Reviewed, UniProtKB/Swiss-Prot Q9U5W9 (TAF10_DROME)

Names and origin

Protein names

Recommended name:
    Transcription initiation factor TFIID subunit 10
Alternative name(s):
    Transcription initiation factor TFIID 24 kDa subunit
      Short name=TAFII-24
      Short name=TAFII24
    dTAF(II)24

Gene names

Name:	Taf10
ORF Names:	CG2859

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Ref.1
Subunit structure	Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). Also a member of the histone acetylase (HAT) complex. Ref.1
Subcellular location	Cytoplasm. Nucleus. Ref.1
Tissue specificity	At embryonic stage 9, highest expression is detected within the ectoderm, ventral chord, and anterior foregut primordium. Later in development preferential expression is in the foregut, proventriculus, and central nervous system. Coexpressed with Taf10b in the lateral epidermis and anal plate. Ref.1
Developmental stage	Expressed both maternally and zygotically. Ref.1
Sequence similarities	Belongs to the TAF10 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription initiation from RNA polymerase II promoter Ref.1 Inferred from direct assay. Source: UniProtKB
Cellular component	SAGA complex Inferred from physical interaction. Source: FlyBase cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell transcription factor TFIID complex Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	RNA polymerase II transcription factor activity Ref.1 Inferred from direct assay. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Ubc-E2H	Q9W3K7	1	EBI-152205,EBI-187464

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Transcription initiation factor TFIID subunit 10		PRO_0000118899

Sequences

	Sequence		Length	Mass (Da)
	Q9U5W9-1 [UniParc]. Last modified March 1, 2001. Version 2. Checksum: 8C8DDCD3BEAEA735	FASTA	167	18,521
	10 20 30 40 50 60 MASDGEDISV TPAESVTSAT DTEEEDIDSP LMQSELHSDE EQPDVEEVPL TTEESEMDEL 70 80 90 100 110 120 IKQLEDYSPT IPDALTMHIL KTAGFCTVDP KIVRLVSVSA QKFISDIAND ALQHCKTRTT 130 140 150 160 NIQHSSGHSS SKDKKNPKDR KYTLAMEDLV PALADHGITM RKPQYFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two novel Drosophila TAFIIs have homology with human TAFII30 and are differentially regulated during development." Georgieva S., Kirschner D.B., Jagla T., Nabirochkina E., Hanke S., Schenkel H., de Lorenzo C., Sinha P., Jagla K., Mechler B., Tora L. Mol. Cell. Biol. 20:1639-1648(2000) [PubMed: 10669741] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Embryo.
[2]	"Prodos is a conserved transcriptional regulator that interacts with dTAF(II)16 in Drosophila melanogaster." Hernandez-Hernandez A., Ferrus A. Mol. Cell. Biol. 21:614-623(2001) [PubMed: 11134347] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ243836 mRNA. Translation: CAB55760.2. AJ276419 mRNA. Translation: CAC08819.1. AE014134 Genomic DNA. Translation: AAF51210.1. AY118419 mRNA. Translation: AAM48448.1.
RefSeq	NP_477463.1.
UniGene	Dm.30758
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9U5W9. 7 interactions.
Genome annotation databases
Ensembl	FBgn0028398. Drosophila melanogaster. [Contig view]
GeneID	33469.
KEGG	dme:Dmel_CG2859.
NMPDR	fig|7227.3.peg.449.
Organism-specific databases
FlyBase	FBgn0028398. Taf10.
Phylogenomic databases
HOGENOM	Q9U5W9.
OMA	Q9U5W9. ILKEYGH.
Gene expression databases
GermOnline	CG2859. Drosophila melanogaster.
Family and domain databases
InterPro	IPR003923. TFIID_30kD. [Graphical view]
PANTHER	PTHR21242. TFIID_30kD. 1 hit.
Pfam	PF03540. TFIID_30kDa. 1 hit. [Graphical view]
PIRSF	PIRSF017246. TFIID_TAF10. 1 hit.
PRINTS	PR01443. TFIID30KDSUB.
ProtoNet	Search...
Other Resources
NextBio	783720.

Entry information

Entry name

TAF10_DROME

Accession

Primary (citable) accession number: Q9U5W9
Secondary accession number(s): Q9VQG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	March 1, 2001
Last modified:	June 16, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project