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Protein
Submitted name:

Y116A8C.36a

Gene

itsn-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • positive regulation of synaptic vesicle endocytosis Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_305147. Rho GTPase cycle.
REACT_325540. EPHB-mediated forward signaling.
REACT_348981. G alpha (12/13) signalling events.
REACT_352293. NRAGE signals death through JNK.
SignaLinkiQ9U2T9.

Names & Taxonomyi

Protein namesi
Submitted name:
Y116A8C.36aImported
Gene namesi
Name:itsn-1Imported
ORF Names:CELE_Y116A8C.36Imported, Y116A8C.36Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY116A8C.36a; CE42665; WBGene00006405; itsn-1.

Subcellular locationi

GO - Cellular componenti

  • endocytic vesicle Source: WormBase
  • plasma membrane Source: WormBase
  • presynaptic periactive zone Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ9U2T9.

Expressioni

Gene expression databases

ExpressionAtlasiQ9U2T9. baseline.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
figl-1O162993EBI-2414252,EBI-320880
num-1Q9XTY63EBI-2414252,EBI-495781
unc-11Q9XZI63EBI-2414252,EBI-311866

Protein-protein interaction databases

IntActiQ9U2T9. 58 interactions.
STRINGi6239.Y116A8C.36a.2.

Structurei

3D structure databases

ProteinModelPortaliQ9U2T9.
SMRiQ9U2T9. Positions 18-93, 170-259, 287-547, 665-720, 768-1082.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 5 SH3 domains.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotation

Phylogenomic databases

eggNOGiNOG301764.
GeneTreeiENSGT00760000118985.
HOGENOMiHOG000199523.
InParanoidiQ9U2T9.
OMAiNGEDQAQ.
PhylomeDBiQ9U2T9.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EPS15_homology.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00018. SH3_1. 2 hits.
PF07653. SH3_2. 2 hits.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 5 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50002. SH3. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U2T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNPWEVSDA EYQKNFAMFG QLTGGQPFMD AVTARNALMR SNLPTQVLSQ
60 70 80 90 100
IWALSDLDKD GRLDIREYSI AMRLALNCLA GIPIPPQLPP SLLVVPARNA
110 120 130 140 150
PPTWPGSRHG SVDYSQTLPP AIDRRMSQSY IPSAPVSIAG TPSSRHNSIS
160 170 180 190 200
AGSPLNNDRN VFEGRQLENW AIPHHNKLKY SQLFNALDKE RLGSLSSQVG
210 220 230 240 250
RSALGLSGLP TNVLAHIWFL SDVNKDGKLS VDEYAISQYM IEMFKSGFAL
260 270 280 290 300
PKITPLELVR MCGISSRSAN NTPELEPGAE PPQKSPAPKT FEDKRQDNLS
310 320 330 340 350
KGQAELERRR RVLEEEEQRR RAEVEKKERE EEAKKNRERQ EKERQAEVER
360 370 380 390 400
QAELERQRII EAQREEEEKK RRLEMERRRE EDEKMRKVQM EKAKVKQMQN
410 420 430 440 450
QKQQENERLA QRQQREKTLQ FQLQALDEKV IDVEVDIGKA KEAVAEVTGF
460 470 480 490 500
IERMRSTRDE KVARIKELQE TNQKTAIESQ ELGHQLLQKQ SAHKETTQRK
510 520 530 540 550
SELEALRRKR DAIRKAIEDA ALELSTEKEK SYNQTEILKT NKEKYKTDVY
560 570 580 590 600
SKLVAKREEY RNSFELLVHA QTHARSKIGE FEAKSAPASA APAPAPAPAP
610 620 630 640 650
TTTNGFPANF NDAFGEFDKT DASQRFDADF GATSTADPFA QIAQAPAHSK
660 670 680 690 700
GAVDQSAFNI HDTYKCRALF AFEARSEDEL SFEPGDVIIV FQSHAAEPGW
710 720 730 740 750
RAGQLREKVG WFPEAFVEAI AAVPTPGGDP PIQNMPPNMT PSSSVDQIGV
760 770 780 790 800
KAARKAEIAA AMGLTEGGAP PASSAPAAAA VISQCIAQFQ WRARNEEDLS
810 820 830 840 850
FAKGDTIEVL EKQEMKWKGR NPAGEIGWFP KSYVKEVGAT TSTTTPIVSP
860 870 880 890 900
SKASAGAPGA AAGAQYDVVP SDVTLQASET APQQQLYTVI YDFEAVETTD
910 920 930 940 950
LALHVGDTIL VLEKNDEWWK GRCNGREGIF PANYVEISVQ QAGDPTPPTQ
960 970 980 990 1000
APTPAAPPTV LCEAKVVVDF VASAPNQLGI KVGEIVKIRE KSAAGWWEGE
1010 1020 1030 1040 1050
LIRNGKPIAG WFPGEYVKVL EEAASPATRA TAVYDYEASQ PDELGFKTGD
1060 1070 1080
VIIVTDKSEA EWWSGHREQD PSKSGLFPSN YVQQQ
Length:1,085
Mass (Da):120,492
Last modified:July 22, 2008 - v2
Checksum:i256F5E87CC3898CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAB55138.2.
RefSeqiNP_001255927.1. NM_001268998.1.
UniGeneiCel.11645.

Genome annotation databases

EnsemblMetazoaiY116A8C.36a.1; Y116A8C.36a.1; WBGene00006405.
Y116A8C.36a.2; Y116A8C.36a.2; WBGene00006405.
GeneIDi178491.
KEGGicel:CELE_Y116A8C.36.
UCSCiY116A8C.36. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAB55138.2.
RefSeqiNP_001255927.1. NM_001268998.1.
UniGeneiCel.11645.

3D structure databases

ProteinModelPortaliQ9U2T9.
SMRiQ9U2T9. Positions 18-93, 170-259, 287-547, 665-720, 768-1082.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9U2T9. 58 interactions.
STRINGi6239.Y116A8C.36a.2.

Proteomic databases

PaxDbiQ9U2T9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY116A8C.36a.1; Y116A8C.36a.1; WBGene00006405.
Y116A8C.36a.2; Y116A8C.36a.2; WBGene00006405.
GeneIDi178491.
KEGGicel:CELE_Y116A8C.36.
UCSCiY116A8C.36. c. elegans.

Organism-specific databases

CTDi178491.
WormBaseiY116A8C.36a; CE42665; WBGene00006405; itsn-1.

Phylogenomic databases

eggNOGiNOG301764.
GeneTreeiENSGT00760000118985.
HOGENOMiHOG000199523.
InParanoidiQ9U2T9.
OMAiNGEDQAQ.
PhylomeDBiQ9U2T9.

Enzyme and pathway databases

ReactomeiREACT_305147. Rho GTPase cycle.
REACT_325540. EPHB-mediated forward signaling.
REACT_348981. G alpha (12/13) signalling events.
REACT_352293. NRAGE signals death through JNK.
SignaLinkiQ9U2T9.

Miscellaneous databases

NextBioi901344.
PROiQ9U2T9.

Gene expression databases

ExpressionAtlasiQ9U2T9. baseline.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EPS15_homology.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00018. SH3_1. 2 hits.
PF07653. SH3_2. 2 hits.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 5 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50002. SH3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ9U2T9_CAEEL
AccessioniPrimary (citable) accession number: Q9U2T9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: July 22, 2008
Last modified: June 24, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.