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Protein

Uridine kinase

Gene

CELE_F19B6.1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + cytidine = ADP + CMP.UniRule annotation
ATP + uridine = ADP + UMP.UniRule annotation

Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine kinase (CELE_F19B6.1), Uridine kinase (CELE_F19B6.1), Uridine kinase (CELE_F19B6.1), Probable uridine-cytidine kinase (B0001.4)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine kinase (CELE_F19B6.1), Uridine kinase (CELE_F19B6.1), Uridine kinase (CELE_F19B6.1), Probable uridine-cytidine kinase (B0001.4)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine kinaseUniRule annotation (EC:2.7.1.48UniRule annotation)
Gene namesi
ORF Names:CELE_F19B6.1Imported, F19B6.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF19B6.1b; CE20700; WBGene00008948.

PTM / Processingi

Proteomic databases

EPDiQ9U3I7.
PaxDbiQ9U3I7.
PRIDEiQ9U3I7.

Expressioni

Gene expression databases

ExpressionAtlasiQ9U3I7. baseline.

Interactioni

Protein-protein interaction databases

IntActiQ9U3I7. 1 interaction.
STRINGi6239.F19B6.1d.

Structurei

3D structure databases

ProteinModelPortaliQ9U3I7.
SMRiQ9U3I7. Positions 104-302, 312-543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 294189PRKInterPro annotationAdd
BLAST
Domaini341 – 543203PRTase-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the uridine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4203. Eukaryota.
COG0035. LUCA.
COG0572. LUCA.
GeneTreeiENSGT00390000015696.
HOGENOMiHOG000262757.
PhylomeDBiQ9U3I7.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR029057. PRTase-like.
IPR000764. Uridine_kinase-like.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
PF14681. UPRTase. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9U3I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAEKRDANV AASKGDANRK SVKIEDCPTY SHSSGSSVNE MVNQSGGDSE
60 70 80 90 100
DSTSPRAAGC RTRRRTMSGG RAEHHLLTTK TGKKIYTKGR PPWYDKKGKS
110 120 130 140 150
LKHPFVIGVC GGSASGKTTV AEKIVERLGI PWVTILSMDS FYKVLTPEEI
160 170 180 190 200
KAAHESRYNF DGPNAFDFDL LYEVLKRLRE GKSVDVPVYD FNTHSRDPNS
210 220 230 240 250
KMMYGADVLI FEGILAFHDE RIKNLMDMKV FVDTDGDLRL ARRIVRDVTD
260 270 280 290 300
RGRDIDGIME QYFTFVKPAF DKYIAPCMDS ADLIVPRGGE NDVAIDMIVQ
310 320 330 340 350
NVMAQLVERG YDRNQNNRDR HDLVRDDLPD CLPENLFILK ETPQVKGLVT
360 370 380 390 400
FVRDRETSRD NHIFYSDRLM RILIEECMNH MPYKDVEIEM AGGRKTIGKR
410 420 430 440 450
KDAQICGLPI MRAGECMETA LRSIVKDCVI GKILIQTNET TFDPELHYIR
460 470 480 490 500
LPPHITRYKV IIMDATVTTG SAAMMAIRVL LDHDVKEEDI FVASLLMGQQ
510 520 530 540 550
GAHALAYAFP KVKLITTAMD HQMTENCYLI PGMGNFGDRY YGTGLEQDMD

EPFDM
Length:555
Mass (Da):62,674
Last modified:May 1, 2000 - v1
Checksum:iD0786FAB98E8CF98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAA93462.1.
PIRiT21110.
RefSeqiNP_502350.1. NM_069949.3.
UniGeneiCel.38829.

Genome annotation databases

EnsemblMetazoaiF19B6.1b; F19B6.1b; WBGene00008948.
GeneIDi178181.
UCSCiF19B6.1a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAA93462.1.
PIRiT21110.
RefSeqiNP_502350.1. NM_069949.3.
UniGeneiCel.38829.

3D structure databases

ProteinModelPortaliQ9U3I7.
SMRiQ9U3I7. Positions 104-302, 312-543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9U3I7. 1 interaction.
STRINGi6239.F19B6.1d.

Proteomic databases

EPDiQ9U3I7.
PaxDbiQ9U3I7.
PRIDEiQ9U3I7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF19B6.1b; F19B6.1b; WBGene00008948.
GeneIDi178181.
UCSCiF19B6.1a. c. elegans.

Organism-specific databases

CTDi178181.
WormBaseiF19B6.1b; CE20700; WBGene00008948.

Phylogenomic databases

eggNOGiKOG4203. Eukaryota.
COG0035. LUCA.
COG0572. LUCA.
GeneTreeiENSGT00390000015696.
HOGENOMiHOG000262757.
PhylomeDBiQ9U3I7.

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.

Gene expression databases

ExpressionAtlasiQ9U3I7. baseline.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR029057. PRTase-like.
IPR000764. Uridine_kinase-like.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
PF14681. UPRTase. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ9U3I7_CAEEL
AccessioniPrimary (citable) accession number: Q9U3I7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.