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Protein

Protein espinas

Gene

esn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • dendrite self-avoidance Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-4608870. Asymmetric localization of PCP proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein espinas
Gene namesi
Name:esn
ORF Names:CG43722
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0263934. esn.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888271 – 785Protein espinasAdd BLAST785

Proteomic databases

PaxDbiQ9U1I1.
PRIDEiQ9U1I1.

Expressioni

Gene expression databases

BgeeiFBgn0263934.
GenevisibleiQ9U1I1. DM.

Interactioni

Protein-protein interaction databases

BioGridi72789. 34 interactors.
MINTiMINT-279329.
STRINGi7227.FBpp0302896.

Structurei

3D structure databases

ProteinModelPortaliQ9U1I1.
SMRiQ9U1I1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 243PETPROSITE-ProRule annotationAdd BLAST109
Domaini242 – 306LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST65
Domaini307 – 367LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini368 – 430LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the prickle / espinas / testin family.Curated
Contains 3 LIM zinc-binding domains.PROSITE-ProRule annotation
Contains 1 PET domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1704. Eukaryota.
ENOG410XP0W. LUCA.
GeneTreeiENSGT00550000074438.
InParanoidiQ9U1I1.
OrthoDBiEOG091G07C5.

Family and domain databases

CDDicd09415. LIM1_Prickle. 1 hit.
cd09418. LIM2_Prickle. 1 hit.
cd09420. LIM3_Prickle. 1 hit.
cd09827. PET_Prickle. 1 hit.
Gene3Di2.10.110.10. 3 hits.
InterProiIPR033725. LIM1_prickle.
IPR033726. LIM2_prickle.
IPR033727. LIM3_prickle.
IPR010442. PET_domain.
IPR033723. PET_prickle.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9U1I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQAPQQQQH PHPPSSSYYT QTESELLQIE AGGTGLTFAS HSQRPESAIS
60 70 80 90 100
QVASTAHLDV PSAASSGSGG SAVSGGSGGA PESAGRFVSP LQRRHCQPPS
110 120 130 140 150
HLPLNSVASP LRTASYKSAA AVAGHGFHHS HHQQLDFQRN SQSDDDSGCA
160 170 180 190 200
LEEYTWVPPG LRPDQVRLYF SQLPDDKVPY VNSPGEKYRV KQLLHQLPPQ
210 220 230 240 250
DNEVRYCHSL SDEERKELRI FSAQRKREAL GRGAVRLLSD ERPCKGCEEP
260 270 280 290 300
LSGGDIVVFA QRLGAQLCWH PGCFVCSVCK ELLVDLIYFQ RDGNLYCGRH
310 320 330 340 350
HAETQKPRCS ACDEIIFSDE CTEAEGRTWH MKHFACQECE HQLGGQRYIM
360 370 380 390 400
REGKPYCLAC FDTMFAEYCD YCGEVIGVDQ GQMSHDGQHW HATDQCFSCC
410 420 430 440 450
TCRCSLLGRP FLPRRGTIYC SIACSKGEPP TPSDTSSGPQ LRPTHRASTS
460 470 480 490 500
SQIAKSPRRG GERERDPGRK AHHGHPKATG SAGDLLERQE RQRMEAAGVA
510 520 530 540 550
DLLLGGGVPG MPRPAHPPPI DLTELGISLD NICAGDKSIF GDTQTLTNSM
560 570 580 590 600
PDMLLSKADD SHSYQSIDKI NLNSPSNSDL TQSTQELANE LELDNEPVRE
610 620 630 640 650
LPHDGYEQLF ANNRNQEHPA EQYDDEQLDN RPMKEVRFHS VQDTMSRSKS
660 670 680 690 700
YTDNSNARRR RRRRNQSRSS SEMQINQTNL RLHNAQTQVG TTPLNLLNNL
710 720 730 740 750
DNCDVASICS TCSSSSSSDM DDYVYRLPAR KHYGGVRVAY VPNDALAYER
760 770 780
KKKMAQDSSL APGAGNASVG GAPAIMHESK NCTIS
Length:785
Mass (Da):86,608
Last modified:May 1, 2000 - v1
Checksum:i5EF4029A593EA70E
GO

Sequence cautioni

The sequence AAM11251 differs from that shown. Reason: Frameshift at position 677.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251892 mRNA. Translation: CAB64381.1.
AE013599 Genomic DNA. Translation: AAF59292.2.
AY094898 mRNA. Translation: AAM11251.1. Frameshift.
BT030763 mRNA. Translation: ABV82145.1.
RefSeqiNP_524990.1. NM_080251.4.
NP_724533.1. NM_165507.2.
UniGeneiDm.1620.

Genome annotation databases

EnsemblMetazoaiFBtr0329856; FBpp0302894; FBgn0263934.
FBtr0329857; FBpp0302895; FBgn0263934.
GeneIDi53557.
KEGGidme:Dmel_CG43722.
UCSCiCG12833-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251892 mRNA. Translation: CAB64381.1.
AE013599 Genomic DNA. Translation: AAF59292.2.
AY094898 mRNA. Translation: AAM11251.1. Frameshift.
BT030763 mRNA. Translation: ABV82145.1.
RefSeqiNP_524990.1. NM_080251.4.
NP_724533.1. NM_165507.2.
UniGeneiDm.1620.

3D structure databases

ProteinModelPortaliQ9U1I1.
SMRiQ9U1I1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi72789. 34 interactors.
MINTiMINT-279329.
STRINGi7227.FBpp0302896.

Proteomic databases

PaxDbiQ9U1I1.
PRIDEiQ9U1I1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0329856; FBpp0302894; FBgn0263934.
FBtr0329857; FBpp0302895; FBgn0263934.
GeneIDi53557.
KEGGidme:Dmel_CG43722.
UCSCiCG12833-RA. d. melanogaster.

Organism-specific databases

CTDi53557.
FlyBaseiFBgn0263934. esn.

Phylogenomic databases

eggNOGiKOG1704. Eukaryota.
ENOG410XP0W. LUCA.
GeneTreeiENSGT00550000074438.
InParanoidiQ9U1I1.
OrthoDBiEOG091G07C5.

Enzyme and pathway databases

ReactomeiR-DME-4608870. Asymmetric localization of PCP proteins.

Miscellaneous databases

ChiTaRSiesn. fly.
GenomeRNAii53557.
PROiQ9U1I1.

Gene expression databases

BgeeiFBgn0263934.
GenevisibleiQ9U1I1. DM.

Family and domain databases

CDDicd09415. LIM1_Prickle. 1 hit.
cd09418. LIM2_Prickle. 1 hit.
cd09420. LIM3_Prickle. 1 hit.
cd09827. PET_Prickle. 1 hit.
Gene3Di2.10.110.10. 3 hits.
InterProiIPR033725. LIM1_prickle.
IPR033726. LIM2_prickle.
IPR033727. LIM3_prickle.
IPR010442. PET_domain.
IPR033723. PET_prickle.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESN_DROME
AccessioniPrimary (citable) accession number: Q9U1I1
Secondary accession number(s): A8E6H1, Q8SX20, Q9V4H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.