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Q9U9R3

- Q9U9R3_LEIDO

UniProt

Q9U9R3 - Q9U9R3_LEIDO

Protein

Peptidyl-prolyl cis-trans isomerase

Gene

CYP

Organism
Leishmania donovani
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins.UniRule annotation
    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).SAAS annotation

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, RotamaseUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
    Gene namesi
    Name:CYPImported
    OrganismiLeishmania donovaniImported
    Taxonomic identifieri5661 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2HAQX-ray1.97A22-187[»]
    3BT8X-ray2.70A22-187[»]
    3EOVX-ray2.60A/B22-187[»]
    ProteinModelPortaliQ9U9R3.
    SMRiQ9U9R3. Positions 22-187.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9U9R3.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclophilin-type PPIase family.UniRule annotation
    Contains 1 PPIase cyclophilin-type domain.UniRule annotation
    Contains PPIase cyclophilin-type domain.SAAS annotation

    Family and domain databases

    Gene3Di2.40.100.10. 1 hit.
    InterProiIPR029000. Cyclophilin-like_dom.
    IPR024936. Cyclophilin-type_PPIase.
    IPR020892. Cyclophilin-type_PPIase_CS.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view]
    PfamiPF00160. Pro_isomerase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
    PRINTSiPR00153. CSAPPISMRASE.
    SUPFAMiSSF50891. SSF50891. 1 hit.
    PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
    PS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9U9R3-1 [UniParc]FASTAAdd to Basket

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    MRFVAVLAVV LCALSFLNVA AEPEVTAKVY FDVMIDSEPL GRITIGLFGK    50
    DAPLTTENFR QLCTGEHGFG YKDSIFHRVI QNFMIQGGDF TNFDGTGGKS 100
    IYGEKFADEN LNVKHFVGAL SMANAGPNTN GSQFFITTAP TPWLDGRHVV 150
    FGKVLDGMDV VLRIEKTKTN SHDRPVKPVK IVASGEL 187
    Length:187
    Mass (Da):20,429
    Last modified:May 1, 2000 - v1
    Checksum:iA35EC99752114F1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF158368 Genomic DNA. Translation: AAD46565.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF158368 Genomic DNA. Translation: AAD46565.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2HAQ X-ray 1.97 A 22-187 [» ]
    3BT8 X-ray 2.70 A 22-187 [» ]
    3EOV X-ray 2.60 A/B 22-187 [» ]
    ProteinModelPortali Q9U9R3.
    SMRi Q9U9R3. Positions 22-187.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q9U9R3.

    Family and domain databases

    Gene3Di 2.40.100.10. 1 hit.
    InterProi IPR029000. Cyclophilin-like_dom.
    IPR024936. Cyclophilin-type_PPIase.
    IPR020892. Cyclophilin-type_PPIase_CS.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view ]
    Pfami PF00160. Pro_isomerase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001467. Peptidylpro_ismrse. 1 hit.
    PRINTSi PR00153. CSAPPISMRASE.
    SUPFAMi SSF50891. SSF50891. 1 hit.
    PROSITEi PS00170. CSA_PPIASE_1. 1 hit.
    PS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a cyclophilin homolog that is predominantly expressed in free living Leishmania donovani: implications for cyclosporin resistance."
      Dutta M., Delhi P., Sinha K.M., Banerjee R.K., Datta A.K.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: D1700Imported.
    2. "Structure of cyclophilin from Leishmania donovani at 1.97 A resolution."
      Venugopal V., Sen B., Datta A.K., Banerjee R.
      Acta Crystallogr. F 63:60-64(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 22-187.
    3. "Crystal Structure of Mutant Cyclophilin from Leishmania Donovani."
      Venugopal V., Sen B., Datta A.K., Banerjee R.
      Submitted (DEC-2007) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 22-187.
    4. "Structure of cyclophilin from Leishmania donovani bound to cyclosporin at 2.6 A resolution: correlation between structure and thermodynamic data."
      Venugopal V., Datta A.K., Bhattacharyya D., Dasgupta D., Banerjee R.
      Acta Crystallogr. D 65:1187-1195(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 22-187.

    Entry informationi

    Entry nameiQ9U9R3_LEIDO
    AccessioniPrimary (citable) accession number: Q9U9R3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3