Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9U616

- GCSH_DROME

UniProt

Q9U616 - GCSH_DROME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine cleavage system H protein, mitochondrial

Gene

ppl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity).By similarity

Cofactori

(R)-lipoateBy similarityNote: Binds 1 lipoyl cofactor covalently.By similarity

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: InterPro
  2. wing disc development Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine cleavage system H protein, mitochondrial
Alternative name(s):
Protein pumpless
Gene namesi
Name:ppl
ORF Names:CG7758
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0027945. ppl.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. glycine cleavage complex Source: InterPro
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 165Glycine cleavage system H protein, mitochondrialPRO_0000010728
Transit peptidei1 – ?MitochondrionBy similarity

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei98 – 981N6-lipoyllysineBy similarityPROSITE-ProRule annotation

Proteomic databases

PaxDbiQ9U616.
PRIDEiQ9U616.

Expressioni

Gene expression databases

BgeeiQ9U616.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

Protein-protein interaction databases

BioGridi65597. 1 interaction.
DIPiDIP-19395N.
IntActiQ9U616. 4 interactions.
MINTiMINT-1578911.
STRINGi7227.FBpp0078066.

Structurei

3D structure databases

ProteinModelPortaliQ9U616.
SMRiQ9U616. Positions 42-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 13983Lipoyl-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GcvH family.Curated
Contains 1 lipoyl-binding domain.CuratedPROSITE-ProRule annotation

Keywords - Domaini

Lipoyl, Transit peptide

Phylogenomic databases

eggNOGiCOG0509.
GeneTreeiENSGT00390000011666.
InParanoidiQ9U616.
KOiK02437.
OMAiSSCYEKG.
OrthoDBiEOG7RNK1M.
PhylomeDBiQ9U616.

Family and domain databases

HAMAPiMF_00272. GcvH.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR002930. GCV_H.
IPR017453. GCV_H_sub.
IPR011053. Single_hybrid_motif.
[Graphical view]
PANTHERiPTHR11715. PTHR11715. 1 hit.
PfamiPF01597. GCV_H. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00527. gcvH. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9U616-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVFITKFARI GLQAARQLSV TPLGAVQARA IHLTSLLAKE RRYTNKHEWV
60 70 80 90 100
EVVSGSNAIV GISSYAQEAL GDVVFAQLPE PGTELKQDDE CGALESVKAA
110 120 130 140 150
SEVYSPVSGK VIEKNAEVED TPALVNSSCY EKGWLFKVDL KNPKELEALM
160
TEDQYKAFLS SSGDH
Length:165
Mass (Da):18,002
Last modified:May 1, 2000 - v1
Checksum:iCCEBD650304D359E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203725 mRNA. Translation: AAF13277.1.
AE014296 Genomic DNA. Translation: AAF51697.3.
AY075433 mRNA. Translation: AAL68248.1.
RefSeqiNP_524197.1. NM_079473.4.
UniGeneiDm.29757.

Genome annotation databases

EnsemblMetazoaiFBtr0078412; FBpp0078066; FBgn0027945.
GeneIDi40349.
KEGGidme:Dmel_CG7758.
UCSCiCG7758-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203725 mRNA. Translation: AAF13277.1 .
AE014296 Genomic DNA. Translation: AAF51697.3 .
AY075433 mRNA. Translation: AAL68248.1 .
RefSeqi NP_524197.1. NM_079473.4.
UniGenei Dm.29757.

3D structure databases

ProteinModelPortali Q9U616.
SMRi Q9U616. Positions 42-158.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 65597. 1 interaction.
DIPi DIP-19395N.
IntActi Q9U616. 4 interactions.
MINTi MINT-1578911.
STRINGi 7227.FBpp0078066.

Proteomic databases

PaxDbi Q9U616.
PRIDEi Q9U616.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0078412 ; FBpp0078066 ; FBgn0027945 .
GeneIDi 40349.
KEGGi dme:Dmel_CG7758.
UCSCi CG7758-RA. d. melanogaster.

Organism-specific databases

CTDi 5493.
FlyBasei FBgn0027945. ppl.

Phylogenomic databases

eggNOGi COG0509.
GeneTreei ENSGT00390000011666.
InParanoidi Q9U616.
KOi K02437.
OMAi SSCYEKG.
OrthoDBi EOG7RNK1M.
PhylomeDBi Q9U616.

Miscellaneous databases

GenomeRNAii 40349.
NextBioi 818315.
PROi Q9U616.

Gene expression databases

Bgeei Q9U616.

Family and domain databases

HAMAPi MF_00272. GcvH.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR002930. GCV_H.
IPR017453. GCV_H_sub.
IPR011053. Single_hybrid_motif.
[Graphical view ]
PANTHERi PTHR11715. PTHR11715. 1 hit.
Pfami PF01597. GCV_H. 1 hit.
[Graphical view ]
SUPFAMi SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR00527. gcvH. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Suppression of food intake and growth by amino acids in Drosophila: the role of pumpless, a fat body expressed gene with homology to vertebrate glycine cleavage system."
    Zinke I., Kirchner C., Chao L.C., Tetzlaff M.T., Pankratz M.J.
    Development 126:5275-5284(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Larva and Pupae.

Entry informationi

Entry nameiGCSH_DROME
AccessioniPrimary (citable) accession number: Q9U616
Secondary accession number(s): Q9VP59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3