Q9U9I5 (SWA_DROPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein swallow

Gene names

Name:	swa
ORF Names:	GA17446

Organism

Drosophila pseudoobscura pseudoobscura (Fruit fly)

Taxonomic identifier

46245 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	537 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis By similarity.
Subunit structure	May be constituted of an homo- or heterodimer By similarity.
Subcellular location	Nucleus. Note: Uniformly distributed in eggs, becomes localized to the nuclei during early mitotic divisions in early embryogenesis. Swallow enters each nucleus at the beginning of mitosis, occupies a position complementary to that of condensed chromatin, and leaves each nucleus at the end of mitosis By similarity.
Sequence caution	The sequence AAD49350.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Nucleus
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 537	537	Protein swallow		PRO_0000072343
Experimental info
	Sequence conflict	350	1	P → L in AAD49350. Ref.1
	Sequence conflict	390 – 391	2	RG → A in AAD49350. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9U9I5 [UniParc]. Last modified March 3, 2009. Version 3. Checksum: BC0715A31691CCE7	FASTA	537	59,641
	10 20 30 40 50 60 MSLEDESFPA DELFEQLNSA SIGASRQFKS QFGEHDQPEA FERNPAPFLT SDCSDESSFI 70 80 90 100 110 120 DAANKSAKTC VSDPVGLDQC EEEEEVDKDF EDSALANGNS ELQIKSARSS KSVSYQDIHS 130 140 150 160 170 180 AHTKRRYKHV TSKVAKYIAD IHAQDQQRRN ATKKFQRHSS MPEYLTPTAR ERGAHFSVDE 190 200 210 220 230 240 LHNLDESLDN SSAGNITDAK TPNDSYERLL SENERLQNDK EDLKSYSDYL QTKLDEKAME 250 260 270 280 290 300 NMQLRRNFDV LRTDLTDCKE KLKRNQSYSL RSLNFCPPAS VPKATQTDHE LLSHAPNISR 310 320 330 340 350 360 LSNMVAIADS GTPLPGSNTN NLTYDSSAGS IEVALLSVAP AARQPNAGKP KKNIQPHSLD 370 380 390 400 410 420 FSNDSTEAEP NGNGTTSTGH SSSRAITSRR GAAPNNSESS HPSSNDSAIE VEALDLRSPY 430 440 450 460 470 480 HRQPQGSIYP PMQDWGHSDG IYFFDKRNSR VIEVRSINVS QSSNPEQNSG TSETNLLNQS 490 500 510 520 530 HVQFRHKRTS MGTRMLRLLG PCVRCTDTNQ SVNASSATYT IGLPLLREEY GGRHTDR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of a swallow homologue from Drosophila pseudoobscura." Huang Z., Pokrywka N.J., Yoder J.H., Stephenson E.C. Dev. Genes Evol. 210:157-161(2000) [PubMed: 11180817] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution." Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L. , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A. Genome Res. 15:1-18(2005) [PubMed: 15632085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MV2-25 / Tucson 14011-0121.94.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF169634 Genomic DNA. Translation: AAD49350.1. Sequence problems. CH379063 Genomic DNA. Translation: EAL32307.2.
RefSeq	XP_001355250.2. XM_001355214.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4815687.
KEGG	dpo:Dpse_GA17446.
Organism-specific databases
FlyBase	FBgn0027807. Dpse\swa.
Phylogenomic databases
InParanoid	Q9U9I5.
OrthoDB	EOG4TB2SS.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

SWA_DROPS

Accession

Primary (citable) accession number: Q9U9I5
Secondary accession number(s): Q29JJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 47 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project