Unreviewed, UniProtKB/TrEMBL Q9U3Y5 (Q9U3Y5_DROME)

Names and origin

Protein names

Submitted name:
    Dynein heavy chain EMBL AAF21041.1

Gene names

Name:	kl-5 FlyBase FBgn0001315
ORF Names:	CG40444 FlyBase FBgn0001315

Organism

Drosophila melanogaster (Fruit fly) EMBL AAF21041.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	4559 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Domain	Coiled coil Spearmint SPM013602
Ligand	ATP-binding RuleBase RU003299V0 Nucleotide-binding
Gene Ontology (GO)
Biological process	microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular component	dynein complex Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro ATPase activity Inferred from electronic annotation. Source: InterPro microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9U3Y5-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D5B251B5A16728A9	FASTA	4,559	526,121
	10 20 30 40 50 60 MADEKEKKEP VDNRPEFFWN YLTKTMRLKL DKWTKMITTN EFRDVIIEFL NNPNKKRIIF 70 80 90 100 110 120 TINSGGQLYP SYSFPVRPRY KVAYFIRYLT PLHLTDENML NSLLIGDLLP NPLANLSILC 130 140 150 160 170 180 DEVFFPLLNN TVNQVGWTNV IANDMKTESQ EMRNGIAQMK GLVINRTIFP LPICMDEVMQ 190 200 210 220 230 240 AAPAIAMGDI SVVNPLMKHS LEFMVVKWLD SVEDLVNIKA GEKIYSKENF PLPEAIFSFW 250 260 270 280 290 300 ESRLENLENL AEQLGDRRIK TIGFVLEKIQ SIFEHSYRRI VELVLESLAE ARDITKCLSP 310 320 330 340 350 360 LKRKMDKFET NDMDENRSDI RPLMLTIGLV WGHSRYFHTL NNITLFFNLF HNSLIDCVNR 370 380 390 400 410 420 TVEPDSIFQG DVDEAYKKLD INMQHLEYYK LIYNECRNSL KKFKIGTTFN SQDWTWHQDE 430 440 450 460 470 480 IFGRLDKFLV RLEELKDLFN TVRDFQKLEK IVMGGLKGRQ ITFALEKILE EYNSIYREWT 490 500 510 520 530 540 NIQYNPIDPD AENSLFQRDR LSFKANTDVM ERMVSFQFEK GLEDTHDLLL AGSLLLRPII 550 560 570 580 590 600 KKHVEPLMHV IVDDFEEEIM CVKKEFINFK NVFTALGLNE LPTDDCFPKV SGAISFLKKL 610 620 630 640 650 660 RHRIIGLHKE HELYEYPLFD NERGGYVSDI FNIMVQEIDD FTKMLLDKWT VECWQGIQQD 670 680 690 700 710 720 ITLTLIEKDE ANELRVNFTE RLIFALKDIK VVRLLGCDVS VNLTKFFCRE DELWQARVKL 730 740 750 760 770 780 MRIAEWYNDT FERAHPTEKR LIAAEMILIE EQMKPLLDFI KWNAFSQRFI VMIFKMVKYL 790 800 810 820 830 840 HDRLVAAQEN LEAIKESIRS WGKVPLFQRK DLNPALLLHT DPREPILSIR AANAADTQRL 850 860 870 880 890 900 IDLLMYVNLK LFFDIPRRYS LPPGEHGEED EESDGIWPPI ISLSVMTSVK FKKKREVIDE 910 920 930 940 950 960 EDDLEEFEEE QSESEEEIIT PFHRYELLKG LSQEERALFR EYEIYVDEII