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Protein

Putative U5 small nuclear ribonucleoprotein 200 kDa helicase

Gene

Y46G5A.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Putative RNA helicase involved in the second step of RNA splicing.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi497 – 5048ATPPROSITE-ProRule annotation
Nucleotide bindingi1344 – 13518ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-72163. mRNA Splicing - Major Pathway.
R-CEL-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative U5 small nuclear ribonucleoprotein 200 kDa helicase (EC:3.6.4.13)
Gene namesi
ORF Names:Y46G5A.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiY46G5A.4; CE21971; WBGene00012896.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21452145Putative U5 small nuclear ribonucleoprotein 200 kDa helicasePRO_0000102088Add
BLAST

Proteomic databases

EPDiQ9U2G0.
PaxDbiQ9U2G0.
PRIDEiQ9U2G0.

Interactioni

Protein-protein interaction databases

BioGridi40201. 2 interactions.
IntActiQ9U2G0. 1 interaction.
MINTiMINT-1062451.
STRINGi6239.Y46G5A.4.

Structurei

3D structure databases

ProteinModelPortaliQ9U2G0.
SMRiQ9U2G0. Positions 471-917, 978-1237, 1313-1727, 1811-2130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini484 – 667184Helicase ATP-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini677 – 894218Helicase ATP-binding 2PROSITE-ProRule annotationAdd
BLAST
Domaini974 – 1279306SEC63 1Add
BLAST
Domaini1331 – 1506176Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini1811 – 2126316SEC63 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi609 – 6124DEIH box
Motifi1448 – 14514DDLH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi221 – 2288Poly-Glu

Domaini

Composed of two similar domains.

