Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9U5P1 (FABP_LEPDS) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fatty acid-binding protein
Alternative name(s):
Allergen=Lep d 13
OrganismLepidoglyphus destructor (Fodder mite)
Taxonomic identifier36936 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataGlycyphagoideaGlycyphagidaeLepidoglyphus

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters By similarity.

Subcellular location

Cytoplasm Potential.

Domain

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.

Allergenic properties

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Sequence similarities

Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCytoplasm
   DiseaseAllergen
   LigandLipid-binding
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: UniProtKB-KW

transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 131131Fatty acid-binding protein
PRO_0000067421

Regions

Region126 – 1283Fatty acid binding By similarity

Sites

Binding site1061Fatty acid By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9U5P1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 9E68624A2F82D6D3

FASTA13114,723
        10         20         30         40         50         60 
MANIAGQYKL DKSENFDQFL DKLGVGFLVK TAAKTVKPTL EVAVDGDTYI FRSLSTFKNT 

        70         80         90        100        110        120 
EIKFKLGEEF EEDRADGKRV KTVIVKDGDN KFVQTQYGDK EVKVVREFKG DEVEVTASVD 

       130 
GVTSVRPYKR A 

« Hide

References

[1]"Cloning of three new allergens from the dust mite Lepidoglyphus destructor using phage surface display technology."
Eriksson T.L.J., Rasool O., Huecas S., Whitley P., Crameri R., Appenzeller U., Gafvelin G., van Hage-Hamsten M.
Eur. J. Biochem. 268:287-294(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ250279 mRNA. Translation: CAB62213.1.

3D structure databases

ProteinModelPortalQ9U5P1.
SMRQ9U5P1. Positions 1-130.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3350. Lep d 13.0101.
438. Lep d 13.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.40.128.20. 1 hit.
InterProIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSPR00178. FATTYACIDBP.
SUPFAMSSF50814. SSF50814. 1 hit.
PROSITEPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABP_LEPDS
AccessionPrimary (citable) accession number: Q9U5P1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: October 16, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries