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Q9U9A3

- PPP6_DICDI

UniProt

Q9U9A3 - PPP6_DICDI

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Protein

Serine/threonine-protein phosphatase 6 catalytic subunit

Gene

ppp6c

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Manganese 1By similarity
Metal bindingi56 – 561Manganese 1By similarity
Metal bindingi82 – 821Manganese 1By similarity
Metal bindingi82 – 821Manganese 2By similarity
Metal bindingi114 – 1141Manganese 2By similarity
Active sitei115 – 1151Proton donorBy similarity
Metal bindingi164 – 1641Manganese 2By similarity
Metal bindingi238 – 2381Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 catalytic subunit (EC:3.1.3.16)
Short name:
PP6C
Gene namesi
Name:ppp6c
Synonyms:pppD
ORF Names:DDB_G0272118
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272118. ppp6c.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Serine/threonine-protein phosphatase 6 catalytic subunitPRO_0000327846Add
BLAST

Proteomic databases

PRIDEiQ9U9A3.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0185210.

Structurei

3D structure databases

ProteinModelPortaliQ9U9A3.
SMRiQ9U9A3. Positions 7-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
InParanoidiQ9U9A3.
KOiK15498.
OMAiVPETSYI.
PhylomeDBiQ9U9A3.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U9A3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNALPLDEW VETARQCKYL PENDLKKLCE RVKELLLEES NVQPVRSPVT
60 70 80 90 100
ICGDIHGQFY DLLELFKTGG EVPDTNYVFM GDFVDRGYYS LETFTYLLAL
110 120 130 140 150
KARYPDKITL LRGNHESRQI TQVYGFYDEC QQKYGNVNAW KYCTSVFDFL
160 170 180 190 200
TLAAIIDGKV LCVHGGLSPK VRTLDQIRII SRNLEIPHEG PFCDLMWSDP
210 220 230 240 250
EDIEQWQPSP RGAGWLFGSK VTAEFEHING LNLICRAHQL VQEGYRYMFD
260 270 280 290 300
NSLVTVWSAP NYCYRCGNVA SILSLNENLD RDFKIFQAVQ EERNIPTRPT

MQYFF
Length:305
Mass (Da):35,294
Last modified:April 8, 2008 - v2
Checksum:iA3A187FC11CF13CE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 2991P → T in AAD51079. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176121 mRNA. Translation: AAD51079.1.
AAFI02000008 Genomic DNA. Translation: EAL71211.1.
RefSeqiXP_645278.1. XM_640186.1.

Genome annotation databases

EnsemblProtistsiDDB0185210; DDB0185210; DDB_G0272118.
GeneIDi8618444.
KEGGiddi:DDB_G0272118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176121 mRNA. Translation: AAD51079.1 .
AAFI02000008 Genomic DNA. Translation: EAL71211.1 .
RefSeqi XP_645278.1. XM_640186.1.

3D structure databases

ProteinModelPortali Q9U9A3.
SMRi Q9U9A3. Positions 7-286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0185210.

Proteomic databases

PRIDEi Q9U9A3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0185210 ; DDB0185210 ; DDB_G0272118 .
GeneIDi 8618444.
KEGGi ddi:DDB_G0272118.

Organism-specific databases

dictyBasei DDB_G0272118. ppp6c.

Phylogenomic databases

eggNOGi COG0639.
InParanoidi Q9U9A3.
KOi K15498.
OMAi VPETSYI.
PhylomeDBi Q9U9A3.

Miscellaneous databases

PROi Q9U9A3.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional analysis of Dictyostelium discoideum PP6."
    Fiorini L.C., da Silva A.M.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AX4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPPP6_DICDI
AccessioniPrimary (citable) accession number: Q9U9A3
Secondary accession number(s): Q559Q6, Q75JR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3