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Q9U8F1 (CDO_SCHJA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine dioxygenase

Short name=CDO
EC=1.13.11.20
Gene names
Name:CDO
OrganismSchistosoma japonicum (Blood fluke)
Taxonomic identifier6182 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-cysteine + O2 = 3-sulfinoalanine.

Cofactor

Binds 1 iron ion per subunit By similarity.

Pathway

Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.

Post-translational modification

The thioether cross-link between Cys-102 and Tyr-178 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.

Sequence similarities

Belongs to the cysteine dioxygenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Cysteine dioxygenase
PRO_0000206613

Sites

Metal binding951Iron; catalytic By similarity
Metal binding971Iron; catalytic By similarity
Metal binding1611Iron; catalytic By similarity

Amino acid modifications

Cross-link102 ↔ 1783'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9U8F1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 39BE01713721F46C

FASTA21225,035
        10         20         30         40         50         60 
MSMYTHQSNN ELIPLKTVST LNDLIKTIRI IFNQKEINVN EIHKILNDFQ CDFTEWQKYI 

        70         80         90        100        110        120 
YFNKTHYTRN LIDEGNGRYN LFLLCWSEDQ GTRIHDHSGA HCFVKLIKGC IKETIFEWPK 

       130        140        150        160        170        180 
YFTVEKSNYS INQIDLPLTV KSVSEMRPGD VTYMHDKIGI HRLHNPSTTE TAITLHLYFP 

       190        200        210 
PYTNSMIFEE STSRMKKMDV TFHSKFGKQI PQ 

« Hide

References

[1]"Cloning and expression in Escherichia coli of a cysteine dioxygenase from Schistosoma japonicum."
Fan J., Brindley P.J.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Philippines.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF091540 mRNA. Translation: AAD52701.1.

3D structure databases

ProteinModelPortalQ9U8F1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6182.Q9U8F1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG126313.

Enzyme and pathway databases

UniPathwayUPA00012; UER00537.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCDO_SCHJA
AccessionPrimary (citable) accession number: Q9U8F1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 2000
Last modified: October 16, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways