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Q9U485

- Q9U485_DROME

UniProt

Q9U485 - Q9U485_DROME

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Protein
Submitted name:

Numb-associated kinase

Gene

Nak

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. AP-2 adaptor complex binding Source: FlyBase
  2. ATP binding Source: InterPro
  3. protein kinase activity Source: FlyBase
  4. protein serine/threonine kinase activity Source: FlyBase

GO - Biological processi

  1. asymmetric cell division Source: FlyBase
  2. dendrite morphogenesis Source: FlyBase
  3. protein phosphorylation Source: FlyBase
  4. regulation of clathrin-mediated endocytosis Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9U485.

Names & Taxonomyi

Protein namesi
Submitted name:
Numb-associated kinaseImported
Gene namesi
Name:NakImported
ORF Names:CG10637Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0015772. Nak.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: FlyBase
  2. dendrite Source: FlyBase
  3. neuronal cell body Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ9U485.

Expressioni

Gene expression databases

BgeeiQ9U485.
ExpressionAtlasiQ9U485. differential.

Interactioni

Protein-protein interaction databases

MINTiMINT-1530267.

Structurei

3D structure databases

ProteinModelPortaliQ9U485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U485-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKILSKFER NENSRLENPP NSSSSSSSNE KNSFVGKVFT VGRVTVTVED
60 70 80 90 100
VLAEGGFAMV FLARGNGGGS SSATKYALKR MYVNNEHDLN VAKREIQIAS
110 120 130 140 150
NLSGHKNIIG YVDSSITPTG NGVCEVLLLM PYCKHHMLAM MNARLHVGFT
160 170 180 190 200
EPEVLNIFCD IAEAVSRLHY CQTPIIHRDL KVENILQTDA GNFVLCDFGS
210 220 230 240 250
ATAKTLNPQQ HGVTVVQEEI QKYTTLSYRA PEMIDLYGGK SITTKADIWA
260 270 280 290 300
LGCMLYKLCF FSLPFGESTL AIQNGQFSIP DSSKYSKGMH QLIKYMLEPD
310 320 330 340 350
MEKRPNIWQV CEVAFRLAGK DNPVQNLHKT PIPNFDLLVV PPFESEAKRI
360 370 380 390 400
SAAASKAAKA QNVSVVEAGT SVAPRSRPKG SSSVHGGNPL GLGLPPSPSP
410 420 430 440 450
RQNITSPQPQ PQPVVEQFQA NFPAMPPAVP PPPQAVTPAA PAASKLFESS
460 470 480 490 500
GYPDPFNEPA AAVIPTEFLP AAEEPNKEEV PQDLNVIAGT PTKSMLTPPK
510 520 530 540 550
PSGGGGHRRN VSDTSAFNKT FANETSQFLA PFNNNLAAMG DGQQTLASAA
560 570 580 590 600
SNPGIYASST ANSAAVSISE LMKPGQTAVE KRVEAWNPFE EEQPFSQMTE
610 620 630 640 650
DHIFEAEFDK IRQRGSQGSI TAKSASTTST LTPTEQIPSA VVAPVTAAPG
660 670 680 690 700
AVPPPPIAAA VSPYPSQVSE DPFGSAPFSL PPGLREKASS LRKTGAKFIG
710 720 730 740 750
VSSGGTGGGV ATPIGLVAGG ANTATSSNSS KWMLSPTLEV SSEEKTSLIS
760 770 780 790 800
KLKTDSECGI PGAVGGAGEG VSGYVKLPVE DRNKYEKLRS KDQPTSDDSD
810 820 830 840 850
SEASEFFQQD SDEGGGGIFR QMQMVTSNLP ETIHKIQQVA YHKVDKTAHL
860 870 880 890 900
PIVKKLRDKT KKPTTAAHQA AQQLNLMAAA VAAQAEEAAK AAESDGDSIG
910 920 930 940 950
SASDLRAEDD DLFDENPRQT QAKQRRPLPT EMDGISESVK TCSSSAYHAE
960 970 980 990 1000
CESVTTHEDD VRSRVVVKVR MRKKDRALVT ATGDPSAPSE ELSPTSSDLL
1010 1020 1030 1040 1050
HKFGDRPLLL DDELDYGSGE SKSSTESPVA PTLPTNPDVQ ESEEDVFALA
1060 1070 1080 1090 1100
PFKLPVGVPL KRKTKPKAKP KPAEPEMWTS TPVKSAAVGD PSTNFASFPA
1110 1120 1130 1140 1150
NVTPTNNVGN SAQLDEFNAP IFNPFQENAQ NTQSGETNQC DLFGLEPFPQ
1160 1170 1180 1190 1200
VIRTIEQNPQ HHQIHQFPSH NNNNNVIKVP ASVSVALPAS VPVSVSVNSS
1210 1220 1230 1240 1250
APQLVTINHS IIINKTPEPP MNYNNNNNNN NQTAKSTGTS SVYVNVPSFS
1260 1270 1280 1290 1300
SMSTSSCSIN QPQSSPAAVI PVQAPLPVPV PAPVSVPAVP VPIPAVVTHL
1310 1320 1330 1340 1350
RPLLPIADNA YVQISQDRCS DFTPDDEEEP VVLRDADVVA DGIGIPTPAK
1360 1370 1380 1390 1400
PKKEKSNLAV RVLPGKLTQK VKGHSYKKVS AAALGSTSSL SSGSKQKHQR
1410 1420 1430 1440 1450
LQYQSHDDDD DEQDQDENRG AGGGRNFQSN TIQNSAKTGF SNMSFEDFPS
1460 1470 1480 1490
DQEMDRLSRT IPFEVVRNEK MLLEAEKKFG SLKRRNNLFS
Length:1,490
Mass (Da):159,797
Last modified:May 1, 2000 - v1
Checksum:i816F66B9D7E4B7A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197910 mRNA. Translation: AAF15596.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197910 mRNA. Translation: AAF15596.1 .

3D structure databases

ProteinModelPortali Q9U485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1530267.

Proteomic databases

PRIDEi Q9U485.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0015772. Nak.

Enzyme and pathway databases

SignaLinki Q9U485.

Miscellaneous databases

ChiTaRSi Atpalpha. fly.

Gene expression databases

Bgeei Q9U485.
ExpressionAtlasi Q9U485. differential.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo."
    Chien C.T., Wang S., Rothenberg M., Jan L.Y., Jan Y.N.
    Mol. Cell. Biol. 18:598-607(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Chien C.T., Wang S., Rothenberg M., Jan L.Y., Jan Y.N.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9U485_DROME
AccessioniPrimary (citable) accession number: Q9U485
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)