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Protein

Kappa-conotoxin BtX

Gene
N/A
Organism
Conus betulinus (Beech cone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Modulator of potassium channels, specifically up-modulates the calcium and voltage-gated BK channels, has no effect on single channel conductance, but increases the open probability of BK channels.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin BtX1 Publication
Alternative name(s):
BeTxImported
OrganismiConus betulinus (Beech cone)
Taxonomic identifieri89764 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1106. BtX precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
PeptideiPRO_000003508627 – 57Kappa-conotoxin BtXAdd BLAST31
PropeptideiPRO_000003508761 – 7010

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 41By similarity
Modified residuei304-carboxyglutamate1 Publication1
Disulfide bondi34 ↔ 46By similarity
Modified residuei354-carboxyglutamate1 Publication1
Disulfide bondi40 ↔ 50By similarity
Modified residuei444-carboxyglutamate1 Publication1
Disulfide bondi45 ↔ 54By similarity
Modified residuei534-hydroxyproline1 Publication1
Modified residuei57Proline amide1 Publication1

Post-translational modificationi

Contains 4 disulfide bonds.1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

SMRiQ9U3Z3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).Curated

Sequence similaritiesi

Belongs to the conotoxin I2 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013141. Conotoxin-I_CS.
IPR020242. Conotoxin_I2-superfamily.
PfamiView protein in Pfam
PF17557. Conotoxin_I2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162. Conotoxin_I2-superfamily. 1 hit.
PROSITEiView protein in PROSITE
PS60019. I_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9U3Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFRVTSVGC LLLVIVFLNL VVPTSACRAE GTYCENDSQC CLNECCWGGC
60 70
GHPCRHPGKR SKLQEFFRQR
Length:70
Mass (Da):7,900
Last modified:May 1, 2000 - v1
Checksum:iF6575A2E830AD903
GO

Mass spectrometryi

Molecular mass is 3569 Da from positions 27 - 57. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208661 mRNA. Translation: AAF23167.1.

Similar proteinsi

Entry informationi

Entry nameiCI2B_CONBE
AccessioniPrimary (citable) accession number: Q9U3Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families