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Protein

Organic cation transporter 1

Gene

oct-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports organic cations such as tetraethylammonium (TEA). Displays a broad substrate specificity.1 Publication

GO - Molecular functioni

GO - Biological processi

  • determination of adult lifespan Source: WormBase
  • organic cation transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-561048. Organic anion transport.

Protein family/group databases

TCDBi2.A.1.19.37. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Organic cation transporter 1
Alternative name(s):
CeOCT1
Gene namesi
Name:oct-1
ORF Names:F52F12.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF52F12.1a; CE41244; WBGene00003842; oct-1.
F52F12.1b; CE29329; WBGene00003842; oct-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040CytoplasmicSequence analysisAdd
BLAST
Transmembranei41 – 6121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini62 – 15594ExtracellularSequence analysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini177 – 1848CytoplasmicSequence analysis
Transmembranei185 – 20521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini206 – 2127ExtracellularSequence analysis
Transmembranei213 – 23321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini234 – 24310CytoplasmicSequence analysis
Transmembranei244 – 26421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini265 – 2695ExtracellularSequence analysis
Transmembranei270 – 29021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini291 – 36070CytoplasmicSequence analysisAdd
BLAST
Transmembranei361 – 38121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini382 – 3898ExtracellularSequence analysis
Transmembranei390 – 41021Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini411 – 4166CytoplasmicSequence analysis
Transmembranei417 – 43721Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini438 – 4469ExtracellularSequence analysis
Transmembranei447 – 46721Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini468 – 4769CytoplasmicSequence analysis
Transmembranei477 – 49721Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini498 – 5047ExtracellularSequence analysis
Transmembranei505 – 52521Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini526 – 58560CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Organic cation transporter 1PRO_0000220513Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)1 Publication
Glycosylationi98 – 981N-linked (GlcNAc...)1 Publication
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9U539.
PaxDbiQ9U539.
PRIDEiQ9U539.

Interactioni

Protein-protein interaction databases

IntActiQ9U539. 1 interaction.
STRINGi6239.F52F12.1a.

Structurei

3D structure databases

ProteinModelPortaliQ9U539.
SMRiQ9U539. Positions 156-530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000017414.
InParanoidiQ9U539.
KOiK08202.
OMAiPHTCHIP.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ9U539.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q9U539-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFQAMETFA EISQEILMSA TKPPDFDFVL EQVGNYGTYQ IVFFFIICLP
60 70 80 90 100
TSLPSAFSAF NIPFVVGNPP HTCHIPEGKE YLRPLTNDTQ ILSCKQYNET
110 120 130 140 150
QINVFRAFTS APVDTYSDRI SLVPCQNGWD YDNSTYLDSL VTEFNLVCDQ
160 170 180 190 200
QAWIEISTTS FYVGSFIGNC LFGYVADKFG RRRSFFVILT VLIVCGTASS
210 220 230 240 250
FAKDIESFII LRFFTGLAFP ALFQIPFIIC MEFMGNSGRI FSGLMTSLFF
260 270 280 290 300
GAAMALLGVV AMFIRRWRQL TFFCNAPFAF YIIYYFFLPE SPRWSVSVGK
310 320 330 340 350
WADAKKQLKK IAKMNGKSNV DVDELVDSMK NHQNAAEEKE TKRSHNVTDL
360 370 380 390 400
FKTPNLRRKT LIVTYIWVMN AIIYNGLTLN VSNLPVDDYW SFIINGAVEL
410 420 430 440 450
PGYFVVWPLL QCAGRRWTLA ATMIVCGIGC VSAMFMPDGY PWLVASASFI
460 470 480 490 500
GKFGVGSGFA VIYIFAGELY PTVVRAIGMG MSSMVAGSGL LLAPHIVNLG
510 520 530 540 550
KIVKILPLLI MGLMALSAGI LTFFLPETLG APLPMTIEDA ENFGKKPEPD
560 570 580
SGMFTQAAKK RESQPLLEPH TPMDRRRRSS RLMNI
Note: No experimental confirmation available.
Length:585
Mass (Da):65,462
Last modified:January 15, 2008 - v3
Checksum:i20DA0B3E73386B62
GO
Isoform b (identifier: Q9U539-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.

Show »
Length:568
Mass (Da):63,505
Checksum:iC0A3E73851F44056
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717Missing in isoform b. 1 PublicationVSP_011122Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110415 mRNA. Translation: AAF21932.1.
Z83228 Genomic DNA. Translation: CAB05732.2.
Z83228 Genomic DNA. Translation: CAC70093.1.
PIRiT22509.
RefSeqiNP_001021482.1. NM_001026311.4. [Q9U539-2]
NP_492617.4. NM_060216.5. [Q9U539-1]
UniGeneiCel.19533.

Genome annotation databases

EnsemblMetazoaiF52F12.1a; F52F12.1a; WBGene00003842. [Q9U539-1]
GeneIDi172841.
KEGGicel:CELE_F52F12.1.
UCSCiF52F12.1a. c. elegans. [Q9U539-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110415 mRNA. Translation: AAF21932.1.
Z83228 Genomic DNA. Translation: CAB05732.2.
Z83228 Genomic DNA. Translation: CAC70093.1.
PIRiT22509.
RefSeqiNP_001021482.1. NM_001026311.4. [Q9U539-2]
NP_492617.4. NM_060216.5. [Q9U539-1]
UniGeneiCel.19533.

3D structure databases

ProteinModelPortaliQ9U539.
SMRiQ9U539. Positions 156-530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9U539. 1 interaction.
STRINGi6239.F52F12.1a.

Protein family/group databases

TCDBi2.A.1.19.37. the major facilitator superfamily (mfs).

Proteomic databases

EPDiQ9U539.
PaxDbiQ9U539.
PRIDEiQ9U539.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF52F12.1a; F52F12.1a; WBGene00003842. [Q9U539-1]
GeneIDi172841.
KEGGicel:CELE_F52F12.1.
UCSCiF52F12.1a. c. elegans. [Q9U539-1]

Organism-specific databases

CTDi172841.
WormBaseiF52F12.1a; CE41244; WBGene00003842; oct-1.
F52F12.1b; CE29329; WBGene00003842; oct-1.

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000017414.
InParanoidiQ9U539.
KOiK08202.
OMAiPHTCHIP.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ9U539.

Enzyme and pathway databases

ReactomeiR-CEL-561048. Organic anion transport.

Miscellaneous databases

PROiQ9U539.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identity of the F52F12.1 gene product in Caenorhabditis elegans as an organic cation transporter."
    Wu X., Fei Y.-J., Huang W., Chancy C., Leibach F.H., Ganapathy V.
    Biochim. Biophys. Acta 1418:239-244(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), FUNCTION.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  3. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-87 AND ASN-98, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiOCT1_CAEEL
AccessioniPrimary (citable) accession number: Q9U539
Secondary accession number(s): O02270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 15, 2008
Last modified: July 6, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.