ID   Q9U2T9_CAEEL            Unreviewed;      1085 AA.
AC   Q9U2T9;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2008, sequence version 2.
DT   27-MAR-2024, entry version 172.
DE   SubName: Full=Intersectin-1 {ECO:0000313|EMBL:CAB55138.2};
GN   Name=itsn-1 {ECO:0000313|EMBL:CAB55138.2,
GN   ECO:0000313|WormBase:Y116A8C.36a};
GN   ORFNames=CELE_Y116A8C.36 {ECO:0000313|EMBL:CAB55138.2}, Y116A8C.36
GN   {ECO:0000313|WormBase:Y116A8C.36a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB55138.2, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CAB55138.2, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB55138.2,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- INTERACTION:
CC       Q9U2T9; O16299: figl-1; NbExp=3; IntAct=EBI-2414252, EBI-320880;
CC       Q9U2T9; Q9XTY6: num-1; NbExp=3; IntAct=EBI-2414252, EBI-495781;
CC       Q9U2T9; Q9XZI6: unc-11; NbExp=3; IntAct=EBI-2414252, EBI-311866;
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DR   EMBL; BX284604; CAB55138.2; -; Genomic_DNA.
DR   RefSeq; NP_001255927.1; NM_001268998.1.
DR   AlphaFoldDB; Q9U2T9; -.
DR   SMR; Q9U2T9; -.
DR   IntAct; Q9U2T9; 56.
DR   EPD; Q9U2T9; -.
DR   PaxDb; 6239-Y116A8C-36a-1; -.
DR   PeptideAtlas; Q9U2T9; -.
DR   EnsemblMetazoa; Y116A8C.36a.1; Y116A8C.36a.1; WBGene00006405.
DR   GeneID; 178491; -.
DR   UCSC; Y116A8C.36; c. elegans.
DR   AGR; WB:WBGene00006405; -.
DR   WormBase; Y116A8C.36a; CE42665; WBGene00006405; itsn-1.
DR   eggNOG; KOG1029; Eukaryota.
DR   GeneTree; ENSGT00940000168347; -.
DR   HOGENOM; CLU_002819_0_0_1; -.
DR   OrthoDB; 2910300at2759; -.
DR   PhylomeDB; Q9U2T9; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00006405; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR   ExpressionAtlas; Q9U2T9; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030139; C:endocytic vesicle; IDA:WormBase.
DR   GO; GO:0097708; C:intracellular vesicle; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:WormBase.
DR   GO; GO:0042734; C:presynaptic membrane; IBA:GO_Central.
DR   GO; GO:0036062; C:presynaptic periactive zone; IDA:WormBase.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0150007; P:clathrin-dependent synaptic vesicle endocytosis; IBA:GO_Central.
DR   GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR   GO; GO:1900244; P:positive regulation of synaptic vesicle endocytosis; IMP:WormBase.
DR   CDD; cd00052; EH; 2.
DR   CDD; cd00174; SH3; 2.
DR   CDD; cd11836; SH3_Intersectin_1; 1.
DR   CDD; cd11837; SH3_Intersectin_2; 1.
DR   CDD; cd11839; SH3_Intersectin_4; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   Gene3D; 2.30.30.40; SH3 Domains; 5.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR000261; EH_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR14167:SF119; LD44138P; 1.
DR   PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR   Pfam; PF12763; EF-hand_4; 2.
DR   Pfam; PF00018; SH3_1; 3.
DR   Pfam; PF07653; SH3_2; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00027; EH; 2.
DR   SMART; SM00326; SH3; 5.
DR   SUPFAM; SSF47473; EF-hand; 2.
DR   SUPFAM; SSF50044; SH3-domain; 5.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50031; EH; 2.
DR   PROSITE; PS50002; SH3; 5.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Proteomics identification {ECO:0007829|EPD:Q9U2T9,
KW   ECO:0007829|PeptideAtlas:Q9U2T9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          8..99
FT                   /note="EH"
FT                   /evidence="ECO:0000259|PROSITE:PS50031"
FT   DOMAIN          43..78
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          176..259
FT                   /note="EH"
FT                   /evidence="ECO:0000259|PROSITE:PS50031"
FT   DOMAIN          661..722
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          780..839
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          882..940
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          959..1022
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          1025..1085
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          269..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          366..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1063..1085
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..351
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        366..393
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1085 AA;  120492 MW;  256F5E87CC3898CF CRC64;
     MTNPWEVSDA EYQKNFAMFG QLTGGQPFMD AVTARNALMR SNLPTQVLSQ IWALSDLDKD
     GRLDIREYSI AMRLALNCLA GIPIPPQLPP SLLVVPARNA PPTWPGSRHG SVDYSQTLPP
     AIDRRMSQSY IPSAPVSIAG TPSSRHNSIS AGSPLNNDRN VFEGRQLENW AIPHHNKLKY
     SQLFNALDKE RLGSLSSQVG RSALGLSGLP TNVLAHIWFL SDVNKDGKLS VDEYAISQYM
     IEMFKSGFAL PKITPLELVR MCGISSRSAN NTPELEPGAE PPQKSPAPKT FEDKRQDNLS
     KGQAELERRR RVLEEEEQRR RAEVEKKERE EEAKKNRERQ EKERQAEVER QAELERQRII
     EAQREEEEKK RRLEMERRRE EDEKMRKVQM EKAKVKQMQN QKQQENERLA QRQQREKTLQ
     FQLQALDEKV IDVEVDIGKA KEAVAEVTGF IERMRSTRDE KVARIKELQE TNQKTAIESQ
     ELGHQLLQKQ SAHKETTQRK SELEALRRKR DAIRKAIEDA ALELSTEKEK SYNQTEILKT
     NKEKYKTDVY SKLVAKREEY RNSFELLVHA QTHARSKIGE FEAKSAPASA APAPAPAPAP
     TTTNGFPANF NDAFGEFDKT DASQRFDADF GATSTADPFA QIAQAPAHSK GAVDQSAFNI
     HDTYKCRALF AFEARSEDEL SFEPGDVIIV FQSHAAEPGW RAGQLREKVG WFPEAFVEAI
     AAVPTPGGDP PIQNMPPNMT PSSSVDQIGV KAARKAEIAA AMGLTEGGAP PASSAPAAAA
     VISQCIAQFQ WRARNEEDLS FAKGDTIEVL EKQEMKWKGR NPAGEIGWFP KSYVKEVGAT
     TSTTTPIVSP SKASAGAPGA AAGAQYDVVP SDVTLQASET APQQQLYTVI YDFEAVETTD
     LALHVGDTIL VLEKNDEWWK GRCNGREGIF PANYVEISVQ QAGDPTPPTQ APTPAAPPTV
     LCEAKVVVDF VASAPNQLGI KVGEIVKIRE KSAAGWWEGE LIRNGKPIAG WFPGEYVKVL
     EEAASPATRA TAVYDYEASQ PDELGFKTGD VIIVTDKSEA EWWSGHREQD PSKSGLFPSN
     YVQQQ
//