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Q9UBB5

- MBD2_HUMAN

UniProt

Q9UBB5 - MBD2_HUMAN

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Protein

Methyl-CpG-binding domain protein 2

Gene

MBD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.6 Publications

GO - Molecular functioni

  1. C2H2 zinc finger domain binding Source: UniProtKB
  2. chromatin binding Source: Ensembl
  3. methyl-CpG binding Source: UniProtKB
  4. mRNA binding Source: Ensembl
  5. protein domain specific binding Source: UniProtKB
  6. satellite DNA binding Source: ProtInc
  7. siRNA binding Source: Ensembl

GO - Biological processi

  1. ATP-dependent chromatin remodeling Source: UniProt
  2. cellular protein complex assembly Source: Ensembl
  3. maternal behavior Source: Ensembl
  4. negative regulation of transcription, DNA-templated Source: UniProtKB
  5. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  6. positive regulation of Wnt signaling pathway Source: Ensembl
  7. regulation of cell proliferation Source: Ensembl
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_200856. NoRC negatively regulates rRNA expression.
REACT_2232. RNA Polymerase I Promoter Opening.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-CpG-binding domain protein 2
Alternative name(s):
Demethylase
Short name:
DMTase
Methyl-CpG-binding protein MBD2
Gene namesi
Name:MBD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:6917. MBD2.

Subcellular locationi

Nucleus 2 Publications
Note: Nuclear, in discrete foci. Detected at replication foci in late S phase.

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. heterochromatin Source: Ensembl
  3. histone deacetylase complex Source: Ensembl
  4. nuclear chromatin Source: UniProt
  5. nucleus Source: UniProtKB
  6. protein complex Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30660.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Methyl-CpG-binding domain protein 2PRO_0000096260Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei181 – 1811Phosphoserine2 Publications
Modified residuei407 – 4071Phosphoserine4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UBB5.
PaxDbiQ9UBB5.
PRIDEiQ9UBB5.

PTM databases

PhosphoSiteiQ9UBB5.

Expressioni

Tissue specificityi

Highly expressed in brain, heart, kidney, stomach, testis and placenta.1 Publication

Gene expression databases

BgeeiQ9UBB5.
CleanExiHS_MBD2.
ExpressionAtlasiQ9UBB5. baseline and differential.
GenevestigatoriQ9UBB5.

Organism-specific databases

HPAiCAB037282.

Interactioni

Subunit structurei

Heterodimer with MBD3. Component of the MeCP1 complex that contains HDAC1 and HDAC2. Binds DNMT1, MIZF, GPN1, SIN3A, GATAD2A/p66-alpha and GATAD2B/p66-beta. Interacts with DHX9.10 Publications

Protein-protein interaction databases

BioGridi114445. 36 interactions.
IntActiQ9UBB5. 6 interactions.
MINTiMINT-210249.
STRINGi9606.ENSP00000256429.

Structurei

Secondary structure

1
411
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi366 – 38823Combined sources
Turni389 – 3924Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L2LNMR-B360-393[»]
ProteinModelPortaliQ9UBB5.
SMRiQ9UBB5. Positions 149-213, 360-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 21369MBDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 149149Necessary for interaction with DHX9Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 140135Gly-richAdd
BLAST
Compositional biasi50 – 9647Arg-richAdd
BLAST

Sequence similaritiesi

Contains 1 MBD (methyl-CpG-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG316386.
GeneTreeiENSGT00410000025376.
HOGENOMiHOG000013073.
HOVERGENiHBG052417.
InParanoidiQ9UBB5.
KOiK11590.
OMAiNCISICC.
OrthoDBiEOG7QNVMV.
PhylomeDBiQ9UBB5.
TreeFamiTF325032.

Family and domain databases

Gene3Di3.30.890.10. 2 hits.
InterProiIPR016177. DNA-bd_dom.
IPR025884. MeCpG-bd_2/3_C_dom.
IPR001739. Methyl_CpG_DNA-bd.
[Graphical view]
PfamiPF01429. MBD. 1 hit.
PF14048. MBD_C. 1 hit.
[Graphical view]
SMARTiSM00391. MBD. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS50982. MBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UBB5-1) [UniParc]FASTAAdd to Basket

Also known as: MBD2a, MBD2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAHPGGGRC CPEQEEGESA AGGSGAGGDS AIEQGGQGSA LAPSPVSGVR
60 70 80 90 100
REGARGGGRG RGRWKQAGRG GGVCGRGRGR GRGRGRGRGR GRGRGRPPSG
110 120 130 140 150
GSGLGGDGGG CGGGGSGGGG APRREPVPFP SGSAGPGPRG PRATESGKRM
160 170 180 190 200
DCPALPPGWK KEEVIRKSGL SAGKSDVYYF SPSGKKFRSK PQLARYLGNT
210 220 230 240 250
VDLSSFDFRT GKMMPSKLQK NKQRLRNDPL NQNKGKPDLN TTLPIRQTAS
260 270 280 290 300
IFKQPVTKVT NHPSNKVKSD PQRMNEQPRQ LFWEKRLQGL SASDVTEQII
310 320 330 340 350
KTMELPKGLQ GVGPGSNDET LLSAVASALH TSSAPITGQV SAAVEKNPAV
360 370 380 390 400
WLNTSQPLCK AFIVTDEDIR KQEERVQQVR KKLEEALMAD ILSRAADTEE
410
MDIEMDSGDE A
Length:411
Mass (Da):43,255
Last modified:May 1, 2000 - v1
Checksum:iFC4E5E0CF9BA0FFA
GO
Isoform 3 (identifier: Q9UBB5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     235-302: GKPDLNTTLP...SDVTEQIIKT → LRWNTHRPAP...YSRQNQSFPP
     303-411: Missing.

Note: Incomplete sequence.

Show »
Length:302
Mass (Da):31,745
Checksum:iCCEC65D926222717
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei235 – 30268GKPDL…QIIKT → LRWNTHRPAPWHALSRLCLL IRCLLCLECAYPLPLHLVNS YSSKTQLHCLHLWEACPAYS RQNQSFPP in isoform 3. 1 PublicationVSP_011077Add
BLAST
Alternative sequencei303 – 411109Missing in isoform 3. 1 PublicationVSP_011078Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072242 mRNA. Translation: AAC68871.1.
AF072246 mRNA. Translation: AAC68875.1.
AF120989, AF120988 Genomic DNA. Translation: AAD56596.1.
AF120993
, AF120988, AF120989, AF120990, AF120991, AF120992 Genomic DNA. Translation: AAD56597.1.
BC032638 mRNA. Translation: AAH32638.1.
CCDSiCCDS11953.1. [Q9UBB5-1]
CCDS45871.1. [Q9UBB5-3]
RefSeqiNP_003918.1. NM_003927.4. [Q9UBB5-1]
NP_056647.1. NM_015832.4. [Q9UBB5-3]
UniGeneiHs.25674.

Genome annotation databases

EnsembliENST00000256429; ENSP00000256429; ENSG00000134046. [Q9UBB5-1]
ENST00000583046; ENSP00000464554; ENSG00000134046. [Q9UBB5-3]
GeneIDi8932.
KEGGihsa:8932.
UCSCiuc002lfg.2. human. [Q9UBB5-1]
uc002lfh.2. human. [Q9UBB5-3]

Polymorphism databases

DMDMi50401198.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072242 mRNA. Translation: AAC68871.1 .
AF072246 mRNA. Translation: AAC68875.1 .
AF120989 , AF120988 Genomic DNA. Translation: AAD56596.1 .
AF120993
, AF120988 , AF120989 , AF120990 , AF120991 , AF120992 Genomic DNA. Translation: AAD56597.1 .
BC032638 mRNA. Translation: AAH32638.1 .
CCDSi CCDS11953.1. [Q9UBB5-1 ]
CCDS45871.1. [Q9UBB5-3 ]
RefSeqi NP_003918.1. NM_003927.4. [Q9UBB5-1 ]
NP_056647.1. NM_015832.4. [Q9UBB5-3 ]
UniGenei Hs.25674.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2L2L NMR - B 360-393 [» ]
ProteinModelPortali Q9UBB5.
SMRi Q9UBB5. Positions 149-213, 360-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114445. 36 interactions.
IntActi Q9UBB5. 6 interactions.
MINTi MINT-210249.
STRINGi 9606.ENSP00000256429.

PTM databases

PhosphoSitei Q9UBB5.

Polymorphism databases

DMDMi 50401198.

Proteomic databases

MaxQBi Q9UBB5.
PaxDbi Q9UBB5.
PRIDEi Q9UBB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256429 ; ENSP00000256429 ; ENSG00000134046 . [Q9UBB5-1 ]
ENST00000583046 ; ENSP00000464554 ; ENSG00000134046 . [Q9UBB5-3 ]
GeneIDi 8932.
KEGGi hsa:8932.
UCSCi uc002lfg.2. human. [Q9UBB5-1 ]
uc002lfh.2. human. [Q9UBB5-3 ]

Organism-specific databases

CTDi 8932.
GeneCardsi GC18M051615.
HGNCi HGNC:6917. MBD2.
HPAi CAB037282.
MIMi 603547. gene.
neXtProti NX_Q9UBB5.
PharmGKBi PA30660.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG316386.
GeneTreei ENSGT00410000025376.
HOGENOMi HOG000013073.
HOVERGENi HBG052417.
InParanoidi Q9UBB5.
KOi K11590.
OMAi NCISICC.
OrthoDBi EOG7QNVMV.
PhylomeDBi Q9UBB5.
TreeFami TF325032.

