ID   ESN_DROME               Reviewed;         785 AA.
AC   Q9U1I1; A8E6H1; Q8SX20; Q9V4H9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   24-JAN-2024, entry version 150.
DE   RecName: Full=Protein espinas;
GN   Name=esn; ORFNames=CG43722;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1] {ECO:0000312|EMBL:CAB64381.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=DP CN BW; TISSUE=Embryo {ECO:0000269|PubMed:10485852};
RX   PubMed=10485852; DOI=10.1101/gad.13.17.2315;
RA   Gubb D., Green C., Huen D., Coulson D., Johnson G., Tree D.R.P.,
RA   Collier S., Roote J.;
RT   "The balance between isoforms of the prickle LIM domain protein is critical
RT   for planar polarity in Drosophila imaginal discs.";
RL   Genes Dev. 13:2315-2327(1999).
RN   [2] {ECO:0000312|EMBL:AAF59292.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3] {ECO:0000305, ECO:0000312|EMBL:AAF59292.2}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000312|EMBL:AAM11251.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley {ECO:0000312|EMBL:AAM11251.1};
RC   TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA   Celniker S.E.;
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the prickle / espinas / testin family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM11251.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AJ251892; CAB64381.1; -; mRNA.
DR   EMBL; AE013599; AAF59292.2; -; Genomic_DNA.
DR   EMBL; AY094898; AAM11251.1; ALT_FRAME; mRNA.
DR   EMBL; BT030763; ABV82145.1; -; mRNA.
DR   RefSeq; NP_524990.1; NM_080251.4.
DR   RefSeq; NP_724533.1; NM_165507.2.
DR   AlphaFoldDB; Q9U1I1; -.
DR   SMR; Q9U1I1; -.
DR   BioGRID; 72789; 35.
DR   STRING; 7227.FBpp0302896; -.
DR   PaxDb; 7227-FBpp0302896; -.
DR   DNASU; 53557; -.
DR   EnsemblMetazoa; FBtr0329856; FBpp0302894; FBgn0263934.
DR   EnsemblMetazoa; FBtr0329857; FBpp0302895; FBgn0263934.
DR   GeneID; 53557; -.
DR   KEGG; dme:Dmel_CG43722; -.
DR   UCSC; CG12833-RA; d. melanogaster.
DR   AGR; FB:FBgn0263934; -.
DR   CTD; 53557; -.
DR   FlyBase; FBgn0263934; esn.
DR   VEuPathDB; VectorBase:FBgn0263934; -.
DR   eggNOG; KOG1704; Eukaryota.
DR   GeneTree; ENSGT00940000153629; -.
DR   HOGENOM; CLU_008937_4_0_1; -.
DR   InParanoid; Q9U1I1; -.
DR   OMA; CKGCEES; -.
DR   PhylomeDB; Q9U1I1; -.
DR   BioGRID-ORCS; 53557; 0 hits in 3 CRISPR screens.
DR   ChiTaRS; esn; fly.
DR   GenomeRNAi; 53557; -.
DR   PRO; PR:Q9U1I1; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0263934; Expressed in wing disc and 30 other cell types or tissues.
DR   ExpressionAtlas; Q9U1I1; baseline and differential.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0070593; P:dendrite self-avoidance; IMP:FlyBase.
DR   CDD; cd09415; LIM1_Prickle; 1.
DR   CDD; cd09418; LIM2_Prickle; 1.
DR   CDD; cd09420; LIM3_Prickle; 1.
DR   CDD; cd09827; PET_Prickle; 1.
DR   Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR   InterPro; IPR033725; LIM1_prickle.
DR   InterPro; IPR033726; LIM2_prickle.
DR   InterPro; IPR033727; LIM3_prickle.
DR   InterPro; IPR010442; PET_domain.
DR   InterPro; IPR033723; PET_prickle.
DR   InterPro; IPR047120; Pk/Esn/Tes.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR24211; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24211:SF20; PROTEIN ESPINAS-RELATED; 1.
DR   Pfam; PF00412; LIM; 2.
DR   Pfam; PF06297; PET; 1.
DR   SMART; SM00132; LIM; 3.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 3.
DR   PROSITE; PS51303; PET; 1.
DR   Genevisible; Q9U1I1; DM.
PE   2: Evidence at transcript level;
KW   LIM domain; Metal-binding; Reference proteome; Repeat; Zinc.
FT   CHAIN           1..785
FT                   /note="Protein espinas"
FT                   /id="PRO_0000288827"
FT   DOMAIN          135..243
FT                   /note="PET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00636"
FT   DOMAIN          242..306
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          307..367
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          368..430
FT                   /note="LIM zinc-binding 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   REGION          1..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          427..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          638..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        428..456
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        457..473
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   785 AA;  86608 MW;  5EF4029A593EA70E CRC64;
     MQQAPQQQQH PHPPSSSYYT QTESELLQIE AGGTGLTFAS HSQRPESAIS QVASTAHLDV
     PSAASSGSGG SAVSGGSGGA PESAGRFVSP LQRRHCQPPS HLPLNSVASP LRTASYKSAA
     AVAGHGFHHS HHQQLDFQRN SQSDDDSGCA LEEYTWVPPG LRPDQVRLYF SQLPDDKVPY
     VNSPGEKYRV KQLLHQLPPQ DNEVRYCHSL SDEERKELRI FSAQRKREAL GRGAVRLLSD
     ERPCKGCEEP LSGGDIVVFA QRLGAQLCWH PGCFVCSVCK ELLVDLIYFQ RDGNLYCGRH
     HAETQKPRCS ACDEIIFSDE CTEAEGRTWH MKHFACQECE HQLGGQRYIM REGKPYCLAC
     FDTMFAEYCD YCGEVIGVDQ GQMSHDGQHW HATDQCFSCC TCRCSLLGRP FLPRRGTIYC
     SIACSKGEPP TPSDTSSGPQ LRPTHRASTS SQIAKSPRRG GERERDPGRK AHHGHPKATG
     SAGDLLERQE RQRMEAAGVA DLLLGGGVPG MPRPAHPPPI DLTELGISLD NICAGDKSIF
     GDTQTLTNSM PDMLLSKADD SHSYQSIDKI NLNSPSNSDL TQSTQELANE LELDNEPVRE
     LPHDGYEQLF ANNRNQEHPA EQYDDEQLDN RPMKEVRFHS VQDTMSRSKS YTDNSNARRR
     RRRRNQSRSS SEMQINQTNL RLHNAQTQVG TTPLNLLNNL DNCDVASICS TCSSSSSSDM
     DDYVYRLPAR KHYGGVRVAY VPNDALAYER KKKMAQDSSL APGAGNASVG GAPAIMHESK
     NCTIS
//