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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

sdhA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdhA), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhB)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei253FADBy similarity1
Binding sitei274SubstrateBy similarity1
Binding sitei286SubstrateBy similarity1
Active sitei318Proton acceptorBy similarity1
Binding sitei385SubstrateBy similarity1
Binding sitei418FADBy similarity1
Binding sitei429SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 51FADBy similarity6
Nucleotide bindingi69 – 84FADBy similarityAdd BLAST16
Nucleotide bindingi434 – 435FADBy similarity2

GO - Molecular functioni

GO - Biological processi

  • anaerobic respiration Source: GO_Central
  • mitochondrial electron transport, succinate to ubiquinone Source: dictyBase
  • positive phototaxis Source: dictyBase
  • tricarboxylic acid cycle Source: GO_Central

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-DDI-71403 Citric acid cycle (TCA cycle)
UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1By similarity)
Alternative name(s):
Flavoprotein subunit of complex II
Short name:
FP
Gene namesi
Name:sdhA
ORF Names:DDB_G0280535
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280535 sdhA

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionSequence analysisAdd BLAST24
ChainiPRO_000032782825 – 626Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialAdd BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77Tele-8alpha-FAD histidineBy similarity1

Proteomic databases

PaxDbiQ9U3X4
PRIDEiQ9U3X4

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0214886

Structurei

3D structure databases

ProteinModelPortaliQ9U3X4
SMRiQ9U3X4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
InParanoidiQ9U3X4
KOiK00234
OMAiGDSPWEH
PhylomeDBiQ9U3X4

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9U3X4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSALKLTK KVCSTKSNGL IRSFSTQTQS RDYAVVDHTY DAIVVGAGGA
60 70 80 90 100
GLRAALGLTE KGYKTACITK LFPTRSHTVA AQGGINAALG NADQDDWRWH
110 120 130 140 150
AYDTVKGSDF LGDQDAIHYM CKEAVPTVLE LEQYGVPFSR MDDGRIYQRA
160 170 180 190 200
FGGQSKNFGK GGQATRCCAA ADRTGHALLH TLYGQAVKHN TKFFIEYFVT
210 220 230 240 250
DLIMENGDCR GVVAINLEDG TIHRFRSHAT VIATGGYGRA YFSATSAHTC
260 270 280 290 300
TGDGNAMVIR AGLPCQDLEF VQFHPTGIYG SGCLITEGAR GEGGYLLNSS
310 320 330 340 350
GERFMPRYAP SVADLASRDV VSRSETMEIR EGRGVGPEKD HCLLNLTHLS
360 370 380 390 400
PEIIDERLPG IRETAMIFAG VDVTKEPIPV IPTVHYNMGG IPTNYKGQVI
410 420 430 440 450
TQVDGKDKLV KGLYAAGESA CVSVHGANRL GANSLLDIVV FGRAVANEIE
460 470 480 490 500
NTLAKDTPHK PLPPNAGEES IANIDAIRFS NGTRSTAEIR LEMQKIMQRN
510 520 530 540 550
AAVFRDGQVL KEGVELIDKC ARSLINDLKT TDRTMIWNTD LIESLELQNL
560 570 580 590 600
MTQAVLTMHS AEARKESRGA HAREDYKERD DANWMKHTLS YLDVNTGKVT
610 620
LNYRPVVSET LDQSEMETIK PFKRVY
Length:626
Mass (Da):68,516
Last modified:May 1, 2000 - v1
Checksum:iC8F27868BD063D67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211482 Genomic DNA Translation: AAF21045.1
AAFI02000037 Genomic DNA Translation: EAL67069.1
RefSeqiXP_641069.1, XM_635977.1

Genome annotation databases

EnsemblProtistsiEAL67069; EAL67069; DDB_G0280535
GeneIDi8622627
KEGGiddi:DDB_G0280535

Similar proteinsi

Entry informationi

Entry nameiSDHA_DICDI
AccessioniPrimary (citable) accession number: Q9U3X4
Secondary accession number(s): Q54V62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health