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Protein

NTF2-related export protein

Gene

nxt-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.

Names & Taxonomyi

Protein namesi
Recommended name:
NTF2-related export protein
Gene namesi
Name:nxt-1
Synonyms:nxt1
ORF Names:Y71F9AM.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY71F9AM.5a; CE26780; WBGene00003836; nxt-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001947971 – 137NTF2-related export proteinAdd BLAST137

Proteomic databases

EPDiQ9U757.
PaxDbiQ9U757.
PRIDEiQ9U757.

Expressioni

Gene expression databases

BgeeiWBGene00003836.
ExpressionAtlasiQ9U757. differential.

Interactioni

Subunit structurei

Preferentially binds Ran-GTP.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
nxf-2Q9XVS85EBI-2006451,EBI-2007577

Protein-protein interaction databases

BioGridi37344. 1 interactor.
IntActiQ9U757. 1 interactor.
STRINGi6239.Y71F9AM.5a.

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 33Combined sources28
Helixi35 – 41Combined sources7
Beta strandi42 – 50Combined sources9
Beta strandi53 – 57Combined sources5
Helixi58 – 67Combined sources10
Beta strandi71 – 82Combined sources12
Helixi89 – 91Combined sources3
Beta strandi95 – 105Combined sources11
Beta strandi111 – 122Combined sources12
Beta strandi125 – 135Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NV0X-ray1.84B2-137[»]
ProteinModelPortaliQ9U757.
SMRiQ9U757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 135NTF2PROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Contains 1 NTF2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4353. Eukaryota.
ENOG4111TWR. LUCA.
GeneTreeiENSGT00510000046494.
HOGENOMiHOG000272629.
InParanoidiQ9U757.
KOiK14285.
OMAiYYSTMDK.
OrthoDBiEOG091G0SMX.
PhylomeDBiQ9U757.

Family and domain databases

CDDicd00780. NTF2. 1 hit.
Gene3Di3.10.450.50. 1 hit.
InterProiIPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
[Graphical view]
PfamiPF02136. NTF2. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMKTTQEIN KEDEELCNES KKFMDVYYDV MDRKREKIGF LYTQVSNAVW
60 70 80 90 100
NGNPINGYDS ICEFMKALPS TQHDIQSLDA QRLPEGVTGD MSGGMLLNVA
110 120 130
GAVTVDGDSK RAFTQTLLLG VEDGKYKVKS DRFRYVD
Length:137
Mass (Da):15,479
Last modified:May 1, 2000 - v1
Checksum:iB99ABE3CA3479962
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156960 mRNA. Translation: AAD54945.1.
FO081820 Genomic DNA. Translation: CCD73516.1.
RefSeqiNP_491077.1. NM_058676.4.
UniGeneiCel.37564.

Genome annotation databases

EnsemblMetazoaiY71F9AM.5a; Y71F9AM.5a; WBGene00003836.
GeneIDi171866.
KEGGicel:CELE_Y71F9AM.5.
UCSCiY71F9AM.5b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156960 mRNA. Translation: AAD54945.1.
FO081820 Genomic DNA. Translation: CCD73516.1.
RefSeqiNP_491077.1. NM_058676.4.
UniGeneiCel.37564.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NV0X-ray1.84B2-137[»]
ProteinModelPortaliQ9U757.
SMRiQ9U757.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi37344. 1 interactor.
IntActiQ9U757. 1 interactor.
STRINGi6239.Y71F9AM.5a.

Proteomic databases

EPDiQ9U757.
PaxDbiQ9U757.
PRIDEiQ9U757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY71F9AM.5a; Y71F9AM.5a; WBGene00003836.
GeneIDi171866.
KEGGicel:CELE_Y71F9AM.5.
UCSCiY71F9AM.5b. c. elegans.

Organism-specific databases

CTDi171866.
WormBaseiY71F9AM.5a; CE26780; WBGene00003836; nxt-1.

Phylogenomic databases

eggNOGiKOG4353. Eukaryota.
ENOG4111TWR. LUCA.
GeneTreeiENSGT00510000046494.
HOGENOMiHOG000272629.
InParanoidiQ9U757.
KOiK14285.
OMAiYYSTMDK.
OrthoDBiEOG091G0SMX.
PhylomeDBiQ9U757.

Enzyme and pathway databases

ReactomeiR-CEL-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.

Miscellaneous databases

PROiQ9U757.

Gene expression databases

BgeeiWBGene00003836.
ExpressionAtlasiQ9U757. differential.

Family and domain databases

CDDicd00780. NTF2. 1 hit.
Gene3Di3.10.450.50. 1 hit.
InterProiIPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
[Graphical view]
PfamiPF02136. NTF2. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNXT1_CAEEL
AccessioniPrimary (citable) accession number: Q9U757
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.