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Reviewed, UniProtKB/Swiss-Prot Q9U8S9 (ADH_DROPU)

Last modified June 16, 2009. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase
    EC=1.1.1.1
Gene names
Name: Adh
OrganismDrosophila paulistorum (Fruit fly)
Taxonomic identifier46793 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

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Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processalcohol catabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionalcohol dehydrogenase activity

Inferred from sequence or structural similarity. Source: UniProtKB

binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Alcohol dehydrogenase
PRO_0000054492

Regions

Nucleotide binding9 – 3224NAD By similarity UniProtKB Q05114

Sites

Active site1511Proton acceptor By similarity UniProtKB Q05114
Binding site1381Substrate By similarity

Experimental info

Sequence conflict411N → K in AAF72720. Ref.3
Sequence conflict451I → M in AAF72720. Ref.3
Sequence conflict561T → I in AAF72720. Ref.3
Sequence conflict1131N → K in AAF72720. Ref.3
Sequence conflict1321V → I in AAF72720. Ref.3
Sequence conflict1451I → M in AAF72720. Ref.3
Sequence conflict2421E → G in BAA85831. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q9U8S9-1 [UniParc].

Last modified March 15, 2004. Version 2.
Checksum: C20FDF95E89D6E16

FASTA25427,620
        10         20         30         40         50         60 
MALTNKNIIF VAGLGGIGLD TSRELVKRDL KNLVILDRID NPAAIAELKA INPKVTVTFY 

        70         80         90        100        110        120 
PYDVTTPLTE TTKLLKTIFA QLKTVDVLIN GAGILDDHQI ERTIAVNFTG LVNTTTAILD 

       130        140        150        160        170        180 
FWDKRKGGPG GVICNIGSVT GFNAIYQVPV YSASKAAVVS FTQSIAKLAN VTGVTAFTVN 

       190        200        210        220        230        240 
PGITKTTLVH KFNSWLDVET RVAEKLLEHP TQTTLACAQN FVKAIELNKN GAIWKLDLGT 

       250 
LEPIEWTKHW DSGI

« Hide

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References

[1]"A molecular phylogeny of the Drosophila willistoni group: conflicts between species concepts?"
Gleason J.M., Griffith E.C., Powell J.R.
Evolution 52:1093-1103(1998) [Agricola: IND21806050]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 0771.4, Andean-Brazilian and Tame.
[2]"Phylogenetic position of the subgenus Lordiphosa of the genus Drosophila (Diptera: Drosophilidae) inferred from alcohol dehydrogenase (Adh) gene sequences."
Katoh T., Tamura K., Aotsuka T.
J. Mol. Evol. 51:122-130(2000) [PubMed: 10948268] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-248.
[3]"Phylogenetic relationships of flies in family Drosophilidae inferred by combined analysis of morphological and molecular characters."
O'Grady P.M.
Thesis (2000), University of Arizona / Tucson, United States
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-166.

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Cross-references

Sequence databases

U95270 Genomic DNA. Translation: AAD00796.1.
U95271 Genomic DNA. Translation: AAD00797.1.
U95272 Genomic DNA. Translation: AAD00798.1.
AB026529 Genomic DNA. Translation: BAA85831.1.
AF264078 Genomic DNA. Translation: AAF72720.1.

3D structure databases

HSSPHSSP built from PDB template 1B16 based on UniProtKB P10807.
SMRQ9U8S9. Positions 3-254.
ModBaseSearch...

Organism-specific databases

FlyBaseFBgn0016290. Dpau\Adh.

Enzyme and pathway databases

BRENDA1.1.1.1. 301113.

Family and domain databases

InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002425. Insect_ADH.
IPR002424. Insect_AlcDH_fam.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR19410. ADH_short_C2. 1 hit.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADH_DROPU
AccessionPrimary (citable) accession number: Q9U8S9
Secondary accession number(s): Q9NG38
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 15, 2004
Last modified: June 16, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents