Q9U280 (Q9U280_CAEEL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein TAT-1, isoform a EMBL CAB11550.4

Gene names

Name:	tat-1 WormBase Y49E10.11a
ORF Names:	Y49E10.11 EMBL CAB11550.4

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	1139 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(Out). SAAS SAAS023299

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS023306
Ligand	ATP-binding SAAS SAAS023306 Magnesium SAAS SAAS023299 Nucleotide-binding
Molecular function	Hydrolase SAAS SAAS023299
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cation transport Inferred from electronic annotation. Source: InterPro embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase endocytosis Inferred from mutant phenotype. Source: WormBase lysosome organization Inferred from mutant phenotype. Source: WormBase necrotic cell death Inferred from mutant phenotype. Source: WormBase negative regulation of phagocytosis, engulfment Inferred from mutant phenotype. Source: WormBase phospholipid translocation Inferred from mutant phenotype. Source: WormBase positive regulation of phagocytosis, engulfment Inferred from mutant phenotype. Source: WormBase
Cellular component	Golgi apparatus Inferred from direct assay. Source: WormBase apical plasma membrane Inferred from direct assay. Source: WormBase basolateral plasma membrane Inferred from direct assay. Source: WormBase integral to plasma membrane Inferred from direct assay. Source: WormBase
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro phospholipid-translocating ATPase activity Inferred from mutant phenotype. Source: WormBase protein binding Inferred from physical interaction. Source: WormBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9U280 [UniParc]. Last modified October 1, 2001. Version 3. Checksum: 4EB9BABE669824AC	FASTA	1,139	128,411
	10 20 30 40 50 60 MPTEARDNNR HIHLGKVRDP HHQHAQRFCS NRISTCKYNG FSFLPRFLYE QFRRYNNIFF 70 80 90 100 110 120 LAIALLQQIP DVSPTGRYTT AVPFLIILSV SALKEIFEDV KRRRSDNKVN AFSVEILVDG 130 140 150 160 170 180 HWIEKQWKDV SVGDFIRIDN DSLFPADLLL LASSEQQGMA YIETSNLDGE TNLKIKQALD 190 200 210 220 230 240 ITSTMTSPEK LSQFESEITC EPPSRHVNEF NGNIEINGVA RHFGIDQLLL RGARLKNTAW 250 260 270 280 290 300 IFGAVIYTGH DSKLLMNSKR APLKSGTIDV QTNYRIIFLF FVLVALALIS ATGSEIWRGN 310 320 330 340 350 360 NIPQAWYLSF LEHDPKGSFL WGVLTFFILY NNLIPISLQV TLEVVRFFQA IYINNDIEMY 370 380 390 400 410 420 DVNSDSCAIA RTSNLNEELG QVKFIMSDKT GTLTRNVMKF KRLSIGSRNY GNNEDDEFAD 430 440 450 460 470 480 ASLIEDYRQG DEHSTSILEV LKMMAVCHTV VPENKDGQLI YQSSSPDEAA LVRGAASQSV 490 500 510 520 530 540 SFHTRQPQKV ICNVFGEDET IEILDVIDFT SDRKRMSVIV RDGAGGDIKL YTKGADTVIF 550 560 570 580 590 600 ERLEHGKEQE EAVEYCTEHL EDYASFGYRT LCFSMRHLTE QEYSQWAPEY KKAILAIDNR 610 620 630 640 650 660 AKLLADAAEK LERNMILVGA TAIEDKLQEW VPETIQALMA ADIRVWMLTG DKRETAINIA 670 680 690 700 710 720 HSCALCHTNT ELLIVDKTTY EETYQKLEQF VARAIELEKQ EKGFAMVIDG KSLLHALTGE 730 740 750 760 770 780 ARKHFGDLAL RCHAVVCCRM SPMQKAEVVE MVRKLAKHVV LAIGDGANDV AMIQAANVGV 790 800 810 820 830 840 GISGEEGLQA ASASDYAIPR FHFLRRLLLV HGAWNHDRSV KVILYSFYKN ICLYIIELWF 850 860 870 880 890 900 AMFSAWSGQT IFERWTIGMF NVIFTAWPPV VLGLFDHPVP AEQIMKYPAL YASFQNRAFS 910 920 930 940 950 960 IGNFSLWIGL AIVHSLSLFF LTYATMEHQV VWDNGLTGGW LMLGNCAYTF VVATVCFKAL 970 980 990 1000 1010 1020 LECDSWTWPV VVACIGSIGL WIVFVIVYSL VFPHIGGIGA DMAGMAAIMM SSYTFWLALL 1030 1040 1050 1060 1070 1080 FIPLATLLWD LVIKSLFTIA MPTPRELAVM YNKRTTSFNG FERLASYSSN VLENMRLLTS 1090 1100 1110 1120 1130 SLRGSTTGST RSRTASEASL ALAEQTRYGF AFSQDESSAV AQTELIRNVD STREKPTGR

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z98866 Genomic DNA. Translation: CAB11550.4.
PIR	D88601. T27057.
RefSeq	NP_001022894.1. NM_001027723.1.
UniGene	Cel.17289.
3D structure databases
ProteinModelPortal	Q9U280.
SMR	Q9U280. Positions 743-785.
ModBase	Search...
Proteomic databases
PRIDE	Q9U280.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	Y49E10.11a; Y49E10.11a; Y49E10.11.
GeneID	176666.
KEGG	cel:Y49E10.11.
UCSC	Y49E10.11a. c. elegans.
Organism-specific databases
CTD	176666.
WormBase	Y49E10.11a; CE28133; WBGene00013034; tat-1.
Phylogenomic databases
GeneTree	EMGT00050000009037.
HOGENOM	HBG745019.
InParanoid	Q9U280.
OMA	PTEARDN.
PhylomeDB	Q9U280.
Gene expression databases
ArrayExpress	Q9U280.
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transl. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K14802.
Pfam	PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	893526.

Entry information

Entry name

Q9U280_CAEEL

Accession

Primary (citable) accession number: Q9U280

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 95 of the entry and version 3 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)