Sequence similaritiesi

Belongs to the helicase family. SKI2 subfamily.Curated
Contains 2 helicase ATP-binding domains.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 2 SEC63 domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0952. Eukaryota.
COG1204. LUCA.
GeneTreeiENSGT00640000091272.
HOGENOMiHOG000157749.
InParanoidiQ9U2G0.
KOiK12854.
OMAiKKMENWW.
OrthoDBiEOG7PGDPQ.
PhylomeDBiQ9U2G0.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
3.40.50.300. 5 hits.
InterProiIPR003593. AAA+_ATPase.
IPR000008. C2_dom.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR027417. P-loop_NTPase.
IPR004179. Sec63-dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00270. DEAD. 2 hits.
PF00271. Helicase_C. 1 hit.
PF02889. Sec63. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM00487. DEXDc. 2 hits.
SM00490. HELICc. 1 hit.
SM00973. Sec63. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.
SSF52540. SSF52540. 4 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 2 hits.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U2G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADELARIQQ YEYRQNSNLV LSVDYNLTDR RGREEPTGEV LPITDKEMRK
60 70 80 90 100
MKMGDRAIKG KAPVQDQKKK RKKKDDEKAQ QFGRNVLVDN NELMGAYKPR
110 120 130 140 150
TQETKQTYEV ILSFILDALG DVPREVLCGA ADEVLLTLKN DKFRDKEKKK
160 170 180 190 200
EVEALLGPLT DDRIAVLINL SKKISDFSIE EENKPEGDGD IYENEGVNVQ
210 220 230 240 250
FDSDEEEDDG GMVNEIKGDS EEESEEEEGV DTDYTATLKG DGHLTEDEQK
260 270 280 290 300
ARGILHPRDI DAHWIQRSLA KYFKDPLIAQ QKQTEVIGIL KNAADDRDAE
310 320 330 340 350
NQLVLLLGFD QFEFIKCLRQ NRLMILYCTL LRQANEKERL QIEDDMRSRP
360 370 380 390 400
ELHPILALLQ ETDEGSVVQV EKSKRDAEKS KKAATAANEA ISAGQWQAGR
410 420 430 440 450
KMLDLNDLTF SQGSHLMSNK RCELPDGSYR RQKKSYEEIH VPALKPRPFA
460 470 480 490 500
EGEKLVSVSE LPKWAQPAFD GYKSLNRIQS RLCDSALRSK EHLLLCAPTG
510 520 530 540 550
AGKTNVALLT MLQEIGNHLA EDGSVKLDEF KIVYIAPMKS LVQEMVGSFS
560 570 580 590 600
KRLAPFGITV GEMTGDAQMS KEQFMATQVI VCTPEKYDVV TRKGGERAYN
610 620 630 640 650
QMVRLLIIDE IHLLHDDRGP VLESIVVRTI RQMEQNHDEC RLVGLSATLP
660 670 680 690 700
NYQDVATFLR VKPEHLHFFD NSYRPVPLEQ QYIGVTEKKA LKRFQAMNEV
710 720 730 740 750
VYDKIMEHAG KSQVLVFVHS RKETAKTAKA IRDACLEKDT LSAFMREGSA
760 770 780 790 800
STEILRTEAE QAKNLDLKDL LPYGFAIHHA GMNRVDRTLV EDLFADRHIQ
810 820 830 840 850
VLFSTATLAW GVNLPAHTVI IKGTQIYNPE KGRWTELGAL DIMQMLGRAG
860 870 880 890 900
RPQYDDRGEG ILITNHSELQ YYLSLMNQQL PVESQMVSRL TDMLNAEVVL
910 920 930 940 950
GTVSSVSEAT NWLGYTFLFV RMLKNPTLYG ITHEQARADP LLEQRRADLI
960 970 980 990 1000
HTACVLLDKA GLIKYDKRSG IIQATELGRI ASHFYCTYES MQTYNKLLVE
1010 1020 1030 1040 1050
TCSDIDLFRI FSMSSEFKLL SVRDEEKLEL QKMAEHAPIP IKENLDEASA
1060 1070 1080 1090 1100
KTNVLLQAYI SQLKLEGFAL QADMVFVAQS AGRLFRALFE IVLWRGWAGL
1110 1120 1130 1140 1150
AQKVLTLCKM VTQRQWGSLN PLHQFKKIPS EVVRSIDKKN YSFDRLYDLD
1160 1170 1180 1190 1200
QHQLGDLIKM PKMGKPLFKF IRQFPKLEMT TLIQPITRTT MRIELTITPD
1210 1220 1230 1240 1250
FKWDEKVHGS AEGFWIFIED TDGEKILHHE FFLLKQKFCS DEHVVKMIVP
1260 1270 1280 1290 1300
MFDPMPPLYY VRIVSDRWIG AETVLPISFR HLILPEKYPP PTELLDLQPL
1310 1320 1330 1340 1350
PISAVTNKEF QTVFAESGFK VFNPIQTQVF RTVFESNENV IVCAPNGSGK
1360 1370 1380 1390 1400
TAIAELAVLR HFENTPEAKA VYITPMEDMA TKVYADWKRR LEPAIGHTIV
1410 1420 1430 1440 1450
LLTGEQTMDL KLAQRGQLII STPERWDNIS RRWKQRKSVQ NVKLFIADDL
1460 1470 1480 1490 1500
HMIGASNGAV FEVVCSRTRY ISSQLESAVR VVALSSSLTN ARDLGMWLGC
1510 1520 1530 1540 1550
SASATFNFMP STRPVPLDLE IKSFNLSHNA SRFAAMERPV YQAICRHAGK
1560 1570 1580 1590 1600
LEPKPALVFV PVRRQTRPVA VALLTMALAD GAPKRFLRLA EHDDTFQALL
1610 1620 1630 1640 1650
ADIEDESLRE SVSCGVGFLH EGTAPKDVHI VQQLFESNAI QVCVVPRGMC
1660 1670 1680 1690 1700
YQIEMSAYLV VVMDTQFYNG KYHVYEDYPI ADMLHMVGLA NRPILDSDAK
1710 1720 1730 1740 1750
CVVMCQTSKR AYYKKFLCDP LPVESHLDHC LHDHFNAEIV TKTIENKQDA
1760 1770 1780 1790 1800
IDYLTWTLLY RRMTQNPNYY NLQGTTHRHL SDALSELVEL TLKDLENSKC
1810 1820 1830 1840 1850
IAVKDEMDTV SLNLGMIASY YYISYQTIEL FSMSLKEKTK TRALIEIISA
1860 1870 1880 1890 1900
SSEFGNVPMR HKEDVILRQL AERLPGQLKN QKFTDPHVKV NLLIHAHLSR
1910 1920 1930 1940 1950
VKLTAELNKD TELIVLRACR LVQACVDVLS SNGWLSPAIH AMELSQMLTQ
1960 1970 1980 1990 2000
AMYSNEPYLK QLPHCSAALL ERAKAKEVTS VFELLELEND DRSDILQMEG
2010 2020 2030 2040 2050
AELADVARFC NHYPSIEVAT ELENDVVTSN DNLMLAVSLE RDNDIDGLAP
2060 2070 2080 2090 2100
PVVAPLFPQK RKEEGWWLVI GDSESNALLT IKRLVINEKS SVQLDFAAPR
2110 2120 2130 2140
PGHHKFKLFF ISDSYLGADQ EFDVAFKVEE PGRSNRKRKH EKEED
Length:2,145
Mass (Da):243,831
Last modified:May 1, 2000 - v1
Checksum:i2C1EE0F69583891F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL110485 Genomic DNA. Translation: CAB60351.1.
RefSeqiNP_496710.1. NM_064309.3.
UniGeneiCel.14062.

