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Protein

Cysteine dioxygenase

Gene

CDO

Organism
Schistosoma japonicum (Blood fluke)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Pathwayi: taurine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes hypotaurine from L-cysteine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Cysteine dioxygenase (CDO)
  2. no protein annotated in this organism
This subpathway is part of the pathway taurine biosynthesis, which is itself part of Organosulfur biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes hypotaurine from L-cysteine, the pathway taurine biosynthesis and in Organosulfur biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi95Iron; via tele nitrogen; catalyticBy similarity1
Metal bindingi97Iron; via tele nitrogen; catalyticBy similarity1
Metal bindingi161Iron; via tele nitrogen; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00012; UER00537

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine dioxygenase (EC:1.13.11.20)
Short name:
CDO
Gene namesi
Name:CDO
OrganismiSchistosoma japonicum (Blood fluke)
Taxonomic identifieri6182 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066131 – 212Cysteine dioxygenaseAdd BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki102 ↔ 1783'-(S-cysteinyl)-tyrosine (Cys-Tyr)By similarity

Post-translational modificationi

The thioether cross-link between Cys-102 and Tyr-178 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.By similarity

Keywords - PTMi

Thioether bond

Proteomic databases

PRIDEiQ9U8F1

Structurei

3D structure databases

ProteinModelPortaliQ9U8F1
SMRiQ9U8F1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cysteine dioxygenase family.Curated

Family and domain databases

Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR010300 CDO_1
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR12918 PTHR12918, 1 hit
PfamiView protein in Pfam
PF05995 CDO_I, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

Sequencei

Sequence statusi: Complete.

Q9U8F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMYTHQSNN ELIPLKTVST LNDLIKTIRI IFNQKEINVN EIHKILNDFQ
60 70 80 90 100
CDFTEWQKYI YFNKTHYTRN LIDEGNGRYN LFLLCWSEDQ GTRIHDHSGA
110 120 130 140 150
HCFVKLIKGC IKETIFEWPK YFTVEKSNYS INQIDLPLTV KSVSEMRPGD
160 170 180 190 200
VTYMHDKIGI HRLHNPSTTE TAITLHLYFP PYTNSMIFEE STSRMKKMDV
210
TFHSKFGKQI PQ
Length:212
Mass (Da):25,035
Last modified:May 1, 2000 - v1
Checksum:i39BE01713721F46C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091540 mRNA Translation: AAD52701.1

Similar proteinsi

Entry informationi

Entry nameiCDO_SCHJA
AccessioniPrimary (citable) accession number: Q9U8F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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