Reviewed, UniProtKB/Swiss-Prot Q9U6V9 (HUGA_POLAN)

Names and origin

Protein names	Recommended name:     Hyaluronidase       Short name=Hya     EC=3.2.1.35 Alternative name(s):     Hyaluronoglucosaminidase     Allergen=Pol a 2
Organism	Polistes annularis (Paper wasp)
Taxonomic identifier	27505 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Aculeata › Vespoidea › Vespidae › Polistinae › Polistini › Polistes

Protein attributes

Sequence length	367 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in reproduction By similarity.
Catalytic activity	Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the glycosyl hydrolase 56 family.

Ontologies

Keywords
Disease	Allergen
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Disulfide bond Glycoprotein Zymogen
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro defense response Inferred from electronic annotation. Source: InterPro
Molecular function	hyalurononglucosaminidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	‹1 – ?
	Propeptide	? – 29				PRO_0000012107
	Chain	30 – 367	338	Hyaluronidase		PRO_0000012108
Sites
	Active site	138	1	Proton donor By similarity
Amino acid modifications
	Glycosylation	108	1	N-linked (GlcNAc...) Potential
	Glycosylation	354	1	N-linked (GlcNAc...) Potential
	Disulfide bond	48 ↔ 337		By similarity
	Disulfide bond	214 ↔ 226		By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q9U6V9-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 8127056216957562	FASTA	367	43,020
	10 20 30 40 50 60 YVSLSPDSVF NIITDDISHQ ILSRSNCERS KRPKRVFSIY WNVPTFMCHQ YGMNFDEVTD 70 80 90 100 110 120 FNIKHNSKDN FRGETISIYY DPGKFPALMP LKNGNYEERN GGVPQRGNIT IHLQQFNEDL 130 140 150 160 170 180 DKMTPDKNFG GIGVIDFERW KPIFRQNWGN TEIHKKYSIE LVRKEHPKWS ESMIEAEATK 190 200 210 220 230 240 KFEKYARYFM EETLKLAKKT RKRAKWGYYG FPYCYNVTPN NPGPDCDAKA TIENDRLSWM 250 260 270 280 290 300 YNNQEILFPS VYVRHEQKPE ERVYLVQGRI KEAVRISNNL EHSPSVLAYW WYVYQDKMDI 310 320 330 340 350 360 YLSETDVEKT FQEIVTNGGD GIIIWGSSSD VNSLSKCKRL REYLLNTLGP FAVNVTETVN GRSSLNF

References

[1]	King T.P., Lu G. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF174528 mRNA. Translation: AAD52616.1.
3D structure databases
SMR	Q9U6V9. Positions 35-357.
ModBase	Search...
Protein family/group databases
CAZy	GH56. Glycoside Hydrolase Family 56.
Enzyme and pathway databases
BRENDA	3.2.1.35. 311710.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001329. Glyco_hydro_56_Api/Dol. IPR017853. Glyco_hydro_catalytic_core. IPR001968. Glycoside_hydrolase_family_56. IPR018155. Hyaluronidase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR11769. Glyco_hydro_56. 1 hit. PTHR11769:SF2. Glyco_hydro_56_Api/Dol. 1 hit.
Pfam	PF01630. Glyco_hydro_56. 1 hit. [Graphical view]
PRINTS	PR00846. GLHYDRLASE56. PR00847. HYALURONDASE.
ProtoNet	Search...

Entry information

Entry name

HUGA_POLAN

Accession

Primary (citable) accession number: Q9U6V9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 1, 2000
Last modified:	November 24, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)