SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9U6D2

- JNK1_ANCCA

UniProt

Q9U6D2 - JNK1_ANCCA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Stress-activated protein kinase JNK-1
Gene
JNK-1
Organism
Ancylostoma caninum (Dog hookworm)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity By similarity.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.By similarity

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551ATP By similarityBy similarity
Active sitei151 – 1511Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 386ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. JNK cascade Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-activated protein kinase JNK-1 (EC:2.7.11.24)
Gene namesi
Name:JNK-1
OrganismiAncylostoma caninum (Dog hookworm)
Taxonomic identifieri29170 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaAncylostomatoideaAncylostomatidaeAncylostomatinaeAncylostoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Stress-activated protein kinase JNK-1
PRO_0000186269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831Phosphothreonine By similarityBy similarity
Modified residuei185 – 1851Phosphotyrosine By similarityBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9U6D2.

Structurei

3D structure databases

ProteinModelPortaliQ9U6D2.
SMRiQ9U6D2. Positions 10-362.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 321296Protein kinaseBy similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi183 – 1853TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01772. JNKMAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U6D2-1 [UniParc]FASTAAdd to Basket

« Hide

MASTSVPENY YVVPIGETQM VILKRYENLR LIGSGAQGIV CAATDMVTNK    50
PVAIKKLSRP FQNVTHAKRA YREFILMNLV NHKNIIGLLN AFSPQREVEE 100
FNDLYIVMEL MDANLCQVIQ MDLDHERLSY LLYQMLCGIK HLHSAGIIHR 150
DLKPSNIVVK SDCTLKILDF GLARTAVEAF MMTPYVVTRY YRAPEVILGM 200
GYGENVDVWS VGCIFGELIR GRVLFPGADH IDQWTRIIEL LGTPEPQFLA 250
RLQTTVRNYV ENRQKYQPVP FETLFADNMF PPGADNARLT AAKARDLLSR 300
MLVIDPEKRI SVDDALAHEY VNVWYDASRG SCSSAGPSTI LLVDGEHTVE 350
EWRAMLFAEL QNYYRTHDVY GVGQRR 376
Length:376
Mass (Da):42,770
Last modified:October 1, 2002 - v2
Checksum:i2EDFA15CC28AD3A4
GO

Sequence cautioni

The sequence AAF00539.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF187690 mRNA. Translation: AAF00539.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF187690 mRNA. Translation: AAF00539.1 . Different initiation.

3D structure databases

ProteinModelPortali Q9U6D2.
SMRi Q9U6D2. Positions 10-362.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9U6D2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR01772. JNKMAPKINASE.
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "JNK-1 kinase of the hookworm nematode, Ancylostoma caninum."
    Arasu P.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiJNK1_ANCCA
AccessioniPrimary (citable) accession number: Q9U6D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi