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Q9U969

- SWS_DROME

UniProt

Q9U969 - SWS_DROME

Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (25 Mar 2003)
      Previous versions | rss
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    Functioni

    Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain.3 Publications

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei985 – 9851

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi174 – 301128cNMP 1Add
    BLAST
    Nucleotide bindingi482 – 609128cNMP 2Add
    BLAST
    Nucleotide bindingi598 – 727130cNMP 3Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. glial cell apoptotic process Source: UniProtKB
    2. membrane lipid metabolic process Source: FlyBase
    3. membrane organization Source: FlyBase
    4. nervous system development Source: UniProtKB-KW
    5. neuron apoptotic process Source: FlyBase
    6. phosphatidylcholine metabolic process Source: FlyBase
    7. sensory perception of smell Source: FlyBase

    Keywords - Molecular functioni

    Developmental protein, Hydrolase

    Keywords - Biological processi

    Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropathy target esterase sws
    Alternative name(s):
    Swiss cheese (EC:3.1.1.5)
    Short name:
    DSWS
    Gene namesi
    Name:sws
    ORF Names:CG2212
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0003656. sws.

    Subcellular locationi

    Endoplasmic reticulum membrane 2 Publications; Single-pass type I membrane protein 2 Publications
    Note: Sws tethers Pka-C3 to the membrane.

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Progressive degeneration of the adult nervous system, associated with apoptotic cell death, glial hyperwrapping, and neuronal apoptosis. Also, vacuolization in the neuropil.1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi133 – 1331R → A: Has no effect on nervous system function but reduces binding to Pka-C3. 1 Publication
    Mutagenesisi648 – 6481G → R in allele sws-5; age-dependent neurodegeneration. 1 Publication
    Mutagenesisi956 – 9561G → D in allele sws-4; age-dependent neurodegeneration. 1 Publication
    Mutagenesisi985 – 9851S → D: Loss of enzymatic activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14251425Neuropathy target esterase swsPRO_0000172527Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei444 – 4441Phosphoserine1 Publication
    Modified residuei453 – 4531Phosphoserine1 Publication
    Modified residuei1160 – 11601Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9U969.

    Expressioni

    Tissue specificityi

    Isoform A and isoform B are expressed in the entire brain cortex; cortical cell bodies of adult brain. Sws and Pka-C3 are colocalized in all neurons.3 Publications

    Developmental stagei

    Isoform A is expressed in all developmental stages with highest levels in young embryos and adults. Isoform B is detected only in adult head.1 Publication

    Gene expression databases

    BgeeiQ9U969.

