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Q9U9K0 (ADD1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adducin-related protein 1
Gene names
Name:add-1
ORF Names:F39C12.2
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length732 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network By similarity.

Subcellular location

Cytoplasm › cytoskeleton By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the aldolase class II family. Adducin subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Cytoplasm
Cytoskeleton
Membrane
   Coding sequence diversityAlternative splicing
   LigandActin-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionactin binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.
Isoform b (identifier: Q9U9K0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform a (identifier: Q9U9K0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     665-679: CDHPSPMSISTEYPE → YPDILRPIYRQETYV
     680-732: Missing.
Isoform c (identifier: Q9U9K0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     666-695: Missing.
Isoform d (identifier: Q9U9K0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     645-694: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 732732Adducin-related protein 1
PRO_0000218540

Natural variations

Alternative sequence645 – 69450Missing in isoform d.
VSP_000193
Alternative sequence665 – 67915CDHPS…TEYPE → YPDILRPIYRQETYV in isoform a.
VSP_000194
Alternative sequence666 – 69530Missing in isoform c.
VSP_000195
Alternative sequence680 – 73253Missing in isoform a.
VSP_000196

Experimental info

Sequence conflict3771P → S in AAD49856. Ref.1
Sequence conflict3771P → S in AAD49857. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform b [UniParc].

Last modified August 2, 2002. Version 2.
Checksum: CBEA2AAD053C6322

FASTA73282,170
        10         20         30         40         50         60 
MIGRKEKERE RPYYRDPDDP EYIKDLQRPA VIKEDLSEME RRKRVQQILE SKSFCHELEE 

        70         80         90        100        110        120 
VIRQECDTAR TDPDHLQVLQ KLSDLTVPQG NMSFGNLHTY GGNTIAIADL RGNEKYSKAE 

       130        140        150        160        170        180 
RIQRNKLACL FRLADLFQWS QGIHNEISYR TNDEDNTFLM NPFGLLYHEI TAATIVKIDE 

       190        200        210        220        230        240 
NGKILDCGTL KAGVNQPAFL LHSAIYKAHP MVRCILHMHT AIVAAVASMK CGLLPLCKEA 

       250        260        270        280        290        300 
MVLGPVGYHD YQDIGDDDIQ FDEIIANLGD KNVLFLRNQG FLVVGDTIEH ATFLANNTVI 

       310        320        330        340        350        360 
ACETQVRAAR AGLDNLIIPE EKAIQRAFRN SRNTNSLKRN GTVDWRVGEL EWESWMRVLD 

       370        380        390        400        410        420 
HANFQTGHVY RQPQLRPKSA MSTSMVNNND VAVPPTTSAY GQIDETNLES VSAHRLALLR 

       430        440        450        460        470        480 
KEQERVRWMN SPNAYQKVEF LEYGADNPKK ITKWVHDVNV PSASGTPVKI SSVHQFSPAS 

       490        500        510        520        530        540 
SNPKEFKEKQ KAIKENNRLG TLSAGPQSQI LDSVTYEDIA LLIKPDNDGT VGQSSTADRA 

       550        560        570        580        590        600 
ILIGTASKGI IDRQFQHHAQ VYHQIYAPNP FSVETDADIK KYVDMVKAKN SQSAPVSARS 

       610        620        630        640        650        660 
GYSQYDEVEA DTVSLMQGVR EHKLSQAALS ASDDGLNAGI SPNNVRTSEE SVNTSYMSQS 

       670        680        690        700        710        720 
VVFDCDHPSP MSISTEYPEK VKMTRFSSTQ GTSEGNTTSR SCTTASEEEK PTKDEKKKKK 

       730 
KGFLSFMRKK DK

« Hide

Isoform a [UniParc].

Checksum: 692841752A61D8AD
Show »

FASTA67976,373
Isoform c [UniParc].

Checksum: 200652C0AE243303
Show »

FASTA70278,872
Isoform d [UniParc].

Checksum: 1FA125B56ED80D33
Show »

FASTA68276,578

References

« Hide 'large scale' references
[1]"Molecular and functional analysis of the spectrin based membrane skeleton in Caenorhabditis elegans."
Moorthy S., Bennett V.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF166167 mRNA. Translation: AAD49856.1.
AF166168 mRNA. Translation: AAD49857.1.
FO081331 Genomic DNA. Translation: CCD70842.1.
FO081331 Genomic DNA. Translation: CCD70843.1.
FO081331 Genomic DNA. Translation: CCD70844.1.
FO081331 Genomic DNA. Translation: CCD70845.1.
RefSeqNP_001024639.1. NM_001029468.1.
NP_001024640.1. NM_001029469.1.
NP_001024641.1. NM_001029470.1.
NP_001024642.1. NM_001029471.1.
UniGeneCel.7980.

3D structure databases

ProteinModelPortalQ9U9K0.
SMRQ9U9K0. Positions 114-372.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9U9K0. 2 interactions.
MINTMINT-116561.
STRINGQ9U9K0.

Proteomic databases

PRIDEQ9U9K0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF39C12.2b; F39C12.2b; F39C12.2.
GeneID180760.
KEGGcel:F39C12.2.
UCSCF39C12.2b. c. elegans.

Organism-specific databases

CTD180760.
WormBaseF39C12.2a; CE28308; WBGene00000072; add-1.
F39C12.2b; CE28309; WBGene00000072; add-1.
F39C12.2c; CE29794; WBGene00000072; add-1.
F39C12.2d; CE30979; WBGene00000072; add-1.

Phylogenomic databases

eggNOGmeNOG04703.
GeneTreeEMGT00050000013962.
HOGENOMHBG388064.
InParanoidQ9U9K0.
OMAELEWESW.
PhylomeDBQ9U9K0.

Gene expression databases

ArrayExpressQ9U9K0.

Family and domain databases

InterProIPR001303. Aldolase_II/adducin_N.
[Graphical view]
Gene3DG3DSA:3.40.225.10. Aldolase_II/adducin_N. 1 hit.
PfamPF00596. Aldolase_II. 1 hit.
[Graphical view]
SMARTSM01007. Aldolase_II. 1 hit.
[Graphical view]
SUPFAMSSF53639. Aldolase_II_N. 1 hit.
ProtoNetSearch...

Other

NextBio910812.

Entry information

Entry nameADD1_CAEEL
AccessionPrimary (citable) accession number: Q9U9K0
Secondary accession number(s): O44581, Q95X64, Q9U9J9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 2, 2002
Last modified: January 25, 2012
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents