Reviewed, UniProtKB/Swiss-Prot Q9U8R2 (AGH_ARMVU)

Names and origin

Protein names	Recommended name:     Androgenic gland hormone Alternative name(s):     Arv-AGH Cleaved into the following 2 chains:     1- Recommended name:             Androgenic gland hormone B chain     2- Recommended name:             Androgenic gland hormone A chain
Organism	Armadillidium vulgare (Woodlice) (Pillbugs)
Taxonomic identifier	13347 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Crustacea › Malacostraca › Eumalacostraca › Peracarida › Isopoda › Oniscidea › Crinocheta › Armadillidiidae › Armadillidium

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Controls sex differentiation and the formation of male appendages, spermatogenesis, pigmentation, and male specific behavior.
Subcellular location	Secreted.
Tissue specificity	Androgenic gland.

Ontologies

Keywords
Biological process	Differentiation Sexual differentiation Spermatogenesis
Cellular component	Secreted
Domain	Signal
Molecular function	Developmental protein Hormone
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW sex differentiation Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21
	Peptide	22 – 65	44	Androgenic gland hormone B chain		PRO_0000020644
	Propeptide	68 – 113	46	C peptide		PRO_0000020645
	Peptide	116 – 144	29	Androgenic gland hormone A chain		PRO_0000020646
Amino acid modifications
	Glycosylation	133	1	N-linked (GlcNAc...) (complex) Ref.2		CAR_000163
	Disulfide bond	33 ↔ 123		Or C-33 with C-124
	Disulfide bond	42 ↔ 59		Or C-44 with C-59
	Disulfide bond	44 ↔ 141		Or C-42 with C-141
	Disulfide bond	124 ↔ 132		Or C-123 with C-132

Sequences

	Sequence		Length	Mass (Da)
	Q9U8R2-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: ED1541134628500B	FASTA	144	16,893
	10 20 30 40 50 60 MKGLVILVSL MCLALYNRIC AYQVRGMRSD VLCGDIRFTV QCICNELGYF PTERLDKPCP 70 80 90 100 110 120 WPNREKRSAP EDELAFEDYE DQDYFHPRAL SIPSEIEHDN EKESDAFSIL SRGKREIAFY 130 140 QECCNIRTEH KCNRTTVSLY CRTY

References

[1]	"Characterization and cDNA cloning of androgenic gland hormone of the terrestrial isopod Armadillidium vulgare." Okuno A., Hasegawa Y., Ohira T., Katakura Y., Nagasawa H. Biochem. Biophys. Res. Commun. 264:419-423(1999) [PubMed: 10529379] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Androgenic gland.
[2]	"The structure of a glycosylated protein hormone responsible for sex determination in the isopod, Armadillidium vulgare." Martin G., Sorokine O., Moniatte M., Bulet P., Hetru C., van Dorsselaer A. Eur. J. Biochem. 262:727-736(1999) [PubMed: 10411634] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION AT ASN-133. Tissue: Androgenic gland.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB029615 mRNA. Translation: BAA86893.1.
PIR	JC7121.
3D structure databases
ModBase	Search...
PTM databases
GlycoSuiteDB	Q9U8R2.
Family and domain databases
InterPro	IPR020382. Androgenic_gland_hormone_art. IPR016179. Insulin-like. [Graphical view]
ProDom	PD299589. Androgenic_gland_hormone_art. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00078. IlGF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AGH_ARMVU

Accession

Primary (citable) accession number: Q9U8R2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 2000
Last modified:	November 24, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)