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Q9UB00

- GLCM4_CAEEL

UniProt

Q9UB00 - GLCM4_CAEEL

Protein

Putative glucosylceramidase 4

Gene

gba-4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei256 – 2561Proton donorBy similarity
    Active sitei361 – 3611NucleophileBy similarity

    GO - Molecular functioni

    1. glucosylceramidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. sphingolipid metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00222.

    Protein family/group databases

    CAZyiGH30. Glycoside Hydrolase Family 30.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative glucosylceramidase 4 (EC:3.2.1.45)
    Gene namesi
    Name:gba-4
    ORF Names:Y4C6B.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiY4C6B.6; CE28522; WBGene00021160; gba-4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 519495Putative glucosylceramidase 4PRO_0000421456Add
    BLAST

    Proteomic databases

    PaxDbiQ9UB00.
    PRIDEiQ9UB00.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.Y4C6B.6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UB00.
    SMRiQ9UB00. Positions 26-510.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 30 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5520.
    GeneTreeiENSGT00390000009464.
    HOGENOMiHOG000270031.
    InParanoidiQ9UB00.
    KOiK01201.
    OMAiRWAQVVL.
    OrthoDBiEOG76DTRZ.
    PhylomeDBiQ9UB00.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR013780. Glyco_hydro_13_b.
    IPR001139. Glyco_hydro_30.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR11069. PTHR11069. 1 hit.
    PfamiPF02055. Glyco_hydro_30. 1 hit.
    [Graphical view]
    PRINTSiPR00843. GLHYDRLASE30.
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UB00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILNISVSLL IFLAFYGFSS DAKSLPCSEV KKEYGIVCRC NATYCDTIEP    50
    LGTVTSGKAV VYTTSRNGKR MNRSELKHTT SSTAKTKVYV NTTQSFQPVM 100
    GFGAAFTDAA GINMKMLPQT MQDQIIQQYF SDDGLGYVFG RVPMASTDFS 150
    THEYSYDDVK FDFDLKNFNL TVEDLQYKIP FIKKAMTASG GKLKLFATPW 200
    SSPGWMKTSG RMVGAGELLG DQNGKYYQTW AQYFVKFFEA YHAQGIDFWS 250
    LTPQNEPTTG IDPLWKWQTL FFDASMERNF IKKLLGPALA SSPVTKNLKI 300
    MINDDQRINL PHWPNVILTD PTAAQYVHGI AIHWYEDFID PATVLTETHE 350
    KFPDYFLLAT EACAGYFPAD GPKLGSWSRA EQYANDLIKD MGNWVGGWVD 400
    WNYILDLQGG PNLAKNFVDS TIIVNATAQE YYKQPIWHVM AQFSKFVKPG 450
    AIRVGINIIE KSVDVEGLSF LNQDGTKTVV LLNKNEVLSF DVAISDVSAP 500
    NVIYDLTIQP NSLITIVYK 519
    Length:519
    Mass (Da):58,247
    Last modified:October 1, 2001 - v2
    Checksum:iFD822081D820C80A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081369 Genomic DNA. Translation: CCD71128.1.
    PIRiT34017.
    RefSeqiNP_500785.1. NM_068384.4.
    UniGeneiCel.7806.

    Genome annotation databases

    EnsemblMetazoaiY4C6B.6; Y4C6B.6; WBGene00021160.
    GeneIDi177314.
    KEGGicel:CELE_Y4C6B.6.
    UCSCiY4C6B.6. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081369 Genomic DNA. Translation: CCD71128.1 .
    PIRi T34017.
    RefSeqi NP_500785.1. NM_068384.4.
    UniGenei Cel.7806.

    3D structure databases

    ProteinModelPortali Q9UB00.
    SMRi Q9UB00. Positions 26-510.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.Y4C6B.6.

    Protein family/group databases

    CAZyi GH30. Glycoside Hydrolase Family 30.

    Proteomic databases

    PaxDbi Q9UB00.
    PRIDEi Q9UB00.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y4C6B.6 ; Y4C6B.6 ; WBGene00021160 .
    GeneIDi 177314.
    KEGGi cel:CELE_Y4C6B.6.
    UCSCi Y4C6B.6. c. elegans.

    Organism-specific databases

    CTDi 177314.
    WormBasei Y4C6B.6 ; CE28522 ; WBGene00021160 ; gba-4.

    Phylogenomic databases

    eggNOGi COG5520.
    GeneTreei ENSGT00390000009464.
    HOGENOMi HOG000270031.
    InParanoidi Q9UB00.
    KOi K01201.
    OMAi RWAQVVL.
    OrthoDBi EOG76DTRZ.
    PhylomeDBi Q9UB00.

    Enzyme and pathway databases

    UniPathwayi UPA00222 .

    Miscellaneous databases

    NextBioi 896226.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR013780. Glyco_hydro_13_b.
    IPR001139. Glyco_hydro_30.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR11069. PTHR11069. 1 hit.
    Pfami PF02055. Glyco_hydro_30. 1 hit.
    [Graphical view ]
    PRINTSi PR00843. GLHYDRLASE30.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGLCM4_CAEEL
    AccessioniPrimary (citable) accession number: Q9UB00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2013
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3