Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Valine--tRNA ligase

Gene

glp-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei645ATPSequence analysis1

GO - Molecular functioni

GO - Biological processi

  • determination of adult lifespan Source: UniProtKB
  • valyl-tRNA aminoacylation Source: GO_Central

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Valine--tRNA ligase (EC:6.1.1.9)
Alternative name(s):
Valyl-tRNA synthetase
Short name:
ValRS
Gene namesi
Name:glp-4Imported
Synonyms:vars-2Imported, vrs-2Imported
ORF Names:Y87G2A.5Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY87G2A.5 ; CE24685 ; WBGene00006936 ; glp-4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002520861 – 1050Valine--tRNA ligaseAdd BLAST1050

Proteomic databases

EPDiQ9U1Q4
PaxDbiQ9U1Q4
PeptideAtlasiQ9U1Q4
PRIDEiQ9U1Q4

PTM databases

iPTMnetiQ9U1Q4

Expressioni

Gene expression databases

BgeeiWBGene00006936

Interactioni

Protein-protein interaction databases

STRINGi6239.Y87G2A.5

Structurei

3D structure databases

ProteinModelPortaliQ9U1Q4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 137"HIGH" regionSequence analysisAdd BLAST11
Motifi642 – 646"KMSKS" regionSequence analysis5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0432 Eukaryota
COG0525 LUCA
GeneTreeiENSGT00550000074727
HOGENOMiHOG000020094
InParanoidiQ9U1Q4
KOiK01873
OMAiFATKLWN
OrthoDBiEOG091G01XH
PhylomeDBiQ9U1Q4

Family and domain databases

CDDicd07962 Anticodon_Ia_Val, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_02004 Val_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR033705 Anticodon_Ia_Val
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
IPR002303 Valyl-tRNA_ligase
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PRINTSiPR00986 TRNASYNTHVAL
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00422 valS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9U1Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPAGNRPK TEKELKKEAE KAAKLAKFEE KQKKLAEKKA AASDKPVKEA
60 70 80 90 100
KAKKEQTVEA AEPVDQTPTG QRKKIDGEIP AAYFPGYVES GWYSWWEKEG
110 120 130 140 150
FFKPEYIDKL NPGSNPADSF TVCIPPPNVT GNLHVGHALA TTVEDTITRF
160 170 180 190 200
NRMHGKRTLF NPGCDHAGIA TQVVVEKRLK RERGLTRHDL GRDRFNQEVW
210 220 230 240 250
HWKNEKGDVI YDQFRKLGAS VDWDRAVFTM DPKMCRAVTE AFIRMHESGT
260 270 280 290 300
IYRSNRLVNW SCALRSAISD IEVDKKELTG STLIAVPGYD KKIEFGVLNS
310 320 330 340 350
FAYKIQGSDE EIVVSTTRIE TMLGDSGVAV HPDDQRYKHL VGKQCIHPFI
360 370 380 390 400
PTRNLPIFAD SFVEMEFGTG AVKITPAHDH NDYEVGIRQN LPFHNCITDD
410 420 430 440 450
GLISQGCGEF SGMKRFDART AVIEALKEKG LYRGKEDNPM VVPTCSRSKD
460 470 480 490 500
VIEPILKPQW YVKCAHMAEK AVAAVANGDL QIIPEFHKAT WNRWLESSRD
510 520 530 540 550
WCISRQLWWG HRIPAYYISF ADGREQPLPE ENYWVSARTE QEALAKAAQK
560 570 580 590 600
FQVPEAEILL KWDEDVLDTW FSSGMWPFAV FGWPDATKDM DLFFPGAVLE
610 620 630 640 650
TGHDILFFWV ARMVFMAQEL TGKLPFKEIL LHAMIRDAHG RKMSKSLGNV
660 670 680 690 700
IDPLDVIRGI SLNDLQAQLL GGNLDEKEIA VAKEGQARDY PDGIPECGVD
710 720 730 740 750
ALRFALLSYT SQGRDINLDV LRVHGYRKFC NKLWQVVRFA LARISDKPEQ
760 770 780 790 800
KPTFEINLKS ATPTDLWILS RLAKAVKETN EALKAYNFTQ ATTVTYNFWL
810 820 830 840 850
YDFCDVYVET IKPVLYGDNT TLRQVAISVL HKCIDTGLRL ISPLMPFISE
860 870 880 890 900
ELWQRMPRLD DSDYTSPSII VAQYPLTQKY EKYQNEKLEA AFEFAQELIG
910 920 930 940 950
KVRSLRADYD LKKTKITMQI LSETPEDESM LNDISAVITT LTFSEKVSIL
960 970 980 990 1000
NKCESDKIEK GSAHIACGGR CQVYINLTGI IDVPKEIEKL GAKLQKNQIS
1010 1020 1030 1040 1050
VKKIGDIQSS ADYEQKVPVD IRALDQEKKA TLEKEIENIT AAIAQLKALN
Length:1,050
Mass (Da):118,921
Last modified:May 1, 2000 - v1
Checksum:iF33DB53587EAC057
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL110500 Genomic DNA Translation: CAB60428.1
RefSeqiNP_493377.1, NM_060976.4
UniGeneiCel.17835

Genome annotation databases

EnsemblMetazoaiY87G2A.5.1; Y87G2A.5.1; WBGene00006936
Y87G2A.5.2; Y87G2A.5.2; WBGene00006936
GeneIDi173224
KEGGicel:CELE_Y87G2A.5
UCSCiY87G2A.5 c. elegans

Similar proteinsi

Entry informationi

Entry nameiSYV_CAEEL
AccessioniPrimary (citable) accession number: Q9U1Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health