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Q9U8F1

- CDO_SCHJA

UniProt

Q9U8F1 - CDO_SCHJA

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Protein
Cysteine dioxygenase
Gene
CDO
Organism
Schistosoma japonicum (Blood fluke)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.

Cofactori

Binds 1 iron ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi95 – 951Iron; catalytic By similarity
Metal bindingi97 – 971Iron; catalytic By similarity
Metal bindingi161 – 1611Iron; catalytic By similarity

GO - Molecular functioni

  1. cysteine dioxygenase activity Source: UniProtKB-EC
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. L-cysteine metabolic process Source: InterPro
  2. taurine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00012; UER00537.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine dioxygenase (EC:1.13.11.20)
Short name:
CDO
Gene namesi
Name:CDO
OrganismiSchistosoma japonicum (Blood fluke)
Taxonomic identifieri6182 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Cysteine dioxygenase
PRO_0000206613Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki102 ↔ 1783'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Post-translational modificationi

The thioether cross-link between Cys-102 and Tyr-178 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.

Keywords - PTMi

Thioether bond

Interactioni

Protein-protein interaction databases

STRINGi6182.Q9U8F1.

Structurei

3D structure databases

ProteinModelPortaliQ9U8F1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG126313.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9U8F1-1 [UniParc]FASTAAdd to Basket

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MSMYTHQSNN ELIPLKTVST LNDLIKTIRI IFNQKEINVN EIHKILNDFQ    50
CDFTEWQKYI YFNKTHYTRN LIDEGNGRYN LFLLCWSEDQ GTRIHDHSGA 100
HCFVKLIKGC IKETIFEWPK YFTVEKSNYS INQIDLPLTV KSVSEMRPGD 150
VTYMHDKIGI HRLHNPSTTE TAITLHLYFP PYTNSMIFEE STSRMKKMDV 200
TFHSKFGKQI PQ 212
Length:212
Mass (Da):25,035
Last modified:May 1, 2000 - v1
Checksum:i39BE01713721F46C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF091540 mRNA. Translation: AAD52701.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF091540 mRNA. Translation: AAD52701.1 .

3D structure databases

ProteinModelPortali Q9U8F1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6182.Q9U8F1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG126313.

Enzyme and pathway databases

UniPathwayi UPA00012 ; UER00537 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF05995. CDO_I. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression in Escherichia coli of a cysteine dioxygenase from Schistosoma japonicum."
    Fan J., Brindley P.J.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Philippines.

Entry informationi

Entry nameiCDO_SCHJA
AccessioniPrimary (citable) accession number: Q9U8F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 2000
Last modified: October 16, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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