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Q9U5P1

- FABP_LEPDS

UniProt

Q9U5P1 - FABP_LEPDS

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Protein

Fatty acid-binding protein

Gene
N/A
Organism
Lepidoglyphus destructor (Fodder mite)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061Fatty acidBy similarity

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW
  2. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein
Alternative name(s):
Allergen: Lep d 13
OrganismiLepidoglyphus destructor (Fodder mite)
Taxonomic identifieri36936 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataGlycyphagoideaGlycyphagidaeLepidoglyphus

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3350. Lep d 13.0101.
438. Lep d 13.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Fatty acid-binding proteinPRO_0000067421Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9U5P1.
SMRiQ9U5P1. Positions 1-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni126 – 1283Fatty acid bindingBy similarity

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U5P1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANIAGQYKL DKSENFDQFL DKLGVGFLVK TAAKTVKPTL EVAVDGDTYI
60 70 80 90 100
FRSLSTFKNT EIKFKLGEEF EEDRADGKRV KTVIVKDGDN KFVQTQYGDK
110 120 130
EVKVVREFKG DEVEVTASVD GVTSVRPYKR A
Length:131
Mass (Da):14,723
Last modified:May 1, 2000 - v1
Checksum:i9E68624A2F82D6D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250279 mRNA. Translation: CAB62213.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250279 mRNA. Translation: CAB62213.1 .

3D structure databases

ProteinModelPortali Q9U5P1.
SMRi Q9U5P1. Positions 1-130.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 3350. Lep d 13.0101.
438. Lep d 13.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view ]
Pfami PF00061. Lipocalin. 1 hit.
[Graphical view ]
PRINTSi PR00178. FATTYACIDBP.
SUPFAMi SSF50814. SSF50814. 1 hit.
PROSITEi PS00214. FABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of three new allergens from the dust mite Lepidoglyphus destructor using phage surface display technology."
    Eriksson T.L.J., Rasool O., Huecas S., Whitley P., Crameri R., Appenzeller U., Gafvelin G., van Hage-Hamsten M.
    Eur. J. Biochem. 268:287-294(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFABP_LEPDS
AccessioniPrimary (citable) accession number: Q9U5P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3