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Protein

NTF2-related export protein

Gene

nxt-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript

Names & Taxonomyi

Protein namesi
Recommended name:
NTF2-related export protein
Gene namesi
Name:nxt-1
Synonyms:nxt1
ORF Names:Y71F9AM.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY71F9AM.5a ; CE26780 ; WBGene00003836 ; nxt-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001947971 – 137NTF2-related export proteinAdd BLAST137

Proteomic databases

EPDiQ9U757
PaxDbiQ9U757
PRIDEiQ9U757

Expressioni

Gene expression databases

BgeeiWBGene00003836
ExpressionAtlasiQ9U757 baseline and differential

Interactioni

Subunit structurei

Preferentially binds Ran-GTP.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
nxf-2Q9XVS85EBI-2006451,EBI-2007577

Protein-protein interaction databases

BioGridi37344, 1 interactor
IntActiQ9U757, 1 interactor
STRINGi6239.Y71F9AM.5a

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 33Combined sources28
Helixi35 – 41Combined sources7
Beta strandi42 – 50Combined sources9
Beta strandi53 – 57Combined sources5
Helixi58 – 67Combined sources10
Beta strandi71 – 82Combined sources12
Helixi89 – 91Combined sources3
Beta strandi95 – 105Combined sources11
Beta strandi111 – 122Combined sources12
Beta strandi125 – 135Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NV0X-ray1.84B2-137[»]
ProteinModelPortaliQ9U757
SMRiQ9U757
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 135NTF2PROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

eggNOGiKOG4353 Eukaryota
ENOG4111TWR LUCA
GeneTreeiENSGT00510000046494
HOGENOMiHOG000272629
InParanoidiQ9U757
KOiK14285
OMAiTHVDQAC
OrthoDBiEOG091G0SMX
PhylomeDBiQ9U757

Family and domain databases

CDDicd00780 NTF2, 1 hit
InterProiView protein in InterPro
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
PROSITEiView protein in PROSITE
PS50177 NTF2_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9U757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMKTTQEIN KEDEELCNES KKFMDVYYDV MDRKREKIGF LYTQVSNAVW
60 70 80 90 100
NGNPINGYDS ICEFMKALPS TQHDIQSLDA QRLPEGVTGD MSGGMLLNVA
110 120 130
GAVTVDGDSK RAFTQTLLLG VEDGKYKVKS DRFRYVD
Length:137
Mass (Da):15,479
Last modified:May 1, 2000 - v1
Checksum:iB99ABE3CA3479962
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156960 mRNA Translation: AAD54945.1
FO081820 Genomic DNA Translation: CCD73516.1
RefSeqiNP_491077.1, NM_058676.4
UniGeneiCel.37564

Genome annotation databases

EnsemblMetazoaiY71F9AM.5a; Y71F9AM.5a; WBGene00003836
GeneIDi171866
KEGGicel:CELE_Y71F9AM.5
UCSCiY71F9AM.5b c. elegans

Similar proteinsi

Entry informationi

Entry nameiNXT1_CAEEL
AccessioniPrimary (citable) accession number: Q9U757
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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