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Q9U943

- APLP_LOCMI

UniProt

Q9U943 - APLP_LOCMI

Protein

Apolipophorins

Gene
N/A
Organism
Locusta migratoria (Migratory locust)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Constitutes the major component of lipophorin, which mediates transport for various types of lipids in hemolymph. Acts by forming lipoprotein particles that bind lipoproteins and lipids. May be required for morphogens wingless (wg) and hedgehog (hh) function, possibly by acting as vehicles for the movement of wg and hh By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei720 – 7212Cleavage; by furin

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW
    2. lipid transporter activity Source: InterPro

    GO - Biological processi

    1. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Biological processi

    Lipid transport, Transport, Wnt signaling pathway

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipophorins
    Cleaved into the following 2 chains:
    Alternative name(s):
    Apolipophorin II
    apoLp-2
    Alternative name(s):
    Apolipophorin I
    apoLp-1
    OrganismiLocusta migratoria (Migratory locust)
    Taxonomic identifieri7004 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaOrthopteraCaeliferaAcridomorphaAcridoideaAcrididaeOedipodinaeLocusta

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi717 – 7171R → D: Abolishes cleavage by furin. 1 Publication
    Mutagenesisi717 – 7171R → Q: Partially affects cleavage by furin. 1 Publication
    Mutagenesisi719 – 7191K → A: Does not affect cleavage by furin. 1 Publication
    Mutagenesisi720 – 7201R → Q: Abolishes cleavage by furin. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 720699Apolipophorin-2PRO_0000041528Add
    BLAST
    Chaini721 – 33802660Apolipophorin-1PRO_0000041529Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi649 – 6491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi969 – 9691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2174 – 21741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2851 – 28511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3177 – 31771N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Cleaved into 2 chains by furin protease. However, prevention of cleavage does not impair its function.1 Publication
    N-glycosylated.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Expressioni

    Tissue specificityi

    Present in brain, hemolymph, fat body and eyes.1 Publication

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 646607VitellogeninPROSITE-ProRule annotationAdd
    BLAST
    Domaini2816 – 3012197VWFDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 vitellogenin domain.PROSITE-ProRule annotation
    Contains 1 VWFD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di1.25.10.20. 1 hit.
    2.20.50.20. 2 hits.
    2.20.80.10. 1 hit.
    2.30.230.10. 1 hit.
    InterProiIPR015819. Lipid_transp_b-sht_shell.
    IPR001747. Lipid_transpt_N.
    IPR009454. Lipid_transpt_open_b-sht.
    IPR015816. Vitellinogen_b-sht_N.
    IPR015255. Vitellinogen_open_b-sht.
    IPR015817. Vitellinogen_open_b-sht_sub1.
    IPR015818. Vitellinogen_open_b-sht_sub2.
    IPR011030. Vitellinogen_superhlx.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF06448. DUF1081. 1 hit.
    PF09172. DUF1943. 1 hit.
    PF01347. Vitellogenin_N. 1 hit.
    PF00094. VWD. 1 hit.
    [Graphical view]
    SMARTiSM00638. LPD_N. 1 hit.
    SM00216. VWD. 1 hit.
    [Graphical view]
    SUPFAMiSSF48431. SSF48431. 1 hit.
    SSF56968. SSF56968. 3 hits.
    PROSITEiPS51211. VITELLOGENIN. 1 hit.
    PS51233. VWFD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9U943-1 [UniParc]FASTAAdd to Basket