    Interactioni

    Subunit structurei

    Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.1 Publication

    Protein-protein interaction databases

    IntActiQ9U969. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9U969.
    SMRiQ9U969. Positions 610-714.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434LumenalSequence AnalysisAdd
    BLAST
    Topological domaini56 – 14251370CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini952 – 1118167PatatinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    GeneTreeiENSGT00390000002533.
    InParanoidiQ8IRN7.
    KOiK14676.
    OMAiNKIHLES.
    OrthoDBiEOG7QRQT1.
    PhylomeDBiQ9U969.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 3 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q9U969-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDVLEMLRAS ASGSYNTIFS DAWCQYVSKQ ITATVYMYFA LVMMSLLFIA     50
    WFLYFKRMAR LRLRDEIARS ISTVTNSSGD MRGLRFRKRD KMLFYGRRML 100
    RKMKNVSGQM YSSGKGYKRR AVMRFARRIL QLRRDNMPLE MRTVEPPAEY 150
    LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PVFLRLCKHT QLLELMAGDY 200
    LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE SVTSLLSFID 250
    VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI 300
    RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQAPN 350
    GPPMVISQMN LMQSAVSGTG SSGVSVTVTR PPSSPSRHSR EEHTLSDPNP 400
    NPDGSFHGTT NLFTEVHGDA PNADLFHQQQ QQHSVGNLST RRSSITLMAP 450
    DGSHSCLQTP GVTTSIDMRL VQSSAVDSLR KELGLSEEDS HIIEPFVELR 500
    ELEPNVTLIT EGNADDVCVW FVMTGTLAVY QSNQDATRAK QDKSDMLIHF 550
    VHPGEIVGGL AMLTGEASAY TIRSRSITRI AFIRRAAIYQ IMRQRPRIVL 600
    DLGNGVVRRL SPLVRQCDYA LDWIFLESGR AVYRQDESSD STYIVLSGRM 650
    RSVITHPGGK KEIVGEYGKG DLVGIVEMIT ETSRTTTVMA VRDSELAKLP 700
    EGLFNAIKLR YPIVVTKLIS FLSHRFLGSM QTRSGSGAPG APVEANPVTH 750
    KYSTVALVPI TDEVPMTPFT YELYHSLCAI GPVLRLTSDV VRKQLGSNIF 800
    EAANEYRLTS WLAQQEDRNI ITLYQCDSSL SAWTQRCMRQ ADVILIVGLG 850
    DRSHLVGKFE REIDRLAMRT QKELVLLYPE ASNAKPANTL SWLNARPWVT 900
    KHHHVLCVKR IFTRKSQYRI NDLYSRVLLS EPNMHSDFSR LARWLTGNSI 950
    GLVLGGGGAR GAAHIGMLKA IQEAGIPVDM VGGVSIGALM GALWCSERNI 1000
    TTVTQKAREW SKKMTKWFLQ LLDLTYPITS MFSGREFNKT IHDTFGDVSI 1050
    EDLWIPYFTL TTDITASCHR IHTNGSLWRY VRSSMSLSGY MPPLCDPKDG 1100
    HLLLDGGYVN NLPADVMHNL GAAHIIAIDV GSQDDTDLTN YGDDLSGWWL 1150
    LYKKWNPFTS PVKVPDLPDI QSRLAYVSCV RQLEEVKNSD YCEYIRPPID 1200
    KYKTLAFGSF DEIRDVGYVF GKNYFESMAK AGRLGRFNQW FNKEPPKRVN 1250
    HASLNEYTFI DLAQIVCRLP ETYAVNTAEL FSEDEDCDGY ISEPTTLNTD 1300
    RRRIQVSRAG NSLSFSETEM DSDVELDLKL ERKTDKSTQS SPPSNSRSDM 1350
    RGKEEARHMS NWHWGVKHKD ETGSGATEAT KTQTGQEQEL QQEQQDQGAT 1400
    AEQLVDKDKE ENKENRSSPN NETKN 1425
    Length:1,425
    Mass (Da):160,573
    Last modified:March 25, 2003 - v2
    Checksum:iA7FEE533B1C2B628
    GO
    Isoform B (identifier: Q9U969-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1084: Missing.
         1087-1098: LSGYMPPLCDPK → IAGVFPPFCDYR
         1107-1112: GYVNNL → CYTNNV

    Show »
    Length:341
    Mass (Da):38,784
    Checksum:i27425E1327272860
    GO
    Isoform C (identifier: Q9U969-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1087-1098: LSGYMPPLCDPK → IAGVFPPFCDYR
         1107-1112: GYVNNL → CYTNNV

    Note: No experimental confirmation available.

    Show »
    Length:1,425
    Mass (Da):160,671
    Checksum:i98FBA2A5E1A368D6
    GO

