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Protein
Submitted name:

Peroxisome targeting signal 1 receptor PEX5

Gene
N/A
Organism
Trypanosoma brucei
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome targeting signal 1 receptor PEX5Imported
OrganismiTrypanosoma bruceiImported
Taxonomic identifieri5691 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

PTM / Processingi

Proteomic databases

PaxDbiQ9U7C3.

Interactioni

Protein-protein interaction databases

STRINGi5691.AAZ11225.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HXIX-ray1.60A333-453[»]
3CVLX-ray2.15A332-655[»]
3CVNX-ray2.00A332-655[»]
ProteinModelPortaliQ9U7C3.
SMRiQ9U7C3. Positions 334-445.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9U7C3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini349 – 601253TPR_REGIONInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1125. Eukaryota.
ENOG410XQ6Q. LUCA.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 2 hits.
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U7C3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCGAGFALG QQLAKDALHM QGGVRPGTTG NVEQDALMTG MMVPPTGPME
60 70 80 90 100
DWAQHFAAHQ HHHQQHQQMM MQRQHNDALM IQQQHRDMEE AFRASARAGA
110 120 130 140 150
PQQANAGPLM MPPGPMMMAG GMAPMMHAGG FMMGGMPQMM PCAPMGMNMG
160 170 180 190 200
MAPVATMSPA TTNTVSGARE GATAVSSAAP GVVDLGGDSA WAEKLHQAEW
210 220 230 240 250
GQDYKDVEVH TVEGSTAQTV EEHAKTSKFY EFMDKIRKKE LLVDEDSGEV
260 270 280 290 300
VQGPGPDPDV EADTEYLARL AAMEGINVPP SVMDHMQGQD GVQRGTDEDM
310 320 330 340 350
EGMMGDDVYD PSADVEQWAQ EYAQMQAMQE RLQNNTDYPF EANNPYMYHE
360 370 380 390 400
NPMEEGLSML KLANLAEAAL AFEAVCQKEP EREEAWRSLG LTQAENEKDG
410 420 430 440 450
LAIIALNHAR MLDPKDIAVH AALAVSHTNE HNANAALASL RAWLLSQPQY
460 470 480 490 500
EQLGSVNLQA DVDIDDLNVQ SEDFFFAAPN EYRECRTLLH AALEMNPNDA
510 520 530 540 550
QLHASLGVLY NLSNNYDSAA ANLRRAVELR PDDAQLWNKL GATLANGNRP
560 570 580 590 600
QEALDAYNRA LDINPGYVRV MYNMAVSYSN MSQYDLAAKQ LVRAIYMQVG
610 620 630 640 650
GTTPTGEASR EATRSMWDFF RMLLNVMNRP DLVELTYAQN VEPFAKEFGL

QSMLL
Length:655
Mass (Da):72,066
Last modified:May 1, 2000 - v1
Checksum:i312676CD7F9F68FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142475 Genomic DNA. Translation: AAD54220.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142475 Genomic DNA. Translation: AAD54220.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HXIX-ray1.60A333-453[»]
3CVLX-ray2.15A332-655[»]
3CVNX-ray2.00A332-655[»]
ProteinModelPortaliQ9U7C3.
SMRiQ9U7C3. Positions 334-445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5691.AAZ11225.

Proteomic databases

PaxDbiQ9U7C3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1125. Eukaryota.
ENOG410XQ6Q. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ9U7C3.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 2 hits.
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and analysis of the PTS-1 receptor in Trypanosoma brucei."
    de Walque S., Kiel J.A.K.W., Veenhuis M., Opperdoes F.R., Michels P.A.M.
    Mol. Biochem. Parasitol. 104:107-119(1999)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 427Imported.
  2. "An unexpected extended conformation for the third TPR motif of the peroxin PEX5 from Trypanosoma brucei."
    Kumar A., Roach C., Hirsh I.S., Turley S., deWalque S., Michels P.A., Hol W.G.
    J. Mol. Biol. 307:271-282(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 333-453.
  3. "Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5."
    Sampathkumar P., Roach C., Michels P.A., Hol W.G.
    J. Mol. Biol. 381:867-880(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 332-655.

Entry informationi

Entry nameiQ9U7C3_9TRYP
AccessioniPrimary (citable) accession number: Q9U7C3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.