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    MGTPPHIWFL LILAISSGGL SAAVGGCNHQ CTPQSSVFQY QKGQTYTYSF     50
    EGTTLTSLPG TQGEPVRLKL KATADLSVAD DCNKVLRLRG VTVSGPDSKN 100
    YANLKDLEAH PVLANFKGSS INKQLCSEDG DNQSSLNIKR AILSLLQTPN 150
    TKSSTASEVD VFGICPTNVR HSQRGDVTVI SKTRNLNRYA SRENLIQETL 200
    STRFTGQSDL HATPFLDADL HVEQQIKGGL IVSATSRESY LFRPFSNQGN 250
    GAKTIVETKL TLTSQNAQPA PPLASFTVPK SIVFEAPHAL ASVPGGSSAI 300
    TAALHAAESS TKDGVTVDAA EKFRTLVSVL RQSSTTDILK VYNDVKAGAG 350
    FSNKHSARNL LLDALFRTST GDAVEVIARL LKTKEITANH WYLSLAFIQH 400
    ASLKSVVSIS SLLDQKNLPT EAFLGIGSFI GRYCREHNCE NVAEFDEVLN 450
    KFSKHLSGST TSKAGENRAI AALKALGNIR HLNNALGEKV KQLALDKSLP 500
    PRVRVAALEV IQSDPCRKNI KQAALQILRD QVEDSELRIK AYLAVVECPC 550
    DNVVKTISNL LENEPIIQVG SFVVSHLKNL QASTDPSKAE AKEKLGQLKP 600
    KKIFSSDIRK YSQNYELSYA IDAINAGASV ESNVIFSQSS YLPRSVSLNL 650
    TADVFGHSYN VFEIAARTEN LDHIIESFLG PKGYIETEDD DKFVDEVEEK 700
    TKSLYNRITE RFEKTFRQKR SVSKDAVDNI RQQAYKSLLP SQRDRSLDVD 750
    LSLKTFGSEL AWFNYDGKHE QKSSERVVDE IFDAIDEGLK KSKKFNYDFE 800
    PHFTFLDSEL SYPTNLGFPL KLAIDGSIAA RLKLNGEVDV RSILRQPENA 850
    AFRLEFVPSA AVELTGKLLV DAYVVEGGLK LDYNVHSSTG INVAVHNLND 900
    LGIDIKVGLP VKKQDIIDVK TDVLTTVKER GHPETSTPLH FNLKGNDYKQ 950
    YRGCFDQLSP VSGLTFCGNV SVPWVSPTQA AAFYPLNGPS HLSVSIEADD 1000
    VSEYHFRAEI KKDESAFKSA AVLFDTPGSS ADRKVLLLVE KKEKPHQGIT 1050
    AHLKSGWKEI VAEGLLIDDN NEKSVSAKLV IESDEYSIKG GVKISGNPSR 1100
    QVYKPILEYK APAKDSGAKV KKSHKTSEGI TVDGAVVVER TSDKGKYTFQ 1150
    DLSLKTPKGT FVINGQLDIV PRNYAFDLKL SVDKNELLLN GHLNYAEPKS 1200
    IDVALEVTSP QFPDYGSGFQ LINKRGDDYS DTKIILACGR DLKSDGSRLI 1250
    LEHFIKGKYE TPDTFNLETK GEVLGTGHKI FGKFDIDSKP KHLEYDLKLG 1300
    FDENEVTSDL VAKRDIKSPD DYELKFSAKI LDNSIRIESS REVKPKDDSA 1350
    FLNTLVVLSG KKYEFQVDVK LAAEDEYHTS LKAESNLKIE GKTSVRLITD 1400
    FTTDAQTVNG HVKVSNEGED FFELIYKLNR GSGNPSGNAK LFVKNYLDGA 1450
    ATFKYNNGVG SGTLQIDVLK LHRKIKATGD LTLSGSQRSA AIDLYWDADR 1500
    DQSKQLLFKT ENDVKEKSID SKNTLKILDK LTTLNFKGSL SGAIDDGEVE 1550
    GQGELILPVG TYLGVKFGRA LHLTQADTKV GLHLQAEGRE SASSTQPVWK 1600
    SDFLLESALT RDSFVGEAKL LFETKGKDDL KLFLSGKSLP QGEKKLISGQ 1650
    FSGQGSLIGG RTSVIKLNSE IDETFIAYNL NSECNQGYRA NIVGKINRGY 1700
    SPVAVKQIEN TLELLLPFDK LKQLKHTIIG TFSSQPESTP EFTVSNVIIW 1750
    NNENTLKLTG EAAGDEKEGR TKWDLILPKE EPRTLETTWS NAGDNKKAGS 1800
    LSFKWGGNKE AKVSTDIEFT SDNQPQILHL KATSPTEKFG IFDLALSLKK 1850
    NADPADKIDF ELTVTADQKK TDVKGSLGLA PGVPIIDVVA VQPSGTSKVF 1900
    VDFLRKSDSE LHGAIELQWV AFGGGHLTAN GDIKLDIDDF YLKLDVDSPK 1950
    FNFNKWHLEA GQRAAKGSKR IVFTAKSAEK VLFSGSTNFH SKAENNKISY 2000
    SGNGQVRIGD KAHAFNFRSS RQNLIQDANK EIGVEYNLDF KIAGHGSLHN 2050
    ILKVTNKELH ALGKQCSEGK PNCAVVEIKS KVSAADAKET THDLVFLVDL 2100
    KSVGVDTGVA FTAETVRRGF WLIDEQASLT LSHNGETTYK YKGYLKESGS 2150
    GFTLTLPSRV IAAEVKLSSD VKPNHSKQQI SASVWLDKTR LPNSFSSVSI 2200
    LLEEIEDKNT DKYVSQLRFT HPNLEKDLTV KGYVQIGLEN KLFDSNLEID 2250
    IFKQKNQKIS ISSTVVEQKQ NDVVKYLSTL DVKSKGHELD VTGRGEATVK 2300
    PSLIALQSVL KYKKDKRIKE FKNFQFEVST EKLLVHVKVP NHHLLHIDAN 2350
    TKINDKHASG DASVHIIGLP TSVIHIEGEN KGFPVVKGTI SSEGTPNKLE 2400
    LIADLSDGLL VEADFISESG KKELFYTFLS GKKDSRKPEF RWSVENIQSA 2450
    LEPHKNDIQE VLNKLKEISD EAGNEITKES SRLADSLKAG LPNFRRFVNT 2500
    YETQLKALKE EIANDKVLKE ISENWKEVIG DAAEVVSTLV NGILVTIDAL 2550
    LKTLNELAES VLDALKKSLP ALKDSYKQAV DAIVGIAKSL TQSLVNILSS 2600
    AAEILKKHEA DIKEYLSVLA DLANDVGKFV TKITGVIYEG VVEFSKPIKE 2650
