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Q9U9A3

- PPP6_DICDI

UniProt

Q9U9A3 - PPP6_DICDI

Protein

Serine/threonine-protein phosphatase 6 catalytic subunit

Gene

ppp6c

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541Manganese 1By similarity
    Metal bindingi56 – 561Manganese 1By similarity
    Metal bindingi82 – 821Manganese 1By similarity
    Metal bindingi82 – 821Manganese 2By similarity
    Metal bindingi114 – 1141Manganese 2By similarity
    Active sitei115 – 1151Proton donorBy similarity
    Metal bindingi164 – 1641Manganese 2By similarity
    Metal bindingi238 – 2381Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 6 catalytic subunit (EC:3.1.3.16)
    Short name:
    PP6C
    Gene namesi
    Name:ppp6c
    Synonyms:pppD
    ORF Names:DDB_G0272118
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0272118. ppp6c.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Serine/threonine-protein phosphatase 6 catalytic subunitPRO_0000327846Add
    BLAST

    Proteomic databases

    PRIDEiQ9U9A3.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0185210.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9U9A3.
    SMRiQ9U9A3. Positions 7-286.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0639.
    KOiK15498.
    OMAiVPETSYI.
    PhylomeDBiQ9U9A3.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9U9A3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNALPLDEW VETARQCKYL PENDLKKLCE RVKELLLEES NVQPVRSPVT    50
    ICGDIHGQFY DLLELFKTGG EVPDTNYVFM GDFVDRGYYS LETFTYLLAL 100
    KARYPDKITL LRGNHESRQI TQVYGFYDEC QQKYGNVNAW KYCTSVFDFL 150
    TLAAIIDGKV LCVHGGLSPK VRTLDQIRII SRNLEIPHEG PFCDLMWSDP 200
    EDIEQWQPSP RGAGWLFGSK VTAEFEHING LNLICRAHQL VQEGYRYMFD 250
    NSLVTVWSAP NYCYRCGNVA SILSLNENLD RDFKIFQAVQ EERNIPTRPT 300
    MQYFF 305
    Length:305
    Mass (Da):35,294
    Last modified:April 8, 2008 - v2
    Checksum:iA3A187FC11CF13CE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti299 – 2991P → T in AAD51079. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF176121 mRNA. Translation: AAD51079.1.
    AAFI02000008 Genomic DNA. Translation: EAL71211.1.
    RefSeqiXP_645278.1. XM_640186.1.

    Genome annotation databases

    EnsemblProtistsiDDB0185210; DDB0185210; DDB_G0272118.
    GeneIDi8618444.
    KEGGiddi:DDB_G0272118.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF176121 mRNA. Translation: AAD51079.1 .
    AAFI02000008 Genomic DNA. Translation: EAL71211.1 .
    RefSeqi XP_645278.1. XM_640186.1.

    3D structure databases

    ProteinModelPortali Q9U9A3.
    SMRi Q9U9A3. Positions 7-286.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0185210.

    Proteomic databases

    PRIDEi Q9U9A3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0185210 ; DDB0185210 ; DDB_G0272118 .
    GeneIDi 8618444.
    KEGGi ddi:DDB_G0272118.

    Organism-specific databases

    dictyBasei DDB_G0272118. ppp6c.

    Phylogenomic databases

    eggNOGi COG0639.
    KOi K15498.
    OMAi VPETSYI.
    PhylomeDBi Q9U9A3.

    Miscellaneous databases

    PROi Q9U9A3.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional analysis of Dictyostelium discoideum PP6."
      Fiorini L.C., da Silva A.M.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: AX4.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    3. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiPPP6_DICDI
    AccessioniPrimary (citable) accession number: Q9U9A3
    Secondary accession number(s): Q559Q6, Q75JR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3