AENLVDSVIT 970 980 990 1000 1010 1020 SSTYLRMEVD NRYENNTPIF EIFMELQEPN VVYFRNLDTS SKTGFAFFIE TILDDMNNMM 1030 1040 1050 1060 1070 1080 SLLKRVAQDP TEVTNMNPYS FYDELQDKSE LDKQRVEIMN KIKRALQAWR VHGKGFMEFS 1090 1100 1110 1120 1130 1140 SLWIWDKSTY LSEVKKFGRN LTLDERDAEA DLEGSSGVKL LGLEYPRLSV YKEQLDKFIE 1150 1160 1170 1180 1190 1200 LQDQIRTWET YEDFFVFLRL NMTGFKVAVL SQVGQWISLF KLDLINRVKN SLKELQDFVD 1210 1220 1230 1240 1250 1260 EANIVLKIEL QKDDFEGLVK ILSVLNQINE KQCIYDSMFD PLKEIIDLLR QYNYEFKDTE 1270 1280 1290 1300 1310 1320 LAQINELPDA WMKVKRLAAT TKQLIAPIQS YQVNLIEKRI LLCDNMANTY RKKFLSKKFF 1330 1340 1350 1360 1370 1380 FVPCLSCYEL IDESDLELVA LEERQRSLAE SAVLFELQGP DPVKIELCRF DLKLVKIMWD 1390 1400 1410 1420 1430 1440 FAITIQSTIN DWKKTPWKKI DIENMDQECK KFGRELRGLD KAMQTWEPFI FMEASLKNLM 1450 1460 1470 1480 1490 1500 TSLRAVTELQ NPAIRDRHWI ELMQTTKVKF SMDDSTTLKD LIDLNLHEYE EEVKNIVDKS 1510 1520 1530 1540 1550 1560 VKEMAMEKQL RDIATAWGTM EFGTDIHDRT SIKLLKASEE LIETLEDHQG QLQNMASSKY 1570 1580 1590 1600 1610 1620 IAFFEHEVRL WQNRLSNADQ IIGSWFEVQR KWQYLESIFI GSEDIRSQLP EDSRRFDYID 1630 1640 1650 1660 1670 1680 KEFKALLAQM NADRNVVRST NRSGSKLYEH LEILLKMLLL SQKALNDYLE TKRLSYPRFY 1690 1700 1710 1720 1730 1740 FVSSADLLDI LSNGNNPALV ARHLTKLYDS MGKLNLISGS KNAAGMVAKE LEEYVPFLEN 1750 1760 1770 1780 1790 1800 CDCSGKVEVW LNRITDKMRD TLRDQLKRSL TFYDHKPRHV WIFEWPAQPA LVGTQIMWTT 1810 1820 1830 1840 1850 1860 ETNDAFAKVQ QRYENALKDY NKKQITQLNN LIILLLGDLT AAERQKIMTI CTIDVHSRDV 1870 1880 1890 1900 1910 1920 VGTIIAKKVE VQTAFQWQSQ LRHRWDPKID DCFANICDAQ FRYDYEYLGN TPRLVITPLT 1930 1940 1950 1960 1970 1980 DRCYITLTQS LHLVMGGAPA GPAGTGKTET TKDLGRALGM MVYVFNCSEQ MDYKSIGDIH 1990 2000 2010 2020 2030 2040 KGLAQTGAWG CFDEFNRISV EVGSVVAVQV KCIQDAIKSK KQTFSFLGEH IALRTTVGVF 2050 2060 2070 2080 2090 2100 ITMNPGYAGR AELPENLKAL YRPCAMVVPD FALISEIMLV AEGFQEARLL ARKFITLYTL 2110 2120 2130 2140 2150 2160 CKELLSKQDH YDWGLRAIKS VLVVAGALRR DDRQRPEDQV LMRALRDFNI PKIVTDDVPV 2170 2180 2190 2200 2210 2220 FMGLIGDLFP ALDVPRKRNP EFEAVIKRSA LDLKLQPEDG FILKIVQLEE LFAVRHSVFI 2230 2240 2250 2260 2270 2280 IGFAGTGKSE VWKTLNKTYQ NQKRKPHYND LNPKAVTNDE LFGIVNPLTR EGKDGLFSIL 2290 2300 2310 2320 2330 2340 MRDQANHGGT GPKWIVLDGD IDPMCIESLN TVMDDNKVLT LASNERIALT KEMRLLFEIA 2350 2360 2370 2380 2390 2400 SLRTATPATV SRAGILYINP QDLGWTPFIQ SWLGTRTNSS EVSMLNVLFD KYVPPLLDIF 