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Protein

DNA helicase

Gene

CDC47

Organism
Trypanosoma brucei
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase

Keywords - Biological processi

DNA replicationSAAS annotation

Keywords - Ligandi

ATP-binding, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicaseSAAS annotation (EC:3.6.4.12SAAS annotation)
Gene namesi
Name:CDC47Imported
OrganismiTrypanosoma bruceiImported
Taxonomic identifieri5691 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ9U9L0.

Interactioni

Protein-protein interaction databases

STRINGi5691.EAN80559.

Structurei

3D structure databases

ProteinModelPortaliQ9U9L0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini336 – 540MCMInterPro annotationAdd BLAST205

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili303 – 330Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the MCM family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0482. Eukaryota.
COG1241. LUCA.
HOGENOMiHOG000224125.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031327. MCM.
IPR008050. MCM7.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027925. MCM_N.
IPR033762. MCM_OB.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11630:SF26. PTHR11630:SF26. 1 hit.
PfamiPF00493. MCM. 1 hit.
PF14551. MCM_N. 1 hit.
PF17207. MCM_OB. 1 hit.
[Graphical view]
PRINTSiPR01657. MCMFAMILY.
SMARTiSM00350. MCM. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U9L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGPTQEQT KKAAFAVAAT SKYPNYLADR DLCRRFFEEF RDASGGMKYM
60 70 80 90 100
DMAARVARRE TNVFTVDLDD IQLYGQLYLA QRIQMNVMGY REEVYRVVDE
110 120 130 140 150
IIPEAYFEED MIDHLILEAQ TAGQHLPPLL TRRYELVVMP LTSFSEPVPL
160 170 180 190 200
RQLKGGLIGT LVVLRGICIA ATAVRPKLSM LVSVCEVCAE TTFQQVIGDR
210 220 230 240 250
LTPLMVCQSQ RCRLNNTVGR LLPQYKASKF TKHQELRLQE LPQYVPRGAI
260 270 280 290 300
PRTIRVICEG EQTRIATPGQ VVKVVGTYCP DPSTGQGHEA FRASTMVKTL
310 320 330 340 350
FRALRIELER RSYQEAADDL KIQVDNVKQH PDKEVVIEKL TRSVAPEIWG
360 370 380 390 400
MEDVKKALLC LLVGGSSIAN GIRIRSDTNI CLMGDPGVAK SQLLKWIASV
410 420 430 440 450
APRSIFTTGK GSSGVGLTAA VTRDTYTGEV MLEGGALVLS DRGICCIDEF
460 470 480 490 500
DKMDDSDRTA LHEVMEQQMV SIAKAGIITS LNARTSILAA ANPKYGRWRR
510 520 530 540 550
NLTPSENVNL PPALLSRFDV LWLLLDESNR ERDAELSMHV TYVHLHGVAP
560 570 580 590 600
GTVSDNGFYG LSSDYFGKDF LQAYVGEAKK IHPIVDSSAA KVISDIYCEM
610 620 630 640 650
RAQSVRHTNV VTARTLLSII RLSQACARLR FSDRVVEADV REAGRLLDCS
660 670 680 690 700
KISLQERVDT GGRRMVTTSD AAIFSTIKEL ARSRGSIDLA EVRPALMIKG
710 720 730
IDESHLQRCL NTYADVGVWE VSGNTVHFSL E
Length:731
Mass (Da):81,263
Last modified:May 1, 2000 - v1
Checksum:i223AEEE518EA3703
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164200 Genomic DNA. Translation: AAD48445.1.

Genome annotation databases

EnsemblProtistsiEAN80559; EAN80559; Tb11.01.7810.
GeneDBiTb927.11.16140:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164200 Genomic DNA. Translation: AAD48445.1.

3D structure databases

ProteinModelPortaliQ9U9L0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5691.EAN80559.

Proteomic databases

PaxDbiQ9U9L0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAN80559; EAN80559; Tb11.01.7810.
GeneDBiTb927.11.16140:pep.

Phylogenomic databases

eggNOGiKOG0482. Eukaryota.
COG1241. LUCA.
HOGENOMiHOG000224125.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031327. MCM.
IPR008050. MCM7.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027925. MCM_N.
IPR033762. MCM_OB.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11630:SF26. PTHR11630:SF26. 1 hit.
PfamiPF00493. MCM. 1 hit.
PF14551. MCM_N. 1 hit.
PF17207. MCM_OB. 1 hit.
[Graphical view]
PRINTSiPR01657. MCMFAMILY.
SMARTiSM00350. MCM. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9U9L0_9TRYP
AccessioniPrimary (citable) accession number: Q9U9L0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.