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Q9U6D2 (JNK1_ANCCA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Stress-activated protein kinase JNK-1

EC=2.7.11.24
Gene names
Name:JNK-1
OrganismAncylostoma caninum (Dog hookworm)
Taxonomic identifier29170 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaAncylostomatoideaAncylostomatidaeAncylostomatinaeAncylostoma

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity By similarity. UniProtKB P45983

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity. UniProtKB P45983

Enzyme regulation

Activated by threonine and tyrosine phosphorylation By similarity. UniProtKB P45983

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAF00539.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Stress-activated protein kinase JNK-1
PRO_0000186269

Regions

Domain26 – 321296Protein kinase UniProtKB P53779
Nucleotide binding33 – 386ATP By similarity UniProtKB P53779
Motif183 – 1853TXY

Sites

Active site1511Proton acceptor By similarity UniProtKB P53779
Binding site551ATP By similarity UniProtKB P53779

Amino acid modifications

Modified residue1831Phosphothreonine By similarity UniProtKB P53779
Modified residue1851Phosphotyrosine By similarity UniProtKB P53779

Sequences

Sequence LengthMass (Da)Tools
Q9U6D2 [UniParc].

Last modified October 1, 2002. Version 2.
Checksum: 2EDFA15CC28AD3A4

FASTA37642,770
        10         20         30         40         50         60 
MASTSVPENY YVVPIGETQM VILKRYENLR LIGSGAQGIV CAATDMVTNK PVAIKKLSRP 

        70         80         90        100        110        120 
FQNVTHAKRA YREFILMNLV NHKNIIGLLN AFSPQREVEE FNDLYIVMEL MDANLCQVIQ 

       130        140        150        160        170        180 
MDLDHERLSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAVEAF 

       190        200        210        220        230        240 
MMTPYVVTRY YRAPEVILGM GYGENVDVWS VGCIFGELIR GRVLFPGADH IDQWTRIIEL 

       250        260        270        280        290        300 
LGTPEPQFLA RLQTTVRNYV ENRQKYQPVP FETLFADNMF PPGADNARLT AAKARDLLSR 

       310        320        330        340        350        360 
MLVIDPEKRI SVDDALAHEY VNVWYDASRG SCSSAGPSTI LLVDGEHTVE EWRAMLFAEL 

       370 
QNYYRTHDVY GVGQRR 

« Hide

References

[1]"JNK-1 kinase of the hookworm nematode, Ancylostoma caninum."
Arasu P.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF187690 mRNA. Translation: AAF00539.1. Different initiation.

3D structure databases

ProteinModelPortalQ9U6D2.
SMRQ9U6D2. Positions 10-362.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9U6D2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01772. JNKMAPKINASE.
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJNK1_ANCCA
AccessionPrimary (citable) accession number: Q9U6D2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families