Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative glucosylceramidase 4

Gene

gba-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.

Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei256Proton donorBy similarity1
Active sitei361NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00222

Protein family/group databases

CAZyiGH30 Glycoside Hydrolase Family 30

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glucosylceramidase 4 (EC:3.2.1.45)
Gene namesi
Name:gba-4
ORF Names:Y4C6B.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY4C6B.6 ; CE28522 ; WBGene00021160 ; gba-4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000042145625 – 519Putative glucosylceramidase 4Add BLAST495

Proteomic databases

EPDiQ9UB00
PaxDbiQ9UB00
PeptideAtlasiQ9UB00
PRIDEiQ9UB00

Expressioni

Gene expression databases

BgeeiWBGene00021160

Interactioni

Protein-protein interaction databases

STRINGi6239.Y4C6B.6

Structurei

3D structure databases

ProteinModelPortaliQ9UB00
SMRiQ9UB00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 30 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2566 Eukaryota
COG5520 LUCA
GeneTreeiENSGT00390000009464
HOGENOMiHOG000270031
InParanoidiQ9UB00
KOiK01201
OMAiFGGIAWH
OrthoDBiEOG091G06I4
PhylomeDBiQ9UB00

Family and domain databases

Gene3Di2.60.40.1180, 2 hits
InterProiView protein in InterPro
IPR033452 GH30_C
IPR001139 Glyco_hydro_30
IPR033453 Glyco_hydro_30_TIM-barrel
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR11069 PTHR11069, 1 hit
PfamiView protein in Pfam
PF02055 Glyco_hydro_30, 1 hit
PF17189 Glyco_hydro_30C, 1 hit
PRINTSiPR00843 GLHYDRLASE30
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UB00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNISVSLL IFLAFYGFSS DAKSLPCSEV KKEYGIVCRC NATYCDTIEP
60 70 80 90 100
LGTVTSGKAV VYTTSRNGKR MNRSELKHTT SSTAKTKVYV NTTQSFQPVM
110 120 130 140 150
GFGAAFTDAA GINMKMLPQT MQDQIIQQYF SDDGLGYVFG RVPMASTDFS
160 170 180 190 200
THEYSYDDVK FDFDLKNFNL TVEDLQYKIP FIKKAMTASG GKLKLFATPW
210 220 230 240 250
SSPGWMKTSG RMVGAGELLG DQNGKYYQTW AQYFVKFFEA YHAQGIDFWS
260 270 280 290 300
LTPQNEPTTG IDPLWKWQTL FFDASMERNF IKKLLGPALA SSPVTKNLKI
310 320 330 340 350
MINDDQRINL PHWPNVILTD PTAAQYVHGI AIHWYEDFID PATVLTETHE
360 370 380 390 400
KFPDYFLLAT EACAGYFPAD GPKLGSWSRA EQYANDLIKD MGNWVGGWVD
410 420 430 440 450
WNYILDLQGG PNLAKNFVDS TIIVNATAQE YYKQPIWHVM AQFSKFVKPG
460 470 480 490 500
AIRVGINIIE KSVDVEGLSF LNQDGTKTVV LLNKNEVLSF DVAISDVSAP
510
NVIYDLTIQP NSLITIVYK
Length:519
Mass (Da):58,247
Last modified:October 1, 2001 - v2
Checksum:iFD822081D820C80A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081369 Genomic DNA Translation: CCD71128.1
PIRiT34017
RefSeqiNP_500785.1, NM_068384.4
UniGeneiCel.7806

Genome annotation databases

EnsemblMetazoaiY4C6B.6; Y4C6B.6; WBGene00021160
GeneIDi177314
KEGGicel:CELE_Y4C6B.6
UCSCiY4C6B.6 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGLCM4_CAEEL
AccessioniPrimary (citable) accession number: Q9UB00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: October 1, 2001
Last modified: March 28, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health