Q9U5W9 (TAF10_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription initiation factor TFIID subunit 10

Alternative name(s):
Transcription initiation factor TFIID 24 kDa subunit
Short name=TAFII-24
Short name=TAFII24
dTAF(II)24

Gene names

Name:	Taf10
ORF Names:	CG2859

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Ref.1
Subunit structure	Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). Also a member of the histone acetylase (HAT) complex. Ref.1
Subcellular location	Cytoplasm. Nucleus Ref.1.
Tissue specificity	At embryonic stage 9, highest expression is detected within the ectoderm, ventral chord, and anterior foregut primordium. Later in development preferential expression is in the foregut, proventriculus, and central nervous system. Coexpressed with Taf10b in the lateral epidermis and anal plate. Ref.1
Developmental stage	Expressed both maternally and zygotically. Ref.1
Sequence similarities	Belongs to the TAF10 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription initiation from RNA polymerase II promoter Inferred from direct assay Ref.1. Source: UniProtKB
Cellular component	SAGA complex Inferred from physical interaction. Source: FlyBase cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell transcription factor TFIID complex Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Transcription initiation factor TFIID subunit 10		PRO_0000118899

Sequences

	Sequence		Length	Mass (Da)
	Q9U5W9 [UniParc]. Last modified March 1, 2001. Version 2. Checksum: 8C8DDCD3BEAEA735	FASTA	167	18,521
	10 20 30 40 50 60 MASDGEDISV TPAESVTSAT DTEEEDIDSP LMQSELHSDE EQPDVEEVPL TTEESEMDEL 70 80 90 100 110 120 IKQLEDYSPT IPDALTMHIL KTAGFCTVDP KIVRLVSVSA QKFISDIAND ALQHCKTRTT 130 140 150 160 NIQHSSGHSS SKDKKNPKDR KYTLAMEDLV PALADHGITM RKPQYFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two novel Drosophila TAFIIs have homology with human TAFII30 and are differentially regulated during development." Georgieva S., Kirschner D.B., Jagla T., Nabirochkina E., Hanke S., Schenkel H., de Lorenzo C., Sinha P., Jagla K., Mechler B., Tora L. Mol. Cell. Biol. 20:1639-1648(2000) [PubMed: 10669741] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Embryo.
[2]	"Prodos is a conserved transcriptional regulator that interacts with dTAF(II)16 in Drosophila melanogaster." Hernandez-Hernandez A., Ferrus A. Mol. Cell. Biol. 21:614-623(2001) [PubMed: 11134347] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ243836 mRNA. Translation: CAB55760.2. AJ276419 mRNA. Translation: CAC08819.1. AE014134 Genomic DNA. Translation: AAF51210.1. AY118419 mRNA. Translation: AAM48448.1.
RefSeq	NP_477463.1. NM_058115.4.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-23060N.
IntAct	Q9U5W9. 8 interactions.
MINT	MINT-891946.
STRING	Q9U5W9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0077717; FBpp0077401; FBgn0028398.
GeneID	33469.
KEGG	dme:Dmel_CG2859.
NMPDR	fig|7227.3.peg.449.
Organism-specific databases
CTD	6881.
FlyBase	FBgn0028398. Taf10.
Phylogenomic databases
eggNOG	inNOG10541.
GeneTree	EMGT00050000016689.
InParanoid	Q9U5W9.
OMA	YTLAMED.
OrthoDB	EOG4VT4DP.
PhylomeDB	Q9U5W9.
Gene expression databases
Bgee	Q9U5W9.
GermOnline	CG2859. Drosophila melanogaster.
Family and domain databases
InterPro	IPR003923. TFIID_30kDa. [Graphical view]
KO	K03134.
PANTHER	PTHR21242. TFIID_30kD. 1 hit.
Pfam	PF03540. TFIID_30kDa. 1 hit. [Graphical view]
PIRSF	PIRSF017246. TFIID_TAF10. 1 hit.
PRINTS	PR01443. TFIID30KDSUB.
ProtoNet	Search...
Other
NextBio	783720.

Entry information

Entry name

TAF10_DROME

Accession

Primary (citable) accession number: Q9U5W9
Secondary accession number(s): Q9VQG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project