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Q9U943

- APLP_LOCMI

UniProt

Q9U943 - APLP_LOCMI

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Protein

Apolipophorins

Gene
N/A
Organism
Locusta migratoria (Migratory locust)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Constitutes the major component of lipophorin, which mediates transport for various types of lipids in hemolymph. Acts by forming lipoprotein particles that bind lipoproteins and lipids. May be required for morphogens wingless (wg) and hedgehog (hh) function, possibly by acting as vehicles for the movement of wg and hh (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei720 – 7212Cleavage; by furin

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW
  2. lipid transporter activity Source: InterPro

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport, Wnt signaling pathway

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipophorins
Cleaved into the following 2 chains:
Alternative name(s):
Apolipophorin II
apoLp-2
Alternative name(s):
Apolipophorin I
apoLp-1
OrganismiLocusta migratoria (Migratory locust)
Taxonomic identifieri7004 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaOrthopteraCaeliferaAcridomorphaAcridoideaAcrididaeOedipodinaeLocusta

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi717 – 7171R → D: Abolishes cleavage by furin. 1 Publication
Mutagenesisi717 – 7171R → Q: Partially affects cleavage by furin. 1 Publication
Mutagenesisi719 – 7191K → A: Does not affect cleavage by furin. 1 Publication
Mutagenesisi720 – 7201R → Q: Abolishes cleavage by furin. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 720699Apolipophorin-2PRO_0000041528Add
BLAST
Chaini721 – 33802660Apolipophorin-1PRO_0000041529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi649 – 6491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi969 – 9691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2174 – 21741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2851 – 28511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3177 – 31771N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Cleaved into 2 chains by furin protease. However, prevention of cleavage does not impair its function.1 Publication
N-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Expressioni

