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Q9U6V9 (HUGA_POLAN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronidase

Short name=Hya
EC=3.2.1.35
Alternative name(s):
Hyaluronoglucosaminidase
Allergen=Pol a 2
OrganismPolistes annularis (Paper wasp)
Taxonomic identifier27505 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaePolistiniPolistes

Protein attributes

Sequence length367 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in reproduction By similarity.

Catalytic activity

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the glycosyl hydrolase 56 family.

Ontologies

Keywords
   DiseaseAllergen
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
Zymogen
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

defense response

Inferred from electronic annotation. Source: InterPro

   Molecular_functionhyalurononglucosaminidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide‹1 – ?
Propeptide? – 29PRO_0000012107
Chain30 – 367338Hyaluronidase
PRO_0000012108

Sites

Active site1381Proton donor By similarity

Amino acid modifications

Glycosylation1081N-linked (GlcNAc...) Potential
Glycosylation3541N-linked (GlcNAc...) Potential
Disulfide bond48 ↔ 337 By similarity
Disulfide bond214 ↔ 226 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q9U6V9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 8127056216957562

FASTA36743,020
        10         20         30         40         50         60 
YVSLSPDSVF NIITDDISHQ ILSRSNCERS KRPKRVFSIY WNVPTFMCHQ YGMNFDEVTD 

        70         80         90        100        110        120 
FNIKHNSKDN FRGETISIYY DPGKFPALMP LKNGNYEERN GGVPQRGNIT IHLQQFNEDL 

       130        140        150        160        170        180 
DKMTPDKNFG GIGVIDFERW KPIFRQNWGN TEIHKKYSIE LVRKEHPKWS ESMIEAEATK 

       190        200        210        220        230        240 
KFEKYARYFM EETLKLAKKT RKRAKWGYYG FPYCYNVTPN NPGPDCDAKA TIENDRLSWM 

       250        260        270        280        290        300 
YNNQEILFPS VYVRHEQKPE ERVYLVQGRI KEAVRISNNL EHSPSVLAYW WYVYQDKMDI 

       310        320        330        340        350        360 
YLSETDVEKT FQEIVTNGGD GIIIWGSSSD VNSLSKCKRL REYLLNTLGP FAVNVTETVN 


GRSSLNF 

« Hide

References

[1]King T.P., Lu G.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF174528 mRNA. Translation: AAD52616.1.

3D structure databases

ProteinModelPortalQ9U6V9.
SMRQ9U6V9. Positions 35-357.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3431. Pol a 2.0101.
584. Pol a 2.
CAZyGH56. Glycoside Hydrolase Family 56.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR001329. Venom_Hyaluronidase.
[Graphical view]
PANTHERPTHR11769. PTHR11769. 1 hit.
PfamPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PRINTSPR00846. GLHYDRLASE56.
PR00847. HYALURONDASE.
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHUGA_POLAN
AccessionPrimary (citable) accession number: Q9U6V9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: December 11, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Allergens

Nomenclature of allergens and list of entries