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Protein

Valine--tRNA ligase

Gene

vrs-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei645 – 6451ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Valine--tRNA ligase (EC:6.1.1.9)
Alternative name(s):
Valyl-tRNA synthetase
Short name:
ValRS
Gene namesi
Name:vrs-2Imported
ORF Names:Y87G2A.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY87G2A.5; CE24685; WBGene00006936; vars-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10501050Valine--tRNA ligasePRO_0000252086Add
BLAST

Proteomic databases

EPDiQ9U1Q4.
PaxDbiQ9U1Q4.
PRIDEiQ9U1Q4.

PTM databases

iPTMnetiQ9U1Q4.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y87G2A.5.

Structurei

3D structure databases

ProteinModelPortaliQ9U1Q4.
SMRiQ9U1Q4. Positions 78-1046.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 13711"HIGH" regionSequence analysisAdd
BLAST
Motifi642 – 6465"KMSKS" regionSequence analysis

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0432. Eukaryota.
COG0525. LUCA.
GeneTreeiENSGT00550000074727.
HOGENOMiHOG000020094.
InParanoidiQ9U1Q4.
KOiK01873.
OMAiSENSIHI.
OrthoDBiEOG7DZ8J5.
PhylomeDBiQ9U1Q4.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02004. Val_tRNA_synth_type1.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PANTHERiPTHR11946:SF5. PTHR11946:SF5. 3 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U1Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPAGNRPK TEKELKKEAE KAAKLAKFEE KQKKLAEKKA AASDKPVKEA
60 70 80 90 100
KAKKEQTVEA AEPVDQTPTG QRKKIDGEIP AAYFPGYVES GWYSWWEKEG
110 120 130 140 150
FFKPEYIDKL NPGSNPADSF TVCIPPPNVT GNLHVGHALA TTVEDTITRF
160 170 180 190 200
NRMHGKRTLF NPGCDHAGIA TQVVVEKRLK RERGLTRHDL GRDRFNQEVW
210 220 230 240 250
HWKNEKGDVI YDQFRKLGAS VDWDRAVFTM DPKMCRAVTE AFIRMHESGT
260 270 280 290 300
IYRSNRLVNW SCALRSAISD IEVDKKELTG STLIAVPGYD KKIEFGVLNS
310 320 330 340 350
FAYKIQGSDE EIVVSTTRIE TMLGDSGVAV HPDDQRYKHL VGKQCIHPFI
360 370 380 390 400
PTRNLPIFAD SFVEMEFGTG AVKITPAHDH NDYEVGIRQN LPFHNCITDD
410 420 430 440 450
GLISQGCGEF SGMKRFDART AVIEALKEKG LYRGKEDNPM VVPTCSRSKD
460 470 480 490 500
VIEPILKPQW YVKCAHMAEK AVAAVANGDL QIIPEFHKAT WNRWLESSRD
510 520 530 540 550
WCISRQLWWG HRIPAYYISF ADGREQPLPE ENYWVSARTE QEALAKAAQK
560 570 580 590 600
FQVPEAEILL KWDEDVLDTW FSSGMWPFAV FGWPDATKDM DLFFPGAVLE
610 620 630 640 650
TGHDILFFWV ARMVFMAQEL TGKLPFKEIL LHAMIRDAHG RKMSKSLGNV
660 670 680 690 700
IDPLDVIRGI SLNDLQAQLL GGNLDEKEIA VAKEGQARDY PDGIPECGVD
710 720 730 740 750
ALRFALLSYT SQGRDINLDV LRVHGYRKFC NKLWQVVRFA LARISDKPEQ
760 770 780 790 800
KPTFEINLKS ATPTDLWILS RLAKAVKETN EALKAYNFTQ ATTVTYNFWL
810 820 830 840 850
YDFCDVYVET IKPVLYGDNT TLRQVAISVL HKCIDTGLRL ISPLMPFISE
860 870 880 890 900
ELWQRMPRLD DSDYTSPSII VAQYPLTQKY EKYQNEKLEA AFEFAQELIG
910 920 930 940 950
KVRSLRADYD LKKTKITMQI LSETPEDESM LNDISAVITT LTFSEKVSIL
960 970 980 990 1000
NKCESDKIEK GSAHIACGGR CQVYINLTGI IDVPKEIEKL GAKLQKNQIS
1010 1020 1030 1040 1050
VKKIGDIQSS ADYEQKVPVD IRALDQEKKA TLEKEIENIT AAIAQLKALN
Length:1,050
Mass (Da):118,921
Last modified:May 1, 2000 - v1
Checksum:iF33DB53587EAC057
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL110500 Genomic DNA. Translation: CAB60428.1.
RefSeqiNP_493377.1. NM_060976.4.
UniGeneiCel.17835.

Genome annotation databases

EnsemblMetazoaiY87G2A.5; Y87G2A.5; WBGene00006936.
GeneIDi173224.
KEGGicel:CELE_Y87G2A.5.
UCSCiY87G2A.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL110500 Genomic DNA. Translation: CAB60428.1.
RefSeqiNP_493377.1. NM_060976.4.
UniGeneiCel.17835.

3D structure databases

ProteinModelPortaliQ9U1Q4.
SMRiQ9U1Q4. Positions 78-1046.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y87G2A.5.

PTM databases

iPTMnetiQ9U1Q4.

Proteomic databases

EPDiQ9U1Q4.
PaxDbiQ9U1Q4.
PRIDEiQ9U1Q4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY87G2A.5; Y87G2A.5; WBGene00006936.
GeneIDi173224.
KEGGicel:CELE_Y87G2A.5.
UCSCiY87G2A.5. c. elegans.

Organism-specific databases

CTDi173224.
WormBaseiY87G2A.5; CE24685; WBGene00006936; vars-2.

Phylogenomic databases

eggNOGiKOG0432. Eukaryota.
COG0525. LUCA.
GeneTreeiENSGT00550000074727.
HOGENOMiHOG000020094.
InParanoidiQ9U1Q4.
KOiK01873.
OMAiSENSIHI.
OrthoDBiEOG7DZ8J5.
PhylomeDBiQ9U1Q4.

Miscellaneous databases

PROiQ9U1Q4.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02004. Val_tRNA_synth_type1.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PANTHERiPTHR11946:SF5. PTHR11946:SF5. 3 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. Bienvenut W.V.
    Submitted (MAR-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 513-524; 646-658; 704-714 AND 760-771, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSYV_CAEEL
AccessioniPrimary (citable) accession number: Q9U1Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.