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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila paulistorum (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotationCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 32NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
OrganismiDrosophila paulistorum (Fruit fly)Imported
Taxonomic identifieri46793 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0016290. Dpau\Adh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000544921 – 254Alcohol dehydrogenaseAdd BLAST254

Interactioni

Subunit structurei

Homodimer.Curated

Structurei

3D structure databases

ProteinModelPortaliQ9U8S9.
SMRiQ9U8S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotationCurated

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9U8S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTNKNIIF VAGLGGIGLD TSRELVKRDL KNLVILDRID NPAAIAELKA
60 70 80 90 100
INPKVTVTFY PYDVTTPLTE TTKLLKTIFA QLKTVDVLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNFTG LVNTTTAILD FWDKRKGGPG GVICNIGSVT GFNAIYQVPV
160 170 180 190 200
YSASKAAVVS FTQSIAKLAN VTGVTAFTVN PGITKTTLVH KFNSWLDVET
210 220 230 240 250
RVAEKLLEHP TQTTLACAQN FVKAIELNKN GAIWKLDLGT LEPIEWTKHW

DSGI
Length:254
Mass (Da):27,620
Last modified:March 15, 2004 - v2
Checksum:iC20FDF95E89D6E16
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41N → K in AAF72720 (Ref. 3) Curated1
Sequence conflicti45I → M in AAF72720 (Ref. 3) Curated1
Sequence conflicti56T → I in AAF72720 (Ref. 3) Curated1
Sequence conflicti113N → K in AAF72720 (Ref. 3) Curated1
Sequence conflicti132V → I in AAF72720 (Ref. 3) Curated1
Sequence conflicti145I → M in AAF72720 (Ref. 3) Curated1
Sequence conflicti242E → G in BAA85831 (PubMed:10948268).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95270 Genomic DNA. Translation: AAD00796.1.
U95271 Genomic DNA. Translation: AAD00797.1.
U95272 Genomic DNA. Translation: AAD00798.1.
AB026529 Genomic DNA. Translation: BAA85831.1.
AF264078 Genomic DNA. Translation: AAF72720.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95270 Genomic DNA. Translation: AAD00796.1.
U95271 Genomic DNA. Translation: AAD00797.1.
U95272 Genomic DNA. Translation: AAD00798.1.
AB026529 Genomic DNA. Translation: BAA85831.1.
AF264078 Genomic DNA. Translation: AAF72720.1.

3D structure databases

ProteinModelPortaliQ9U8S9.
SMRiQ9U8S9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0016290. Dpau\Adh.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROPU
AccessioniPrimary (citable) accession number: Q9U8S9
Secondary accession number(s): Q9NG38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 15, 2004
Last modified: April 12, 2017
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.