Q9TZZ2 (ALL2_EURMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mite group 2 allergen Eur m 2

Alternative name(s):
Allergen=Eur m 2

Gene names

Name:

EURM2

Organism

Euroglyphus maynei (Mayne's house dust mite)

Taxonomic identifier

6958 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Acariformes › Sarcoptiformes › Astigmata › Psoroptidia › Analgoidea › Pyroglyphidae › Pyroglyphinae › Euroglyphus

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted By similarity.
Polymorphism	The sequence shown is that of isoform Eur m 2.0101.
Allergenic properties	Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
Sequence similarities	Belongs to the NPC2 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Disease	Allergen
Domain	Signal
PTM	Disulfide bond
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 145	129	Mite group 2 allergen Eur m 2		PRO_0000019862
Amino acid modifications
	Disulfide bond	24 ↔ 135		By similarity
	Disulfide bond	37 ↔ 43		By similarity
	Disulfide bond	89 ↔ 94		By similarity
Natural variations
	Natural variant	21	1	I → V in Eur m 2 0102.

Sequences

	Sequence		Length	Mass (Da)
	Q9TZZ2 [UniParc]. Last modified June 20, 2001. Version 2. Checksum: 6655B16C8503A565	FASTA	145	15,747
	10 20 30 40 50 60 MYKILCLSLL VAAVAADQVD IKDCANHEIK KVMVPGCKGS EPCVIHRGTA FQLEAVFDAN 70 80 90 100 110 120 QNSNAAKIEI KATIDGVEID VPGIDNNLCH FMKCPLVKGQ EYDIKYTWNV PRIAPKSENV 130 140 VVTVKLLGDN GVLACAIATH AKIRD

References

[1]	"Molecular analysis of the group 1 and 2 allergens from the house dust mite, Euroglyphus maynei." Smith W., Mills K., Hazell L., Hart B.J., Thomas W. Int. Arch. Allergy Immunol. 118:15-22(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF047613 mRNA. Translation: AAC82349.1. AF047614 mRNA. Translation: AAC82350.1.
3D structure databases
ProteinModelPortal	Q9TZZ2.
SMR	Q9TZZ2. Positions 18-145.
ModBase	Search...
Protein family/group databases
Allergome	340. Eur m 2. 341. Eur m 2.0101. 342. Eur m 2.0102.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.60.40.770. 1 hit.
InterPro	IPR014756. Ig_E-set. IPR003172. MD-2_lipid-recog_dom. [Graphical view]
Pfam	PF02221. E1_DerP2_DerF2. 1 hit. [Graphical view]
SMART	SM00737. ML. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ALL2_EURMA

Accession

Primary (citable) accession number: Q9TZZ2
Secondary accession number(s): O96430

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	June 20, 2001
Last modified:	May 1, 2013
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)