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Protein

DNA replication licensing factor MCM7

Gene

CDC47

Organism
Trypanosoma brucei
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, HelicaseUniRule annotationSAAS annotation, Hydrolase
Biological processCell cycleUniRule annotation, DNA replicationUniRule annotationSAAS annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication licensing factor MCM7UniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:CDC47Imported
Synonyms:MCM7UniRule annotation
OrganismiTrypanosoma bruceiImported
Taxonomic identifieri5691 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ9U9L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini336 – 540MCMInterPro annotationAdd BLAST205

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili303 – 330Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the MCM family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0482 Eukaryota
COG1241 LUCA
HOGENOMiHOG000224125

Family and domain databases

InterProiView protein in InterPro
IPR031327 MCM
IPR008050 MCM7
IPR018525 MCM_CS
IPR001208 MCM_dom
IPR027925 MCM_N
IPR033762 MCM_OB
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
PANTHERiPTHR11630 PTHR11630, 1 hit
PTHR11630:SF26 PTHR11630:SF26, 1 hit
PfamiView protein in Pfam
PF00493 MCM, 1 hit
PF14551 MCM_N, 1 hit
PF17207 MCM_OB, 1 hit
PRINTSiPR01657 MCMFAMILY
SMARTiView protein in SMART
SM00350 MCM, 1 hit
SUPFAMiSSF50249 SSF50249, 2 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00847 MCM_1, 1 hit
PS50051 MCM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9U9L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGPTQEQT KKAAFAVAAT SKYPNYLADR DLCRRFFEEF RDASGGMKYM
60 70 80 90 100
DMAARVARRE TNVFTVDLDD IQLYGQLYLA QRIQMNVMGY REEVYRVVDE
110 120 130 140 150
IIPEAYFEED MIDHLILEAQ TAGQHLPPLL TRRYELVVMP LTSFSEPVPL
160 170 180 190 200
RQLKGGLIGT LVVLRGICIA ATAVRPKLSM LVSVCEVCAE TTFQQVIGDR
210 220 230 240 250
LTPLMVCQSQ RCRLNNTVGR LLPQYKASKF TKHQELRLQE LPQYVPRGAI
260 270 280 290 300
PRTIRVICEG EQTRIATPGQ VVKVVGTYCP DPSTGQGHEA FRASTMVKTL
310 320 330 340 350
FRALRIELER RSYQEAADDL KIQVDNVKQH PDKEVVIEKL TRSVAPEIWG
360 370 380 390 400
MEDVKKALLC LLVGGSSIAN GIRIRSDTNI CLMGDPGVAK SQLLKWIASV
410 420 430 440 450
APRSIFTTGK GSSGVGLTAA VTRDTYTGEV MLEGGALVLS DRGICCIDEF
460 470 480 490 500
DKMDDSDRTA LHEVMEQQMV SIAKAGIITS LNARTSILAA ANPKYGRWRR
510 520 530 540 550
NLTPSENVNL PPALLSRFDV LWLLLDESNR ERDAELSMHV TYVHLHGVAP
560 570 580 590 600
GTVSDNGFYG LSSDYFGKDF LQAYVGEAKK IHPIVDSSAA KVISDIYCEM
610 620 630 640 650
RAQSVRHTNV VTARTLLSII RLSQACARLR FSDRVVEADV REAGRLLDCS
660 670 680 690 700
KISLQERVDT GGRRMVTTSD AAIFSTIKEL ARSRGSIDLA EVRPALMIKG
710 720 730
IDESHLQRCL NTYADVGVWE VSGNTVHFSL E
Length:731
Mass (Da):81,263
Last modified:May 1, 2000 - v1
Checksum:i223AEEE518EA3703
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164200 Genomic DNA Translation: AAD48445.1

Genome annotation databases

EnsemblProtistsiEAN80559; EAN80559; Tb11.01.7810
GeneDBiTb927.11.16140:pep

Similar proteinsi

Entry informationi

Entry nameiQ9U9L0_9TRYP
AccessioniPrimary (citable) accession number: Q9U9L0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health