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Protein
Submitted name:

U2AF splicing factor

Gene

uaf-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • nucleotide binding Source: InterPro
  • pre-mRNA 3'-splice site binding Source: WormBase

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-109688. Cleavage of Growing Transcript in the Termination Region.
R-CEL-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-CEL-72163. mRNA Splicing - Major Pathway.
R-CEL-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Submitted name:
U2AF splicing factorImported
Gene namesi
Name:uaf-2Imported
ORF Names:CELE_Y116A8C.35Imported, Y116A8C.35Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY116A8C.35a; CE23341; WBGene00006698; uaf-2.

Subcellular locationi

GO - Cellular componenti

  • U2AF Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ9U2U0.
PaxDbiQ9U2U0.

Expressioni

Gene expression databases

BgeeiWBGene00006698.
ExpressionAtlasiQ9U2U0. baseline.

Interactioni

Protein-protein interaction databases

DIPiDIP-26717N.
IntActiQ9U2U0. 3 interactions.
MINTiMINT-1068324.
STRINGi6239.Y116A8C.35.2.

Structurei

3D structure databases

ProteinModelPortaliQ9U2U0.
SMRiQ9U2U0. Positions 23-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 4829C3H1-typeInterPro annotationAdd
BLAST
Domaini88 – 15669RRM (RNA recognition motif)InterPro annotationAdd
BLAST
Domaini158 – 18528C3H1-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains RRM (RNA recognition motif) domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG2202. Eukaryota.
ENOG410Z5PX. LUCA.
HOGENOMiHOG000178619.
InParanoidiQ9U2U0.
KOiK12836.
OMAiEVEEMNI.
OrthoDBiEOG091G0CUI.
PhylomeDBiQ9U2U0.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
IPR009145. U2AF_small.
IPR000571. Znf_CCCH.
[Graphical view]
PANTHERiPTHR12620. PTHR12620. 1 hit.
PfamiPF00076. RRM_1. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
PRINTSiPR01848. U2AUXFACTOR.
SMARTiSM00361. RRM_1. 1 hit.
SM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U2U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYGDGLSGA EYLASIYGTE KDKVNCSFFF KTGACRHGDK CSRAHHTPTF
60 70 80 90 100
SPTVVLKNFY HNPVVDVRQA DAFDKVGKRN DQEQRYFDDF YEEVFVEMER
110 120 130 140 150
KYGEVEEINV CENIGEHMVG NVYVKFMKEE DAEKAKNDLN NRWFNGQPIY
160 170 180 190 200
AELCPVTDFR ESRCRQHEVT TCSKGGFCNF MHLKAISAEL GDRLYGRRGR
210 220 230 240 250
RADAAGHYPS QRGGSGGGGG GGGGGGYGSG GGWGGGGGGR DRDRGGWGGG
260 270 280
GGGRGYGGGG GGGGYGYGGG GGGRRRSRSR DRRRY
Length:285
Mass (Da):30,856
Last modified:May 1, 2000 - v1
Checksum:iE2B932629653C040
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAB55137.1.
PIRiT31503.
RefSeqiNP_503036.1. NM_070635.3.
UniGeneiCel.5051.

Genome annotation databases

EnsemblMetazoaiY116A8C.35; Y116A8C.35; WBGene00006698.
Y116A8C.35a; Y116A8C.35a; WBGene00006698.
GeneIDi178489.
KEGGicel:CELE_Y116A8C.35.
UCSCiY116A8C.35. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAB55137.1.
PIRiT31503.
RefSeqiNP_503036.1. NM_070635.3.
UniGeneiCel.5051.

3D structure databases

ProteinModelPortaliQ9U2U0.
SMRiQ9U2U0. Positions 23-190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-26717N.
IntActiQ9U2U0. 3 interactions.
MINTiMINT-1068324.
STRINGi6239.Y116A8C.35.2.

Proteomic databases

EPDiQ9U2U0.
PaxDbiQ9U2U0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY116A8C.35; Y116A8C.35; WBGene00006698.
Y116A8C.35a; Y116A8C.35a; WBGene00006698.
GeneIDi178489.
KEGGicel:CELE_Y116A8C.35.
UCSCiY116A8C.35. c. elegans.

Organism-specific databases

CTDi178489.
WormBaseiY116A8C.35a; CE23341; WBGene00006698; uaf-2.

Phylogenomic databases

eggNOGiKOG2202. Eukaryota.
ENOG410Z5PX. LUCA.
HOGENOMiHOG000178619.
InParanoidiQ9U2U0.
KOiK12836.
OMAiEVEEMNI.
OrthoDBiEOG091G0CUI.
PhylomeDBiQ9U2U0.

Enzyme and pathway databases

ReactomeiR-CEL-109688. Cleavage of Growing Transcript in the Termination Region.
R-CEL-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-CEL-72163. mRNA Splicing - Major Pathway.
R-CEL-72187. mRNA 3'-end processing.

Gene expression databases

BgeeiWBGene00006698.
ExpressionAtlasiQ9U2U0. baseline.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
IPR009145. U2AF_small.
IPR000571. Znf_CCCH.
[Graphical view]
PANTHERiPTHR12620. PTHR12620. 1 hit.
PfamiPF00076. RRM_1. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
PRINTSiPR01848. U2AUXFACTOR.
SMARTiSM00361. RRM_1. 1 hit.
SM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9U2U0_CAEEL
AccessioniPrimary (citable) accession number: Q9U2U0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.