Genome annotation databases

EnsemblMetazoaiY46G5A.4; Y46G5A.4; WBGene00012896.
GeneIDi174901.
KEGGicel:CELE_Y46G5A.4.
UCSCiY46G5A.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL110485 Genomic DNA. Translation: CAB60351.1.
RefSeqiNP_496710.1. NM_064309.3.
UniGeneiCel.14062.

3D structure databases

ProteinModelPortaliQ9U2G0.
SMRiQ9U2G0. Positions 471-917, 978-1237, 1313-1727, 1811-2130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40201. 2 interactions.
IntActiQ9U2G0. 1 interaction.
MINTiMINT-1062451.
STRINGi6239.Y46G5A.4.

Proteomic databases

EPDiQ9U2G0.
PaxDbiQ9U2G0.
PRIDEiQ9U2G0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY46G5A.4; Y46G5A.4; WBGene00012896.
GeneIDi174901.
KEGGicel:CELE_Y46G5A.4.
UCSCiY46G5A.4. c. elegans.

Organism-specific databases

CTDi174901.
WormBaseiY46G5A.4; CE21971; WBGene00012896.

Phylogenomic databases

eggNOGiKOG0952. Eukaryota.
COG1204. LUCA.
GeneTreeiENSGT00640000091272.
HOGENOMiHOG000157749.
InParanoidiQ9U2G0.
KOiK12854.
OMAiKKMENWW.
OrthoDBiEOG7PGDPQ.
PhylomeDBiQ9U2G0.

Enzyme and pathway databases

ReactomeiR-CEL-72163. mRNA Splicing - Major Pathway.
R-CEL-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

NextBioi885976.
PROiQ9U2G0.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
3.40.50.300. 5 hits.
InterProiIPR003593. AAA+_ATPase.
IPR000008. C2_dom.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR027417. P-loop_NTPase.
IPR004179. Sec63-dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00270. DEAD. 2 hits.
PF00271. Helicase_C. 1 hit.
PF02889. Sec63. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM00487. DEXDc. 2 hits.
SM00490. HELICc. 1 hit.
SM00973. Sec63. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.
SSF52540. SSF52540. 4 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 2 hits.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiU520_CAEEL
AccessioniPrimary (citable) accession number: Q9U2G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.