    Sequence cautioni

    The sequence AAL28979.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181I → T in CAB51772. (PubMed:9295388)Curated
    Sequence conflicti314 – 3141L → F in ABV82201. 1 PublicationCurated
    Sequence conflicti452 – 4521G → P in CAB51772. (PubMed:9295388)Curated
    Sequence conflicti785 – 7851R → H in CAB51772. (PubMed:9295388)Curated
    Sequence conflicti1076 – 10761S → H in ABV82201. 1 PublicationCurated
    Sequence conflicti1081 – 10833VRS → CRA in ABV82201. 1 PublicationCurated
    Sequence conflicti1377 – 13771T → N in CAB51772. (PubMed:9295388)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 10841084Missing in isoform B. CuratedVSP_038398Add
    BLAST
    Alternative sequencei1087 – 109812LSGYM…LCDPK → IAGVFPPFCDYR in isoform B and isoform C. 1 PublicationVSP_038399Add
    BLAST
    Alternative sequencei1107 – 11126GYVNNL → CYTNNV in isoform B and isoform C. 1 PublicationVSP_038400

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z97187 mRNA. Translation: CAB51772.1.
    AE014298 Genomic DNA. Translation: AAF46305.3.
    AE014298 Genomic DNA. Translation: AAN09223.1.
    BT030819 mRNA. Translation: ABV82201.1.
    AY061431 mRNA. Translation: AAL28979.1. Different initiation.
    RefSeqiNP_511075.3. NM_078520.3. [Q9U969-1]
    NP_727225.1. NM_167141.2. [Q9U969-2]
    UniGeneiDm.3604.

    Genome annotation databases

    EnsemblMetazoaiFBtr0071125; FBpp0071077; FBgn0003656. [Q9U969-1]
    GeneIDi31716.
    KEGGidme:Dmel_CG2212.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z97187 mRNA. Translation: CAB51772.1 .
    AE014298 Genomic DNA. Translation: AAF46305.3 .
    AE014298 Genomic DNA. Translation: AAN09223.1 .
    BT030819 mRNA. Translation: ABV82201.1 .
    AY061431 mRNA. Translation: AAL28979.1 . Different initiation.
    RefSeqi NP_511075.3. NM_078520.3. [Q9U969-1 ]
    NP_727225.1. NM_167141.2. [Q9U969-2 ]
    UniGenei Dm.3604.

    3D structure databases

    ProteinModelPortali Q9U969.
    SMRi Q9U969. Positions 610-714.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9U969. 1 interaction.

    Proteomic databases

    PaxDbi Q9U969.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0071125 ; FBpp0071077 ; FBgn0003656 . [Q9U969-1 ]
    GeneIDi 31716.
    KEGGi dme:Dmel_CG2212.

    Organism-specific databases

    CTDi 31716.
    FlyBasei FBgn0003656. sws.

    Phylogenomic databases

    eggNOGi COG0664.
    GeneTreei ENSGT00390000002533.
    InParanoidi Q8IRN7.
    KOi K14676.
    OMAi NKIHLES.
    OrthoDBi EOG7QRQT1.
    PhylomeDBi Q9U969.

    Miscellaneous databases

    GenomeRNAii 31716.
    NextBioi 774978.

    Gene expression databases

    Bgeei Q9U969.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 3 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila."
      Kretzschmar D., Hasan G., Sharma S., Heisenberg M., Benzer S.
      J. Neurosci. 17:7425-7432(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MUTAGENESIS OF GLY-648 AND GLY-956.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    4. Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
      Strain: Berkeley.
      Tissue: Head.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1052-1425 (ISOFORM A).
      Strain: Berkeley.
      Tissue: Embryo.
    6. "Loss of swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila."
      Muehlig-Versen M., da Cruz A.B., Tschaepe J.-A., Moser M., Buettner R., Athenstaedt K., Glynn P., Kretzschmar D.
      J. Neurosci. 25:2865-2873(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF SER-985.
    7. "Swiss cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3."
      Bettencourt da Cruz A., Wentzell J., Kretzschmar D.
      J. Neurosci. 28:10885-10892(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PKA-C3, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, MUTAGENESIS OF ARG-133.
    8. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-444; SER-453 AND SER-1160, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiSWS_DROME
    AccessioniPrimary (citable) accession number: Q9U969
    Secondary accession number(s): A8E6M7
    , Q8IRN7, Q95RE9, Q9W3M0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: March 25, 2003
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3