2410 2420 2430 2440 2450 2460 RTRLRSITPI SDIARLQMTC YLLDSMLTPQ NVPNDCPKDW YEIYFVFCIV WGFGSSLFQD 2470 2480 2490 2500 2510 2520 QIIDWSNEFS KWFLNEYKAV KFPLSGTIFS FYIDHETKKF FPWTNLVPQF ELDMDLPLQS 2530 2540 2550 2560 2570 2580 NLVNTAETTR LRFFMDTLIE ADHPLMLIGP SGSGKTILMN AKLSALPSDK YSVTNVPFNF 2590 2600 2610 2620 2630 2640 YTTSEMLQRI LEKPLEKKAG RNYGPIGNKR MIYFVDDMNM PEVDKYFTVQ PHTLIRQFMD 2650 2660 2670 2680 2690 2700 YHHWYDRQKM TLRDIHKCNI VACMNPSAGS FTIDPRLQRH FCSFAVNPPS QDALFHILNS 2710 2720 2730 2740 2750 2760 ILSQHMDNPI QKFDKAVIKL CENMVTTAIT LHLKVVSSFL PTAIKFHYNF NLRDIANIFT 2770 2780 2790 2800 2810 2820 GVLYSNSETC PNSNQMIRLW IHECYRVYGD KLVDYTDINS FKKIVSDIVR KGIEGVNDDV 2830 2840 2850 2860 2870 2880 VYAQPLIYCH FAKGLTDIKY MPISGWDRLK SLLDEAQDRY NDYIGAMNLV LFDDAMSHVC 2890 2900 2910 2920 2930 2940 RISRILESSR GYALLIGVGG SGKQSLTRLA SFISSLDVFQ IQLTKDYSVS DLKANIATLY 2950 2960 2970 2980 2990 3000 MKAGVKTSAC CFLMTDSEVA REQFLVLVND LLASGDIHEL FPDDEVENIV NAVRNEVKQL 3010 3020 3030 3040 3050 3060 GIVDNRENCW KYFIEKVRSL LKVVLCFSPV GATLRVRSRK FPALVNCTTI DWFHEWPQQA 3070 3080 3090 3100 3110 3120 LESVSLRFLS EITVLPKELA LPVSNFMAFV HKTVNDISKL YLANAKRYNY TTPKSFLELI 3130 3140 3150 3160 3170 3180 ALYSKLLHEK VKANLDRRLR LENGLIKLAS CTKEVDALQD VLKVQEVELK IKNQEADNLI 3190 3200 3210 3220 3230 3240 IVVGTENEKV SKERAFASKE EKNVRQIEED VTAKAKLCEE DFLKAQPALI AAQEALNTLN 3250 3260 3270 3280 3290 3300 KNNLTELKSF GSPPDAVVSV CGAVLVLFSS KGKIPKDRSW KACRAFMGNV DKFLDNLINY 3310 3320 3330 3340 3350 3360 DKKHIHPDVI KALQPYILDA EFSPEKILAK SSAAAGLCSW VININRFYDV YLVVEPKERA 3370 3380 3390 3400 3410 3420 LLESEKEVKD ARDKLTALNL RLTELEEQLN ALQMEYDEAL AKKQKCQDEA SKTAFTIDIA 3430 3440 3450 3460 3470 3480 NRLIGGLATE KIRWMESVKS LTFGIQQLPG DILIISCFIS YVGCFTRAYR QELQEKLWMP 3490 3500 3510 3520 3530 3540 AFKNSQPPIP STDGVDPFEM ICDDAQIAEW NNQGLPSDRM SAENAAILVQ SERYPLMIDP 3550 3560 3570 3580 3590 3600 QLQGIKWVKT KYGTGLVVLR LSQRNYLDQV ERAVSNGSVL LIENIGENID PVLNPLLGRQ 3610 3620 3630 3640 3650 3660 LIKKGTVLKI GDREIDFNSR FRLILHTKLA NPHYKPEMQA QTTLINFTVT RDGLEDQLLA 3670 3680 3690 3700 3710 3720 EVVKVERPDL EAMRTRLTQQ QNHFKITLKF LEDDLLARLS SAGDNVLEDV TLVMNLEKTK 3730 3740 3750 3760 3770 3780 KTADEIEVKV AEAKITGVQI DSAREAYRPA AERASIIYFI LNDLFKINPI YQFSLKAFTV 3790 3800 3810 3820 3830 3840 VFNNAMLKAM AAEKLKDRVE NLIDSITFCS FVYTSRGLFE QDKLIFLTQL CIQILVNLGE 3850 3860 