Q9U9A3 (PPP6_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 6 catalytic subunit
Short name=PP6C
EC=3.1.3.16

Gene names

Name:	ppp6c
Synonyms:	pppD
ORF Names:	DDB_G0272118

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 manganese ion per subunit By similarity.
Sequence similarities	Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.

Ontologies

Keywords
Ligand	Iron Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Serine/threonine-protein phosphatase 6 catalytic subunit		PRO_0000327846
Sites
	Active site	115	1	Proton donor By similarity
	Metal binding	54	1	Iron By similarity
	Metal binding	56	1	Iron By similarity
	Metal binding	82	1	Iron By similarity
	Metal binding	82	1	Manganese By similarity
	Metal binding	114	1	Manganese By similarity
	Metal binding	164	1	Manganese By similarity
	Metal binding	238	1	Manganese By similarity
Experimental info
	Sequence conflict	299	1	P → T in AAD51079. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9U9A3 [UniParc]. Last modified April 8, 2008. Version 2. Checksum: A3A187FC11CF13CE	FASTA	305	35,294
	10 20 30 40 50 60 MSNALPLDEW VETARQCKYL PENDLKKLCE RVKELLLEES NVQPVRSPVT ICGDIHGQFY 70 80 90 100 110 120 DLLELFKTGG EVPDTNYVFM GDFVDRGYYS LETFTYLLAL KARYPDKITL LRGNHESRQI 130 140 150 160 170 180 TQVYGFYDEC QQKYGNVNAW KYCTSVFDFL TLAAIIDGKV LCVHGGLSPK VRTLDQIRII 190 200 210 220 230 240 SRNLEIPHEG PFCDLMWSDP EDIEQWQPSP RGAGWLFGSK VTAEFEHING LNLICRAHQL 250 260 270 280 290 300 VQEGYRYMFD NSLVTVWSAP NYCYRCGNVA SILSLNENLD RDFKIFQAVQ EERNIPTRPT MQYFF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional analysis of Dictyostelium discoideum PP6." Fiorini L.C., da Silva A.M. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: AX4.
[2]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF176121 mRNA. Translation: AAD51079.1. AAFI02000008 Genomic DNA. Translation: EAL71211.1.
RefSeq	XP_645278.1. XM_640186.1.
3D structure databases
HSSP	HSSP built from PDB template 1FJM based on UniProtKB P62139.
ProteinModelPortal	Q9U9A3.
SMR	Q9U9A3. Positions 7-286.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDB_0185210.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0185210; DDB0185210; DDB_G0272118.
GeneID	8618444.
KEGG	ddi:DDB_G0272118.
Organism-specific databases
dictyBase	DDB_G0272118. ppp6c.
Phylogenomic databases
eggNOG	COG0639.
KO	K15427.
OMA	NKYGNAN.
ProtClustDB	CLSZ2431298.
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPP6_DICDI

Accession

Primary (citable) accession number: Q9U9A3
Secondary accession number(s): Q559Q6, Q75JR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)