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Protein

Protein espinas

Gene

esn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • dendrite self-avoidance Source: FlyBase

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-4608870 Asymmetric localization of PCP proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Protein espinas
Gene namesi
Name:esn
ORF Names:CG43722
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0263934 esn

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888271 – 785Protein espinasAdd BLAST785

Proteomic databases

PaxDbiQ9U1I1
PRIDEiQ9U1I1

Expressioni

Gene expression databases

BgeeiFBgn0263934
ExpressionAtlasiQ9U1I1 baseline and differential
GenevisibleiQ9U1I1 DM

Interactioni

Protein-protein interaction databases

BioGridi72789, 35 interactors
STRINGi7227.FBpp0302896

Structurei

3D structure databases

ProteinModelPortaliQ9U1I1
SMRiQ9U1I1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 243PETPROSITE-ProRule annotationAdd BLAST109
Domaini242 – 306LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST65
Domaini307 – 367LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini368 – 430LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the prickle / espinas / testin family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00550000074438
InParanoidiQ9U1I1
KOiK04511
OMAiHNAQTQA
OrthoDBiEOG091G07C5

Family and domain databases

CDDicd09415 LIM1_Prickle, 1 hit
cd09418 LIM2_Prickle, 1 hit
cd09420 LIM3_Prickle, 1 hit
cd09827 PET_Prickle, 1 hit
InterProiView protein in InterPro
IPR033725 LIM1_prickle
IPR033726 LIM2_prickle
IPR033727 LIM3_prickle
IPR010442 PET_domain
IPR033723 PET_prickle
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
PF06297 PET, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 3 hits
PS51303 PET, 1 hit

Sequencei

Sequence statusi: Complete.

Q9U1I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQAPQQQQH PHPPSSSYYT QTESELLQIE AGGTGLTFAS HSQRPESAIS
60 70 80 90 100
QVASTAHLDV PSAASSGSGG SAVSGGSGGA PESAGRFVSP LQRRHCQPPS
110 120 130 140 150
HLPLNSVASP LRTASYKSAA AVAGHGFHHS HHQQLDFQRN SQSDDDSGCA
160 170 180 190 200
LEEYTWVPPG LRPDQVRLYF SQLPDDKVPY VNSPGEKYRV KQLLHQLPPQ
210 220 230 240 250
DNEVRYCHSL SDEERKELRI FSAQRKREAL GRGAVRLLSD ERPCKGCEEP
260 270 280 290 300
LSGGDIVVFA QRLGAQLCWH PGCFVCSVCK ELLVDLIYFQ RDGNLYCGRH
310 320 330 340 350
HAETQKPRCS ACDEIIFSDE CTEAEGRTWH MKHFACQECE HQLGGQRYIM
360 370 380 390 400
REGKPYCLAC FDTMFAEYCD YCGEVIGVDQ GQMSHDGQHW HATDQCFSCC
410 420 430 440 450
TCRCSLLGRP FLPRRGTIYC SIACSKGEPP TPSDTSSGPQ LRPTHRASTS
460 470 480 490 500
SQIAKSPRRG GERERDPGRK AHHGHPKATG SAGDLLERQE RQRMEAAGVA
510 520 530 540 550
DLLLGGGVPG MPRPAHPPPI DLTELGISLD NICAGDKSIF GDTQTLTNSM
560 570 580 590 600
PDMLLSKADD SHSYQSIDKI NLNSPSNSDL TQSTQELANE LELDNEPVRE
610 620 630 640 650
LPHDGYEQLF ANNRNQEHPA EQYDDEQLDN RPMKEVRFHS VQDTMSRSKS
660 670 680 690 700
YTDNSNARRR RRRRNQSRSS SEMQINQTNL RLHNAQTQVG TTPLNLLNNL
710 720 730 740 750
DNCDVASICS TCSSSSSSDM DDYVYRLPAR KHYGGVRVAY VPNDALAYER
760 770 780
KKKMAQDSSL APGAGNASVG GAPAIMHESK NCTIS
Length:785
Mass (Da):86,608
Last modified:May 1, 2000 - v1
Checksum:i5EF4029A593EA70E
GO

Sequence cautioni

The sequence AAM11251 differs from that shown. Reason: Frameshift at position 677.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251892 mRNA Translation: CAB64381.1
AE013599 Genomic DNA Translation: AAF59292.2
AY094898 mRNA Translation: AAM11251.1 Frameshift.
BT030763 mRNA Translation: ABV82145.1
RefSeqiNP_524990.1, NM_080251.4
NP_724533.1, NM_165507.2
UniGeneiDm.1620

Genome annotation databases

EnsemblMetazoaiFBtr0329856; FBpp0302894; FBgn0263934
FBtr0329857; FBpp0302895; FBgn0263934
FBtr0329858; FBpp0302896; FBgn0263934
GeneIDi53557
KEGGidme:Dmel_CG43722
UCSCiCG12833-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiESN_DROME
AccessioniPrimary (citable) accession number: Q9U1I1
Secondary accession number(s): A8E6H1, Q8SX20, Q9V4H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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