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Q9U3X4

- SDHA_DICDI

UniProt

Q9U3X4 - SDHA_DICDI

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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene
sdhA, DDB_G0280535
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FAD By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei253 – 2531FAD By similarity
Binding sitei274 – 2741Substrate By similarity
Binding sitei286 – 2861Substrate By similarity
Active sitei318 – 3181Proton acceptor By similarity
Binding sitei385 – 3851Substrate By similarity
Binding sitei418 – 4181FAD By similarity
Binding sitei429 – 4291Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 516FAD By similarity
Nucleotide bindingi69 – 8416FAD By similarityAdd
BLAST
Nucleotide bindingi434 – 4352FAD By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. mitochondrial electron transport, succinate to ubiquinone Source: dictyBase
  2. positive phototaxis Source: dictyBase
  3. tricarboxylic acid cycle Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiREACT_215657. Respiratory electron transport.
UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Flavoprotein subunit of complex II
Short name:
FP
Gene namesi
Name:sdhA
ORF Names:DDB_G0280535
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280535. sdhA.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial respiratory chain complex II Source: dictyBase
  2. mitochondrion Source: dictyBase
  3. phagocytic vesicle Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424Mitochondrion Reviewed predictionAdd
BLAST
Chaini25 – 626602Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialPRO_0000327828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771Tele-8alpha-FAD histidine By similarity

Proteomic databases

PRIDEiQ9U3X4.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0214886.

Structurei

3D structure databases

ProteinModelPortaliQ9U3X4.
SMRiQ9U3X4. Positions 33-626.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1053.
KOiK00234.
OMAiNVFRTEE.
PhylomeDBiQ9U3X4.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9U3X4-1 [UniParc]FASTAAdd to Basket

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MLSSALKLTK KVCSTKSNGL IRSFSTQTQS RDYAVVDHTY DAIVVGAGGA    50
GLRAALGLTE KGYKTACITK LFPTRSHTVA AQGGINAALG NADQDDWRWH 100
AYDTVKGSDF LGDQDAIHYM CKEAVPTVLE LEQYGVPFSR MDDGRIYQRA 150
FGGQSKNFGK GGQATRCCAA ADRTGHALLH TLYGQAVKHN TKFFIEYFVT 200
DLIMENGDCR GVVAINLEDG TIHRFRSHAT VIATGGYGRA YFSATSAHTC 250
TGDGNAMVIR AGLPCQDLEF VQFHPTGIYG SGCLITEGAR GEGGYLLNSS 300
GERFMPRYAP SVADLASRDV VSRSETMEIR EGRGVGPEKD HCLLNLTHLS 350
PEIIDERLPG IRETAMIFAG VDVTKEPIPV IPTVHYNMGG IPTNYKGQVI 400
TQVDGKDKLV KGLYAAGESA CVSVHGANRL GANSLLDIVV FGRAVANEIE 450
NTLAKDTPHK PLPPNAGEES IANIDAIRFS NGTRSTAEIR LEMQKIMQRN 500
AAVFRDGQVL KEGVELIDKC ARSLINDLKT TDRTMIWNTD LIESLELQNL 550
MTQAVLTMHS AEARKESRGA HAREDYKERD DANWMKHTLS YLDVNTGKVT 600
LNYRPVVSET LDQSEMETIK PFKRVY 626
Length:626
Mass (Da):68,516
Last modified:May 1, 2000 - v1
Checksum:iC8F27868BD063D67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF211482 Genomic DNA. Translation: AAF21045.1.
AAFI02000037 Genomic DNA. Translation: EAL67069.1.
RefSeqiXP_641069.1. XM_635977.1.

Genome annotation databases

EnsemblProtistsiDDB0214886; DDB0214886; DDB_G0280535.
GeneIDi8622627.
KEGGiddi:DDB_G0280535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF211482 Genomic DNA. Translation: AAF21045.1 .
AAFI02000037 Genomic DNA. Translation: EAL67069.1 .
RefSeqi XP_641069.1. XM_635977.1.

3D structure databases

ProteinModelPortali Q9U3X4.
SMRi Q9U3X4. Positions 33-626.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0214886.

Proteomic databases

PRIDEi Q9U3X4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0214886 ; DDB0214886 ; DDB_G0280535 .
GeneIDi 8622627.
KEGGi ddi:DDB_G0280535.

Organism-specific databases

dictyBasei DDB_G0280535. sdhA.

Phylogenomic databases

eggNOGi COG1053.
KOi K00234.
OMAi NVFRTEE.
PhylomeDBi Q9U3X4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .
Reactomei REACT_215657. Respiratory electron transport.

Miscellaneous databases

PROi Q9U3X4.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The flavoprotein subunit 1 of Dictyostelium succinate dehydrogenase."
    Lay S.P., Fisher P.R.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AX2.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiSDHA_DICDI
AccessioniPrimary (citable) accession number: Q9U3X4
Secondary accession number(s): Q54V62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi