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Q9U1I1

- ESN_DROME

UniProt

Q9U1I1 - ESN_DROME

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Protein

Protein espinas

Gene
esn, CG43722
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. dendrite self-avoidance Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_184330. Asymmetric localization of PCP proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein espinas
Gene namesi
Name:esn
ORF Names:CG43722
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0263934. esn.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 785785Protein espinasPRO_0000288827Add
BLAST

Proteomic databases

PRIDEiQ9U1I1.

Expressioni

Gene expression databases

BgeeiQ9U1I1.

Interactioni

Protein-protein interaction databases

BioGridi72789. 16 interactions.
MINTiMINT-279329.
STRINGi7227.FBpp0088109.

Structurei

3D structure databases

ProteinModelPortaliQ9U1I1.
SMRiQ9U1I1. Positions 244-426.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini135 – 243109PETAdd
BLAST
Domaini242 – 30665LIM zinc-binding 1Add
BLAST
Domaini307 – 36761LIM zinc-binding 2Add
BLAST
Domaini368 – 43063LIM zinc-binding 3Add
BLAST

Sequence similaritiesi

Contains 1 PET domain.

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG314122.
GeneTreeiENSGT00550000074438.
InParanoidiQ9U1I1.

Family and domain databases

Gene3Di2.10.110.10. 3 hits.
InterProiIPR010442. PET_domain.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U1I1-1 [UniParc]FASTAAdd to Basket

« Hide

MQQAPQQQQH PHPPSSSYYT QTESELLQIE AGGTGLTFAS HSQRPESAIS    50
QVASTAHLDV PSAASSGSGG SAVSGGSGGA PESAGRFVSP LQRRHCQPPS 100
HLPLNSVASP LRTASYKSAA AVAGHGFHHS HHQQLDFQRN SQSDDDSGCA 150
LEEYTWVPPG LRPDQVRLYF SQLPDDKVPY VNSPGEKYRV KQLLHQLPPQ 200
DNEVRYCHSL SDEERKELRI FSAQRKREAL GRGAVRLLSD ERPCKGCEEP 250
LSGGDIVVFA QRLGAQLCWH PGCFVCSVCK ELLVDLIYFQ RDGNLYCGRH 300
HAETQKPRCS ACDEIIFSDE CTEAEGRTWH MKHFACQECE HQLGGQRYIM 350
REGKPYCLAC FDTMFAEYCD YCGEVIGVDQ GQMSHDGQHW HATDQCFSCC 400
TCRCSLLGRP FLPRRGTIYC SIACSKGEPP TPSDTSSGPQ LRPTHRASTS 450
SQIAKSPRRG GERERDPGRK AHHGHPKATG SAGDLLERQE RQRMEAAGVA 500
DLLLGGGVPG MPRPAHPPPI DLTELGISLD NICAGDKSIF GDTQTLTNSM 550
PDMLLSKADD SHSYQSIDKI NLNSPSNSDL TQSTQELANE LELDNEPVRE 600
LPHDGYEQLF ANNRNQEHPA EQYDDEQLDN RPMKEVRFHS VQDTMSRSKS 650
YTDNSNARRR RRRRNQSRSS SEMQINQTNL RLHNAQTQVG TTPLNLLNNL 700
DNCDVASICS TCSSSSSSDM DDYVYRLPAR KHYGGVRVAY VPNDALAYER 750
KKKMAQDSSL APGAGNASVG GAPAIMHESK NCTIS 785
Length:785
Mass (Da):86,608
Last modified:May 1, 2000 - v1
Checksum:i5EF4029A593EA70E
GO

Sequence cautioni

The sequence AAM11251.1 differs from that shown. Reason: Frameshift at position 677.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ251892 mRNA. Translation: CAB64381.1.
AE013599 Genomic DNA. Translation: AAF59292.2.
AY094898 mRNA. Translation: AAM11251.1. Frameshift.
BT030763 mRNA. Translation: ABV82145.1.
RefSeqiNP_524990.1. NM_080251.3.
NP_724533.1. NM_165507.2.
UniGeneiDm.1620.

Genome annotation databases

EnsemblMetazoaiFBtr0329856; FBpp0302894; FBgn0263934.
FBtr0329857; FBpp0302895; FBgn0263934.
GeneIDi53557.
KEGGidme:Dmel_CG43722.
UCSCiCG12833-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ251892 mRNA. Translation: CAB64381.1 .
AE013599 Genomic DNA. Translation: AAF59292.2 .
AY094898 mRNA. Translation: AAM11251.1 . Frameshift.
BT030763 mRNA. Translation: ABV82145.1 .
RefSeqi NP_524990.1. NM_080251.3.
NP_724533.1. NM_165507.2.
UniGenei Dm.1620.

3D structure databases

ProteinModelPortali Q9U1I1.
SMRi Q9U1I1. Positions 244-426.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 72789. 16 interactions.
MINTi MINT-279329.
STRINGi 7227.FBpp0088109.

Proteomic databases

PRIDEi Q9U1I1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0329856 ; FBpp0302894 ; FBgn0263934 .
FBtr0329857 ; FBpp0302895 ; FBgn0263934 .
GeneIDi 53557.
KEGGi dme:Dmel_CG43722.
UCSCi CG12833-RA. d. melanogaster.

Organism-specific databases

CTDi 53557.
FlyBasei FBgn0263934. esn.

Phylogenomic databases

eggNOGi NOG314122.
GeneTreei ENSGT00550000074438.
InParanoidi Q9U1I1.

Enzyme and pathway databases

Reactomei REACT_184330. Asymmetric localization of PCP proteins.

Miscellaneous databases

GenomeRNAii 53557.
NextBioi 841369.

Gene expression databases

Bgeei Q9U1I1.

Family and domain databases

Gene3Di 2.10.110.10. 3 hits.
InterProi IPR010442. PET_domain.
IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00412. LIM. 2 hits.
PF06297. PET. 1 hit.
[Graphical view ]
SMARTi SM00132. LIM. 3 hits.
[Graphical view ]
PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs."
    Gubb D., Green C., Huen D., Coulson D., Johnson G., Tree D.R.P., Collier S., Roote J.
    Genes Dev. 13:2315-2327(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DP CN BW.
    Tissue: Embryo.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiESN_DROME
AccessioniPrimary (citable) accession number: Q9U1I1
Secondary accession number(s): A8E6H1, Q8SX20, Q9V4H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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