Tissue specificityi

Present in brain, hemolymph, fat body and eyes.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 646607VitellogeninPROSITE-ProRule annotationAdd
BLAST
Domaini2816 – 3012197VWFDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 vitellogenin domain.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR009454. Lipid_transpt_open_b-sht.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF06448. DUF1081. 1 hit.
PF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 3 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9U943-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGTPPHIWFL LILAISSGGL SAAVGGCNHQ CTPQSSVFQY QKGQTYTYSF
60 70 80 90 100
EGTTLTSLPG TQGEPVRLKL KATADLSVAD DCNKVLRLRG VTVSGPDSKN
110 120 130 140 150
YANLKDLEAH PVLANFKGSS INKQLCSEDG DNQSSLNIKR AILSLLQTPN
160 170 180 190 200
TKSSTASEVD VFGICPTNVR HSQRGDVTVI SKTRNLNRYA SRENLIQETL
210 220 230 240 250
STRFTGQSDL HATPFLDADL HVEQQIKGGL IVSATSRESY LFRPFSNQGN
260 270 280 290 300
GAKTIVETKL TLTSQNAQPA PPLASFTVPK SIVFEAPHAL ASVPGGSSAI
310 320 330 340 350
TAALHAAESS TKDGVTVDAA EKFRTLVSVL RQSSTTDILK VYNDVKAGAG
360 370 380 390 400
FSNKHSARNL LLDALFRTST GDAVEVIARL LKTKEITANH WYLSLAFIQH
410 420 430 440 450
ASLKSVVSIS SLLDQKNLPT EAFLGIGSFI GRYCREHNCE NVAEFDEVLN
460 470 480 490 500
KFSKHLSGST TSKAGENRAI AALKALGNIR HLNNALGEKV KQLALDKSLP
510 520 530 540 550
PRVRVAALEV IQSDPCRKNI KQAALQILRD QVEDSELRIK AYLAVVECPC
560 570 580 590 600
DNVVKTISNL LENEPIIQVG SFVVSHLKNL QASTDPSKAE AKEKLGQLKP
610 620 630 640 650
KKIFSSDIRK YSQNYELSYA IDAINAGASV ESNVIFSQSS YLPRSVSLNL
660 670 680 690 700
TADVFGHSYN VFEIAARTEN LDHIIESFLG PKGYIETEDD DKFVDEVEEK
710 720 730 740 750
TKSLYNRITE RFEKTFRQKR SVSKDAVDNI RQQAYKSLLP SQRDRSLDVD
760 770 780 790 800
LSLKTFGSEL AWFNYDGKHE QKSSERVVDE IFDAIDEGLK KSKKFNYDFE
810 820 830 840 850
PHFTFLDSEL SYPTNLGFPL KLAIDGSIAA RLKLNGEVDV RSILRQPENA
860 870 880 890 900
AFRLEFVPSA AVELTGKLLV DAYVVEGGLK LDYNVHSSTG INVAVHNLND
910 920 930 940 950
LGIDIKVGLP VKKQDIIDVK TDVLTTVKER GHPETSTPLH FNLKGNDYKQ
960 970 980 990 1000
YRGCFDQLSP VSGLTFCGNV SVPWVSPTQA AAFYPLNGPS HLSVSIEADD
1010 1020 1030 1040 1050
VSEYHFRAEI KKDESAFKSA AVLFDTPGSS ADRKVLLLVE KKEKPHQGIT
1060 1070 1080 1090 1100
AHLKSGWKEI VAEGLLIDDN NEKSVSAKLV IESDEYSIKG GVKISGNPSR
1110 1120 1130 1140 1150
QVYKPILEYK APAKDSGAKV KKSHKTSEGI TVDGAVVVER TSDKGKYTFQ
1160 1170 1180 1190 1200
DLSLKTPKGT FVINGQLDIV PRNYAFDLKL SVDKNELLLN GHLNYAEPKS
1210 1220 1230 1240 1250
IDVALEVTSP QFPDYGSGFQ LINKRGDDYS DTKIILACGR DLKSDGSRLI
1260 1270 1280 1290 1300
LEHFIKGKYE TPDTFNLETK GEVLGTGHKI FGKFDIDSKP KHLEYDLKLG
1310 1320 1330 1340 1350
FDENEVTSDL VAKRDIKSPD DYELKFSAKI LDNSIRIESS REVKPKDDSA
1360 1370 1380 1390 1400
FLNTLVVLSG KKYEFQVDVK LAAEDEYHTS LKAESNLKIE GKTSVRLITD
1410 1420 1430 1440 1450
FTTDAQTVNG HVKVSNEGED FFELIYKLNR GSGNPSGNAK LFVKNYLDGA
1460 1470 1480 1490 1500
ATFKYNNGVG SGTLQIDVLK LHRKIKATGD LTLSGSQRSA AIDLYWDADR
1510 1520 1530 1540 1550
DQSKQLLFKT ENDVKEKSID SKNTLKILDK LTTLNFKGSL SGAIDDGEVE
1560 1570 1580 1590 1600
GQGELILPVG TYLGVKFGRA LHLTQADTKV GLHLQAEGRE SASSTQPVWK
1610 1620 1630 1640 1650
SDFLLESALT RDSFVGEAKL LFETKGKDDL KLFLSGKSLP QGEKKLISGQ
1660 1670 1680 1690 1700
FSGQGSLIGG RTSVIKLNSE IDETFIAYNL NSECNQGYRA NIVGKINRGY
1710 1720 1730 1740 1750
SPVAVKQIEN TLELLLPFDK LKQLKHTIIG TFSSQPESTP EFTVSNVIIW
1760 1770 1780 1790 1800
NNENTLKLTG EAAGDEKEGR TKWDLILPKE EPRTLETTWS NAGDNKKAGS
1810 1820 1830 1840 1850
LSFKWGGNKE AKVSTDIEFT SDNQPQILHL KATSPTEKFG IFDLALSLKK
1860 1870 1880 1890 1900
NADPADKIDF ELTVTADQKK TDVKGSLGLA PGVPIIDVVA VQPSGTSKVF
1910 1920 1930 1940 1950
VDFLRKSDSE LHGAIELQWV AFGGGHLTAN GDIKLDIDDF YLKLDVDSPK
1960 1970 1980 1990 2000
FNFNKWHLEA GQRAAKGSKR IVFTAKSAEK VLFSGSTNFH SKAENNKISY
2010 2020 2030 2040 2050
SGNGQVRIGD KAHAFNFRSS RQNLIQDANK EIGVEYNLDF KIAGHGSLHN
2060 2070 2080 2090 2100
ILKVTNKELH ALGKQCSEGK PNCAVVEIKS KVSAADAKET THDLVFLVDL
2110 2120 2130 2140 2150
KSVGVDTGVA FTAETVRRGF WLIDEQASLT LSHNGETTYK YKGYLKESGS
2160 2170 2180 2190 2200
GFTLTLPSRV IAAEVKLSSD VKPNHSKQQI SASVWLDKTR LPNSFSSVSI
2210 2220 2230 2240 2250
LLEEIEDKNT DKYVSQLRFT HPNLEKDLTV KGYVQIGLEN KLFDSNLEID
2260 2270 2280 2290 2300
IFKQKNQKIS ISSTVVEQKQ NDVVKYLSTL DVKSKGHELD VTGRGEATVK
2310 2320 2330 2340 2350
PSLIALQSVL KYKKDKRIKE FKNFQFEVST EKLLVHVKVP NHHLLHIDAN
2360 2370 2380 2390 2400
TKINDKHASG DASVHIIGLP TSVIHIEGEN KGFPVVKGTI SSEGTPNKLE
2410 2420 2430 2440 2450
LIADLSDGLL VEADFISESG KKELFYTFLS GKKDSRKPEF RWSVENIQSA
2460 2470 2480 2490 2500
LEPHKNDIQE VLNKLKEISD EAGNEITKES SRLADSLKAG LPNFRRFVNT
2510 2520 2530 2540 2550
YETQLKALKE EIANDKVLKE ISENWKEVIG DAAEVVSTLV NGILVTIDAL
2560 2570 2580 2590 2600
LKTLNELAES VLDALKKSLP ALKDSYKQAV DAIVGIAKSL TQSLVNILSS
2610 2620 2630 2640 2650
AAEILKKHEA DIKEYLSVLA DLANDVGKFV TKITGVIYEG VVEFSKPIKE
2660 2670 2680 2690 2700
KLDGLKFGVA IEFGKVVEQL QNLIVPQELL AFAQEIVSEL KETTLTPEIQ
2710 2720 2730 2740 2750
DLLQAIEKYL EKVSKKKDAD VEKELKLIFE KAIDAVESVI NFVVSEITGG
2760 2770 2780 2790 2800
DHTKDLYDIN IPTVLPSFIQ LPRVFSVRFS PLIYLVSNGV PCLSDLLASY
2810 2820 2830 2840 2850
RPSLRFDNII PPYDATAILL NSHHFFTFDR RHLTFKGICS YILAQDVQDG
2860 2870 2880 2890 2900
NFTIIANIEG GSLKSIIVSD QATTFELASD KSLLVNGRPT EYPADEGEFH
2910 2920 2930 2940 2950
AWREYNRVGI QTKAGVKVTC ETSIELCTFE INGFYFGKTR GLLGTINNEP
2960 2970 2980 2990 3000
WDDFTKPDGQ VASKANEFGN AWKVDAQCAN VDGVDHHEHS IKVEECEEVF
3010 3020 3030 3040 3050
SKASLLSPCS LFLDPAPYLE ACSHIAHEAT TKEEKQLAAC RTAAAYVQAC
3060 3070 3080 3090 3100
SVENVFVSVP PHCVHCSVNG DAAIDIGQSF SVKVPQKSAD ILIVLEQVTG
3110 3120 3130 3140 3150
NAETVKDFVS PIVSQLTQEL SSRGISDVWI SLLGYGAPGQ EYPHLYTSSG
3160 3170 3180 3190 3200
GKLSYDGKQK NIQFGERKVL GPFPFDNFTE SIDWLDEFTD QAFHLITTAD
3210 3220 3230 3240 3250
TILDYPFRPG AAKSIIYVLD TSCETTLFLK HLPVKALKLK DAIGSPGIVL
3260 3270 3280 3290 3300
HLVTNVDSVQ SKNIVGFDTN HAYYNQEGKK RVVSEVTGNE KAALKISETA
3310 3320 3330 3340 3350
CGQIALATSG TVFNKNNLKQ TKKFVAQHIA DSLTNVELTQ DCKCLPVEGI
3360 3370 3380
HTRAVCAVTG AREKEHLSVK GVKGTKGVKG
Length:3,380
Mass (Da):371,809
Last modified:July 10, 2007 - v2
Checksum:i62526A263A041111
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130944 mRNA. Translation: CAB51918.2.

