Q9U4X4 (SODC_DROER) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Cu-Zn]
EC=1.15.1.1

Gene names

Name:

Sod

Organism

Drosophila erecta (Fruit fly)

Taxonomic identifier

7220 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 153	152	Superoxide dismutase [Cu-Zn]		PRO_0000164084
Sites
	Metal binding	45	1	Copper; catalytic By similarity
	Metal binding	47	1	Copper; catalytic By similarity
	Metal binding	62	1	Copper; catalytic By similarity
	Metal binding	62	1	Zinc; structural By similarity
	Metal binding	70	1	Zinc; structural By similarity
	Metal binding	79	1	Zinc; structural By similarity
	Metal binding	82	1	Zinc; structural By similarity
	Metal binding	119	1	Copper; catalytic By similarity
Amino acid modifications
	Disulfide bond	56 ↔ 145		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9U4X4 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 578EBF0A8738EBD0	FASTA	153	15,764
	10 20 30 40 50 60 MVVKAVCVIN GDAKGTVFFE QESSETPVKV SGEVCGLAKC LHGFHVHEFG DNTNGCMSSG 70 80 90 100 110 120 PHFNPHGKEH GAPVDENRHL GDLGNIEATG DCPTKVSITD SKITLFGADS IIGRTVVVHA 130 140 150 DADDLGKGGH ELSKSTGNAG ARIGCGVIGI AKV

References

[1]	"Phylogenetic analysis of Drosophila melanogaster group based on Cu-Zn superoxide dismutase gene sequences." Arxontaki K., Kastanis P., Tsakas S., Loukas M., Eliopoulos E. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF127156 Genomic DNA. Translation: AAF23595.1.
3D structure databases
ProteinModelPortal	Q9U4X4.
SMR	Q9U4X4. Positions 4-152.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0029421. Dere\Sod.
Phylogenomic databases
GeneTree	EMGT00050000015939.
OrthoDB	EOG43TXBZ.
Family and domain databases
InterPro	IPR024134. SOD_Cu/Zn_/chaperones. IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn_dom. [Graphical view]
Gene3D	G3DSA:2.60.40.200. SOD_Cu_Zn. 1 hit.
PANTHER	PTHR10003. SOD_Cu_Zn. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
SUPFAM	SSF49329. SOD_Cu_Zn. 1 hit.
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODC_DROER

Accession

Primary (citable) accession number: Q9U4X4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 54 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project