Q9UB83 (TPM_PERAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Tropomyosin Alternative name(s): Major allergen Per a 7 Allergen=Per a 7
Organism	Periplaneta americana (American cockroach) (Blatta americana)
Taxonomic identifier	6978 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Orthopteroidea › Dictyoptera › Blattodea › Blattoidea › Blattidae › Blattinae › Periplaneta

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Subunit structure	Homodimer By similarity.
Domain	The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the tropomyosin family.

Ontologies

Keywords
Disease	Allergen
Domain	Coiled coil Repeat
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Tropomyosin		PRO_0000205689
Regions
	Coiled coil	1 – 284	284	By similarity
Experimental info
	Sequence conflict	21	1	C → R in AAD19606. Ref.2
	Sequence conflict	120	1	V → A in AAD19606. Ref.2
	Sequence conflict	282 – 284	3	AGY → IGN in AAD19606. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9UB83 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 1B91486A94446CF1	FASTA	284	32,777
	10 20 30 40 50 60 MDAIKKKMQA MKLEKDNAMD CALLCEQQAR DANLRAEKAE EEARSLQKKI QQIENDLDQT 70 80 90 100 110 120 MEQLMQVNAK LDEKDKALQN AESEVAALNR RIQLLEEDLE RSEERLATAT AKLAEASQAV 130 140 150 160 170 180 DESERARKIL ESKGLADEER MDALENQLKE ARFMAEEADK KYDEVARKLA MVEADLERAE 190 200 210 220 230 240 ERAESGESKI VELEEELRVV GNNLKSLEVS EEKANLREEE YKQQIKTLTT RLKEAEARAE 250 260 270 280 FAERSVQKLQ KEVDRLEDEL VHEKEKYKFI CDDLDMTFTE LAGY

References

[1]	"New allergen from the american cockroach (Periplaneta americana)." Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez J., Martinez A., Palacios R. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of Periplaneta americana tropomyosin, a major allergen from the american cockroach with homology with tropomyosins from mites and shrimp." Santos A.B.R., Naspitz C.K., Rizzo M.C., Ferriani V.P.L., Vailes L.D., Chapman M.D., Arruda L.K. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y14854 mRNA. Translation: CAB38086.1. AF106961 mRNA. Translation: AAD19606.1.
3D structure databases
ProteinModelPortal	Q9UB83.
SMR	Q9UB83. Positions 1-282.
ModBase	Search...
Protein family/group databases
Allergome	542. Per a 7. 543. Per a 7.0101. 544. Per a 7.0102.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000533. Tropomyosin. [Graphical view]
Pfam	PF00261. Tropomyosin. 1 hit. [Graphical view]
PRINTS	PR00194. TROPOMYOSIN.
PROSITE	PS00326. TROPOMYOSIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPM_PERAM

Accession

Primary (citable) accession number: Q9UB83
Secondary accession number(s): O97144

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 1, 2000
Last modified:	October 3, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)