Enzyme and pathway databases

Reactomei REACT_200856. NoRC negatively regulates rRNA expression.
REACT_2232. RNA Polymerase I Promoter Opening.

Miscellaneous databases

ChiTaRSi MBD2. human.
GeneWikii Methyl-CpG-binding_domain_protein_2.
GenomeRNAii 8932.
NextBioi 33582.
PROi Q9UBB5.
SOURCEi Search...

Gene expression databases

Bgeei Q9UBB5.
CleanExi HS_MBD2.
ExpressionAtlasi Q9UBB5. baseline and differential.
Genevestigatori Q9UBB5.

Family and domain databases

Gene3Di 3.30.890.10. 2 hits.
InterProi IPR016177. DNA-bd_dom.
IPR025884. MeCpG-bd_2/3_C_dom.
IPR001739. Methyl_CpG_DNA-bd.
[Graphical view ]
Pfami PF01429. MBD. 1 hit.
PF14048. MBD_C. 1 hit.
[Graphical view ]
SMARTi SM00391. MBD. 1 hit.
[Graphical view ]
SUPFAMi SSF54171. SSF54171. 1 hit.
PROSITEi PS50982. MBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a family of mammalian methyl-CpG binding proteins."
    Hendrich B., Bird A.
    Mol. Cell. Biol. 18:6538-6547(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 157-411 (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Testis.
  2. "Genomic structure and chromosomal mapping of the murine and human mbd1, mbd2, mbd3, and mbd4 genes."
    Hendrich B., Abbott C., McQueen H., Chambers D., Cross S.H., Bird A.
    Mamm. Genome 10:906-912(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph.
  4. "A mammalian protein with specific demethylase activity for mCpG DNA."
    Bhattacharya S.K., Ramchandani S., Cervoni N., Szyf M.
    Nature 397:579-583(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORM 1), TISSUE SPECIFICITY.
  5. "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex."
    Ng H.-H., Zhang Y., Hendrich B., Johnson C.A., Turner B.M., Erdjument-Bromage H., Tempst P., Reinberg D., Bird A.
    Nat. Genet. 23:58-61(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH MECP1 AND HDAC1.
  6. "MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase."
    Tatematsu K., Yamazaki T., Ishikawa F.
    Genes Cells 5:677-688(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, HETERODIMERIZATION WITH MBD3, INTERACTION WITH DNMT1.
  7. "The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A."
    Boeke J., Ammerpohl O., Kegel S., Moehren U., Renkawitz R.
    J. Biol. Chem. 275:34963-34967(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORM 1), INTERACTION WITH SIN3A.
  8. "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1."
    Humphrey G.W., Wang Y., Russanova V.R., Hirai T., Qin J., Nakatani Y., Howard B.H.
    J. Biol. Chem. 276:6817-6824(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HDAC1, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2."
    Sekimata M., Takahashi A., Murakami-Sekimata A., Homma Y.
    J. Biol. Chem. 276:42632-42638(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MIZF.
  10. "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3."
    Brackertz M., Boeke J., Zhang R., Renkawitz R.
    J. Biol. Chem. 277:40958-40966(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH P66ALPHA AND P66BETA, SUBCELLULAR LOCATION.
  11. "MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters."
    Lembo F., Pero R., Angrisano T., Vitiello C., Iuliano R., Bruni C.B., Chiariotti L.
    Mol. Cell. Biol. 23:1656-1665(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GPN1.
  12. Cited for: FUNCTION, INTERACTION WITH DHX9.
  13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction."
    Brackertz M., Gong Z., Leers J., Renkawitz R.
    Nucleic Acids Res. 34:397-406(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GATAD2A AND GATAD2B.
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181 AND SER-407, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181 AND SER-407, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA."
    Cramer J.M., Scarsdale J.N., Walavalkar N.M., Buchwald W.A., Ginder G.D., Williams D.C. Jr.
    J. Biol. Chem. 289:1294-1302(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.
  21. "p66Alpha-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex."
    Gnanapragasam M.N., Scarsdale J.N., Amaya M.L., Webb H.D., Desai M.A., Walavalkar N.M., Wang S.Z., Zu Zhu S., Ginder G.D., Williams D.C. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 108:7487-7492(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 360-393 IN COMPLEX WITH GATAD2A, SUBUNIT, INTERACTION WITH GATAD2A.

Entry informationi

Entry nameiMBD2_HUMAN
AccessioniPrimary (citable) accession number: Q9UBB5
Secondary accession number(s): O95242, Q9UIS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3