Q9UBB9-1]
PIRiT12531.
RefSeqiNP_001008697.1. NM_001008697.1. [Q9UBB9-1]
NP_036275.1. NM_012143.2. [Q9UBB9-1]
XP_011528381.1. XM_011530079.1. [Q9UBB9-1]
XP_016884224.1. XM_017028735.1. [Q9UBB9-1]
UniGeneiHs.20225.

3D structure databases

ProteinModelPortaliQ9UBB9.
SMRiQ9UBB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117294. 143 interactors.
IntActiQ9UBB9. 231 interactors.
MINTiMINT-3078852.
STRINGi9606.ENSP00000383892.

PTM databases

iPTMnetiQ9UBB9.
PhosphoSitePlusiQ9UBB9.

Polymorphism and mutation databases

BioMutaiTFIP11.
DMDMi22096235.

Proteomic databases

EPDiQ9UBB9.
MaxQBiQ9UBB9.
PaxDbiQ9UBB9.
PeptideAtlasiQ9UBB9.
PRIDEiQ9UBB9.

Protocols and materials databases

DNASUi24144.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405938; ENSP00000384297; ENSG00000100109. [Q9UBB9-1]
ENST00000407148; ENSP00000385861; ENSG00000100109. [Q9UBB9-1]
ENST00000407431; ENSP00000383892; ENSG00000100109. [Q9UBB9-1]
ENST00000407690; ENSP00000384421; ENSG00000100109. [Q9UBB9-1]
ENST00000619735; ENSP00000480171; ENSG00000100109. [Q9UBB9-1]
GeneIDi24144.
KEGGihsa:24144.
UCSCiuc003acr.4. human. [Q9UBB9-1]

Organism-specific databases

CTDi24144.
DisGeNETi24144.
GeneCardsiTFIP11.
HGNCiHGNC:17165. TFIP11.
HPAiHPA027085.
MIMi612747. gene.
neXtProtiNX_Q9UBB9.
OpenTargetsiENSG00000100109.
PharmGKBiPA38441.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2184. Eukaryota.
ENOG410XP4Y. LUCA.
GeneTreeiENSGT00390000012739.
HOGENOMiHOG000230470.
HOVERGENiHBG055868.
InParanoidiQ9UBB9.
KOiK13103.
OMAiDECARVF.
OrthoDBiEOG091G04T2.
PhylomeDBiQ9UBB9.
TreeFamiTF314887.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100109-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiTFIP11. human.
GeneWikiiTFIP11.
GenomeRNAii24144.
PROiQ9UBB9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100109.
CleanExiHS_TFIP11.
ExpressionAtlasiQ9UBB9. baseline and differential.
GenevisibleiQ9UBB9. HS.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR022783. GCFC_dom.
IPR024933. STIP.
IPR022159. STIP/TFIP11_N.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF07842. GCFC. 1 hit.
PF12457. TIP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF017706. TFIP11. 1 hit.
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTFP11_HUMAN
AccessioniPrimary (citable) accession number: Q9UBB9
Secondary accession number(s): O95908
, Q20WL0, Q5H8V8, Q9UGV7, Q9Y2Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.