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Protein

Serine/threonine-protein phosphatase 6 catalytic subunit

Gene

ppp6c

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Manganese 1By similarity1
Metal bindingi56Manganese 1By similarity1
Metal bindingi82Manganese 1By similarity1
Metal bindingi82Manganese 2By similarity1
Metal bindingi114Manganese 2By similarity1
Active sitei115Proton donorBy similarity1
Metal bindingi164Manganese 2By similarity1
Metal bindingi238Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 catalytic subunit (EC:3.1.3.16)
Short name:
PP6C
Gene namesi
Name:ppp6c
Synonyms:pppD
ORF Names:DDB_G0272118
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272118 ppp6c

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003278461 – 305Serine/threonine-protein phosphatase 6 catalytic subunitAdd BLAST305

Proteomic databases

PaxDbiQ9U9A3

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0185210

Structurei

3D structure databases

ProteinModelPortaliQ9U9A3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0373 Eukaryota
ENOG410XNR9 LUCA
InParanoidiQ9U9A3
KOiK15498
OMAiKYCCRVF
PhylomeDBiQ9U9A3

Family and domain databases

Gene3Di3.60.21.101 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9U9A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNALPLDEW VETARQCKYL PENDLKKLCE RVKELLLEES NVQPVRSPVT
60 70 80 90 100
ICGDIHGQFY DLLELFKTGG EVPDTNYVFM GDFVDRGYYS LETFTYLLAL
110 120 130 140 150
KARYPDKITL LRGNHESRQI TQVYGFYDEC QQKYGNVNAW KYCTSVFDFL
160 170 180 190 200
TLAAIIDGKV LCVHGGLSPK VRTLDQIRII SRNLEIPHEG PFCDLMWSDP
210 220 230 240 250
EDIEQWQPSP RGAGWLFGSK VTAEFEHING LNLICRAHQL VQEGYRYMFD
260 270 280 290 300
NSLVTVWSAP NYCYRCGNVA SILSLNENLD RDFKIFQAVQ EERNIPTRPT

MQYFF
Length:305
Mass (Da):35,294
Last modified:April 8, 2008 - v2
Checksum:iA3A187FC11CF13CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299P → T in AAD51079 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176121 mRNA Translation: AAD51079.1
AAFI02000008 Genomic DNA Translation: EAL71211.1
RefSeqiXP_645278.1, XM_640186.1

Genome annotation databases

EnsemblProtistsiEAL71211; EAL71211; DDB_G0272118
GeneIDi8618444
KEGGiddi:DDB_G0272118

Similar proteinsi

Entry informationi

Entry nameiPPP6_DICDI
AccessioniPrimary (citable) accession number: Q9U9A3
Secondary accession number(s): Q559Q6, Q75JR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome