Q9U9K0 (ADD1_CAEEL) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 74.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Adducin-related protein 1 | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 732 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network By similarity. |
| Subcellular location | Cytoplasm › cytoskeleton By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. |
| Sequence similarities | Belongs to the aldolase class II family. Adducin subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Cytoplasm Cytoskeleton Membrane |
| Coding sequence diversity | Alternative splicing |
| Ligand | Actin-binding |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeletonInferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | actin binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] Note: Experimental confirmation may be lacking for some isoforms. | ||||||
| Isoform b (identifier: Q9U9K0-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform a (identifier: Q9U9K0-2) The sequence of this isoform differs from the canonical sequence as follows: 665-679: CDHPSPMSISTEYPE → YPDILRPIYRQETYV 680-732: Missing. | ||||||
| Isoform c (identifier: Q9U9K0-3) The sequence of this isoform differs from the canonical sequence as follows: 666-695: Missing. | ||||||
| Isoform d (identifier: Q9U9K0-4) The sequence of this isoform differs from the canonical sequence as follows: 645-694: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 732 | 732 | Adducin-related protein 1 | PRO_0000218540 | |||||
Natural variations | |||||||||
| Alternative sequence | 645 – 694 | 50 | Missing in isoform d. | VSP_000193 | |||||
| Alternative sequence | 665 – 679 | 15 | CDHPS…TEYPE → YPDILRPIYRQETYV in isoform a. | VSP_000194 | |||||
| Alternative sequence | 666 – 695 | 30 | Missing in isoform c. | VSP_000195 | |||||
| Alternative sequence | 680 – 732 | 53 | Missing in isoform a. | VSP_000196 | |||||
Experimental info | |||||||||
| Sequence conflict | 377 | 1 | P → S in AAD49856. Ref.1 | ||||||
| Sequence conflict | 377 | 1 | P → S in AAD49857. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular and functional analysis of the spectrin based membrane skeleton in Caenorhabditis elegans." Moorthy S., Bennett V. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B). |
| [2] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF166167 mRNA. Translation: AAD49856.1. AF166168 mRNA. Translation: AAD49857.1. FO081331 Genomic DNA. Translation: CCD70842.1. FO081331 Genomic DNA. Translation: CCD70843.1. FO081331 Genomic DNA. Translation: CCD70844.1. FO081331 Genomic DNA. Translation: CCD70845.1. |
| RefSeq | NP_001024639.1. NM_001029468.1. NP_001024640.1. NM_001029469.1. NP_001024641.1. NM_001029470.1. NP_001024642.1. NM_001029471.1. |
| UniGene | Cel.7980. |
3D structure databases | |
| ProteinModelPortal | Q9U9K0. |
| SMR | Q9U9K0. Positions 114-372. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9U9K0. 2 interactions. |
| MINT | MINT-116561. |
| STRING | Q9U9K0. |
Proteomic databases | |
| PRIDE | Q9U9K0. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | F39C12.2b; F39C12.2b; F39C12.2. |
| GeneID | 180760. |
| KEGG | cel:F39C12.2. |
| UCSC | F39C12.2b. c. elegans. |
Organism-specific databases | |
| CTD | 180760. |
| WormBase | F39C12.2a; CE28308; WBGene00000072; add-1. F39C12.2b; CE28309; WBGene00000072; add-1. F39C12.2c; CE29794; WBGene00000072; add-1. F39C12.2d; CE30979; WBGene00000072; add-1. |
Phylogenomic databases | |
| eggNOG | meNOG04703. |
| GeneTree | EMGT00050000013962. |
| HOGENOM | HBG388064. |
| InParanoid | Q9U9K0. |
| OMA | ELEWESW. |
| PhylomeDB | Q9U9K0. |
Gene expression databases | |
| ArrayExpress | Q9U9K0. |
Family and domain databases | |
| InterPro | IPR001303. Aldolase_II/adducin_N. [Graphical view] |
| Gene3D | G3DSA:3.40.225.10. Aldolase_II/adducin_N. 1 hit. |
| Pfam | PF00596. Aldolase_II. 1 hit. [Graphical view] |
| SMART | SM01007. Aldolase_II. 1 hit. [Graphical view] |
| SUPFAM | SSF53639. Aldolase_II_N. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 910812. |
Entry information
| Entry name | ADD1_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q9U9K0 Secondary accession number(s): O44581, Q95X64, Q9U9J9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

Clusters with