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Protein

Uridine kinase

Gene

CELE_F19B6.1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + cytidine = ADP + CMP.UniRule annotation
ATP + uridine = ADP + UMP.UniRule annotation

Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine kinase (CELE_F19B6.1), Uridine kinase (CELE_F19B6.1), Uridine kinase (CELE_F19B6.1), Probable uridine-cytidine kinase (B0001.4)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine kinase (CELE_F19B6.1), Uridine kinase (CELE_F19B6.1), Uridine kinase (CELE_F19B6.1), Probable uridine-cytidine kinase (B0001.4)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-73614 Pyrimidine salvage
UniPathwayiUPA00574; UER00637
UPA00579; UER00640

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine kinaseUniRule annotation (EC:2.7.1.48UniRule annotation)
Gene namesi
ORF Names:CELE_F19B6.1Imported, F19B6.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF19B6.1b ; CE20700 ; WBGene00008948

PTM / Processingi

Proteomic databases

EPDiQ9U3I7

Expressioni

Gene expression databases

BgeeiWBGene00008948
ExpressionAtlasiQ9U3I7 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ9U3I7, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9U3I7
SMRiQ9U3I7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 294PRKInterPro annotationAdd BLAST189

Sequence similaritiesi

Belongs to the uridine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4203 Eukaryota
COG0035 LUCA
COG0572 LUCA
GeneTreeiENSGT00390000015696
HOGENOMiHOG000262757
PhylomeDBiQ9U3I7

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
cd02023 UMPK, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000836 PRibTrfase_dom
IPR006083 PRK/URK
IPR029057 PRTase-like
IPR000764 Uridine_kinase-like
PfamiView protein in Pfam
PF00485 PRK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00235 udk, 1 hit

Sequencei

Sequence statusi: Complete.

Q9U3I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAEKRDANV AASKGDANRK SVKIEDCPTY SHSSGSSVNE MVNQSGGDSE
60 70 80 90 100
DSTSPRAAGC RTRRRTMSGG RAEHHLLTTK TGKKIYTKGR PPWYDKKGKS
110 120 130 140 150
LKHPFVIGVC GGSASGKTTV AEKIVERLGI PWVTILSMDS FYKVLTPEEI
160 170 180 190 200
KAAHESRYNF DGPNAFDFDL LYEVLKRLRE GKSVDVPVYD FNTHSRDPNS
210 220 230 240 250
KMMYGADVLI FEGILAFHDE RIKNLMDMKV FVDTDGDLRL ARRIVRDVTD
260 270 280 290 300
RGRDIDGIME QYFTFVKPAF DKYIAPCMDS ADLIVPRGGE NDVAIDMIVQ
310 320 330 340 350
NVMAQLVERG YDRNQNNRDR HDLVRDDLPD CLPENLFILK ETPQVKGLVT
360 370 380 390 400
FVRDRETSRD NHIFYSDRLM RILIEECMNH MPYKDVEIEM AGGRKTIGKR
410 420 430 440 450
KDAQICGLPI MRAGECMETA LRSIVKDCVI GKILIQTNET TFDPELHYIR
460 470 480 490 500
LPPHITRYKV IIMDATVTTG SAAMMAIRVL LDHDVKEEDI FVASLLMGQQ
510 520 530 540 550
GAHALAYAFP KVKLITTAMD HQMTENCYLI PGMGNFGDRY YGTGLEQDMD

EPFDM
Length:555
Mass (Da):62,674
Last modified:May 1, 2000 - v1
Checksum:iD0786FAB98E8CF98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA93462.1
PIRiT21110
RefSeqiNP_502350.1, NM_069949.3
UniGeneiCel.38829

Genome annotation databases

EnsemblMetazoaiF19B6.1b; F19B6.1b; WBGene00008948
GeneIDi178181
UCSCiF19B6.1a c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ9U3I7_CAEEL
AccessioniPrimary (citable) accession number: Q9U3I7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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