3870 3880 3890 3900 VEPTELDFLL RFPYMPNQTS NFTWLTHVGW GGIRALNNQA VFKGLEKDIE GSHKRWKKFV 3910 3920 3930 3940 3950 3960 DSESPENEKF PGEWKGKSAI QRLCIMRSIR PDRMSYAMRS LIEEKLGSKY IDARSMEFSR 3970 3980 3990 4000 4010 4020 TFEESSPETH IFFVLSPGVD PLKDVEKLGK SLGFSFDHEN FHSVSLCQGQ EIVAENAIEI 4030 4040 4050 4060 4070 4080 ASQYGHWVIL QNIHLVARWL PSLEKKMESS LSNVHTSYRL FLSAEPAGDP AAHILPQGIL 4090 4100 4110 4120 4130 4140 ESAIKITNEP PTGMMANIHK ALDNFSDETL EMCSKETEFK AILFSLCYFH AVVAERRKFG 4150 4160 4170 4180 4190 4200 PQGWNRSYPF NVGDLTISVY VLYNYLEANT RVPWEDLRYL FGEIMYGGHI TDDWDRRLCR 4210 4220 4230 4240 4250 4260 TYLEEFMQPE LIDGELEYCQ GFPAPGILKY TGYHNYIDDN LPSESPSLYG LHSNAEIGFL 4270 4280 4290 4300 4310 4320 TTVSERLFRI VFELQPRMTG GSSGGETVSQ EDIIKNIIED ILDKTPTPFN ILELMGRVED 4330 4340 4350 4360 4370 4380 RSPYIIVAFQ ECERMNNLMT ELKRSLNELD LGLKGELTIS SVMEDLMVCL YMDQVPEQWT 4390 4400 4410 4420 4430 4440 KLAYPSMLGL QSWFSDLMLR LRELEGWVAD FRMPSSIWLA GFFNPQSLLT AIMQQTARKN 4450 4460 4470 4480 4490 4500 EWPLDRMCLN CDVTKKWKEE LTTAPREGAY INGLFMEGAR WDMKMGTIAD AFLKELFPAM 4510 4520 4530 4540 4550 PVLYIKAVTQ DKQDIKNVYE CPVYKIRLRG PTFVWTFNLK SRERASKWTL AGVCLLLQT

References

[1]	"The Y chromosome fertility factor kl-5 of Drosophila melanogaster encodes the dynein heavy chain protein Dhc-Yh3." Kurek R., Buenemann H., Gatti M. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF210453 mRNA. Translation: AAF21041.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:20891N.
Proteomic databases
PRIDE	Q9U3Y5.
Genome annotation databases
Ensembl	FBgn0001315. Drosophila melanogaster. [Contig view]
Organism-specific databases
FlyBase	FBgn0001315. kl-5.
Gene expression databases
ArrayExpress	Q9U3Y5.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR011704. ATPase_AAA-5. IPR004273. Dynein_heavy. IPR013594. Dynein_heavy_N_1. IPR013602. Dynein_heavy_N_2. IPR000169. Pept_cys_AS. [Graphical view]
Pfam	PF07728. AAA_5. 2 hits. PF08385. DHC_N1. 1 hit. PF08393. DHC_N2. 1 hit. PF03028. Dynein_heavy. 1 hit. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00639. THIOL_PROTEASE_HIS. 1 hit. Uncertain. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9U3Y5_DROME

Accession

Primary (citable) accession number: Q9U3Y5

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	July 7, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)