    KLDGLKFGVA IEFGKVVEQL QNLIVPQELL AFAQEIVSEL KETTLTPEIQ 2700
    DLLQAIEKYL EKVSKKKDAD VEKELKLIFE KAIDAVESVI NFVVSEITGG 2750
    DHTKDLYDIN IPTVLPSFIQ LPRVFSVRFS PLIYLVSNGV PCLSDLLASY 2800
    RPSLRFDNII PPYDATAILL NSHHFFTFDR RHLTFKGICS YILAQDVQDG 2850
    NFTIIANIEG GSLKSIIVSD QATTFELASD KSLLVNGRPT EYPADEGEFH 2900
    AWREYNRVGI QTKAGVKVTC ETSIELCTFE INGFYFGKTR GLLGTINNEP 2950
    WDDFTKPDGQ VASKANEFGN AWKVDAQCAN VDGVDHHEHS IKVEECEEVF 3000
    SKASLLSPCS LFLDPAPYLE ACSHIAHEAT TKEEKQLAAC RTAAAYVQAC 3050
    SVENVFVSVP PHCVHCSVNG DAAIDIGQSF SVKVPQKSAD ILIVLEQVTG 3100
    NAETVKDFVS PIVSQLTQEL SSRGISDVWI SLLGYGAPGQ EYPHLYTSSG 3150
    GKLSYDGKQK NIQFGERKVL GPFPFDNFTE SIDWLDEFTD QAFHLITTAD 3200
    TILDYPFRPG AAKSIIYVLD TSCETTLFLK HLPVKALKLK DAIGSPGIVL 3250
    HLVTNVDSVQ SKNIVGFDTN HAYYNQEGKK RVVSEVTGNE KAALKISETA 3300
    CGQIALATSG TVFNKNNLKQ TKKFVAQHIA DSLTNVELTQ DCKCLPVEGI 3350
    HTRAVCAVTG AREKEHLSVK GVKGTKGVKG 3380
    Length:3,380
    Mass (Da):371,809
    Last modified:July 10, 2007 - v2
    Checksum:i62526A263A041111
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ130944 mRNA. Translation: CAB51918.2.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Lipid freight - Issue 59 of June 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ130944 mRNA. Translation: CAB51918.2 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.25.10.20. 1 hit.
    2.20.50.20. 2 hits.
    2.20.80.10. 1 hit.
    2.30.230.10. 1 hit.
    InterProi IPR015819. Lipid_transp_b-sht_shell.
    IPR001747. Lipid_transpt_N.
    IPR009454. Lipid_transpt_open_b-sht.
    IPR015816. Vitellinogen_b-sht_N.
    IPR015255. Vitellinogen_open_b-sht.
    IPR015817. Vitellinogen_open_b-sht_sub1.
    IPR015818. Vitellinogen_open_b-sht_sub2.
    IPR011030. Vitellinogen_superhlx.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF06448. DUF1081. 1 hit.
    PF09172. DUF1943. 1 hit.
    PF01347. Vitellogenin_N. 1 hit.
    PF00094. VWD. 1 hit.
    [Graphical view ]
    SMARTi SM00638. LPD_N. 1 hit.
    SM00216. VWD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48431. SSF48431. 1 hit.
    SSF56968. SSF56968. 3 hits.
    PROSITEi PS51211. VITELLOGENIN. 1 hit.
    PS51233. VWFD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization and gene expression in the eye of the apolipophorin II/I precursor from Locusta migratoria."
      Bogerd J., Babin P.J., Kooiman F.P., Andre M., Ballagny C., van Marrewijk W.J., van der Horst D.J.
      J. Comp. Neurol. 427:546-558(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-33; 100-117; 204-228; 637-645; 668-682; 721-737; 1299-1308; 1489-1498 AND 2232-2242, TISSUE SPECIFICITY.
      Tissue: Fat body.
    2. Bogerd J.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 131; 140; 156; 189; 412-413; 494; 1087; 1103; 1559; 1646-1650; 2614; 2736; 2764; 2888; 3263 AND 3302.
    3. "Biosynthesis and secretion of insect lipoprotein: involvement of furin in cleavage of the apoB homolog, apolipophorin-II/I."
      Smolenaars M.M.W., Kasperaitis M.A.M., Richardson P.E., Rodenburg K.W., Van der Horst D.J.
      J. Lipid Res. 46:412-421(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE BY FURIN, MUTAGENESIS OF ARG-717; LYS-719 AND ARG-720.

    Entry informationi

    Entry nameiAPLP_LOCMI
    AccessioniPrimary (citable) accession number: Q9U943
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3