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Protein
Submitted name:

Proteasome activator protein PA26

Gene
N/A
Organism
Trypanosoma brucei
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • proteolysis Source: GeneDB
  • regulation of proteasomal protein catabolic process Source: GeneDB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Proteasome activator protein PA26Imported
OrganismiTrypanosoma bruceiImported
Taxonomic identifieri5691 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

GO - Cellular componenti

  • proteasome activator complex Source: GeneDB
Complete GO annotation...

Keywords - Cellular componenti

ProteasomeImported

PTM / Processingi

Proteomic databases

PaxDbiQ9U8G2.

Interactioni

Protein-protein interaction databases

IntActiQ9U8G2. 1 interaction.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FNTX-ray3.20c/d/e/f/g/h/i/j/k/l/m/n/o/p1-231[»]
1YA7X-ray2.30O/P/Q/R/S/T/U2-231[»]
1YARX-ray1.90O/P/Q/R/S/T/U2-231[»]
1YAUX-ray2.40O/P/Q/R/S/T/U2-231[»]
1Z7QX-ray3.22c/d/e/f/g/h/i/j/k/l/m/n/o/p1-231[»]
3JRMX-ray2.90O/P/Q/R/S/T/U4-231[»]
3JSEX-ray2.90O/P/Q/R/S/T/U4-231[»]
3JTLX-ray3.20O/P/Q/R/S/T/U4-231[»]
ProteinModelPortaliQ9U8G2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9U8G2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 12260PA28_betaInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG410K3XE. Eukaryota.
ENOG4110DTQ. LUCA.

Family and domain databases

Gene3Di1.20.120.180. 1 hit.
InterProiIPR009077. Proteasome_activ_pa28.
IPR003186. Proteasome_activ_pa28_C.
[Graphical view]
PfamiPF02252. PA28_beta. 1 hit.
[Graphical view]
SUPFAMiSSF47216. SSF47216. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9U8G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKRAALIQ NLRDSYTETS SFAVIEEWAA GTLQEIEGIA KAAAEAHGTI
60 70 80 90 100
RNSTYGRAQA EKSPEQLLGV LQRYQDLCHN VYCQAETIRT VIAIRIPEHK
110 120 130 140 150
EEDNLGVAVQ HAVLKIIDEL EIKTLGSGEK SGSGGAPTPI GMYALREYLS
160 170 180 190 200
ARSTVEDKLL GSVDAESGKT KGGSQSPSLL LELRQIDADF MLKVELATTH
210 220 230
LSTMVRAVIN AYLLNWKKLI QPRTGSDHMV S
Length:231
Mass (Da):25,230
Last modified:May 1, 2000 - v1
Checksum:i25FBF3F53DC6BE96
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei231 – 2311Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085602 mRNA. Translation: AAD50581.1.

Genome annotation databases

GeneDBiTb927.10.3710:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085602 mRNA. Translation: AAD50581.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FNTX-ray3.20c/d/e/f/g/h/i/j/k/l/m/n/o/p1-231[»]
1YA7X-ray2.30O/P/Q/R/S/T/U2-231[»]
1YARX-ray1.90O/P/Q/R/S/T/U2-231[»]
1YAUX-ray2.40O/P/Q/R/S/T/U2-231[»]
1Z7QX-ray3.22c/d/e/f/g/h/i/j/k/l/m/n/o/p1-231[»]
3JRMX-ray2.90O/P/Q/R/S/T/U4-231[»]
3JSEX-ray2.90O/P/Q/R/S/T/U4-231[»]
3JTLX-ray3.20O/P/Q/R/S/T/U4-231[»]
ProteinModelPortaliQ9U8G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9U8G2. 1 interaction.

Proteomic databases

PaxDbiQ9U8G2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiTb927.10.3710:pep.

Phylogenomic databases

eggNOGiENOG410K3XE. Eukaryota.
ENOG4110DTQ. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ9U8G2.

Family and domain databases

Gene3Di1.20.120.180. 1 hit.
InterProiIPR009077. Proteasome_activ_pa28.
IPR003186. Proteasome_activ_pa28_C.
[Graphical view]
PfamiPF02252. PA28_beta. 1 hit.
[Graphical view]
SUPFAMiSSF47216. SSF47216. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Structural and functional characterizations of the proteasome-activating protein PA26 from Trypanosoma brucei."
    Yao Y., Huang L., Krutchinsky A., Wong M.L., Standing K.G., Burlingame A.L., Wang C.C.
    J. Biol. Chem. 274:33921-33930(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: bruceiImported.
  2. "Structural basis for the activation of 20S proteasomes by 11S regulators."
    Whitby F.G., Masters E.I., Kramer L., Knowlton J.R., Yao Y., Wang C.C., Hill C.P.
    Nature 408:115-120(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS).
  3. "The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions."
    Forster A., Masters E.I., Whitby F.G., Robinson H., Hill C.P.
    Mol. Cell 18:589-599(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 2-231.
  4. "Structural models for interactions between the 20S proteasome and its PAN/19S activators."
    Stadtmueller B.M., Ferrell K., Whitby F.G., Heroux A., Robinson H., Myszka D.G., Hill C.P.
    J. Biol. Chem. 285:13-17(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 4-231.

Entry informationi

Entry nameiQ9U8G2_9TRYP
AccessioniPrimary (citable) accession number: Q9U8G2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 13, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.