Cross-referencesi

Web resourcesi

Protein Spotlight

Lipid freight - Issue 59 of June 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130944 mRNA. Translation: CAB51918.2 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProi IPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR009454. Lipid_transpt_open_b-sht.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF06448. DUF1081. 1 hit.
PF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view ]
SMARTi SM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view ]
SUPFAMi SSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 3 hits.
PROSITEi PS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization and gene expression in the eye of the apolipophorin II/I precursor from Locusta migratoria."
    Bogerd J., Babin P.J., Kooiman F.P., Andre M., Ballagny C., van Marrewijk W.J., van der Horst D.J.
    J. Comp. Neurol. 427:546-558(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-33; 100-117; 204-228; 637-645; 668-682; 721-737; 1299-1308; 1489-1498 AND 2232-2242, TISSUE SPECIFICITY.
    Tissue: Fat body.
  2. Bogerd J.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 131; 140; 156; 189; 412-413; 494; 1087; 1103; 1559; 1646-1650; 2614; 2736; 2764; 2888; 3263 AND 3302.
  3. "Biosynthesis and secretion of insect lipoprotein: involvement of furin in cleavage of the apoB homolog, apolipophorin-II/I."
    Smolenaars M.M.W., Kasperaitis M.A.M., Richardson P.E., Rodenburg K.W., Van der Horst D.J.
    J. Lipid Res. 46:412-421(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE BY FURIN, MUTAGENESIS OF ARG-717; LYS-719 AND ARG-720.

Entry informationi

Entry nameiAPLP_LOCMI
AccessioniPrimary (citable) accession number: Q9U943
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3