Reviewed,
UniProtKB/Swiss-Prot Q9U2M4 (HOT_CAEEL)
Last modified
November 3, 2009.
Version 48.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial Short name=HOT EC=1.1.99.24 | ||
| Gene names |
| ||
| Organism | Caenorhabditis elegans [Complete proteome] | ||
| Taxonomic identifier | 6239 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 465 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG By similarity. |
| Catalytic activity | (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate. 2-oxoglutaric acid + 4-hydroxybutanoic acid = (R)-2-hydroxyglutaric acid + succinic semialdehyde. |
| Subcellular location | Mitochondrion By similarity. |
| Sequence similarities | Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | molecular hydrogen transport Inferred from sequence or structural similarity. Source: UniProtKB oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrion Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | hydroxyacid-oxoacid transhydrogenase activity Inferred from sequence or structural similarity. Source: UniProtKB metal ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |
Molecule processing | ||||||
|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion Potential | ||||
| Chain | ? – 465 | Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial | PRO_0000324756 | |||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
Cross-references
Sequence databases | |
|---|---|
| AL032639 Genomic DNA. Translation: CAA21631.2. | |
| PIR | E88343. T26686. |
| RefSeq | NP_496764.1. |
| UniGene | Cel.8339 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:24327N. |
| IntAct | Q9U2M4. 1 interaction. |
| STRING | Q9U2M4. |
Genome annotation databases | |
| Ensembl | Y38F1A.6.1; Y38F1A.6.1; Y38F1A.6; Caenorhabditis elegans. [Genome view] Y38F1A.6.2; Y38F1A.6.2; Y38F1A.6; Caenorhabditis elegans. [Genome view] Y38F1A.6.3; Y38F1A.6.3; Y38F1A.6; Caenorhabditis elegans. [Genome view] Y38F1A.6.4; Y38F1A.6.4; Y38F1A.6; Caenorhabditis elegans. [Genome view] Y38F1A.6.5; Y38F1A.6.5; Y38F1A.6; Caenorhabditis elegans. [Genome view] Y38F1A.6.6; Y38F1A.6.6; Y38F1A.6; Caenorhabditis elegans. [Genome view] Y38F1A.6.7; Y38F1A.6.7; Y38F1A.6; Caenorhabditis elegans. [Genome view] |
| GeneID | 174942. |
| KEGG | cel:Y38F1A.6. |
| UCSC | Y38F1A.6.1. c. elegans. |
Organism-specific databases | |
| CTD | 174942. |
| WormBase | WBGene00012608. Y38F1A.6. |
| WormPep | Y38F1A.6. CE24222. [WorfDB] |
Phylogenomic databases | |
| OMA | YSKADIP. |
Enzyme and pathway databases | |
| BRENDA | 1.1.99.24. 672. |
Gene expression databases | |
| ArrayExpress | Q9U2M4. |
Family and domain databases | |
| InterPro | IPR001670. ADH_Fe. IPR018211. ADH_Fe_CS. [Graphical view] |
| Pfam | PF00465. Fe-ADH. 1 hit. [Graphical view] |
| PROSITE | PS00913. ADH_IRON_1. 1 hit. PS00060. ADH_IRON_2. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 886136. |
Entry information
| Entry name | HOT_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q9U2M4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

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