Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9U1I1 (ESN_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein espinas
Gene names
Name:esn
ORF Names:CG12833
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›

Protein attributes

Sequence length785 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the prickle / espinas / testin family.

Contains 3 LIM zinc-binding domains.

Contains 1 PET domain.

Sequence caution

The sequence AAM11251.1 differs from that shown. Reason: Frameshift at position 677.

Ontologies

Keywords
   DomainLIM domain
Repeat
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdendrite self-avoidance

Inferred from mutant phenotype PubMed 21937715. Source: FlyBase

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 785785Protein espinas
PRO_0000288827

Regions

Domain135 – 243109PET
Domain242 – 30665LIM zinc-binding 1
Domain307 – 36761LIM zinc-binding 2
Domain368 – 43063LIM zinc-binding 3

Sequences

Sequence LengthMass (Da)Tools
Q9U1I1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 5EF4029A593EA70E

FASTA78586,608
        10         20         30         40         50         60 
MQQAPQQQQH PHPPSSSYYT QTESELLQIE AGGTGLTFAS HSQRPESAIS QVASTAHLDV 

        70         80         90        100        110        120 
PSAASSGSGG SAVSGGSGGA PESAGRFVSP LQRRHCQPPS HLPLNSVASP LRTASYKSAA 

       130        140        150        160        170        180 
AVAGHGFHHS HHQQLDFQRN SQSDDDSGCA LEEYTWVPPG LRPDQVRLYF SQLPDDKVPY 

       190        200        210        220        230        240 
VNSPGEKYRV KQLLHQLPPQ DNEVRYCHSL SDEERKELRI FSAQRKREAL GRGAVRLLSD 

       250        260        270        280        290        300 
ERPCKGCEEP LSGGDIVVFA QRLGAQLCWH PGCFVCSVCK ELLVDLIYFQ RDGNLYCGRH 

       310        320        330        340        350        360 
HAETQKPRCS ACDEIIFSDE CTEAEGRTWH MKHFACQECE HQLGGQRYIM REGKPYCLAC 

       370        380        390        400        410        420 
FDTMFAEYCD YCGEVIGVDQ GQMSHDGQHW HATDQCFSCC TCRCSLLGRP FLPRRGTIYC 

       430        440        450        460        470        480 
SIACSKGEPP TPSDTSSGPQ LRPTHRASTS SQIAKSPRRG GERERDPGRK AHHGHPKATG 

       490        500        510        520        530        540 
SAGDLLERQE RQRMEAAGVA DLLLGGGVPG MPRPAHPPPI DLTELGISLD NICAGDKSIF 

       550        560        570        580        590        600 
GDTQTLTNSM PDMLLSKADD SHSYQSIDKI NLNSPSNSDL TQSTQELANE LELDNEPVRE 

       610        620        630        640        650        660 
LPHDGYEQLF ANNRNQEHPA EQYDDEQLDN RPMKEVRFHS VQDTMSRSKS YTDNSNARRR 

       670        680        690        700        710        720 
RRRRNQSRSS SEMQINQTNL RLHNAQTQVG TTPLNLLNNL DNCDVASICS TCSSSSSSDM 

       730        740        750        760        770        780 
DDYVYRLPAR KHYGGVRVAY VPNDALAYER KKKMAQDSSL APGAGNASVG GAPAIMHESK 


NCTIS

« Hide

References

« Hide 'large scale' references
[1]"The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs."
Gubb D., Green C., Huen D., Coulson D., Johnson G., Tree D.R.P., Collier S., Roote J.
Genes Dev. 13:2315-2327(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: DP CN BW.
Tissue: Embryo.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[5]Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ251892 mRNA. Translation: CAB64381.1.
AE013599 Genomic DNA. Translation: AAF59292.2.
AY094898 mRNA. Translation: AAM11251.1. Frameshift.
BT030763 mRNA. Translation: ABV82145.1.
RefSeqNP_524990.1. NM_080251.3.
NP_724533.1. NM_165507.2.
UniGeneDm.1620.

3D structure databases

HSSPHSSP built from PDB template 1X4L based on UniProtKB Q14192.
ProteinModelPortalQ9U1I1.
SMRQ9U1I1. Positions 244-426.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-279329.
STRING7227.FBpp0088109.

Proteomic databases

PRIDEQ9U1I1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0329856; FBpp0302894; FBgn0263934.
FBtr0329857; FBpp0302895; FBgn0263934.
GeneID53557.
KEGGdme:Dmel_CG12833.
UCSCCG12833-RA. d. melanogaster.

Organism-specific databases

CTD53557.
FlyBaseFBgn0028642. esn.

Phylogenomic databases

eggNOGNOG314122.
GeneTreeENSGT00550000074438.
InParanoidQ9U1I1.
KOK04511.
OMATHRASTS.
OrthoDBEOG4T1G2F.
PhylomeDBQ9U1I1.

Gene expression databases

BgeeQ9U1I1.

Family and domain databases

Gene3D2.10.110.10. 3 hits.
InterProIPR010442. PET_domain.
IPR001781. Znf_LIM.
[Graphical view]
PfamPF00412. LIM. 2 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTSM00132. LIM. 3 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi53557.
NextBio841369.

Entry information

Entry nameESN_DROME
AccessionPrimary (citable) accession number: Q9U1I1
Secondary accession number(s): A8E6H1, Q8SX20, Q9V4H9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 2000
Last modified: May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents