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Q9U485

- Q9U485_DROME

UniProt

Q9U485 - Q9U485_DROME

Protein
Submitted name:

Numb-associated kinase

Gene

Nak

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. AP-2 adaptor complex binding Source: FlyBase
    2. ATP binding Source: InterPro
    3. protein binding Source: FlyBase
    4. protein kinase activity Source: FlyBase
    5. protein serine/threonine kinase activity Source: FlyBase

    GO - Biological processi

    1. asymmetric cell division Source: FlyBase
    2. dendrite morphogenesis Source: FlyBase
    3. protein phosphorylation Source: FlyBase
    4. regulation of clathrin-mediated endocytosis Source: FlyBase

    Enzyme and pathway databases

    SignaLinkiQ9U485.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Numb-associated kinaseImported
    Gene namesi
    Name:NakImported
    ORF Names:CG10637Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

    Organism-specific databases

    FlyBaseiFBgn0015772. Nak.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: FlyBase
    2. dendrite Source: FlyBase
    3. neuronal cell body Source: FlyBase

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9U485.

    Expressioni

    Gene expression databases

    BgeeiQ9U485.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1530267.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9U485.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    InParanoidiQ9U485.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9U485-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKILSKFER NENSRLENPP NSSSSSSSNE KNSFVGKVFT VGRVTVTVED     50
    VLAEGGFAMV FLARGNGGGS SSATKYALKR MYVNNEHDLN VAKREIQIAS 100
    NLSGHKNIIG YVDSSITPTG NGVCEVLLLM PYCKHHMLAM MNARLHVGFT 150
    EPEVLNIFCD IAEAVSRLHY CQTPIIHRDL KVENILQTDA GNFVLCDFGS 200
    ATAKTLNPQQ HGVTVVQEEI QKYTTLSYRA PEMIDLYGGK SITTKADIWA 250
    LGCMLYKLCF FSLPFGESTL AIQNGQFSIP DSSKYSKGMH QLIKYMLEPD 300
    MEKRPNIWQV CEVAFRLAGK DNPVQNLHKT PIPNFDLLVV PPFESEAKRI 350
    SAAASKAAKA QNVSVVEAGT SVAPRSRPKG SSSVHGGNPL GLGLPPSPSP 400
    RQNITSPQPQ PQPVVEQFQA NFPAMPPAVP PPPQAVTPAA PAASKLFESS 450
    GYPDPFNEPA AAVIPTEFLP AAEEPNKEEV PQDLNVIAGT PTKSMLTPPK 500
    PSGGGGHRRN VSDTSAFNKT FANETSQFLA PFNNNLAAMG DGQQTLASAA 550
    SNPGIYASST ANSAAVSISE LMKPGQTAVE KRVEAWNPFE EEQPFSQMTE 600
    DHIFEAEFDK IRQRGSQGSI TAKSASTTST LTPTEQIPSA VVAPVTAAPG 650
    AVPPPPIAAA VSPYPSQVSE DPFGSAPFSL PPGLREKASS LRKTGAKFIG 700
    VSSGGTGGGV ATPIGLVAGG ANTATSSNSS KWMLSPTLEV SSEEKTSLIS 750
    KLKTDSECGI PGAVGGAGEG VSGYVKLPVE DRNKYEKLRS KDQPTSDDSD 800
    SEASEFFQQD SDEGGGGIFR QMQMVTSNLP ETIHKIQQVA YHKVDKTAHL 850
    PIVKKLRDKT KKPTTAAHQA AQQLNLMAAA VAAQAEEAAK AAESDGDSIG 900
    SASDLRAEDD DLFDENPRQT QAKQRRPLPT EMDGISESVK TCSSSAYHAE 950
    CESVTTHEDD VRSRVVVKVR MRKKDRALVT ATGDPSAPSE ELSPTSSDLL 1000
    HKFGDRPLLL DDELDYGSGE SKSSTESPVA PTLPTNPDVQ ESEEDVFALA 1050
    PFKLPVGVPL KRKTKPKAKP KPAEPEMWTS TPVKSAAVGD PSTNFASFPA 1100
    NVTPTNNVGN SAQLDEFNAP IFNPFQENAQ NTQSGETNQC DLFGLEPFPQ 1150
    VIRTIEQNPQ HHQIHQFPSH NNNNNVIKVP ASVSVALPAS VPVSVSVNSS 1200
    APQLVTINHS IIINKTPEPP MNYNNNNNNN NQTAKSTGTS SVYVNVPSFS 1250
    SMSTSSCSIN QPQSSPAAVI PVQAPLPVPV PAPVSVPAVP VPIPAVVTHL 1300
    RPLLPIADNA YVQISQDRCS DFTPDDEEEP VVLRDADVVA DGIGIPTPAK 1350
    PKKEKSNLAV RVLPGKLTQK VKGHSYKKVS AAALGSTSSL SSGSKQKHQR 1400
    LQYQSHDDDD DEQDQDENRG AGGGRNFQSN TIQNSAKTGF SNMSFEDFPS 1450
    DQEMDRLSRT IPFEVVRNEK MLLEAEKKFG SLKRRNNLFS 1490
    Length:1,490
    Mass (Da):159,797
    Last modified:May 1, 2000 - v1
    Checksum:i816F66B9D7E4B7A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF197910 mRNA. Translation: AAF15596.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF197910 mRNA. Translation: AAF15596.1 .

    3D structure databases

    ProteinModelPortali Q9U485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1530267.

    Proteomic databases

    PRIDEi Q9U485.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0015772. Nak.

    Phylogenomic databases

    InParanoidi Q9U485.

    Enzyme and pathway databases

    SignaLinki Q9U485.

    Miscellaneous databases

    ChiTaRSi Atpalpha. drosophila.

    Gene expression databases

    Bgeei Q9U485.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo."
      Chien C.T., Wang S., Rothenberg M., Jan L.Y., Jan Y.N.
      Mol. Cell. Biol. 18:598-607(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Chien C.T., Wang S., Rothenberg M., Jan L.Y., Jan Y.N.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9U485_DROME
    AccessioniPrimary (citable) accession number: Q9U485
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)