Q9U485 (Q9U485_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Numb-associated kinase EMBL AAF15596.1

Gene names

Name:	Nak EMBL AAF15596.1 FlyBase FBgn0015772
ORF Names:	CG10637 FlyBase FBgn0015772

Organism

Drosophila melanogaster (Fruit fly) EMBL AAF15596.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1490 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	asymmetric cell division Inferred from mutant phenotype Ref.1. Source: FlyBase dendrite morphogenesis Inferred from mutant phenotype PubMed 22017988. Source: FlyBase regulation of clathrin-mediated endocytosis Inferred from genetic interaction PubMed 22017988. Source: FlyBase
Cellular_component	axon Inferred from direct assay PubMed 22017988. Source: FlyBase dendrite Inferred from direct assay PubMed 22017988. Source: FlyBase neuronal cell body Inferred from direct assay PubMed 22017988. Source: FlyBase
Molecular_function	AP-2 adaptor complex binding Inferred from direct assay PubMed 22017988. Source: FlyBase ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from sequence or structural similarity Ref.1. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9U485 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 816F66B9D7E4B7A8	FASTA	1,490	159,797
	10 20 30 40 50 60 MKKILSKFER NENSRLENPP NSSSSSSSNE KNSFVGKVFT VGRVTVTVED VLAEGGFAMV 70 80 90 100 110 120 FLARGNGGGS SSATKYALKR MYVNNEHDLN VAKREIQIAS NLSGHKNIIG YVDSSITPTG 130 140 150 160 170 180 NGVCEVLLLM PYCKHHMLAM MNARLHVGFT EPEVLNIFCD IAEAVSRLHY CQTPIIHRDL 190 200 210 220 230 240 KVENILQTDA GNFVLCDFGS ATAKTLNPQQ HGVTVVQEEI QKYTTLSYRA PEMIDLYGGK 250 260 270 280 290 300 SITTKADIWA LGCMLYKLCF FSLPFGESTL AIQNGQFSIP DSSKYSKGMH QLIKYMLEPD 310 320 330 340 350 360 MEKRPNIWQV CEVAFRLAGK DNPVQNLHKT PIPNFDLLVV PPFESEAKRI SAAASKAAKA 370 380 390 400 410 420 QNVSVVEAGT SVAPRSRPKG SSSVHGGNPL GLGLPPSPSP RQNITSPQPQ PQPVVEQFQA 430 440 450 460 470 480 NFPAMPPAVP PPPQAVTPAA PAASKLFESS GYPDPFNEPA AAVIPTEFLP AAEEPNKEEV 490 500 510 520 530 540 PQDLNVIAGT PTKSMLTPPK PSGGGGHRRN VSDTSAFNKT FANETSQFLA PFNNNLAAMG 550 560 570 580 590 600 DGQQTLASAA SNPGIYASST ANSAAVSISE LMKPGQTAVE KRVEAWNPFE EEQPFSQMTE 610 620 630 640 650 660 DHIFEAEFDK IRQRGSQGSI TAKSASTTST LTPTEQIPSA VVAPVTAAPG AVPPPPIAAA 670 680 690 700 710 720 VSPYPSQVSE DPFGSAPFSL PPGLREKASS LRKTGAKFIG VSSGGTGGGV ATPIGLVAGG 730 740 750 760 770 780 ANTATSSNSS KWMLSPTLEV SSEEKTSLIS KLKTDSECGI PGAVGGAGEG VSGYVKLPVE 790 800 810 820 830 840 DRNKYEKLRS KDQPTSDDSD SEASEFFQQD SDEGGGGIFR QMQMVTSNLP ETIHKIQQVA 850 860 870 880 890 900 YHKVDKTAHL PIVKKLRDKT KKPTTAAHQA AQQLNLMAAA VAAQAEEAAK AAESDGDSIG 910 920 930 940 950 960 SASDLRAEDD DLFDENPRQT QAKQRRPLPT EMDGISESVK TCSSSAYHAE CESVTTHEDD 970 980 990 1000 1010 1020 VRSRVVVKVR MRKKDRALVT ATGDPSAPSE ELSPTSSDLL HKFGDRPLLL DDELDYGSGE 1030 1040 1050 1060 1070 1080 SKSSTESPVA PTLPTNPDVQ ESEEDVFALA PFKLPVGVPL KRKTKPKAKP KPAEPEMWTS 1090 1100 1110 1120 1130 1140 TPVKSAAVGD PSTNFASFPA NVTPTNNVGN SAQLDEFNAP IFNPFQENAQ NTQSGETNQC 1150 1160 1170 1180 1190 1200 DLFGLEPFPQ VIRTIEQNPQ HHQIHQFPSH NNNNNVIKVP ASVSVALPAS VPVSVSVNSS 1210 1220 1230 1240 1250 1260 APQLVTINHS IIINKTPEPP MNYNNNNNNN NQTAKSTGTS SVYVNVPSFS SMSTSSCSIN 1270 1280 1290 1300 1310 1320 QPQSSPAAVI PVQAPLPVPV PAPVSVPAVP VPIPAVVTHL RPLLPIADNA YVQISQDRCS 1330 1340 1350 1360 1370 1380 DFTPDDEEEP VVLRDADVVA DGIGIPTPAK PKKEKSNLAV RVLPGKLTQK VKGHSYKKVS 1390 1400 1410 1420 1430 1440 AAALGSTSSL SSGSKQKHQR LQYQSHDDDD DEQDQDENRG AGGGRNFQSN TIQNSAKTGF 1450 1460 1470 1480 1490 SNMSFEDFPS DQEMDRLSRT IPFEVVRNEK MLLEAEKKFG SLKRRNNLFS

References

[1]	"Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo." Chien C.T., Wang S., Rothenberg M., Jan L.Y., Jan Y.N. Mol. Cell. Biol. 18:598-607(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Chien C.T., Wang S., Rothenberg M., Jan L.Y., Jan Y.N. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF197910 mRNA. Translation: AAF15596.1.
3D structure databases
ProteinModelPortal	Q9U485.
ModBase	Search...
Proteomic databases
PRIDE	Q9U485.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0015772. Nak.
Phylogenomic databases
InParanoid	Q9U485.
Gene expression databases
ArrayExpress	Q9U485.
Bgee	Q9U485.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	Atpalpha. drosophila.

Entry information

Entry name

Q9U485_DROME

Accession

Primary (citable) accession number: Q9U485

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)