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Q9UB00 (GLCM4_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative glucosylceramidase 4
EC=3.2.1.45
Gene names
Name:gba-4
ORF Names:Y4C6B.6
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.

Pathway

Lipid metabolism; sphingolipid metabolism.

Sequence similarities

Belongs to the glycosyl hydrolase 30 family.

Ontologies

Keywords
   Biological processLipid metabolism
Sphingolipid metabolism
   DomainSignal
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

lysosome organization

Inferred from electronic annotation. Source: InterPro

sphingolipid metabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentlysosome

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglucosylceramidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 519495Putative glucosylceramidase 4
PRO_0000421456

Sites

Active site2561Proton donor By similarity
Active site3611Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9UB00 [UniParc].

Last modified October 1, 2001. Version 2.
Checksum: FD822081D820C80A

FASTA51958,247
        10         20         30         40         50         60 
MILNISVSLL IFLAFYGFSS DAKSLPCSEV KKEYGIVCRC NATYCDTIEP LGTVTSGKAV 

        70         80         90        100        110        120 
VYTTSRNGKR MNRSELKHTT SSTAKTKVYV NTTQSFQPVM GFGAAFTDAA GINMKMLPQT 

       130        140        150        160        170        180 
MQDQIIQQYF SDDGLGYVFG RVPMASTDFS THEYSYDDVK FDFDLKNFNL TVEDLQYKIP 

       190        200        210        220        230        240 
FIKKAMTASG GKLKLFATPW SSPGWMKTSG RMVGAGELLG DQNGKYYQTW AQYFVKFFEA 

       250        260        270        280        290        300 
YHAQGIDFWS LTPQNEPTTG IDPLWKWQTL FFDASMERNF IKKLLGPALA SSPVTKNLKI 

       310        320        330        340        350        360 
MINDDQRINL PHWPNVILTD PTAAQYVHGI AIHWYEDFID PATVLTETHE KFPDYFLLAT 

       370        380        390        400        410        420 
EACAGYFPAD GPKLGSWSRA EQYANDLIKD MGNWVGGWVD WNYILDLQGG PNLAKNFVDS 

       430        440        450        460        470        480 
TIIVNATAQE YYKQPIWHVM AQFSKFVKPG AIRVGINIIE KSVDVEGLSF LNQDGTKTVV 

       490        500        510 
LLNKNEVLSF DVAISDVSAP NVIYDLTIQP NSLITIVYK

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FO081369 Genomic DNA. Translation: CCD71128.1.
PIRT34017.
RefSeqNP_500785.1. NM_068384.4.

3D structure databases

HSSPHSSP built from PDB template 1OGS based on UniProtKB P04062.
ProteinModelPortalQ9UB00.
SMRQ9UB00. Positions 26-510.
ModBaseSearch...

Protein-protein interaction databases

STRING6239.Y4C6B.6.

Protein family/group databases

CAZyGH30. Glycoside Hydrolase Family 30.

Proteomic databases

PaxDbQ9UB00.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaY4C6B.6; Y4C6B.6; Y4C6B.6.
GeneID177314.
KEGGcel:CELE_Y4C6B.6.
UCSCY4C6B.6. c. elegans.

Organism-specific databases

CTD177314.
WormBaseY4C6B.6; CE28522; WBGene00021160; gba-4.

Phylogenomic databases

eggNOGCOG5520.
GeneTreeENSGT00390000009464.
HOGENOMHOG000270031.
InParanoidQ9UB00.
KOK01201.
OMAHRLFPNT.

Enzyme and pathway databases

UniPathwayUPA00222.

Family and domain databases

Gene3D2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProIPR013780. Glyco_hydro_13_b.
IPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR11069. PTHR11069. 1 hit.
PfamPF02055. Glyco_hydro_30. 1 hit.
[Graphical view]
PRINTSPR00843. GLHYDRLASE30.
SUPFAMSSF51445. Glyco_hydro_cat. 1 hit.
ProtoNetSearch...

Other

NextBio896226.

Entry information

Entry nameGLCM4_CAEEL
AccessionPrimary (citable) accession number: Q9UB00
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: October 1, 2001
Last modified: May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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