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Q9U3X4

- SDHA_DICDI

UniProt

Q9U3X4 - SDHA_DICDI

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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

sdhA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FADBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei253 – 2531FADBy similarity
Binding sitei274 – 2741SubstrateBy similarity
Binding sitei286 – 2861SubstrateBy similarity
Active sitei318 – 3181Proton acceptorBy similarity
Binding sitei385 – 3851SubstrateBy similarity
Binding sitei418 – 4181FADBy similarity
Binding sitei429 – 4291SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 516FADBy similarity
Nucleotide bindingi69 – 8416FADBy similarityAdd
BLAST
Nucleotide bindingi434 – 4352FADBy similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. mitochondrial electron transport, succinate to ubiquinone Source: dictyBase
  2. positive phototaxis Source: dictyBase
  3. tricarboxylic acid cycle Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Flavoprotein subunit of complex II
Short name:
FP
Gene namesi
Name:sdhA
ORF Names:DDB_G0280535
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280535. sdhA.

Subcellular locationi

Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

  1. mitochondrial respiratory chain complex II Source: dictyBase
  2. mitochondrion Source: dictyBase
  3. phagocytic vesicle Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionSequence AnalysisAdd
BLAST
Chaini25 – 626602Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialPRO_0000327828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771Tele-8alpha-FAD histidineBy similarity

Proteomic databases

PRIDEiQ9U3X4.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Protein-protein interaction databases

STRINGi44689.DDB_0214886.

Structurei

3D structure databases

ProteinModelPortaliQ9U3X4.
SMRiQ9U3X4. Positions 33-626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1053.
InParanoidiQ9U3X4.
KOiK00234.
OMAiNVFRTEE.
PhylomeDBiQ9U3X4.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9U3X4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSSALKLTK KVCSTKSNGL IRSFSTQTQS RDYAVVDHTY DAIVVGAGGA
60 70 80 90 100
GLRAALGLTE KGYKTACITK LFPTRSHTVA AQGGINAALG NADQDDWRWH
110 120 130 140 150
AYDTVKGSDF LGDQDAIHYM CKEAVPTVLE LEQYGVPFSR MDDGRIYQRA
160 170 180 190 200
FGGQSKNFGK GGQATRCCAA ADRTGHALLH TLYGQAVKHN TKFFIEYFVT
210 220 230 240 250
DLIMENGDCR GVVAINLEDG TIHRFRSHAT VIATGGYGRA YFSATSAHTC
260 270 280 290 300
TGDGNAMVIR AGLPCQDLEF VQFHPTGIYG SGCLITEGAR GEGGYLLNSS
310 320 330 340 350
GERFMPRYAP SVADLASRDV VSRSETMEIR EGRGVGPEKD HCLLNLTHLS
360 370 380 390 400
PEIIDERLPG IRETAMIFAG VDVTKEPIPV IPTVHYNMGG IPTNYKGQVI
410 420 430 440 450
TQVDGKDKLV KGLYAAGESA CVSVHGANRL GANSLLDIVV FGRAVANEIE
460 470 480 490 500
NTLAKDTPHK PLPPNAGEES IANIDAIRFS NGTRSTAEIR LEMQKIMQRN
510 520 530 540 550
AAVFRDGQVL KEGVELIDKC ARSLINDLKT TDRTMIWNTD LIESLELQNL
560 570 580 590 600
MTQAVLTMHS AEARKESRGA HAREDYKERD DANWMKHTLS YLDVNTGKVT
610 620
LNYRPVVSET LDQSEMETIK PFKRVY
Length:626
Mass (Da):68,516
Last modified:May 1, 2000 - v1
Checksum:iC8F27868BD063D67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211482 Genomic DNA. Translation: AAF21045.1.
AAFI02000037 Genomic DNA. Translation: EAL67069.1.
RefSeqiXP_641069.1. XM_635977.1.

Genome annotation databases

EnsemblProtistsiDDB0214886; DDB0214886; DDB_G0280535.
GeneIDi8622627.
KEGGiddi:DDB_G0280535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211482 Genomic DNA. Translation: AAF21045.1 .
AAFI02000037 Genomic DNA. Translation: EAL67069.1 .
RefSeqi XP_641069.1. XM_635977.1.

3D structure databases

ProteinModelPortali Q9U3X4.
SMRi Q9U3X4. Positions 33-626.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0214886.

Proteomic databases

PRIDEi Q9U3X4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0214886 ; DDB0214886 ; DDB_G0280535 .
GeneIDi 8622627.
KEGGi ddi:DDB_G0280535.

Organism-specific databases

dictyBasei DDB_G0280535. sdhA.

Phylogenomic databases

eggNOGi COG1053.
InParanoidi Q9U3X4.
KOi K00234.
OMAi NVFRTEE.
PhylomeDBi Q9U3X4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Miscellaneous databases

PROi Q9U3X4.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The flavoprotein subunit 1 of Dictyostelium succinate dehydrogenase."
    Lay S.P., Fisher P.R.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AX2.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiSDHA_DICDI
AccessioniPrimary (citable) accession number: Q9U3X4
Secondary accession number(s): Q54V62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3