Q9U5P1 (FABP_LEPDS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Fatty acid-binding protein Alternative name(s): Allergen=Lep d 13
Organism	Lepidoglyphus destructor (Fodder mite)
Taxonomic identifier	36936 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Acariformes › Sarcoptiformes › Astigmata › Glycyphagoidea › Glycyphagidae › Lepidoglyphus

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters By similarity.
Subcellular location	Cytoplasm Potential.
Domain	Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.
Allergenic properties	Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
Sequence similarities	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm
Disease	Allergen
Ligand	Lipid-binding
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Fatty acid-binding protein		PRO_0000067421
Regions
	Region	126 – 128	3	Fatty acid binding By similarity
Sites
	Binding site	106	1	Fatty acid By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9U5P1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 9E68624A2F82D6D3	FASTA	131	14,723
	10 20 30 40 50 60 MANIAGQYKL DKSENFDQFL DKLGVGFLVK TAAKTVKPTL EVAVDGDTYI FRSLSTFKNT 70 80 90 100 110 120 EIKFKLGEEF EEDRADGKRV KTVIVKDGDN KFVQTQYGDK EVKVVREFKG DEVEVTASVD 130 GVTSVRPYKR A

References

[1]

"Cloning of three new allergens from the dust mite Lepidoglyphus destructor using phage surface display technology." Eriksson T.L.J., Rasool O., Huecas S., Whitley P., Crameri R., Appenzeller U., Gafvelin G., van Hage-Hamsten M. Eur. J. Biochem. 268:287-294(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ250279 mRNA. Translation: CAB62213.1.
3D structure databases
ProteinModelPortal	Q9U5P1.
SMR	Q9U5P1. Positions 1-130.
ModBase	Search...
Protein family/group databases
Allergome	3350. Lep d 13.0101. 438. Lep d 13.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.40.128.20. 1 hit.
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR000463. Fatty_acid-bd. IPR000566. Lipocln_cytosolic_FA-bd_dom. [Graphical view]
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PRINTS	PR00178. FATTYACIDBP.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00214. FABP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABP_LEPDS

Accession

Primary (citable) accession number: Q9U5P1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)