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Q9U3X4

- SDHA_DICDI

UniProt

Q9U3X4 - SDHA_DICDI

Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

sdhA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei253 – 2531FADBy similarity
    Binding sitei274 – 2741SubstrateBy similarity
    Binding sitei286 – 2861SubstrateBy similarity
    Active sitei318 – 3181Proton acceptorBy similarity
    Binding sitei385 – 3851SubstrateBy similarity
    Binding sitei418 – 4181FADBy similarity
    Binding sitei429 – 4291SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi46 – 516FADBy similarity
    Nucleotide bindingi69 – 8416FADBy similarityAdd
    BLAST
    Nucleotide bindingi434 – 4352FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitochondrial electron transport, succinate to ubiquinone Source: dictyBase
    2. positive phototaxis Source: dictyBase
    3. tricarboxylic acid cycle Source: dictyBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    ReactomeiREACT_215657. Respiratory electron transport.
    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Flavoprotein subunit of complex II
    Short name:
    FP
    Gene namesi
    Name:sdhA
    ORF Names:DDB_G0280535
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0280535. sdhA.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex II Source: dictyBase
    2. mitochondrion Source: dictyBase
    3. phagocytic vesicle Source: dictyBase

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionSequence AnalysisAdd
    BLAST
    Chaini25 – 626602Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialPRO_0000327828Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei77 – 771Tele-8alpha-FAD histidineBy similarity

    Proteomic databases

    PRIDEiQ9U3X4.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0214886.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9U3X4.
    SMRiQ9U3X4. Positions 33-626.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1053.
    KOiK00234.
    OMAiNVFRTEE.
    PhylomeDBiQ9U3X4.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9U3X4-1 [UniParc]FASTAAdd to Basket

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    MLSSALKLTK KVCSTKSNGL IRSFSTQTQS RDYAVVDHTY DAIVVGAGGA    50
    GLRAALGLTE KGYKTACITK LFPTRSHTVA AQGGINAALG NADQDDWRWH 100
    AYDTVKGSDF LGDQDAIHYM CKEAVPTVLE LEQYGVPFSR MDDGRIYQRA 150
    FGGQSKNFGK GGQATRCCAA ADRTGHALLH TLYGQAVKHN TKFFIEYFVT 200
    DLIMENGDCR GVVAINLEDG TIHRFRSHAT VIATGGYGRA YFSATSAHTC 250
    TGDGNAMVIR AGLPCQDLEF VQFHPTGIYG SGCLITEGAR GEGGYLLNSS 300
    GERFMPRYAP SVADLASRDV VSRSETMEIR EGRGVGPEKD HCLLNLTHLS 350
    PEIIDERLPG IRETAMIFAG VDVTKEPIPV IPTVHYNMGG IPTNYKGQVI 400
    TQVDGKDKLV KGLYAAGESA CVSVHGANRL GANSLLDIVV FGRAVANEIE 450
    NTLAKDTPHK PLPPNAGEES IANIDAIRFS NGTRSTAEIR LEMQKIMQRN 500
    AAVFRDGQVL KEGVELIDKC ARSLINDLKT TDRTMIWNTD LIESLELQNL 550
    MTQAVLTMHS AEARKESRGA HAREDYKERD DANWMKHTLS YLDVNTGKVT 600
    LNYRPVVSET LDQSEMETIK PFKRVY 626
    Length:626
    Mass (Da):68,516
    Last modified:May 1, 2000 - v1
    Checksum:iC8F27868BD063D67
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF211482 Genomic DNA. Translation: AAF21045.1.
    AAFI02000037 Genomic DNA. Translation: EAL67069.1.
    RefSeqiXP_641069.1. XM_635977.1.

    Genome annotation databases

    EnsemblProtistsiDDB0214886; DDB0214886; DDB_G0280535.
    GeneIDi8622627.
    KEGGiddi:DDB_G0280535.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF211482 Genomic DNA. Translation: AAF21045.1 .
    AAFI02000037 Genomic DNA. Translation: EAL67069.1 .
    RefSeqi XP_641069.1. XM_635977.1.

    3D structure databases

    ProteinModelPortali Q9U3X4.
    SMRi Q9U3X4. Positions 33-626.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0214886.

    Proteomic databases

    PRIDEi Q9U3X4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0214886 ; DDB0214886 ; DDB_G0280535 .
    GeneIDi 8622627.
    KEGGi ddi:DDB_G0280535.

    Organism-specific databases

    dictyBasei DDB_G0280535. sdhA.

    Phylogenomic databases

    eggNOGi COG1053.
    KOi K00234.
    OMAi NVFRTEE.
    PhylomeDBi Q9U3X4.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .
    Reactomei REACT_215657. Respiratory electron transport.

    Miscellaneous databases

    PROi Q9U3X4.

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The flavoprotein subunit 1 of Dictyostelium succinate dehydrogenase."
      Lay S.P., Fisher P.R.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: AX2.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiSDHA_DICDI
    AccessioniPrimary (citable) accession number: Q9U3X4
    Secondary accession number(s): Q54V62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3