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Protein

Phospholipase A1

Gene
N/A
Organism
Polistes annularis (Paper wasp)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolysis of phosphatidylcholine with phospholipase A1 (EC 3.1.1.32) activity. Has weak hemolytic activity (By similarity).By similarity

Catalytic activityi

Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381NucleophileBy similarity
Active sitei166 – 1661Charge relay systemPROSITE-ProRule annotation
Active sitei227 – 2271Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cytolysis, Hemolysis, Lipid degradation, Lipid metabolism

Protein family/group databases

ESTHERipolan-pla1. Phospholipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A1 (EC:3.1.1.32)
Alternative name(s):
Allergen: Pol a 1
OrganismiPolistes annularis (Paper wasp)
Taxonomic identifieri27505 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaePolistiniPolistes

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE (By similarity).By similarity

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3430. Pol a 1.0101.
583. Pol a 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Phospholipase A1PRO_0000090376Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi5 ↔ 242By similarity
Disulfide bondi88 ↔ 225By similarity
Disulfide bondi177 ↔ 220By similarity
Disulfide bondi182 ↔ 262By similarity
Disulfide bondi237 ↔ 243By similarity
Disulfide bondi269 ↔ 294By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9U6W0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002334. Allerg_PlipaseA1.
IPR013818. Lipase_N.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSiPR00825. DOLALLERGEN.
PR00821. TAGLIPASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U6W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPDCTFNEK DIVFYVYSRD KRDGIILKKE TLTNYDLFTK STISKQVVFL
60 70 80 90 100
IHGFLSTGNN ENFVAMSKAL IEKDDFLVIS VDWKKGACNA FASTKDALGY
110 120 130 140 150
SKAVGNTRHV GKFVADFTKL LVEKYKVLIS NIRLIGHSLG AHTSGFAGKE
160 170 180 190 200
VQKLKLGKYK EIIGLDPAGP YFHRSDCPDR LCVTDAEYVQ VIHTSIILGV
210 220 230 240 250
YYNVGSVDFY VNYGKNQPGC NEPSCSHTKA VKYLTECIKH ECCLIGTPWK
260 270 280 290 300
KYFSTPKPIS QCRGDTCVCV GLNAKSYPAR GAFYAPVEAN APYCHNEGIK

L
Length:301
Mass (Da):33,484
Last modified:May 1, 2000 - v1
Checksum:i6A0B7DC76FDCC047
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174527 mRNA. Translation: AAD52615.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174527 mRNA. Translation: AAD52615.1.

3D structure databases

ProteinModelPortaliQ9U6W0.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3430. Pol a 1.0101.
583. Pol a 1.
ESTHERipolan-pla1. Phospholipase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002334. Allerg_PlipaseA1.
IPR013818. Lipase_N.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSiPR00825. DOLALLERGEN.
PR00821. TAGLIPASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPA1_POLAN
AccessioniPrimary (citable) accession number: Q9U6W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.