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Q9U1I1

- ESN_DROME

UniProt

Q9U1I1 - ESN_DROME

Protein

Protein espinas

Gene

esn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. dendrite self-avoidance Source: FlyBase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_184330. Asymmetric localization of PCP proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein espinas
    Gene namesi
    Name:esn
    ORF Names:CG43722
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0263934. esn.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 785785Protein espinasPRO_0000288827Add
    BLAST

    Proteomic databases

    PRIDEiQ9U1I1.

    Expressioni

    Gene expression databases

    BgeeiQ9U1I1.

    Interactioni

    Protein-protein interaction databases

    BioGridi72789. 16 interactions.
    MINTiMINT-279329.
    STRINGi7227.FBpp0088109.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9U1I1.
    SMRiQ9U1I1. Positions 244-426.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini135 – 243109PETPROSITE-ProRule annotationAdd
    BLAST
    Domaini242 – 30665LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini307 – 36761LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini368 – 43063LIM zinc-binding 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the prickle / espinas / testin family.Curated
    Contains 3 LIM zinc-binding domains.PROSITE-ProRule annotation
    Contains 1 PET domain.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG314122.
    GeneTreeiENSGT00550000074438.
    InParanoidiQ9U1I1.

    Family and domain databases

    Gene3Di2.10.110.10. 3 hits.
    InterProiIPR010442. PET_domain.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 2 hits.
    PF06297. PET. 1 hit.
    [Graphical view]
    SMARTiSM00132. LIM. 3 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 3 hits.
    PS51303. PET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9U1I1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQQAPQQQQH PHPPSSSYYT QTESELLQIE AGGTGLTFAS HSQRPESAIS    50
    QVASTAHLDV PSAASSGSGG SAVSGGSGGA PESAGRFVSP LQRRHCQPPS 100
    HLPLNSVASP LRTASYKSAA AVAGHGFHHS HHQQLDFQRN SQSDDDSGCA 150
    LEEYTWVPPG LRPDQVRLYF SQLPDDKVPY VNSPGEKYRV KQLLHQLPPQ 200
    DNEVRYCHSL SDEERKELRI FSAQRKREAL GRGAVRLLSD ERPCKGCEEP 250
    LSGGDIVVFA QRLGAQLCWH PGCFVCSVCK ELLVDLIYFQ RDGNLYCGRH 300
    HAETQKPRCS ACDEIIFSDE CTEAEGRTWH MKHFACQECE HQLGGQRYIM 350
    REGKPYCLAC FDTMFAEYCD YCGEVIGVDQ GQMSHDGQHW HATDQCFSCC 400
    TCRCSLLGRP FLPRRGTIYC SIACSKGEPP TPSDTSSGPQ LRPTHRASTS 450
    SQIAKSPRRG GERERDPGRK AHHGHPKATG SAGDLLERQE RQRMEAAGVA 500
    DLLLGGGVPG MPRPAHPPPI DLTELGISLD NICAGDKSIF GDTQTLTNSM 550
    PDMLLSKADD SHSYQSIDKI NLNSPSNSDL TQSTQELANE LELDNEPVRE 600
    LPHDGYEQLF ANNRNQEHPA EQYDDEQLDN RPMKEVRFHS VQDTMSRSKS 650
    YTDNSNARRR RRRRNQSRSS SEMQINQTNL RLHNAQTQVG TTPLNLLNNL 700
    DNCDVASICS TCSSSSSSDM DDYVYRLPAR KHYGGVRVAY VPNDALAYER 750
    KKKMAQDSSL APGAGNASVG GAPAIMHESK NCTIS 785
    Length:785
    Mass (Da):86,608
    Last modified:May 1, 2000 - v1
    Checksum:i5EF4029A593EA70E
    GO

    Sequence cautioni

    The sequence AAM11251.1 differs from that shown. Reason: Frameshift at position 677.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251892 mRNA. Translation: CAB64381.1.
    AE013599 Genomic DNA. Translation: AAF59292.2.
    AY094898 mRNA. Translation: AAM11251.1. Frameshift.
    BT030763 mRNA. Translation: ABV82145.1.
    RefSeqiNP_524990.1. NM_080251.3.
    NP_724533.1. NM_165507.2.
    UniGeneiDm.1620.

    Genome annotation databases

    EnsemblMetazoaiFBtr0329856; FBpp0302894; FBgn0263934.
    FBtr0329857; FBpp0302895; FBgn0263934.
    GeneIDi53557.
    KEGGidme:Dmel_CG43722.
    UCSCiCG12833-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251892 mRNA. Translation: CAB64381.1 .
    AE013599 Genomic DNA. Translation: AAF59292.2 .
    AY094898 mRNA. Translation: AAM11251.1 . Frameshift.
    BT030763 mRNA. Translation: ABV82145.1 .
    RefSeqi NP_524990.1. NM_080251.3.
    NP_724533.1. NM_165507.2.
    UniGenei Dm.1620.

    3D structure databases

    ProteinModelPortali Q9U1I1.
    SMRi Q9U1I1. Positions 244-426.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 72789. 16 interactions.
    MINTi MINT-279329.
    STRINGi 7227.FBpp0088109.

    Proteomic databases

    PRIDEi Q9U1I1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0329856 ; FBpp0302894 ; FBgn0263934 .
    FBtr0329857 ; FBpp0302895 ; FBgn0263934 .
    GeneIDi 53557.
    KEGGi dme:Dmel_CG43722.
    UCSCi CG12833-RA. d. melanogaster.

    Organism-specific databases

    CTDi 53557.
    FlyBasei FBgn0263934. esn.

    Phylogenomic databases

    eggNOGi NOG314122.
    GeneTreei ENSGT00550000074438.
    InParanoidi Q9U1I1.

    Enzyme and pathway databases

    Reactomei REACT_184330. Asymmetric localization of PCP proteins.

    Miscellaneous databases

    GenomeRNAii 53557.
    NextBioi 841369.

    Gene expression databases

    Bgeei Q9U1I1.

    Family and domain databases

    Gene3Di 2.10.110.10. 3 hits.
    InterProi IPR010442. PET_domain.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 2 hits.
    PF06297. PET. 1 hit.
    [Graphical view ]
    SMARTi SM00132. LIM. 3 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 3 hits.
    PS51303. PET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs."
      Gubb D., Green C., Huen D., Coulson D., Johnson G., Tree D.R.P., Collier S., Roote J.
      Genes Dev. 13:2315-2327(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DP CN BW.
      Tissue: Embryo1 Publication.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley1 Publication.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: BerkeleyImported.
      Tissue: Embryo1 Publication.
    5. Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiESN_DROME
    AccessioniPrimary (citable) accession number: Q9U1I1
    Secondary accession number(s): A8E6H1, Q8SX20, Q9V4H9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3