Q9U8F1 (CDO_SCHJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteine dioxygenase
Short name=CDO
EC=1.13.11.20

Gene names

Name:

CDO

Organism

Schistosoma japonicum (Blood fluke)

Taxonomic identifier

6182 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Platyhelminthes › Trematoda › Digenea › Strigeidida › Schistosomatoidea › Schistosomatidae › Schistosoma

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-cysteine + O2 = 3-sulfinoalanine.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Post-translational modification	The thioether cross-link between Cys-102 and Tyr-178 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.
Sequence similarities	Belongs to the cysteine dioxygenase family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
PTM	Thioether bond
Gene Ontology (GO)
Biological_process	L-cysteine metabolic process Inferred from electronic annotation. Source: InterPro taurine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	cysteine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Cysteine dioxygenase		PRO_0000206613
Sites
	Metal binding	95	1	Iron; catalytic By similarity
	Metal binding	97	1	Iron; catalytic By similarity
	Metal binding	161	1	Iron; catalytic By similarity
Amino acid modifications
	Cross-link	102 ↔ 178		3'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9U8F1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 39BE01713721F46C	FASTA	212	25,035
	10 20 30 40 50 60 MSMYTHQSNN ELIPLKTVST LNDLIKTIRI IFNQKEINVN EIHKILNDFQ CDFTEWQKYI 70 80 90 100 110 120 YFNKTHYTRN LIDEGNGRYN LFLLCWSEDQ GTRIHDHSGA HCFVKLIKGC IKETIFEWPK 130 140 150 160 170 180 YFTVEKSNYS INQIDLPLTV KSVSEMRPGD VTYMHDKIGI HRLHNPSTTE TAITLHLYFP 190 200 210 PYTNSMIFEE STSRMKKMDV TFHSKFGKQI PQ

References

[1]	"Cloning and expression in Escherichia coli of a cysteine dioxygenase from Schistosoma japonicum." Fan J., Brindley P.J. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Philippines.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF091540 mRNA. Translation: AAD52701.1.
3D structure databases
ProteinModelPortal	Q9U8F1.
ModBase	Search...
Protein-protein interaction databases
STRING	6182.Q9U8F1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG126313.
Enzyme and pathway databases
UniPathway	UPA00012; UER00537.
Family and domain databases
Gene3D	2.60.120.10. 1 hit.
InterPro	IPR010300. Cys_dOase_I. IPR014710. RmlC-like_jellyroll. IPR011051. RmlC_Cupin. [Graphical view]
Pfam	PF05995. CDO_I. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDO_SCHJA

Accession

Primary (citable) accession number: Q9U8F1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)