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Q9U9A3

- PPP6_DICDI

UniProt

Q9U9A3 - PPP6_DICDI

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Protein
Serine/threonine-protein phosphatase 6 catalytic subunit
Gene
ppp6c, pppD, DDB_G0272118
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Manganese 1 By similarity
Metal bindingi56 – 561Manganese 1 By similarity
Metal bindingi82 – 821Manganese 1 By similarity
Metal bindingi82 – 821Manganese 2 By similarity
Metal bindingi114 – 1141Manganese 2 By similarity
Active sitei115 – 1151Proton donor By similarity
Metal bindingi164 – 1641Manganese 2 By similarity
Metal bindingi238 – 2381Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 6 catalytic subunit (EC:3.1.3.16)
    Short name:
    PP6C
    Gene namesi
    Name:ppp6c
    Synonyms:pppD
    ORF Names:DDB_G0272118
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0272118. ppp6c.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Serine/threonine-protein phosphatase 6 catalytic subunit
    PRO_0000327846Add
    BLAST

    Proteomic databases

    PRIDEiQ9U9A3.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0185210.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9U9A3.
    SMRiQ9U9A3. Positions 7-286.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0639.
    KOiK15498.
    OMAiVPETSYI.
    PhylomeDBiQ9U9A3.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9U9A3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNALPLDEW VETARQCKYL PENDLKKLCE RVKELLLEES NVQPVRSPVT    50
    ICGDIHGQFY DLLELFKTGG EVPDTNYVFM GDFVDRGYYS LETFTYLLAL 100
    KARYPDKITL LRGNHESRQI TQVYGFYDEC QQKYGNVNAW KYCTSVFDFL 150
    TLAAIIDGKV LCVHGGLSPK VRTLDQIRII SRNLEIPHEG PFCDLMWSDP 200
    EDIEQWQPSP RGAGWLFGSK VTAEFEHING LNLICRAHQL VQEGYRYMFD 250
    NSLVTVWSAP NYCYRCGNVA SILSLNENLD RDFKIFQAVQ EERNIPTRPT 300
    MQYFF 305
    Length:305
    Mass (Da):35,294
    Last modified:April 8, 2008 - v2
    Checksum:iA3A187FC11CF13CE
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti299 – 2991P → T in AAD51079. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF176121 mRNA. Translation: AAD51079.1.
    AAFI02000008 Genomic DNA. Translation: EAL71211.1.
    RefSeqiXP_645278.1. XM_640186.1.

    Genome annotation databases

    EnsemblProtistsiDDB0185210; DDB0185210; DDB_G0272118.
    GeneIDi8618444.
    KEGGiddi:DDB_G0272118.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF176121 mRNA. Translation: AAD51079.1 .
    AAFI02000008 Genomic DNA. Translation: EAL71211.1 .
    RefSeqi XP_645278.1. XM_640186.1.

    3D structure databases

    ProteinModelPortali Q9U9A3.
    SMRi Q9U9A3. Positions 7-286.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0185210.

    Proteomic databases

    PRIDEi Q9U9A3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0185210 ; DDB0185210 ; DDB_G0272118 .
    GeneIDi 8618444.
    KEGGi ddi:DDB_G0272118.

    Organism-specific databases

    dictyBasei DDB_G0272118. ppp6c.

    Phylogenomic databases

    eggNOGi COG0639.
    KOi K15498.
    OMAi VPETSYI.
    PhylomeDBi Q9U9A3.

    Miscellaneous databases

    PROi Q9U9A3.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Functional analysis of Dictyostelium discoideum PP6."
      Fiorini L.C., da Silva A.M.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: AX4.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    3. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiPPP6_DICDI
    AccessioniPrimary (citable) accession number: Q9U9A3
    Secondary accession number(s): Q559Q6, Q75JR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: September 3, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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