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Protein

Putative glucosylceramidase 4

Gene

gba-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.

Pathway: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei256 – 2561Proton donorBy similarity
Active sitei361 – 3611NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00222.

Protein family/group databases

CAZyiGH30. Glycoside Hydrolase Family 30.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glucosylceramidase 4 (EC:3.2.1.45)
Gene namesi
Name:gba-4
ORF Names:Y4C6B.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY4C6B.6; CE28522; WBGene00021160; gba-4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 519495Putative glucosylceramidase 4PRO_0000421456Add
BLAST

Proteomic databases

PaxDbiQ9UB00.
PRIDEiQ9UB00.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y4C6B.6.

Structurei

3D structure databases

ProteinModelPortaliQ9UB00.
SMRiQ9UB00. Positions 26-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 30 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5520.
GeneTreeiENSGT00390000009464.
HOGENOMiHOG000270031.
InParanoidiQ9UB00.
KOiK01201.
OMAiVWDHNRD.
OrthoDBiEOG76DTRZ.
PhylomeDBiQ9UB00.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR013780. Glyco_hydro_13_b.
IPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR11069. PTHR11069. 1 hit.
PfamiPF02055. Glyco_hydro_30. 1 hit.
[Graphical view]
PRINTSiPR00843. GLHYDRLASE30.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UB00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNISVSLL IFLAFYGFSS DAKSLPCSEV KKEYGIVCRC NATYCDTIEP
60 70 80 90 100
LGTVTSGKAV VYTTSRNGKR MNRSELKHTT SSTAKTKVYV NTTQSFQPVM
110 120 130 140 150
GFGAAFTDAA GINMKMLPQT MQDQIIQQYF SDDGLGYVFG RVPMASTDFS
160 170 180 190 200
THEYSYDDVK FDFDLKNFNL TVEDLQYKIP FIKKAMTASG GKLKLFATPW
210 220 230 240 250
SSPGWMKTSG RMVGAGELLG DQNGKYYQTW AQYFVKFFEA YHAQGIDFWS
260 270 280 290 300
LTPQNEPTTG IDPLWKWQTL FFDASMERNF IKKLLGPALA SSPVTKNLKI
310 320 330 340 350
MINDDQRINL PHWPNVILTD PTAAQYVHGI AIHWYEDFID PATVLTETHE
360 370 380 390 400
KFPDYFLLAT EACAGYFPAD GPKLGSWSRA EQYANDLIKD MGNWVGGWVD
410 420 430 440 450
WNYILDLQGG PNLAKNFVDS TIIVNATAQE YYKQPIWHVM AQFSKFVKPG
460 470 480 490 500
AIRVGINIIE KSVDVEGLSF LNQDGTKTVV LLNKNEVLSF DVAISDVSAP
510
NVIYDLTIQP NSLITIVYK
Length:519
Mass (Da):58,247
Last modified:October 1, 2001 - v2
Checksum:iFD822081D820C80A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081369 Genomic DNA. Translation: CCD71128.1.
PIRiT34017.
RefSeqiNP_500785.1. NM_068384.4.
UniGeneiCel.7806.

Genome annotation databases

EnsemblMetazoaiY4C6B.6; Y4C6B.6; WBGene00021160.
GeneIDi177314.
KEGGicel:CELE_Y4C6B.6.
UCSCiY4C6B.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081369 Genomic DNA. Translation: CCD71128.1.
PIRiT34017.
RefSeqiNP_500785.1. NM_068384.4.
UniGeneiCel.7806.

3D structure databases

ProteinModelPortaliQ9UB00.
SMRiQ9UB00. Positions 26-510.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y4C6B.6.

Protein family/group databases

CAZyiGH30. Glycoside Hydrolase Family 30.

Proteomic databases

PaxDbiQ9UB00.
PRIDEiQ9UB00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY4C6B.6; Y4C6B.6; WBGene00021160.
GeneIDi177314.
KEGGicel:CELE_Y4C6B.6.
UCSCiY4C6B.6. c. elegans.

Organism-specific databases

CTDi177314.
WormBaseiY4C6B.6; CE28522; WBGene00021160; gba-4.

Phylogenomic databases

eggNOGiCOG5520.
GeneTreeiENSGT00390000009464.
HOGENOMiHOG000270031.
InParanoidiQ9UB00.
KOiK01201.
OMAiVWDHNRD.
OrthoDBiEOG76DTRZ.
PhylomeDBiQ9UB00.

Enzyme and pathway databases

UniPathwayiUPA00222.

Miscellaneous databases

NextBioi896226.
PROiQ9UB00.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR013780. Glyco_hydro_13_b.
IPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR11069. PTHR11069. 1 hit.
PfamiPF02055. Glyco_hydro_30. 1 hit.
[Graphical view]
PRINTSiPR00843. GLHYDRLASE30.
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGLCM4_CAEEL
AccessioniPrimary (citable) accession number: Q9UB00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: October 1, 2001
Last modified: April 29, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.